Scientific Publications
Every year Maurice Wilkins Centre investigators produce a large number of peer-reviewed scientific papers and reviews published in international journals. Research directly supported by the Maurice Wilkins Centre generated the following scientific papers.
2013
Affara, M., Sanders, D., Araki, H., Tamada, Y., Dunmore, B. J., Humphreys, S., Imoto, S., Savoie, C., Miyano, S., Kuhara, S., Jeffries, D., Print, C., & Charnock-Jones, D. S. Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis. BMC Genomics (2013) 14(1).
Aitken, H. R. M., Furkert, D. P., Hubert, J. G., Wood, J. M., & Brimble, M. A. Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary. Organic and Biomolecular Chemistry (2013) 11(31): 5147-5155.
Aitken, H. R. M., Johannes, M., Loomes, K. M., & Brimble, M. A. Synthesis of leptosin, a glycoside isolated from manuka honey. Tetrahedron Letters (2013) 54(50): 6916-6919.
Benzler, J., Andrews, Z. B., Pracht, C., Stöhr, S., Shepherd, P. R., Grattan, D. R., & Tups, A. Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice. Endocrinology (2013) 154(12): 4737-4745.
Blackmore, N. J., Reichau, S., Jiao, W., Hutton, R. D., Baker, E. N., Jameson, G. B., & Parker, E. J. Three sites and you are out: Ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis. Journal of Molecular Biology (2013) 425(9): 1582-1592. [pdf]
Blenkiron, C., Hurley, D. G., Fitzgerald, S., Print, C. G., & Lasham, A. Links between the oncoprotein YB-1 and small non-coding RNAs in breast cancer. PLoS ONE (2013) 8(11): e80171.
Bobby, R., Medini, K., Neudecker, P., Lee, T. V., Brimble, M. A., McDonald, F. J., Lott, J. S., & Dingley, A. J. Structure and dynamics of human Nedd4-1 WW3 in complex with the alphaENaC PY motif. Biochimica et Biophysica Acta - Proteins and Proteomics (2013) 1834(8): 1632-1641.
Bridewell, D. J. A., Sperry, J., Smith, J. R., Kosim-Satyaputra, P., Ching, L. M., Jamie, J. F., & Brimble, M. A. Natural product-inspired pyranonaphthoquinone inhibitors of indoleamine 2,3-dioxygenase-1 (IDO-1)*. Australian Journal of Chemistry (2013) 66(1): 40-49.
Britten, R. D., Christie, G. R., Little, C., Miller, A. K., Bradley, C., Wu, A., Yu, T., Hunter, P., & Nielsen, P. FieldML, a proposed open standard for the Physiome project for mathematical model representation. Med Biol Eng Comput (2013) 51(11): 1191-1207.
Brooks, C. R., Van Dalen, C. J., Hermans, I. F., & Douwes, J. Identifying leukocyte populations in fresh and cryopreserved sputum using flow cytometry. Cytometry Part B - Clinical Cytometry (2013) 84 B(2): 104-113.
Buchanan, C. M., Dickson, J. M. J., Lee, W. J., Guthridge, M. A., Kendall, J. D., & Shepherd, P. R. Oncogenic Mutations of p110a Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity. PLoS ONE (2013) 8(8): e71337
Bunker, R. D., Bulloch, E. M. M., Dickson, J. M. J., Loomes, K. M., & Baker, E. N. Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. Journal of Biological Chemistry (2013) 288(3): 1643-1652.
Busby, J. N., Panjikar, S., Landsberg, M. J., Hurst, M. R. H., & Lott, J. S. The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device. Nature (2013) 501(7468): 547-550.
Camberis, M., Prout, M., Tang, S. C., Forbes-Blom, E., Robinson, M., Kyle, R., Belkaid, Y., Paul, W., & Le Gros, G. Evaluating the in vivo Th2 priming potential among common allergens. Journal of Immunological Methods (2013) 394(1-2): 62-72.
Castell, A., Short, F. L., Evans, G. L., Cookson, T. V. M., Bulloch, E. M. M., Joseph, D. D. A., Lee, C. E., Parker, E. J., Baker, E. N., & Lott, J. S. The substrate capture mechanism of mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Biochemistry (2013) 52(10): 1776-1787.
Chai, A. F., Johnston, J. M., Bunker, R. D., Bulloch, E. M., Evans, G. L., Lott, J. S., & Baker, E. N. Purification, crystallization and preliminary X-ray studies of MbtN (Rv1346) from Mycobacterium tuberculosis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2013) 69(Pt 12): 1354-1356.
Chang, J. Y., Lu, G. L., Stevenson, R. J., Brothers, P. J., Clark, G. R., Botting, K. J., Ferry, D. M., Tercel, M., Wilson, W. R., Denny, W. A., & Ware, D. C. Cross-bridged cyclen or cyclam Co(III) complexes containing cytotoxic ligands as hypoxia-activated prodrugs. Inorganic Chemistry (2013) 52(13): 7688-7698.
Cognard, E., Dargaville, C. G., Hay, D. L., & Shepherd, P. R. Identification of a pathway by which glucose regulates beta-catenin signalling via the cAMP/protein kinase A pathway in beta-cell models. Biochem Journal (2013) 449(3): 803-811. [pdf]
Cook, G. M., Robson, J. R., Frampton, R. A., McKenzie, J., Przybilski, R., Fineran, P. C., & Arcus, V. L. Ribonucleases in bacterial toxin-antitoxin systems. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms (2013) 1829(6-7): 523-531. [pdf]
Cross, P. J., Allison, T. M., Dobson, R. C., Jameson, G. B., & Parker, E. J. Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain. Proceedings of the National Academy of Sciences of the United States of America (2013) 110(6): 2111-2116.
Dickson, J. M., Lee, W. J., Shepherd, P. R., & Buchanan, C. M. Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase. Bioscience Reports (2013) 33(6).
Domigan, L., Andersen, K. B., Sasso, L., Dimaki, M., Svendsen, W. E., Gerrard, J. A., & Castillo-Leon, J. Dielectrophoretic manipulation and solubility of protein nanofibrils formed from crude crystallins. Electrophoresis (2013) 34(7): 1105-1112. [pdf]
Erogbogbo, F., May, J., Swihart, M., Prasad, P. N., Smart, K., Jack, S. E., Korcyk, D., Webster, M., Stewart, R., Zeng, I., Jullig, M., Bakeev, K., Jamieson, M., Kasabov, N., Gopalan, B., Liang, L., Hu, R., Schliebs, S., Villas-Boas, S., & Gladding, P. Bioengineering silicon quantum dot theranostics using a network analysis of metabolomic and proteomic data in cardiac ischemia. Theranostics (2013) 3(9): 719-728.
Ferguson, P. M., Feindel, K. W., Slocombe, A., MacKay, M., Wignall, T., Delahunt, B., Tilley, R. D., & Hermans, I. F. Strongly magnetic iron nanoparticles improve the diagnosis of small tumours in the reticuloendothelial system by magnetic resonance imaging. PLoS ONE (2013) 8(2): e56572.
Ferguson, P. M., Slocombe, A., Tilley, R. D., & Hermans, I. F. Using magnetic resonance imaging to evaluate dendritic cell-based vaccination. PLoS ONE (2013) 8(5): e65318.
Fullston, T., Ohlsson Teague, E. M., Palmer, N. O., DeBlasio, M. J., Mitchell, M., Corbett, M., Print, C. G., Owens, J. A., & Lane, M. Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB Journal (2013) 27(10): 4226-4243.
Fung, S. P., Wang, H., Tomek, P., Squire, C. J., Flanagan, J. U., Palmer, B. D., Bridewell, D. J., Tijono, S. M., Jamie, J. F., & Ching, L. M. Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1). Bioorganic and Medicinal Chemistry (2013) 21(24): 7595-7603. [pdf]
Gamage, S. A., Brooke, D. G., Redkar, S., Datta, J., Jacob, S. T., & Denny, W. A. Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1. Bioorganic and Medicinal Chemistry (2013) 21(11): 3147-3153.
Garvey, M., Meehan, S., Gras, S. L., Schirra, H. J., Craik, D. J., Van der Weerden, N. L., Anderson, M. A., Gerrard, J. A., & Carver, J. A. A radish seed antifungal peptide with a high amyloid fibril-forming propensity. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2013) 1834(8): 1615-1623.
Ge, Y., Mansell, A., Ussher, J. E., Brooks, A. E., Manning, K., Wang, C. J., & Taylor, J. A. Rotavirus NSP4 Triggers Secretion of Proinflammatory Cytokines from Macrophages via Toll-Like Receptor 2. Journal of Virology (2013) 87(20): 11160-11167.
Gjuvsland, A. B., Vik, J. O., Beard, D. A., Hunter, P. J., & Omholt, S. W. Bridging the genotype-phenotype gap: what does it take? Journal of Physiology (2013) 591(Pt 8): 2055-2066.
Grasso, C., L. Larsen, M. McConnell, R. A. J. Smith, and M. V. Berridge, Anti-leukemic activity of ubiquinone-based compounds targeting trans-plasma membrane electron transport. Journal of Medicinal Chemistry (2013) 56(8): 3168-3176.
Green, L. K., Storey, M. A., Williams, E. M., Patterson, A. V., Smaill, J. B., Copp, J. N., & Ackerley, D. F. The flavin reductase MsuE is a novel nitroreductase that can efficiently activate two promising next-generation prodrugs for gene-directed enzyme prodrug therapy. Cancers (2013) 5(3): 985-997.
Green, L. K., Syddall, S. P., Carlin, K. M., Bell, G. D., Guise, C. P., Mowday, A. M., Hay, M. P., Smaill, J. B., Patterson, A. V., & Ackerley, D. F. Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy. Molecular Cancer (2013) 12: 58.
Harris, P. W., & Brimble, M. A. A comparison of Boc and Fmoc SPPS strategies for the preparation of C-terminal peptide alpha-thiolesters: NY-ESO-1 (39) Cys-(68) Ala-COSR. Biopolymers (Peptide Science) (2013) 100(4): 356-365.
Harris, P. W. R., Kowalczyk, R., Hay, D. L., & Brimble, M. A. A single pseudoproline and microwave solid phase peptide synthesis facilitates an efficient synthesis of human amylin 1-37. International Journal of Peptide Research and Therapeutics (2013) 19(2): 147-155.
Harvie, M., Camberis, M., & Gros, G. L. Development of CD4 T cell dependent immunity against N. brasiliensis infection. Frontiers in Immunology (2013) 4(MAR).
Heapy, A. M., Dragunow, M., & Brimble, M. A. Synthesis of the cysteine protease inhibitors CPI-2081a and CPI-2081b using a controlled SPPS byproduct forming reaction. Synlett (2013) 24(14): 1818-1824.
Heapy, A. M., Patterson, A. V., Smaill, J. B., Jamieson, S. M. F., Guise, C. P., Sperry, J., Hume, P. A., Rathwell, K., & Brimble, M. A. Synthesis and cytotoxicity of pyranonaphthoquinone natural product analogues under bioreductive conditions. Bioorganic and Medicinal Chemistry (2013) 21(24): 7971-7980.
Heinrich, D. M., Flanagan, J. U., Jamieson, S. M., Silva, S., Rigoreau, L. J., Trivier, E., Raynham, T., Turnbull, A. P., & Denny, W. A. Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3. European Journal of Medicinal Chemistry (2013) 62: 738-744.
Hobbs, J. K., Jiao, W., Easter, A. D., Parker, E. J., Schipper, L. A., & Arcus, V. L. Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates. ACS Chemical Biology (2013) 8(11): 2388-2393. [pdf]
Holtfreter, S., Radcliff, F. J., Grumann, D., Read, H., Johnson, S., Monecke, S., Ritchie, S., Clow, F., Goerke, C., Broker, B. M., Fraser, J. D., & Wiles, S. Characterization of a mouse-adapted Staphylococcus aureus strain. PLoS One (2013) 8(9): e71142.
Huisman, F. H., Squire, C. J., & Parker, E. J. Amino-acid substitutions at the domain interface affect substrate and allosteric inhibitor binding in alpha-isopropylmalate synthase from Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications (2013) 433(2): 249-254. [pdf]
Hume, P. A., Brimble, M. A., & Reynisson, J. DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems. Computational and Theoretical Chemistry (2013) 1005: 9-15.
Hume, P. A., Furkert, D. P., & Brimble, M. A. Total synthesis of virgatolide B. Organic Letters (2013) 15(17): 4588-4591. [pdf]
Hunter, P., Chapman, T., Coveney, P. V., de Bono, B., Diaz, V., Fenner, J., Frangi, A. F., Harris, P., Hose, R., Kohl, P., Lawford, P., McCormack, K., Mendes, M., Omholt, S., Quarteroni, A., Shublaq, N., Skar, J., Stroetmann, K., Tegner, J., Thomas, S. R., Tollis, I., Tsamardinos, I., van Beek, J. H., & Viceconti, M. A vision and strategy for the virtual physiological human: 2012 update. Interface Focus (2013) 3(2): 20130004.
Johnston, J. M., Jiang, M., Guo, Z., & Baker, E. N. Crystal structures of E. coli native MenH and two active site mutants. PLoS One (2013) 8(4): e61325.
Jose, J., Gamage, S. A., Harvey, M. G., Voss, L. J., Sleigh, J. W., & Denny, W. A. Structure-activity relationships for ketamine esters as short-acting anaesthetics. Bioorganic and Medicinal Chemistry (2013) 21(17): 5098-5106. [pdf]
Joseph, D. D., Jiao, W., & Parker, E. J. Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis. Biochemistry (2013) 52(15): 2609-2619.
Kim, R. J., Yin, T., Chen, C. J., Mansell, C. J., Wood, A., Dunbar, P. R., & Douglas, R. G. The interaction between bacteria and mucosal immunity in chronic rhinosinusitis: a prospective cross-sectional analysis. American Journal of Rhinology and Allergy (2013) 27(6): e183-189. [pdf]
Kim, U. B., Dalebrook, A. F., Furkert, D. P., & Brimble, M. A. Total synthesis of chaetoquadrins H and i. Synlett (2013) 24(6): 723-726. [pdf]
Kim, U. B., Furkert, D. P., & Brimble, M. A. Total synthesis of chaetoquadrins A-C. Organic Letters (2013) 15(3): 658-661.
Kueh, J. T., Choi, K. W., Williams, G. M., Moehle, K., Bacsa, B., Robinson, J. A., & Brimble, M. A. Synthesis of a 6,6-spiroketal amino acid and its incorporation into a peptide turn sequence using solid-phase peptide synthesis. Chemistry (2013) 19(12): 3807-3811.
Kuhn, S., Hyde, E. J., Yang, J., Rich, F. J., Harper, J. L., Kirman, J. R., & Ronchese, F. Increased numbers of monocyte-derived dendritic cells during successful tumor immunotherapy with immune-activating agents. Journal of Immunology (2013) 191(4): 1984-1992.
Liu, Y., Lai, Y. C., Hill, E. V., Tyteca, D., Carpentier, S., Ingvaldsen, A., Vertommen, D., Lantier, L., Foretz, M., Dequiedt, F., Courtoy, P. J., Erneux, C., Viollet, B., Shepherd, P. R., Tavare, J. M., Jensen, J., & Rider, M. H. Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle. Biochem Journal (2013) 455(2): 195-206. [pdf]
Liu, J., Xu, A., Lam, K. S., Wong, N. S., Chen, J., Shepherd, P. R., & Wang, Y. Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation. Oncotarget (2013) 4(10): 1804-1818.
Lorenz, N., Clow, F., Radcliff, F. J., & Fraser, J. D. Full functional activity of SSL7 requires binding of both complement C5 and IgA. Immunology and Cell Biology (2013) 91(7): 469-476. [pdf]
Lu, G.-L., Ashoorzadeh, A., Anderson, R. F., Patterson, A. V., & Smaill, J. B. Synthesis of substituted 5-bromomethyl-4-nitroimidazoles and use for the preparation of the hypoxia-selective multikinase inhibitor SN29966. Tetrahedron (2013) 69(43): 9130-9138.
Lu, J., Pontre, B., Pickup, S., Choong, S. Y., Li, M., Xu, H., Gamble, G. D., Phillips, A. R., Cowan, B. R., Young, A. A., & Cooper, G. J. Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment. Cardiovascular Diabetology (2013) 12: 28.
Naysmith, B. J., & Brimble, M. A. Synthesis of the griseusin B framework via a one-pot annulation-methylation-double deprotection-spirocyclization sequence. Organic Letters (2013) 15(8): 2006-2009.
Noisier, A. F., Harris, C. S., & Brimble, M. A. Novel preparation of chiral alpha-amino acids using the Mitsunobu-Tsunoda reaction. Chemical Communications (2013) 49(70): 7744-7746.
Prendergast, K. A., & Kirman, J. R. Dendritic cell subsets in mycobacterial infection: control of bacterial growth and T cell responses. Tuberculosis (2013) 93(2): 115-122.
Prosser, G. A., Copp, J. N., Mowday, A. M., Guise, C. P., Syddall, S. P., Williams, E. M., Horvat, C. N., Swe, P. M., Ashoorzadeh, A., Denny, W. A., Smaill, J. B., Patterson, A. V., & Ackerley, D. F. Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A. Biochemical Pharmacology (2013) 85(8): 1091-1103. [pdf]
Quach, R., Furkert, D. P., & Brimble, M. A. Synthesis of benzannulated spiroacetals using chiral gold-phosphine complexes and chiral anions. Tetrahedron Letters (2013) 54(44): 5865-5868.
Quek, N. C., Matthews, J. H., Bloor, S. J., Jones, D. A., Bircham, P. W., Heathcott, R. W., & Atkinson, P. H. The novel equisetin-like compound, TA-289, causes aberrant mitochondrial morphology which is independent of the production of reactive oxygen species in Saccharomyces cerevisiae. Molecular BioSystems (2013) 9(8): 2125-2133. [pdf]
Rattanapak, T., Birchall, J., Young, K., Ishii, M., Meglinski, I., Rades, T., & Hook, S. Transcutaneous immunization using microneedles and cubosomes: Mechanistic investigations using Optical Coherence Tomography and Two-Photon Microscopy. Journal of Controlled Release (2013) 172(3): 894-903.
Reichau, S., & Parker, E. J. Active site plasticity of a critical enzyme from Mycobacterium tuberculosis. RSC Advances (2013) 3(10): 3209-3212. [pdf]
Rewcastle, G. W., Gamage, S. A., Flanagan, J. U., Kendall, J. D., Denny, W. A., Baguley, B. C., Buchanan, C. M., Chao, M., Kestell, P., Kolekar, S., Lee, W. J., Lill, C. L., Malik, A., Singh, R., Jamieson, S. M., & Shepherd, P. R. Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474). European Journal of Medicinal Chemistry (2013) 64: 137-147.
Roediger, B., Kyle, R., Yip, K. H., Sumaria, N., Guy, T. V., Kim, B. S., Mitchell, A. J., Tay, S. S., Jain, R., Forbes-Blom, E., Chen, X., Tong, P. L., Bolton, H. A., Artis, D., Paul, W. E., De St Groth, B. F., Grimbaldeston, M. A., Le Gros, G., & Weninger, W. Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nature Immunology (2013) 14(6): 564-573.
Shaw, O. M., & Harper, J. L. An efficient single prime protocol for the induction of antigen-induced airways inflammation. Journal of Immunological Methods (2013) 395(1-2): 79-82.
Sheppard, H. M., Ussher, J. E., Verdon, D., Chen, J., Taylor, J. A., & Dunbar, P. R. Recombinant adeno-associated virus serotype 6 efficiently transduces primary human melanocytes. PLoS One (2013) 8(4): e62753.
Slaney, C. Y., Toker, A., Fraser, J. D., Harper, J. L., & Backstrom, B. T. A modified superantigen rescues Ly6G- CD11b+ blood monocyte suppressor function and suppresses antigen-specific inflammation in EAE. Autoimmunity (2013) 46(4): 269-278. [pdf]
Smith, G. C., Ong, W. K., Costa, J. L., Watson, M., Cornish, J., Grey, A., Gamble, G. D., Dickinson, M., Leung, S., Rewcastle, G. W., Han, W., & Shepherd, P. R. Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength. FEBS Journal (2013) 280(21): 5337-5349.
Son, S. J., Brimble, M. A., Yang, S., Harris, P. W. R., Reddingius, T., Muir, B. W., Hutt, O. E., Waddington, L., Guan, J., & Savage, G. P. Synthesis and self-assembly of a peptide-amphiphile as a drug delivery vehicle. Australian Journal of Chemistry (2013) 66(1): 23-29.
Spicer, J. A., Lena, G., Lyons, D. M., Huttunen, K. M., Miller, C. K., O'Connor, P. D., Bull, M., Helsby, N., Jamieson, S. M., Denny, W. A., Ciccone, A., Browne, K. A., Lopez, J. A., Rudd-Schmidt, J., Voskoboinik, I., & Trapani, J. A. Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. Journal of Medicinal Chemistry (2013) 56(23): 9542-9555.
Stone, A., Cowley, M. J., Valdes-Mora, F., McCloy, R. A., Sergio, C. M., Gallego-Ortega, D., Caldon, C. E., Ormandy, C. J., Biankin, A. V., Gee, J. M., Nicholson, R. I., Print, C. G., Clark, S. J., & Musgrove, E. A. BCL-2 hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer. Molecular Cancer Therapeutics (2013) 12(9): 1874-1885.
Strover, L. T., Malmström, J., Laita, O., Reynisson, J., Aydemir, N., Nieuwoudt, M. K., Williams, D. E., Dunbar, P. R., Brimble, M. A., & Travas-Sejdic, J. A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution. Polymer (United Kingdom) (2013) 54(4): 1305-1317.
Stubbing, L. A., Savage, G. P., & Brimble, M. A. N-alkylsulfonylimines as dipolarophiles in cycloaddition reactions. Chemistry - An Asian Journal (2013) 8(1): 42-48.
Su, J., Gu, Y., Pruijn, F. B., Smaill, J. B., Patterson, A. V., Guise, C. P., & Wilson, W. R. Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence. Journal of Biological Chemistry (2013) 288(52): 37138-37153.
Thomas, D., Powell, J. A., Green, B. D., Barry, E. F., Ma, Y., Woodcock, J., Fitter, S., Zannettino, A. C., Pitson, S. M., Hughes, T. P., Lopez, A. F., Shepherd, P. R., Wei, A. H., Ekert, P. G., & Guthridge, M. A. Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. PLoS Biology (2013) 11(3): e1001515.
Till, M., Goldstone, D. C., Attwood, G. T., Moon, C. D., Kelly, W. J., & Arcus, V. L. Structure and function of an acetyl xylan esterase (Est2A) from the rumen bacterium Butyrivibrio proteoclasticus. Proteins: Structure, Function and Bioinformatics (2013) 81(5): 911-917. [pdf]
Tomek, P., Palmer, B. D., Flanagan, J. U., Fung, S. P., Bridewell, D. J., Jamie, J. F., & Ching, L. M. Formation of an N-formylkynurenine-derived fluorophore and its use for measuring indoleamine 2,3-dioxygenase 1 activity. Analytical and Bioanalytical Chemistry (2013) 405(8): 2515-2524.
Tran, A. T., Wen, D., West, N. P., Baker, E. N., Britton, W. J., & Payne, R. J. Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry (2013) 11(46): 8113-8126. [pdf]
Trevarton, A. J., Mann, M. B., Knapp, C., Araki, H., Wren, J. D., Stones-Havas, S., Black, M. A., & Print, C. G. MelanomaDB: A web tool for integrative analysis of melanoma genomic information to identify disease-associated molecular pathways. Frontiers in Oncology (2013) 3: 184.
Valery, C., Pandey, R., & Gerrard, J. A. Protein beta-interfaces as a generic source of native peptide tectons. Chemical Communications (2013) 49(27): 2825-2827.
Van Panhuys, N., Camberis, M., Yamada, M., Tegoshi, T., Arizono, N., & Le Gros, G. Mucosal trapping and degradation of Nippostrongylus brasiliensis occurs in the absence of STAT6. Parasitology (2013) 140(7): 833-843.
Wang, Y. K., Hurley, D. G., Schnell, S., Print, C. G., & Crampin, E. J. Integration of steady-state and temporal gene expression data for the inference of gene regulatory networks. PLoS One (2013) 8(8): e72103.
Wang, Y. K., Print, C. G., & Crampin, E. J. Biclustering reveals breast cancer tumour subgroups with common clinical features and improves prediction of disease recurrence. BMC Genomics (2013) 14: 102.
Watkins, H. A., Au, M., Bobby, R., Archbold, J. K., Abdul-Manan, N., Moore, J. M., Middleditch, M. J., Williams, G. M., Brimble, M. A., Dingley, A. J., & Hay, D. L. Identification of key residues involved in adrenomedullin binding to the AM1 receptor. British Journal of Pharmacology (2013) 169(1): 143-155.
Weinkove, R., Brooks, C. R., Carter, J. M., Hermans, I. F., & Ronchese, F. Efficient depletion of chronic lymphocytic leukemia B cells using serial rounds of immunomagnetic depletion. Journal of Immunological Methods (2013) 396(1-2): 152-156.
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