Scientific Publications

2011

Affara, M., Dunmore, B. J., Sanders, D. A., Johnson, N., Print, C. G., & Charnock- Jones, D. S. MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms. BMC Genomics (2011) 12:43.

Allison, T. M., Hutton, R. D., Cochrane, F. C., Yeoman, J. A., Jameson, G. B., & Parker, E. J. Targeting the role of a key conserved motif for substrate selection and catalysis by 3-Deoxy-D-Manno-octulosonate 8-Phosphate synthase. Biochemistry (2011) 50(18): 3686-3695.

Allison, T. M., Hutton, R. D., Jiao, W., Gloyne, B. J., Nimmo, E. B., Jameson, G. B., & Parker, E. J. An extended beta7alpha7 substrate-binding loop is essential for efficient catalysis by 3-deoxy-d-Manno-octulosonate 8-Phosphate synthase. Biochemistry (2011) 50(43): 9318-9327.

Archbold, J. K., Flanagan, J. U., Watkins, H. A., Gingell, J. J., & Hay, D. L. Structural insights into RAMP modification of secretin family G protein-coupled receptors: Implications for drug development. Trends in Pharmacological Sciences (2011) 32(10): 591-600.

Arcus, V. L., McKenzie, J. L., Robson, J., & Cook, G. M. The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array. Protein Engineering, Design and Selection (2011) 24(1-2): 33-40.

Atkinson, D. J., Sperry, J., & Brimble, M. A. Synthesis of benzotriazole analogues of the helicobactericidal agents CJ-13,015, CJ-13,102, CJ-13,108, and CJ-13,104 using a regioselective 1,3-dipolar cycloaddition. Synlett (2011) 1: 99-103.

Benson, M. A., Lilo, S., Wasserman, G. A., Thoendel, M., Smith, A., Horswill, A. R., Fraser, J., Novick, R. P., Shopsin, B., & Torres, V. J. Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner. Molecular Microbiology (2011) 81(3): 659-675.

Best, N., Fraser, J. D., Rainey, P. B., Roberts, S. A., Thomas, M. G., & Ritchie, S. R. Nasal carriage of Staphylococcus aureus in healthy Aucklanders. New Zealand Medical Journal (2011) 124(1332): 30-39.

Bircham, P. W., Maass, D. R., Roberts, C. A., Kiew, P. Y., Low, Y. S., Yegambaram, M., Matthews, J., Jack, C. A., & Atkinson, P. H. Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Molecular BioSystems (2011) 7(9): 2589-2598.[pdf]

Bonnet, M., Flanagan, J. U., Chan, D. A., Lai, E. W., Nguyen, P., Giaccia, A. J., & Hay, M. P. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells. Bioorganic and Medicinal Chemistry (2011) 19(11): 3347-3356.

Bradley, C., Bowery, A., Britten, R., Budelmann, V., Camara, O., Christie, R., Cookson, A., Frangi, A. F., Gamage, T. B., Heidlauf, T., Krittian, S., Ladd, D., Little, C., Mithraratne, K., Nash, M., Nickerson, D., Nielsen, P., Nordbo, O., Omholt, S., Pashaei, A., Paterson, D., Rajagopal, V., Reeve, A., Rohrle, O., Safaei, S., Sebastian, R., Steghofer, M., Wu, T., Yu, T., Zhang, H. Y., & Hunter, P. OpenCMISS: A multi-physics & multi-scale computational infrastructure for the VPH/Physiome project. Progress in Biophysics & Molecular Biology (2011) 107(1): 32-47. [pdf]

Brimble, M. A., Finch, O. C., Heapy, A. M., Fraser, J. D., Furkert, D. P., & O’Connor, P. D. A convergent synthesis of the [4.4]-Spiroacetal-gamma-lactones cephalosporolides E and F. Tetrahedron (2011) 67(5): 995-1001.

Broadley, K., Larsen, L., Herst, P. M., Smith, R. A. J., Berridge, M. V., & McConnell, M. J. The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress. Journal of Cellular Biochemistry (2011) 112(7): 1869-1879.

Broadley, K. W. R., Hunn, M. K., Farrand, K. J., Price, K. M., Grasso, C., Miller, R. J., Hermans, I. F., & McConnell, M. J. Side population is not necessary or sufficient for a cancer stem cell phenotype in glioblastoma multiforme. Stem Cells (2011) 29(3): 452-461.

Chan, D. A., Sutphin, P. D., Nguyen, P., Turcotte, S., Lai, E. W., Banh, A., Reynolds, G. E., Chi, J. T., Wu, J., Solow-Cordero, D. E., Bonnet, M., Flanagan, J. U., Bouley, D. M., Graves, E. E., Denny, W. A., Hay, M. P., & Giaccia, A. J. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Science Translational Medicine (2011) 3(94): 94ra70.

Chang, A., Khemlani, A., Kang, H., & Proft, T. Functional analysis of Streptococcus pyogenes nuclease A (SpnA), a novel group A streptococcal virulence factor. Molecular Microbiology (2011) 79(6): 1629-1642.

Chen, J. L. Y., & Brimble, M. A. Synthesis of the bis-spiroacetal core of the antimitotic agent spirastrellolide B. Journal of Organic Chemistry (2011) 76(22): 9417-9428.

Chen, J. L. Y., Sperry, J., Ip, N. Y., & Brimble, M. A. Natural products targeting telomere maintenance. MedChemComm (2011) 2(4): 229-245.

Cheng, J. M. H., Chee, S. H., Knight, D. A., Acha-Orbea, H., Hermans, I. F., Timmer, M. S. M., & Stocker, B. L. An improved synthesis of dansylated alpha-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells. Carbohydrate Research (2011) 346(7): 914-926.

Chim, N., Habel, J. E., Johnston, J. M., Krieger, I., Miallau, L., Sankaranarayanan, R., Morse, R. P., Bruning, J., Swanson, S., Kim, H., Kim, C. Y., Li, H., Bulloch, E. M., Payne, R. J., Manos-Turvey, A., Hung, L. W., Baker, E. N., Lott, J. S., James, M. N. G., Terwilliger, T. C., Eisenberg, D. S., Sacchettini, J. C., & Goulding, C. W. The TB Structural Genomics Consortium: A decade of progress. Tuberculosis (2011) 91(2): 155-172.

Cooper, G. J. S. Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer’s disease. Drugs (2011) 71(10): 1281- 1320. [pdf]

Costa, J. L., Smith, G., Watson, M., Lin, J. M., Callon, K., Gamble, G., Cheng, A., Vickers, M. H., Shepherd, P. R., Cornish, J., & Grey, A. The atypical anti-psychotic clozapine decreases bone mass in rats in vivo. Schizophrenia Research (2011) 126(1-3): 291-297.

Cross, P. J., Dobson, R. C. J., Patchett, M. L., & Parker, E. J. Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis. Journal of Biological Chemistry (2011) 286(12): 10216-10224.

Didsbury, A., Wang, C., Verdon, D., Sewell, M., McIntosh, J., & Taylor, J. Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells. Virology Journal (2011) 8(1): 551.

Dogra, M., Palmer, B. D., Bashiri, G., Tingle, M. D., Shinde, S. S., Anderson, R. F., O’Toole, R., Baker, E. N., Denny, W. A., & Helsby, N. A. Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver. British Journal of Pharmacology (2011) 162(1): 226-236.

Flanagan, J. U., & Smythe, M. L. Sigma-class glutathione transferases. Drug Metabolism Reviews (2011) 43(2): 194-214.

Fraser, J. D. Clarifying the mechanism of superantigen toxicity. PLoS Biology (2011) 9(9): e1001145.

Girvan, R. C., Knight, D. A., O’Loughlin, C. J., Hayman, C. M., Hermans, I. F., & Webster, G. A. MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity. Vaccine (2011) 29(3): 545-557. [pdf]

Guéret, S. M., & Brimble, M. A. Synthetic studies toward the spiroimine unit of the spirolides. Pure and Applied Chemistry (2011) 83(3): 425-433.

Hagbom, M., Istrate, C., Engblom, D., Karlsson, T., Rodriguez-Diaz, J., Buesa, J., Taylor, J. A., Loitto, V. M., Magnusson, K. E., Ahlman, H., Lundgren, O., & Svensson, L. Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting. PLoS Pathogens (2011) 7(7): e1002115.

Harris, P. W. R., Yang, S. H., & Brimble, M. A. An improved procedure for the preparation of aminomethyl polystyrene resin and its use in solid phase (peptide) synthesis. Tetrahedron Letters (2011) 52(45): 6024-6026.

Hay, D. L., Walker, C. S., & Poyner, D. R. Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: Opportunities and challenges. Endocrine-Related Cancer (2011) 18(1): C1-C14.

Ho, H., Suresh, V., Kang, W., Cooling, M. T., Watton, P. N., & Hunter, P. J. Multiscale modeling of intracranial aneurysms: Cell signaling, hemodynamics, and remodeling. IEEE Transactions on Biomedical Engineering (2011) 58(10 PART 2): 2974-2977.

Hume, P. A., Sperry, J., & Brimble, M. A. Enantioselective synthesis of pyranonaphthoquinone antibiotics using a CBS reduction/cross-metathesis/oxa- Michael strategy. Organic and Biomolecular Chemistry (2011) 9(15): 5423-5430. [pdf]

Hung, K. Y., Harris, P. W. R., Heapy, A. M., & Brimble, M. A. Synthesis and assignment of stereochemistry of the antibacterial cyclic peptide xenematide. Organic and Biomolecular Chemistry (2011) 9(1): 236-242.

Hurley, D., Araki, H., Tamada, Y., Dunmore, B., Sanders, D., Humphreys, S., Affara, M., Imoto, S., Yasuda, K., Tomiyasu, Y., Tashiro, K., Savoie, C., Cho, V., Smith, S., Kuhara, S., Miyano, S., Charnock-Jones, D. S., Crampin, E. J., & Print, C. G. Gene network inference and visualization tools for biologists: application to new human transcriptome datasets. Nucleic Acids Research (2011): 1-22.

Jamieson, S., Flanagan, J. U., Kolekar, S., Buchanan, C., Kendall, J. D., Lee, W. J., Rewcastle, G. W., Denny, W. A., Singh, R., Dickson, J., Baguley, B. C., & Shepherd, P. R. A drug targeting only p110 alpha can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochemical Journal (2011) 438: 53-62.

Jullig, M., Browett, P., Middleditch, M. M. J., Prijic, G., Kilfoyle, D., Angelo, N., & Cooper, G. J. S. A unique case of neural amyloidoma diagnosed by mass spectrometry of formalin-fixed tissue using a novel preparative technique. Amyloid (2011) 18(3): 147-155.

Kang, H. J., & Baker, E. N. Intramolecular isopeptide bonds: Protein crosslinks built for stress? Trends in Biochemical Sciences (2011) 36(4): 229-237.

Kang, H. J., Coulibaly, F., Proft, T., & Baker, E. N. Crystal structure of spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly. PLoS ONE (2011) 6(1): e15969.

Kaur, H., Heapy, A. M., & Brimble, M. A. The synthesis of dehydrotryptophan and dehydrotryptophan-containing peptides. Organic and Biomolecular Chemistry (2011) 9(17): 5897-5907. [pdf]

Le Nours, J., Bulloch, E. M. M., Zhang, Z., Greenwood, D. R., Middleditch, M. J., Dickson, J. M. J., & Baker, E. N. Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide. Journal of Biological Chemistry (2011) 286(47): 40706-40716.

Lee, D. J., Harris, P. W. R., & Brimble, M. A. Synthesis of MUC1 Neoglycopeptides using efficient microwave-enhanced chaotrope-assisted click chemistry. Organic and Biomolecular Chemistry (2011) 9(5): 1621-1626. [pdf]

Leung, E., Kim, J. E., Rewcastle, G. W., Finlay, G. J., & Baguley, B. C. Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifenresistant breast cancer cells. Cancer Biology & Therapy (2011) 11(11): 938-946.

Locke, M., Feisst, V., & Dunbar, P. R. Concise review: Human adipose-derived stem cells: Separating promise from clinical need. Stem Cells (2011) 29(3): 404-411.

Locke, M., Ussher, J. E., Mistry, R., Taylor, J. A., & Dunbar, P. R. Transduction of human adipose-derived mesenchymal stem cells by recombinant adeno-associated virus vectors. Tissue Engineering - Part C: Methods (2011) 17(9): 949-959.

Loomes, K. M. Survival of an islet beta-cell in type 2 diabetes Curbing the effects of amyloid cytotoxicity. Islets (2011) 3(1): 38-39.

Lu, G. L., Stevenson, R. J., Chang, J. Y. C., Brothers, P. J., Ware, D. C., Wilson, W. R., Denny, W. A., & Tercel, M. N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7- trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f] quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs. Bioorganic and Medicinal Chemistry (2011) 19(16): 4861-4867.

MacDonald, J. R., Oellermann, M., Rynbeck, S., Chang, G., Ruggiero, K., Cooper, G. J. S., & Hickey, A. J. R. Transmural differences in respiratory capacity across the rat left ventricle in health, aging, and streptozotocin-induced diabetes mellitus: Evidence that mitochondrial dysfunction begins in the subepicardium. American Journal of Physiology - Cell Physiology (2011) 300(2): C246-C255.

McLeod, M. C., Wilson, Z. E., & Brimble, M. A. An enantioselective formal synthesis of berkelic acid. Organic Letters (2011) 13(19): 5382-5385.  

McMillan, D. G. G., Ferguson, S. A., Dey, D., Schröder, K., Aung, H. L., Carbone, V., Attwood, G. T., Ronimus, R. S., Meier, T., Janssen, P. H., & Cook, G. M. A 1A o-ATP synthase of Methanobrevibacter ruminantium couples sodium ions for ATP synthesis under physiological conditions. Journal of Biological Chemistry (2011) 286(46): 39882- 39892.

Miller, A. K., Yu, T., Britten, R., Cooling, M. T., Lawson, J., Cowan, D., Garny, A., Halstead, M. D. B., Hunter, P. J., Nickerson, D. P., Nunns, G., Wimalaratne, S. M., & F Nielsen, P. M. Revision history aware repositories of computational models of biological systems. BMC Bioinformatics (2011) 12: 22.

Misirli, G., Hallinan, J. S., Yu, T., Lawson, J. R., Wimalaratne, S. M., Cooling, M. T., & Wipat, A. Model annotation for synthetic biology: Automating model to nucleotide sequence conversion. Bioinformatics (2011) 27(7): 973-979.

Mittal, A., Hickey, A. J. R., Chai, C. C., Loveday, B. P. T., Thompson, N., Dare, A., Delahunt, B., Cooper, G. J. S., Windsor, J. A., & Phillips, A. R. J. Early organ-specific mitochondrial dysfunction of jejunum and lung found in rats with experimental acute pancreatitis. HPB (Oxford) (2011) 13(5): 332-341.

Moir, L. M., Trian, T., Ge, Q., Shepherd, P. R., Burgess, J. K., Oliver, B. G. G., & Black, J. L. Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function. Journal of Pharmacology and Experimental Therapeutics (2011) 337(2): 557-566.

Mönnich, M., Kuriger, Z., Print, C. G., & Horsfield, J. A. A zebrafish model of roberts syndrome reveals that esco2 depletion interferes with development by disrupting the cell cycle. PLoS ONE (2011) 6(5): e20051.

Negron, L., & Parker, E. J. Fluorinated substrates result in variable leakage of a reaction intermediate during catalysis by dehydroquinate synthase. Organic and Biomolecular Chemistry (2011) 9(8): 2861-2867. [pdf]

Paterson, N. G., & Baker, E. N. Structure of the full-length major pilin from Streptococcus pneumoniae: Implications for isopeptide bond formation in grampositive bacterial pili. PLoS ONE (2011) 6(7): e22095.

Pather, K., Helsby, N.A., Palmer, B.D. & Ching, L.M. Development and validation of a high performance liquid chromatography assay for the determination of a fluorinated analogue of thalidomide, N-(2,6-dioxopiperidin-3-yl)-3,4,5,6- tetrafluorophthalamic acid and lenalidomide. Journal of Liquid Chromatography & Related Technologies (2011) 34(2): 83-92.

Pearce, F. G., Dobson, R. C. J., Jameson, G. B., Perugini, M. A., & Gerrard, J. A. Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization. Biochimica Et Biophysica Acta-Proteins and Proteomics (2011) 1814(12): 1900-1909.

Petersen, T. R., Sika-Paotonu, D., Knight, D. A., Simkins, H. M. A., & Hermans, I. F. Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines. PLoS ONE (2011) 6(3): e17657.

Qi, T., Ly, K., Poyner, D. R., Christopoulos, G., Sexton, P. M., & Hay, D. L. Structurefunction analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors. Peptides (2011) 32(5): 1060-1067.

Rehan, A. M., Bashiri, G., Paterson, N. G., Baker, E. N., & Squire, C. J. Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2011) 67(10): 1274-1277.

Reichau, S., Jiao, W., Walker, S. R., Hutton, R. D., Baker, E. N., & Parker, E. J. Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: Combining mechanism- and modeling-based design. Journal of Biological Chemistry (2011) 286(18): 16197-16207.

Rewcastle, G. W., Gamage, S. A., Flanagan, J. U., Frederick, R., Denny, W. A., Baguley, B. C., Kestell, P., Singh, R., Kendall, J. D., Marshall, E. S., Lill, C. L., Lee, W. J., Kolekar, S., Buchanan, C. M., Jamieson, S. M. F., & Shepherd, P. R. Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(Difluoromethyl)-1-[4,6-di(4- morpholinyl)-1,3,5-triazin-2- yl]-1 H -benzimidazole (ZSTK474). Journal of Medicinal Chemistry (2011) 54(20): 7105-7126.

Ritchie, S. R., Fraser, J. D., Libby, E., Morris, A. J., Rainey, P. B., & Thomas, M. G. Demographic variation in community-based MRSA skin and soft tissue infection in Auckland, New Zealand. New Zealand Medical Journal (2011) 124(1332): 21-30.

Shaw, O. M., & Harper, J. L. Bradykinin receptor 2 extends inflammatory cell recruitment in a model of acute gouty arthritis. Biochemical and Biophysical Research Communications (2011) 416(3–4): 266-269.

Simkins, H. M. A., Hyde, E., Farrand, K. J., Ong, M. L., Degli-Esposti, M. A., Hermans, I. F., & Ronchese, F. Administration of alpha-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo. Journal of Leukocyte Biology (2011) 89(5): 753-762.

Smith, G. C., Vickers, M. H., & Shepherd, P. R. Olanzapine effects on body composition, food preference, glucose metabolism and insulin sensitivity in the rat. Archives of Physiology and Biochemistry (2011) 117(4): 241-249.

Sparrow, K., Barker, D., & Brimble, M. A. The enantioselective synthesis of tetracyclic methyllycaconitine analogues. Tetrahedron (2011) 67(41): 7989-7999.

Sperry, J., Liu, Y. C., Wilson, Z. E., Hubert, J. G., & Brimble, M. A. Synthesis of benzannulated spiroketals using an oxidative radical cyclization. Synthesis (2011) (9): 1383-1398.

Stevenson, R. J., Denny, W. A., Ashoorzadeh, A., Pruijn, F. B., Van Leeuwen, W. F., & Tercel, M. The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy. Bioorganic and Medicinal Chemistry (2011) 19(20): 5989-5998.

Stewart, K. W., Phillips, A. R. J., Whiting, L., Jüllig, M., Middleditch, M. J., & Cooper, G. J. S. A simple and rapid method for identifying and semi-quantifying peptide hormones in isolated pancreatic islets by direct-tissue matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry (2011) 25(22): 3387-3395.

Szwergold, B. S., Bunker, R. D., & Loomes, K. M. The physiological substrates of fructosamine-3-kinase-related-protein (FN3KRP) are intermediates of nonenzymatic reactions between biological amines and ketose sugars (fructation products). Medical Hypotheses (2011) 77(5): 739-744.

Tercel, M., Atwell, G. J., Yang, S., Ashoorzadeh, A., Stevenson, R. J., Botting, K. J., Gu, Y., Mehta, S. Y., Denny, W. A., Wilson, W. R., & Pruijn, F. B. Selective treatment of hypoxic tumor cells in vivo: Phosphate pre-prodrugs of nitro analogues of the duocarmycins. Angewandte Chemie - International Edition (2011) 50(11): 2606-2609.

Thompson, A. M., Sutherland, H. S., Palmer, B. D., Kmentova, I., Blaser, A., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., & Denny, W. A. Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6 S)-2-nitro- 6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2011) 54(19): 6563-6585. [pdf]

Tran, D., Pietersma, A. L., Schofield, L. R., Rost, M., Jameson, G. B., & Parker, E. J. Investigating the role of the hydroxyl groups of substrate erythrose 4-phosphate in the reaction catalysed by the first enzyme of the shikimate pathway. Bioorganic & Medicinal Chemistry Letters (2011) 21 (22): 6838-6841.

Vaghefi, E., Pontre, B. P., Jacobs, M. D., & Donaldson, P. J. Visualizing ocular lens fluid dynamics using MRI: Manipulation of steady state water content and water fluxes. American Journal of Physiology - Regulatory Integrative and Comparative Physiology (2011) 301(2): R335-R342.

Waardenberg, A. J., Bernardo, B. C., Ng, D. C. H., Shepherd, P. R., Cemerlang, N., Sbroggio, M., Wells, C. A., Dalrymple, B. P., Brancaccio, M., Lin, R. C. Y., & McMullen, J. R. Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure. Journal of Biological Chemistry (2011) 286(35): 30837-30846.

Walker, S. R., Jiao, W., & Parker, E. J. Synthesis and evaluation of dual site inhibitors of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase. Bioorganic and Medicinal Chemistry Letters (2011) 21(17): 5092-5097.

Waltemath, D., Adams, R., Beard, D. A., Bergmann, F. T., Bhalla, U. S., Britten, R., Chelliah, V., Cooling, M. T., Cooper, J., Crampin, E. J., Garny, A., Hoops, S., Hucka, M., Hunter, P., Klipp, E., Laibe, C., Miller, A. K., Moraru, I., Nickerson, D., Nielsen, P., Nikolski, M., Sahle, S., Sauro, H. M., Schmidt, H., Snoep, J. L., Tolle, D., Wolkenhauer, O., & le Novère, N. Minimum information about a simulation experiment (MIASE). PLoS Computational Biology (2011) 7(4): e1001122.

Wilson, W. R., & Hay, M. P. Targeting hypoxia in cancer therapy. Nature Reviews Cancer (2011) 11(6): 393-410. [pdf]

Wilson, Z. E., Hubert, J. G., & Brimble, M. A. A flexible approach to 6,5-benzannulated spiroketals. European Journal of Organic Chemistry (2011) (20-21): 3938-3945.

Win, S. J., Ward, V. K., Dunbar, P. R., Young, S. L., & Baird, M. A. Cross-presentation of epitopes on virus-like particles via the MHC I receptor recycling pathway. Immunology and Cell Biology (2011) 89(6): 681-688. [pdf]

Wines, B. D., Ramsland, P. A., Trist, H. M., Gardam, S., Brink, R., Fraser, J. D., & Hogarth, P. M. Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor. Journal of Biological Chemistry (2011) 286(38): 33118-33124.

Wojnar, J. M., Evans, C. W., Devries, A. L., & Brimble, M. A. Synthesis of an isotopically-labelled antarctic fish antifreeze glycoprotein probe. Australian Journal of Chemistry (2011) 64(6): 723-731. [pdf]

Wood AJ, Fraser J, Swift S, Amirapu S, Douglas RG. Are biofilms associated with an inflammatory response in chronic rhinosinusitis? International Forum of Allergy and Rhinology (2011) 1(5): 335-339.

Yang, S. H., Lee, D. J., & Brimble, M. A. Synthesis of an NDPK phosphocarrier domain peptide containing a novel triazolylalanine analogue of phosphohistidine using click chemistry. Organic Letters (2011) 13(20): 5604-5607.

Yu, T., Lloyd, C. M., Nickerson, D. P., Cooling, M. T., Miller, A. K., Garny, A., Terkildsen, J. R., Lawson, J., Britten, R. D., Hunter, P. J., & Nielsen, P. M. The physiome model repository 2. Bioinformatics (2011) 27(5): 743-744.

Yuen, T. Y., Yang, S. H., & Brimble, M. A. Total synthesis of paecilospirone. Angewandte Chemie - International Edition (2011) 50(36): 8350-8353.

Zhang, Y. C., Furkert, D. P., Guéret, S. M., Lombard, F., & Brimble, M. A. Gold(I)- catalysed intramolecular hydroamination of alpha-quaternary alkynes: synthetic studies towards spiroimine marine toxins. Tetrahedron Letters (2011) 52(38): 4896-4898.

Zulian, A., Šileikyte, J., Petronilli, V., Bova, S., Dabbeni-Sala, F., Cargnelli, G., Rennison, D., Brimble, M. A., Hopkins, B., Bernardi, P., & Ricchelli, F. The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide. Biochimica et Biophysica Acta - Bioenergetics (2011) 1807(12): 1600-1605.