Scientific Publications
Every year Maurice Wilkins Centre investigators produce a large number of peer-reviewed scientific papers and reviews published in international journals. Research directly supported by the Maurice Wilkins Centre generated the following scientific papers.
2023
Ahangarpour, M., Kavianinia, I. & Brimble, M. A. (2023). Thia-Michael addition: the route to promising opportunities for fast and cysteine-specific modification. Organic and Biomolecular Chemistry 21(15): 3057-3072. https://doi.org/10.1039/D2OB02262A
Alexander, T. I., Tasma, Z., Siow, A., Rees, T. A., Brimble, M. A., Harris, P. W. R., Hay, D. L. & Walker, C. S. (2023). Novel fluorescently labeled PACAP and VIP highlight differences between peptide internalization and receptor pharmacology. ACS Pharmacology and Translational Science 6(1): 52-64. https://doi.org/10.1021/acsptsci.2c00124
Bai, Y., Jiao, W., Vörster, J. & Parker, E. J. (2023). Conformational interdomain flexibility in a bacterial α-isopropylmalate synthase is necessary for leucine biosynthesis. Journal of Biological Chemistry 299(2). https://doi.org/10.1016/j.jbc.2022.102789
Baleivanualala, S. C., Isaia, L., Devi, S. V., Howden, B., Gorrie, C. L., Matanitobua, S., Sharma, S., Wilson, D., Kumar, S., Maharaj, K., Beatson, S., Boseiwaqa, L. V., Dyet, K., Crump, J. A., Hill, P. C. & Ussher, J. E. (2023). Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii ST2 in Oceania: a multicountry cohort study. The Lancet Regional Health - Western Pacific 40. https://doi.org/10.1016/j.lanwpc.2023.100896
Boer, G. A., Hay, D. L. & Tups, A. (2023). Obesity pharmacotherapy: incretin action in the central nervous system. Trends in Pharmacological Sciences 44(1): 50-63. https://doi.org/10.1016/j.tips.2022.11.001
Boss, A. L., Chamley, L. W., Brooks, A. E. S. & James, J. L. (2023). Human placental vascular and perivascular cell heterogeneity differs between first trimester and term, and in pregnancies affected by foetal growth restriction. Molecular Human Reproduction 29(12). https://doi.org/10.1093/molehr/gaad041
Brandon, R., Jiang, Y., Yeu, R. Q., Tweedie-Cullen, R., Smallman, K., Doherty, G., Macaskill-Smith, K. A., Doran, R. J., Clark, P., Moffitt, A., Merry, T., Nehren, N., King, F., Hindmarsh, J. H., Leask, M. P., Merriman, T. R., Orr-Walker, B., Shepherd, P. R., Paul, R. & Murphy, R. (2023). Stratified glucose-lowering response to vildagliptin and pioglitazone by obesity and hypertriglyceridemia in a randomized crossover trial. Frontiers in Endocrinology 13. https://doi.org/10.3389/fendo.2022.1091421
Brown, R. S. E., Jacobs, I. M., Khant Aung, Z., Knowles, P. J., Grattan, D. R. & Ladyman, S. R. (2023). High fat diet-induced maternal obesity in mice impairs peripartum maternal behaviour. Journal of Neuroendocrinology 35(12) e13350. https://doi.org/10.1111/jne.13350
Cooney, T. R., Farrand, K., Draper, S. L., Anderson, R. J., Rendle, P. M., Hermans, I. F., Compton, B. J. & Painter, G. F. (2023). Synthesis and biological evaluation of peptide-adjuvant conjugate vaccines with increasing antigen content. Bioconjugate Chemistry 34(4): 799-808. https://doi.org/10.1021/acs.bioconjchem.3c00106
Dasyam, N., Sharples, K. J., Barrow, C., Huang, Y., Bauer, E., Mester, B., Wood, C. E., Authier-Hall, A., Dzhelali, M., Ostapowicz, T., Kumar, R., Lowe, J., Maxwell, A., Burn, O. K., Williams, G. M., Carley, S. E., Caygill, G., Jones, J., Chan, S. T. S., Hinder, V. A., Macapagal, J., McCusker, M., Weinkove, R., Brimble, M. A., Painter, G. F., Findlay, M. P., Dunbar, P. R., Gasser, O. & Hermans, I. F. (2023). A randomised controlled trial of long NY-ESO-1 peptide-pulsed autologous dendritic cells with or without alpha-galactosylceramide in high-risk melanoma. Cancer Immunology, Immunotherapy 72(7): 2267-2282. https://doi.org/10.1007/s00262-023-03400-y
Ding, X. B., Wung, A., Furkert, D. P. & Brimble, M. A. (2023). Synthesis of the spiroimine fragment of portimines A and B. Organic and Biomolecular Chemistry 21(29): 6008-6017. https://doi.org/10.1039/D3OB00998J
Dissanayake, S., He, J., Yang, S. H., Brimble, M. A., Harris, P. W. R. & Cameron, A. J. (2023). Flow-based Fmoc-SPPS preparation and SAR study of Cathelicidin-PY reveals selective antimicrobial activity. Molecules 28(4). https://www.mdpi.com/1420-3049/28/4/1993#
Eiden, L. E., Grattan, D., Wang, X. D. & Zhang, L. (2023). Advances in peptide modulation in systems physiology. Journal of Neuroendocrinology 35(11) e13345. https://doi.org/10.1111/jne.13345
Eruera, A. R., McSweeney, A. M., McKenzie-Goldsmith, G. M., Opel-Reading, H. K., Thomas, S. X., Campbell, A. C., Stubbing, L., Siow, A., Hubert, J. G., Brimble, M. A., Ward, V. K. & Krause, K. L. (2023). Crystal structure of inhibitor-bound GII.4 sydney 2012 norovirus 3C-like protease. Viruses 15(11). https://doi.org/10.3390/v15112202
Feisst, V., Kelch, I., Dunn, E., Williams, E., Meidinger, S., Chen, C. J. J., Girvan, R., Zhou, L., Sheppard, H., Locke, M. & Dunbar, P. R. (2023). Rapid culture of human keratinocytes in an autologous, feeder-free system with a novel growth medium. Cytotherapy 25(2): 174-184. https://doi.org/10.1016/j.jcyt.2022.09.003
Fernando, S. J. A., Wang, Q., Hay, D. L., Bathgate, R. A. D., Shepherd, P. R. & Lee, K. L. (2023). Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin. Bioscience Reports 43(4). https://doi.org/10.1042/BSR20221956
Fitzgerald, S., Blenkiron, C., Stephens, R., Mathy, J. A., Somers-Edgar, T., Rolfe, G., Martin, R., Jackson, C., Eccles, M., Robb, T., Rodger, E., Lawrence, B., Guilford, P., Lasham, A. & Print, C. G. (2023). Dynamic ctDNA mutational complexity in patients with melanoma receiving immunotherapy. Molecular Diagnosis and Therapy 27(4): 537-550. https://doi.org/10.1007/s40291-023-00651-4
Gane, E. J., Dunbar, P. R., Brooks, A. E., Zhang, F., Chen, D., Wallin, J. J., van Buuren, N., Arora, P., Fletcher, S. P., Tan, S. K., Yang, J. C., Gaggar, A., Kottilil, S. & Tang, L. (2023). Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression. Journal of Hepatology 78(3): 513-523. https://doi.org/10.1016/j.jhep.2022.09.027
Ganley, M., Holz, L. E., Minnell, J. J., de Menezes, M. N., Burn, O. K., Poa, K. C. Y., Draper, S. L., English, K., Chan, S. T. S., Anderson, R. J., Compton, B. J., Marshall, A. J., Cozijnsen, A., Chua, Y. C., Ge, Z., Farrand, K. J., Mamum, J. C., Xu, C., Cockburn, I. A., Yui, K., Bertolino, P., Gras, S., Le Nours, J., Rossjohn, J., Fernandez-Ruiz, D., McFadden, G. I., Ackerley, D. F., Painter, G. F., Hermans, I. F. & Heath, W. R. (2023). mRNA vaccine against malaria tailored for liver-resident memory T cells. Nature Immunology 24(9): 1487-1498. https://doi.org/10.1038/s41590-023-01562-6
Garelja, M. L., Alexander, T. I., Bennie, A., Nimick, M., Petersen, J., Walker, C. S. & Hay, D. L. (2023). Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene-related peptide responsive receptors. British Journal of Pharmacology 181(1): 142-161. https://doi.org/10.1111/bph.16218
Goffin, V., Becu-Villalobos, D., Popovic, V. & Grattan, D. R. (2023). Editorial: Towards targeting prolactin signaling in human diseases: stimulate or inhibit? Frontiers in Endocrinology 14. https://doi.org/10.3389/fendo.2023.1213895
Harjes, E., Edwards, P. J. B., Bisset, S. W., Patchett, M. L., Jameson, G. B., Yang, S. H., Navo, C. D., Harris, P. W. R., Brimble, M. A. & Norris, G. E. (2023). NMR shows why a small chemical change almost abolishes the antimicrobial activity of Glycocin F. Biochemistry 62(17): 2669-2676. https://doi.org/10.1021/acs.biochem.3c00197
Harjes, S., Kurup, H. M., Rieffer, A. E., Bayarjargal, M., Filitcheva, J., Su, Y., Hale, T. K., Filichev, V. V., Harjes, E., Harris, R. S. & Jameson, G. B. (2023). Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nature Communications 14(1): 6382. https://doi.org/10.1101/2023.02.17.528918
Hedges, C. P., Shetty, B., Broome, S. C., MacRae, C., Koutsifeli, P., Buckels, E. J., MacIndoe, C., Boix, J., Tsiloulis, T., Matthews, B. G., Sinha, S., Arendse, M., Jaiswal, J. K., Mellor, K. M., Hickey, A. J. R., Shepherd, P. R. & Merry, T. L. (2023). Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice. Nature Aging 3(2): 162-172. https://doi.org/10.1038/s43587-022-00349-y
Hossain, S. M. & Eccles, M. R. (2023). Phenotype switching and the melanoma microenvironment; Impact on immunotherapy and drug resistance. International Journal of Molecular Sciences 24(2): 1601. https://doi.org/10.3390%2Fijms24021601
Kasim, J. K., Hong, J., Hickey, A. J. R., Phillips, A. R. J., Windsor, J. A., Harris, P. W. R., Brimble, M. A. & Kavianinia, I. (2023). The anti-tubercular aminolipopeptide trichoderin a displays selective toxicity against human pancreatic ductal adenocarcinoma cells cultured under glucose starvation. Pharmaceutics 15(1): 287. https://doi.org/10.3390/pharmaceutics15010287
Kotliar, I. B., Lorenzen, E., Schwenk, J. M., Hay, D. L. & Sakmar, T. P. (2023). Elucidating the interactome of G protein-coupled receptors and receptor activity-modifying proteins. Pharmacological Reviews 75(1): 1-34. https://doi.org/10.1124%2Fpharmrev.120.000180
Kurup, H. M., Kvach, M. V., Harjes, S., Jameson, G. B., Harjes, E. & Filichev, V. V. (2023). Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A. Organic and Biomolecular Chemistry 21(24): 5117-5128. https://doi.org/10.1039%2Fd3ob00392b
McGregor, R., Paterson, A., Sharma, P., Chen, T., Lovell, J. R., Carlton, L. H., Steer, A. C., Osowicki, J., Loh, J. M. S. & Moreland, N. J. (2023). Naturally acquired functional antibody responses to group A Streptococcus differ between major strain types. mSphere 8(5): e0017923. https://doi.org/10.1128/msphere.00179-23
Moors, J., Krishnan, M., Sumpter, N., Takei, R., Bixley, M., Cadzow, M., Major, T. J., Phipps-Green, A., Topless, R., Merriman, M., Rutledge, M., Morgan, B., Carlson, J. C., Zhang, J. Z., Russell, E. M., Sun, G., Cheng, H., Weeks, D. E., Naseri, T., Reupena, M. S., Viali, S., Tuitele, J., Hawley, N. L., Deka, R., McGarvey, S. T., de Zoysa, J., Murphy, R., Dalbeth, N., Stamp, L., Taumoepeau, M., King, F., Wilcox, P., Rapana, N., McCormick, S., Minster, R. L., Merriman, T. R. & Leask, M. (2023). A Polynesian-specific missense CETP variant alters the lipid profile. Human Genetics and Genomics Advances 4(3): 100204. https://doi.org/10.1016%2Fj.xhgg.2023.100204
Palpal-Latoc, D., Brimble, M. A., Harris, P. W. R. & Horsfall, A. J. (2023). Factors influencing on-resin depsipeptide bond formation: case studies on daptomycin- and brevicidine-derived sequences. Organic and Biomolecular Chemistry 19. https://doi.org/10.1039/D3OB00360D
Park, S. M., Chen, C. J. J., Mathy, J. E., Lin, S. C. Y., Martin, R. C. W., Mathy, J. A., Shaw, J. H. F. & Dunbar, P. R. (2023). Seven-colour multiplex immunochemistry/immunofluorescence and whole slide imaging of frozen sections. Journal of Immunological Methods 518. https://doi.org/10.1016/j.jim.2023.113490
Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., Bender, J., Burgess, E. J., Boer, G. A., Keerthisinghe, P., Perry, N. B. & Tups, A. (2023). A dahlia flower extract has antidiabetic properties by improving insulin function in the brain. Life Metabolism 2(4). https://doi.org/10.1093/lifemeta/load026
Raynes, J. M., Young, P. G., Lorenz, N., Loh, J. M. S., McGregor, R., Baker, E. N., Proft, T. & Moreland, N. J. (2023). Identification of an immunodominant region on a group A Streptococcus T-antigen reveals temperature-dependent motion in pili. Virulence 14(1). https://doi.org/10.1080/21505594.2023.2180228
Rees, T. A., Hay, D. L. & Walker, C. S. (2023). Comment on Yoo et al. Amylin protein expression in the rat brain and neuro-2a cells. Int. J. Mol. Sci. 2022, 23, 4348. International Journal of Molecular Sciences 24(2): 1058. https://doi.org/10.3390%2Fijms24021058
Rizwan, M. Z., Kerbus, R., Kamstra, K., Keerthisinghe, P. & Tups, A. (2023). Dietary wheat gluten induces astro- and microgliosis in the hypothalamus of male mice. Journal of Neuroendocrinology 35(8). https://doi.org/10.1111/jne.13326
Robb, T. J., Ward, Z., Houseman, P., Woodhouse, B., Patel, R., Fitzgerald, S., Tsai, P., Lawrence, B., Parker, K., Print, C. G. & Blenkiron, C. (2023). Chromosomal aberrations accumulate during metastasis of virus-negative merkel cell carcinoma. Journal of Investigative Dermatology 143(7): 1168-1177.e1162. https://doi.org/10.1016/j.jid.2023.01.015
Rodger, E. J., Gimenez, G., Ajithkumar, P., Stockwell, P. A., Almomani, S., Bowden, S. A., Leichter, A. L., Ahn, A., Pattison, S., McCall, J. L., Schmeier, S., Frizelle, F. A., Eccles, M. R., Purcell, R. V. & Chatterjee, A. (2023). An epigenetic signature of advanced colorectal cancer metastasis. iScience 26(6): 106986. https://doi.org/10.1016/j.isci.2023.106986
Sander, V., Przepiorski, A., Hukriede, N. A. & Davidson, A. J. (2023). Large-scale production of kidney organoids from human pluripotent stem cells. Methods in Molecular Biology. 2664: 69-83. https://doi.org/10.1007/978-1-0716-3179-9_6
Scully, T. W., Jiao, W., Mittelstädt, G. & Parker, E. J. (2023). Structure, mechanism and inhibition of anthranilate phosphoribosyltransferase. Philosophical Transactions of the Royal Society B: Biological Sciences 378(1871). https://doi.org/10.1098/rstb.2022.0039
Stanborough, T., Ho, N. A. T., Bulloch, E. M. M., Bashiri, G., Dawes, S. S., Akazong, E. W., Titterington, J., Allison, T. M., Jiao, W. & Johnston, J. M. (2023). Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway. Philosophical Transactions of the Royal Society B: Biological Sciences 378(1871). https://doi.org/10.1098/rstb.2022.0035
Stubbing, L. A., Hubert, J. G., Bell-Tyrer, J., Hermant, Y. O., Yang, S. H., McSweeney, A. M., McKenzie-Goldsmith, G. M., Ward, V. K., Furkert, D. P. & Brimble, M. A. (2023). P1 Glutamine isosteres in the design of inhibitors of 3C/3CL protease of human viruses of the Pisoniviricetes class. RSC Chemical Biology 4(8): 533-547. https://doi.org/10.1039/D3CB00075C
Sullivan, M. P., Adams, M., Riisom, M., Herbert, C. D., Tong, K. K. H., Astin, J. W., Jamieson, S. M. F., Hanif, M., Goldstone, D. C. & Hartinger, C. G. (2023). Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo. Dalton Transactions 52(5): 1388-1392. https://doi.org/10.1039/D2DT02539F
Todd Rose, F. O., Darnell, R. L., Morris, S. M., Rose, O. E., Paxie, O., Campbell, G., Cook, G. M. & Gebhard, S. (2023). The two-component system CroRS acts as a master regulator of cell envelope homeostasis to confer antimicrobial tolerance in the bacterial pathogen Enterococcus faecalis. Molecular Microbiology 120(3): 408-424. https://doi.org/10.1111/mmi.15128
Toomata, Z., Leask, M., Krishnan, M., Cadzow, M., Dalbeth, N., Stamp, L. K., de Zoysa, J., Merriman, T., Wilcox, P., Dewes, O. & Murphy, R. (2023). Genetic testing for misclassified monogenic diabetes in Māori and Pacific peoples in Aōtearoa New Zealand with early-onset type 2 diabetes. Frontiers in Endocrinology 14: 1174699. https://doi.org/10.3389/fendo.2023.1174699
Walker, E., van Niekerk, S., Hanning, K., Kelton, W. & Hicks, J. (2023). Mechanisms of host manipulation by Neisseria gonorrhoeae. Frontiers in Microbiology 14. https://doi.org/10.3389/fmicb.2023.1119834
Waller, N. J. E., Cheung, C. Y., Cook, G. M. & McNeil, M. B. (2023). The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis. Nature Communications 14(1): 1517. https://doi.org/10.1038/s41467-023-37184-7