Scientific Publications

2010

Aitken, J. F., Loomes, K. M., Scott, D. W., Reddy, S., Phillips, A. R. J., Prijic, G., Fernando, C., Zhang, S., Broadhurst, R., L’Huillier, P., & Cooper, G. J. S. Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/ islet amyloid polypeptide transgenic mice. Diabetes (2010) 59(1): 161-171.

Atkinson, D. J., Sperry, J., & Brimble, M. A. Improved synthesis of the benzyne precursor 2-(trimethylsilyl) phenyl trifluoromethane sulfonate. Synthesis (2010) (6): 911- 913.

Bashiri, G., Rehan, A. M., Greenwood, D. R., Dickson, J. M. J., & Baker, E. N. Metabolic engineering of cofactor F420 production in mycobacterium smegmatis. PLoS ONE (2010) 5(12).

Brauer, R., Wang, L. C., Woon, S. T., Bridewell, D. J., Henare, K., Malinger, D., Palmer, B. D., Vogel, S. N., Kieda, C., Tijono, S. M., & Ching, L. M. Labeling of oxidizable proteins with a photoactivatable analog of the antitumor agent DMXAA: evidence for redox signaling in its mode of action. Neoplasia (2010) 12(9): 755-765.

Bogle, G., & Dunbar, P. R. Agent-based simulation of T-cell activation and proliferation within a lymph node. Immunology and Cell Biology (2010) 88(2): 172-179. [pdf]

 

Bogle, G. & Dunbar, P. R. T cell responses in lymph nodes. Wiley Interdisciplinary Reviews: Systems Biology & Medicine (2010) 2: 107-116.

Buchanan, C. M., Phillips, A. R. J., & Cooper, G. J. S. A novel two-chain IGF-II-derived peptide from purified b-cell granules. Growth Hormone and IGF Research (2010) 20(5): 360-366.

Chan, Y., Balle, J., Kevin Sparrow, J., Boyd, P. D. W., Brimble, M. A., & Barker, D. A double Mannich approach to the synthesis of substituted piperidones - Application to the synthesis of substituted E-ring analogues of methyllycaconitine. Tetrahedron (2010) 66(35): 7179-7191.

Chang, J. Y. C., Stevenson, R. J., Lu, G. L., Brothers, P. J., Clark, G. R., Denny, W. A., & Ware, D. C. Syntheses of 8-quinolinolatocobalt(III) complexes containing cyclen based auxiliary ligands as models for hypoxia-activated prodrugs. Dalton Transactions (2010) 39(48): 11535-11550.

Chen, J. L. Y., & Brimble, M. A. Synthesis of the bis-spiroacetal C25-C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence. Chemical Communications (2010) 46(22): 3967-3969. [pdf]

Chien, V., Aitken, J. F., Zhang, S., Buchanan, C. M., Hickey, A., Brittain, T., Cooper, G. J. S., & Loomes, K. M. The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of beta-sheet-containing aggregates by human amylin: A potential role for defective chaperone biology in Type 2 diabetes. Biochemical Journal (2010) 432(1): 113-121. [pdf]

Choi, P. J., Sperry, J., & Brimble, M. A. Heteroatom-directed reverse Wacker oxidations. Synthesis of the reported structure of (-)-herbaric acid. Journal of Organic Chemistry (2010) 75(21): 7388-7392. [pdf]

Cooper, G. J. S., Aitken, J. F., & Zhang, S. Is type 2 diabetes an amyloidosis and does it really matter (to patients)? Diabetologia (2010) 53(6): 1011-1016.

Denny, W. A. Hypoxia-activated prodrugs in cancer therapy: Progress to the clinic. Future Oncology (2010) 6(3): 419-428.

Denny, W. A., & Palmer, B. D. The nitroimidazooxazines (PA-824 and analogs): Structure-activity relationship and mechanistic studies. Future Medicinal Chemistry (2010) 2(8): 1295-1304. [pdf]

Garny, A., Cooper, J., & Hunter, P. J. Toward a VPH/Physiome ToolKit. Wiley Interdisciplinary Reviews. Systems Biology and Medicine (2010) 2(2): 134-147.

Gianni, D., McKeever, S., Yu, T., Britten, R., Delingette, H., Frangi, A., Hunter, P., & Smith, N. Sharing and reusing cardiovascular anatomical models over the Web: A step towards the implementation of the virtual physiological human project. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (2010) 368(1921): 3039-3056. [pdf]

Graham, E. S., Angel, C. E., Schwarcz, L. E., Dunbar, P. R., & Glass, M. Detailed characterisation of CB2 receptor protein expression in peripheral blood immune cells from healthy human volunteers using flow cytometry. International Journal of Immunopathology and Pharmacology (2010) 23(1): 25-34.

Grey, A., Chaussade, C., Empson, V., Lin, J. M., Watson, M., O’Sullivan, S., Rewcastle, G., Naot, D., Cornish, J., & Shepherd, P. Evidence for a role for the p110-alpha isoform of PI3K in skeletal function. Biochemical and Biophysical Research Communications (2010) 391(1): 564-569.

Guéret, S. M., Boyd, P. D. W., & Brimble, M. A. (1R,6R,13R,18R)-(Z,Z)-1,18-Bis[(4R)- 2,2-dimethyl-1,3-dioxolan-4-yl]-3, 16-dimethylene-8,20-diazadispiro-[5.6.5.6]tetracosa- 7,19-diene. Acta Crystallographica Section E: Structure Reports Online (2010) 66(7).

Guéret, S. M., & Brimble, M. A. Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: Isolation, structure, biological activity and synthesis. Natural Product Reports (2010) 27(9): 1350-1366.

Guéret, S. M., Furkert, D. P., & Brimble, M. A. Synthesis of a functionalized 7,6-bicyclic spiroimine ring fragment of the spirolides. Organic Letters (2010) 12(22): 5226-5229.

Harris, P. W., & Brimble, M. A. Toward the total chemical synthesis of the cancer protein NY-ESO-1. Biopolymers (2010) 94(4): 542-550. 

Hay, M. P., Turcotte, S., Flanagan, J. U., Bonnet, M., Chan, D. A., Sutphin, P. D., Nguyen, P., Giaccia, A. J., & Denny, W. A. 4-Pyridylanilinothiazoles that selectively target von Hippel - Lindau deficient renal cell carcinoma cells by inducing autophagic cell death. Journal of Medicinal Chemistry (2010) 53(2): 787-797.

Heapy, A. M., & Brimble, M. A. Synthesis of the FG ring fragment of pectenotoxins 1-9. Tetrahedron (2010) 66(29): 5424-5431.

Hicks, K. O., Siim, B. G., Jaiswal, J. K., Pruijn, F. B., Fraser, A. M., Patel, R., Hogg, A., Liyanage, H. D. S., Dorie, M. J., Brown, J. M., Denny, W. A., Hay, M. P., & Wilson, W. R. Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors. Clinical Cancer Research (2010) 16(20): 4946-4957.

Ho, H., Mithraratne, K., Schmid, H., Sands, G., & Hunter, P. Computer simulation of vertebral artery occlusion in endovascular procedures. International Journal of Computer Assisted Radiology and Surgery (2010) 5(1): 29-37. [pdf]

Hung, K. Y., Harris, P. W. R., & Brimble, M. A. Synthesis of methyl N-Boc-(2 S,4 R)-4- methylpipecolate. Journal of Organic Chemistry (2010) 75(24): 8728-8731.

Hunter, P., Coveney, P. V., De Bono, B., Diaz, V., Fenner, J., Frangi, A. F., Harris, P., Hose, R., Kohl, P., Lawford, P., McCormack, K., Mendes, M., Omholt, S., Quarteroni, A., Skår, J., Tegner, J., Thomas, S. R., Tollis, I., Tsamardinos, I., Van Beek, J. H. G. M., & Viceconti, M. A vision and strategy for the virtual physiological human in 2010 and beyond. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (2010) 368(1920): 2595-2614.

Jameson, M. B., Rischin, D., Pegram, M., Gutheil, J., Patterson, A. V., Denny, W. A., & Wilson, W. R. A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors. Cancer Chemotherapy and Pharmacology (2010) 65(4): 791-801.

Johnston, J. M., Jiang, M., Guo, Z., & Baker, E. N. Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: Testing a putative role in menaquinone biosynthesis. Acta Crystallographica Section D: Biological Crystallography (2010) 66(8): 909-917. [pdf]

Jongbloed, S. L., Kassianos, A. J., McDonald, K. J., Clark, G. J., Ju, X., Angel, C. E., Chen, C. J. J., Dunbar, P. R., Wadley, R. B., Jeet, V., Vulink, A. J. E., Hart, D. N. J., & Radford, K. J. Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. Journal of Experimental Medicine (2010) 207(6): 1247-1260.

Jor, J. W. Y., Nash, M. P., Nielsen, P. M. F., & Hunter, P. J. Estimating material parameters of a structurally based constitutive relation for skin mechanics. Biomechanics and Modeling in Mechanobiology (2010): 1-12. [pdf]

Jüllig, M., Chen, X., Middleditch, M. J., Vazhoor, G., Hickey, A. J., Gong, D., Lu, J., Zhang, S., Phillips, A. R. J., & Cooper, G. J. S. Illuminating the molecular basis of diabetic arteriopathy: A proteomic comparison of aortic tissue from diabetic and healthy rats. Proteomics (2010) 10(18): 3367-3378. [pdf]

Kenny, L. C., Broadhurst, D. I., Dunn, W., Brown, M., North, R. A., McCowan, L., Roberts, C., Cooper, G. J. S., Kell, D. B., & Baker, P. N. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension (2010) 56(4): 741-749.

 

Kim, N., Cannell, M. B., & Hunter, P. J. Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart. Progress in Biophysics and Molecular Biology (2010) 103(1): 28-34.

Kmentova, I., Sutherland, H. S., Palmer, B. D., Blaser, A., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., Denny, W. A., & Thompson, A. M. Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6 S)-2- nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H-imidazo[2,1-b][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2010) 53(23): 8421-8439.

Koch, C., Augustine, R. A., Steger, J., Ganjam, G. K., Benzler, J., Pracht, C., Lowe, C., Schwartz, M. W., Shepherd, P. R., Anderson, G. M., Grattan, D. R., & Tups, A. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. Journal of Neuroscience (2010) 30(48): 16180-16187.

Kolnes, A. J., Ingvaldsen, A., Bolling, A., Stuenæs, J. T., Kreft, M., Zorec, R., Shepherd, P. R., & Jensen, J. Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles. Acta Physiologica (2010) 200(1): 65-74.

Langley, R., Patel, D., Jackson, N., Clow, F., & Fraser, J. D. Staphylococcal superantigen super-domains in immune evasion. Critical Reviews in Immunology (2010) 30(2): 149-165.

Laursen, N. S., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Wines, B., Spillner, E., Christensen, J. B., Jensen, M., Fredslund, F., Bjerre, M., Sottrup-Jensen, L., Fraser, J. D., & Andersen, G. R. Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America (2010) 107(8): 3681-3686.

Lee, D. J., Harris, P. W. R., Kowalczyk, R., Dunbar, P. R., & Brimble, M. A. Microwaveassisted synthesis of fluorescein-labelled GalNAca1-O-Ser/ Thr (Tn) glycopeptides as immunological probes. Synthesis (2010) 5: 763-769.

 

Linke, C., Young, P. G., Kang, H. J., Bunker, R. D., Middleditch, M. J., Caradoc- Davies, T. T., Proft, T., & Baker, E. N. Crystal structure of the minor pilin FctB reveals determinants of group A streptococcal pilus anchoring. Journal of Biological Chemistry (2010) 285(26): 20381-20389.

Linke, C., Young, P. G., Kang, H. J., Proft, T., & Baker, E. N. Purification, crystallization and preliminary crystallographic analysis of the minor pilin FctB from Streptococcus pyogenes. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2010) 66(2): 177-179.

Lu, J., Gong, D., Choong, S. Y., Xu, H., Chan, Y. K., Chen, X., Fitzpatrick, S., Glyn- Jones, S., Zhang, S., Nakamura, T., Ruggiero, K., Obolonkin, V., Poppitt, S. D., Phillips, A. R. J., & Cooper, G. J. S. Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: Comparisons between triethylenetetramine and three less copper-selective transitionmetal- targeted treatments. Diabetologia (2010) 53(6): 1217-1226.

Lu, J., Poppitt, S. D., Othman, A. A., Sunderland, T., Ruggiero, K., Willett, M. S., Diamond, L. E., Garcia, W. D., Roesch, B. G., & Cooper, G. J. S. Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: An open-label trial. Journal of Clinical Pharmacology (2010) 50(6): 647-658. [pdf]

Manos-Turvey, A., Bulloch, E. M. M., Rutledge, P. J., Baker, E. N., Lott, J. S., & Payne, R. J. Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI). ChemMedChem (2010) 5(7): 1067-1079. 

Maroz, A., Shinde, S. S., Franzblau, S. G., Ma, Z., Denny, W. A., Palmer, B. D., & Anderson, R. F. Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent. Organic and Biomolecular Chemistry (2010) 8(2): 413-418. [pdf]

Martin, S. K., Fitter, S., Bong, L. F., Drew, J. J., Gronthos, S., Shepherd, P. R., & Zannettino, A. C. W. NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells. Journal of Bone and Mineral Research (2010) 25(10): 2126-2137.

McKay, V. A., Thompson, S. J., Tran, P. M., Goodall, K. J., Brimble, M. A., & Barker, D. Stereoselective synthesis of 4-substituted 4-hydroxypiperidines via epoxidation-ring opening of 4-methylenepiperidines. Synlett (2010) 17: 2631-2635.

Miller, N., Williams, G. M., & Brimble, M. A. Synthesis of Neoglycopeptides via Click Chemistry. International Journal of Peptide Research and Therapeutics (2010): 1-8.

Mittal, A., Göke, F., Flint, R., Loveday, B. P. T., Thompson, N., Delahunt, B., Kilmartin, P. A., Cooper, G. J. S., MacDonald, J., Hickey, A., Windsor, J. A., & Phillips, A. R. J. The redox status of experimental hemorrhagic shock as measured by cyclic voltammetry. Shock (2010) 33(5): 460-466.

Mittal, A., Middleditch, M., Ruggiero, K., Loveday, B., Delahunt, B., Jüllig, M., Cooper, G. J. S., Windsor, J. A., & Phillips, A. R. J. Changes in the mesenteric lymph proteome induced by hemorrhagic shock. Shock (2010) 34(2): 140-149.

Nikac, M., Brimble, M. A., Crumbie, R. L., & Bailey, T. D. Metal binding studies using spiroacetal thiacrown ethers. Tetrahedron Letters (2010) 51(7): 1072-1074.

Palmer, B. D., Thompson, A. M., Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., & Denny, W. A. Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro- 5H-imidazo[2,1-b][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2010) 53(1): 282-294. [pdf]

Patel, D., Wines, B. D., Langley, R. J., & Fraser, J. D. Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain. Journal of Immunology (2010) 184(11): 6283-6292.

Peltier, R., Brimble, M. A., Wojnar, J. M., Williams, D. E., Evans, C. W., & DeVries, A. L. Synthesis and antifreeze activity of fish antifreeze glycoproteins and their analogues. Chemical Science (2010) 1(5): 538-551.

Peltier, R., Evans, C. W., Devries, A. L., Brimble, M. A., Dingley, A. J., & Williams, D. E. Growth habit modification of ice crystals using antifreeze glycoprotein (AFGP) analogues. Crystal Growth and Design (2010) 10(12): 5066-5077.

Prosser, G. A., Copp, J. N., Syddall, S. P., Williams, E. M., Smaill, J. B., Wilson, W. R., Patterson, A. V., & Ackerley, D. F. Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochemical Pharmacology (2010) 79(5): 678-687.

Prosser, G. A., Patterson, A. V., & Ackerley, D. F. uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954. Journal of Biotechnology (2010) 150(1): 190-194.

Rathwell, K., Sperry, J., & Brimble, M. A. Synthesis of triazole analogues of the nanaomycin antibiotics using ‘click chemistry’. Tetrahedron (2010) 66(23): 4002-4009.

Reynolds, H. M., Walker, C. G., Dunbar, P. R., O’Sullivan, M. J., Uren, R. F., Thompson, J. F., & Smith, N. P. Functional anatomy of the lymphatics draining the skin: A detailed statistical analysis. Journal of Anatomy (2010) 216(3): 344-355.

Shinde, S. S., Maroz, A., Hay, M. P., Patterson, A. V., Denny, W. A., & Anderson, R. F. Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4- benzotriazine 1,4-dioxide (tirapazamine). Journal of the American Chemical Society (2010) 132(8): 2591-2599.

Smith, W. D., Pointon, J. A., Abbot, E., Kang, H. J., Baker, E. N., Hirst, B. H., Wilson, J. A., Banfield, M. J., & Kehoe, M. A. Roles of minor pilin subunits Spy0125 and Spy0130 in the serotype M1 Streptococcus pyogenes strain SF370. Journal of Bacteriology (2010) 192(18): 4651-4659.

Sperry, J., Harris, E. B. J., & Brimble, M. A. Total synthesis and absolute configuration of (-)-berkeleyamide A. Organic Letters (2010) 12(3): 420-423.

Sperry, J., Liu, Y. C., & Brimble, M. A. Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction. Organic and Biomolecular Chemistry (2010) 8(1): 29-38.

Sperry, J., Wilson, Z. E., Rathwell, D. C. K., & Brimble, M. A. Isolation, biological activity and synthesis of benzannulated spiroketal natural products. Natural Product Reports (2010) 27(8): 1117-1137. [pdf]

Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., Palmer, B. D., Denny, W. A., & Thompson, A. M. Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains. Journal of Medicinal Chemistry (2010) 53(2): 855-866. [pdf]

Tercel, M., Yang, S., Atwell, G. J., Smith, E., Gu, Y., Anderson, R. F., Denny, W. A., Wilson, W. R., & Pruijn, F. B. Hypoxic selectivity and solubility - Investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e] indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy. Bioorganic and Medicinal Chemistry (2010) 18(14): 4997-5006.

Tups, A., Anderson, G. M., Rizwan, M., Augustine, R. A., Chaussade, C., Shepherd, P. R., & Grattan, D. R. Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of Neuroendocrinology (2010) 22(6): 534-542.

Ussher, J. E., & Taylor, J. A. Optimized transduction of human monocyte-derived dendritic cells by recombinant adeno-associated virus serotype 6. Human Gene Therapy (2010) 21(12): 1675-1686.

Wadsworth, A. D., Sperry, J., & Brimble, M. A. Synthesis of the pyranonaphthoquinones dehydroherbarin, (+)-astropaquinone B and (+)-astropaquinone C en route to ascomycones A and B. Synthesis (2010) 15: 2604-2608.

Walker, C. S., Li, X., Whiting, L., Glyn-Jones, S., Zhang, S., Hickey, A. J., Sewell, M. A., Ruggiero, K., Phillips, A. R. J., Kraegen, E. W., Hay, D. L., Cooper, G. J. S., & Loomes, K. M. Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity. Endocrinology (2010) 151(9): 4257-4269.

Watkins, H. A., & Baker, E. N. Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis. Journal of Bacteriology (2010) 192(11): 2878-2886.

Webby, C. J., Jiao, W., Hutton, R. D., Blackmore, N. J., Baker, H. M., Baker, E. N., Jameson, G. B., & Parker, E. J. Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis. Journal of Biological Chemistry (2010) 285(40): 30567-30576.

Wilson, Z. E., & Brimble, M. A. A flexible asymmetric synthesis of the tetracyclic core of berkelic acid using a Horner-Wadsworth-Emmons/oxa-Michael cascade. Organic and Biomolecular Chemistry (2010) 8(6): 1284-1286. [pdf]

Zhang, H., Li, B., Young, A. A., & Hunter, P. J. Recovery of myocardial kinematic function without the time history of external loads. EURASIP Journal on Advances in Signal Processing (2010) 2010: 1-9.