Scientific Publications

2012

Ancelet, L. R., Aldwell, F. E., Rich, F. J., & Kirman, J. R. Oral vaccination with lipid formulated BCG induces a long-lived, multifunctional CD4+ T cell memory immune response. PLoS ONE (2012) 7(9): e45888.

Ancelet, L., Rich, F. J., Delahunt, B., & Kirman, J. R. Dissecting memory T cell responses to TB: Concerns using adoptive transfer into immunodeficient mice. Tuberculosis (2012) 92(5): 422-433.

Araki, H., Knapp, C., Tsai, P., & Print, C. GeneSetDB: A comprehensive metadatabase, statistical and visualisation framework for gene set analysis. FEBS Open Bio (2012) 2: 76-82.

Araki H, Hurley D, Crampin E, Print C, Kuhara S. Gene network analysis and application. Seibutsu Butsuri - the Biophysical Society of Japan (2012) 51: 182-185 (in Japanese).

Bailey, R. J., Walker, C. S., Ferner, A. H., Loomes, K. M., Prijic, G., Halim, A., Whiting, L., Phillips, A. R. J., & Hay, D. L. Pharmacological characterization of rat amylin receptors: Implications for the identification of amylin receptor subtypes. British Journal of Pharmacology (2012) 166(1): 151-167.

Baker, H. M., & Baker, E. N. A structural perspective on lactoferrin function. Biochemistry and Cell Biology (2012) 90(3): 320-328. [pdf]

Barwell, J., Gingell, J. J., Watkins, H. A., Archbold, J. K., Poyner, D. R., & Hay, D. L. Calcitonin and calcitonin receptor-like receptors: Common themes with family B GPCRs? British Journal of Pharmacology (2012) 166(1): 51-65.

Bashiri, G., Perkowski, E. F., Turner, A. P., Feltcher, M. E., Braunstein, M., & Baker, E. N. Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis. PLoS ONE (2012) 7(10): e45003.

Benzler, J., Ganjam, G. K., Kruger, M., Pinkenburg, O., Kutschke, M., Stohr, S., Steger, J., Koch, C. E., Olkrug, R., Schwartz, M. W., Shepherd, P. R., Grattan, D. R., & Tups, A. Hypothalamic glycogen synthase kinase 3beta has a central role in the regulation of food intake and glucose metabolism. Biochemical Journal (2012) 447: 175-184.

Berney, M., Weimar, M. R., Heikal, A., & Cook, G. M. Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia. Molecular Microbiology (2012) 84(4): 664-681.

Blumenstein, M., McCowan, L. M. E., Wu, S., Cooper, G. J. S., & North, R. A. Plasma clusterin increased prior to small for gestational age (SGA) associated with preeclampsia and decreased prior to SGA in normotensive pregnancies. Reproductive Sciences (2012) 19(6): 650-657.

Bogle, G., & Dunbar, P. R. On-lattice simulation of T cell motility, chemotaxis, and trafficking in the lymph node paracortex. PLoS ONE (2012) 7(9): e45258.

Brimble, M. A., Haym, I., Sperry, J., & Furkert, D. P. Synthesis of the tetracyclic core of berkelic acid using gold(I)-catalyzed hydroarylation and oxidative radical cyclizations. Organic Letters (2012) 14(23): 5820-5823.

Broadbent, E., Kahokehr, A., Booth, R. J., Thomas, J., Windsor, J. A., Buchanan, C. M., Wheeler, B. R. L., Sammour, T., & Hill, A. G. A brief relaxation intervention reduces stress and improves surgical wound healing response: A randomised trial. Brain, Behavior, and Immunity (2012) 26(2): 212-217. [pdf]

Buchanan, C. M., Shih, J. H., Astin, J. W., Rewcastle, G. W., Flanagan, J. U., Crosier, P. S., & Shepherd, P. R. DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. Clinical Science (2012) 122(10): 449-457. [pdf]

Bunker, R. D., Dickson, J. M. J., Caradoc-Davies, T. T., Loomes, K. M., & Baker, E. N. Use of a repetitive seeding protocol to obtain diffraction-quality crystals of a putative human D-xylulokinase. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2012) 68(10): 1259-1262.

Busby, J. N., Landsberg, M. J., Simpson, R. M., Jones, S. A., Hankamer, B., Hurst, M. R. H., & Lott, J. S. Structural analysis of Chi1 chitinase from Yen-Tc: The multisubunit insecticidal ABC toxin complex of Yersinia entomophaga. Journal of Molecular Biology (2012) 415(2): 359-371.

Caldon, C. E., Sergio, C. M., Kang, J., Muthukaruppan, A., Boersma, M. N., Stone, A., Barraclough, J., Lee, C. S., Black, M. A., Miller, L. D., Gee, J. M., Nicholson, R. I., Sutherland, R. L., Print, C. G., & Musgrove, E. A. Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells. Molecular Cancer Therapeutics (2012) 11(7): 1488-1499.

Chi, G., Manos-Turvey, A., O’Connor, P. D., Johnston, J. M., Evans, G. L., Baker, E. N., Payne, R. J., Lott, J. S., & Bulloch, E. M. M. Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry (2012) 51(24): 4868-4879.

Chiu, E., Coulibaly, F., & Metcalf, P. Insect virus polyhedra, infectious protein crystals that contain virus particles. Current Opinion in Structural Biology (2012) 22(2): 234- 240.

Chorley, D. F., Chen, J. L. Y., Furkert, D. P., Sperry, J., & Brimble, M. A. Total synthesis of danshenspiroketallactone. Synlett (2012) 1: 128-130.

Clark, G. R., Pytel, P. D., & Squire, C. J. The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages. Nucleic Acids Research (2012) 40(12): 5731-5738.

Cook, G. M., & Heikal, A. Bridging the gap between a TB drug and its target. Science Translational Medicine (2012) 4(150): 150fs33.

Cooper, G. J. S. Selective divalent copper chelation for the treatment of diabetes mellitus. Current Medicinal Chemistry (2012) 19(17): 2828-2860.

Coulibaly, F., Lassalle, E., Baker, H. M., & Baker, E. N. Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis. Acta Crystallographica Section D: Biological Crystallography (2012) 68(5): 553-563.

Dangerfield, E. M., Cheng, J. M. H., Knight, D. A., Weinkove, R., Dunbar, P. R., Hermans, I. F., Timmer, M. S. M., & Stocker, B. L. Species-specific activity of glycolipid ligands for invariant NKT cells. ChemBioChem (2012) 13(9): 1349-1356.

Dbouk, H. A., Vadas, O., Shymanets, A., Burke, J. E., Salamon, R. S., Khalil, B. D., Barrett, M. O., Waldo, G. L., Surve, C., Hsueh, C., Perisic, O., Harteneck, C., Shepherd, P. R., Harden, T. K., Smrcka, A. V., Taussig, R., Bresnick, A. R., Nurnberg, B., Williams, R. L., & Backer, J. M. G protein-coupled receptor-mediated activation of p110 beta by G beta gamma is required for cellular transformation and invasiveness. Science Signaling (2012) 5(253): ra89.

De Bono, B., & Hunter, P. Integrating knowledge representation and quantitative modelling in physiology. Biotechnology Journal (2012) 7(8): 958-972. [pdf]

Dimitrov, I., Furkert, D. P., Fraser, J. D., Radcliff, F. J., Finch, O., & Brimble, M. A. Synthesis and anti-Helicobacter pylori activity of analogues of spirolaxine methyl ether. MedChemComm (2012) 3(8): 944-949.

Donges, C. E., Burd, N. A., Duffield, R., Smith, G. C., West, D. W. D., Short, M. J., Mackenzie, R., Plank, L. D., Shepherd, P. R., Phillips, S. M., & Edge, J. A. Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men. Journal of Applied Physiology (2012) 112(12): 1992-2001.

Enomoto, N., Hyde, E., Ma, J. Z. I., Yang, J., Forbes-Blom, E., Delahunt, B., Le Gros, G., & Ronchese, F. Allergen-specific CTL require perforin expression to suppress allergic airway inflammation. Journal of Immunology (2012) 188(4): 1734-1741.

Evans, C. W., Hellman, L., Middleditch, M., Wojnar, J. M., Brimble, M. A., & Devries, A. L. Synthesis and recycling of antifreeze glycoproteins in polar fishes. Antarctic Science (2012) 24(3): 259-268. [pdf]

Evans, C. W., Williams, D. E., Vacchi, M., Brimble, M. A., & DeVries, A. L. Metabolic and behavioural adaptations during early development of the Antarctic silverfish, Pleuragramma antarcticum. Polar Biology (2012) 35(6): 891-898.

Evans, G. E., Martinez-Conejero, J. A., Phillipson, G. T. M., Simon, C., Mcnoe, L. A., Sykes, P. H., Horcajadas, J. A., Lam, E. Y. N., Print, C. G., Sin, I. L., & Evans, J. J. Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. Fertility and Sterility (2012) 97(6): 1365-1373.

Fernandez, J. W., Haque, M. Z. U., Hunter, P. J., & Mithraratne, K. Mechanics of the foot Part 1: A continuum framework for evaluating soft tissue stiffening in the pathologic foot. International Journal for Numerical Methods in Biomedical Engineering (2012) 28(10): 1056-1070.

Fernandez, J. W., Shim, V. B., & Hunter, P. J. Integrating degenerative mechanisms in bone and cartilage: A multiscale approach. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) (2012): 6616-6619.

Flanagan, J. U., Yosaatmadja, Y., Teague, R. M., Chai, M. Z. L., Turnbull, A. P., & Squire, C. J. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PLoS ONE (2012) 7(8): e43965.

Forbes-Blom, E., Camberis, M., Prout, M., Tang, S. C., & Le Gros, G. Staphylococcalderived superantigen enhances peanut induced Th2 responses in the skin. Clinical and Experimental Allergy (2012) 42(2): 305-314.

Ge, Q., Moir, L. M., Trian, T., Niimi, K., Poniris, M., Shepherd, P. R., Black, J. L., Oliver, B. G., & Burgess, J. K. The phosphoinositide 3'-kinase p110delta modulates contractile protein production and IL-6 release in human airway smooth muscle. Journal of Cellular Physiology (2012) 227(8): 3044-3052.

Geng, H., Chen, J. Y., Furkert, D., Jiang, S., & Brimble, M. A. A convergent synthesis of the 2-formylpyrrole spiroketal natural product acortatarin A. Synlett (2012) 23(6): 855-858. [pdf]

Goodall, K. J., Brimble, M. A., & Barker, D. A tandem Diels-Alder/Mannich approach to the synthesis of AE and ABE ring analogues of Delphinium alkaloids. Tetrahedron (2012) 68(29): 5759-5778.

Han, J. C., Taberner, A. J., Tran, K., Goo, S., Nickerson, D. P., Nash, M. P., Nielsen, P. M. F., Crampin, E. J., & Loiselle, D. S. Comparison of the Gibbs and Suga formulations of cardiac energetics: The demise of “isoefficiency”. Journal of Applied Physiology (2012) 113(7): 996-1003.

Han, J. C., Taberner, A. J., Tran, K., Nickerson, D. P., Nash, M. P., Nielsen, P. M. F., Crampin, E. J., & Loiselle, D. S. Relating components of pressure-volume area in Suga’s formulation of cardiac energetics to components of the stress-time integral. Journal of Applied Physiology (2012) 113(7): 988-995.

Han, J. C., Tran, K., Taberner, A. J., Nickerson, D. P., Kirton, R. S., Nielsen, P. M. F., Ward, M. L., Nash, M. P., Crampin, E. J., & Loiselle, D. S. Myocardial twitch duration and the dependence of oxygen consumption on pressure-volume area: Experiments and modelling. Journal of Physiology (2012) 590(18): 4603-4622.

Harris, P. W., Lee, D. J., & Brimble, M. A. A slow gradient approach for the purification of synthetic polypeptides by reversed phase high performance liquid chromatography. Journal of Peptide Science (2012) 18(9): 549-555.

Harris, P. W. R., & Brimble, M. A. The chemical synthesis of the collagenous domain of the hormone adiponectin. International Journal of Peptide Research and Therapeutics (2012) 18(1): 63-70.

Harrison, A. N., Reichau, S., & Parker, E. J. Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Bioorganic and Medicinal Chemistry Letters (2012) 22(2): 907-911.

Haym, I., & Brimble, M. A. The Kulinkovich hydroxycyclopropanation reaction in natural product synthesis. Organic & Biomolecular Chemistry (2012) 10(38): 7649- 7665.

Heapy, A. M., Williams, G. M., Fraser, J. D., & Brimble, M. A. Synthesis of a dicarba analogue of human beta-defensin-1 using a combined ring closing metathesis-native chemical ligation strategy. Organic Letters (2012) 14(3): 878-881.

Henare, K., Wang, L., Wang, L. C., Thomsen, L., Tijono, S., Chen, C. J., Winkler, S., Dunbar, P. R., Print, C., & Ching, L. M. Dissection of stromal and cancer cell-derived signals in melanoma xenografts before and after treatment with DMXAA. British Journal of Cancer (2012) 106(6): 1134-1147.

Herbert, K. R., Williams, G. M., Cooper, G. J. S., & Brimble, M. A. Synthesis of glycosylated 5-hydroxylysine, an important amino acid present in collagen-like proteins such as adiponectin. Organic and Biomolecular Chemistry (2012) 10(6): 1137-1144. [pdf]

Herbst, T., Esser, J., Prati, M., Kulagin, M., Stettler, R., Zaiss, M. M., Hewitson, J. P., Merky, P., Verbeek, J. S., Bourquin, C., Camberis, M., Prout, M., Maizels, R. M., Le Gros, G., & Harris, N. L. Antibodies and IL-3 support helminth-induced basophil expansion. Proceedings of the National Academy of Sciences of the United States of America (2012) 109(37): 14954-14959

Hermans, S. J., Baker, H. M., Sequeira, R. P., Langley, R. J., Baker, E. N., & Fraser, J. D. Structural and functional properties of staphylococcal superantigen-like protein 4. Infection and Immunity (2012) 80(11): 4004-4013.

Hickey, A. J. R., Jüllig, M., Aitken, J., Loomes, K., Hauber, M. E., & Phillips, A. R. J. Birds and longevity: Does flight driven aerobicity provide an oxidative sink? Ageing Research Reviews (2012) 11(2): 242-253.

Hobbs, J. K., Shepherd, C., Saul, D. J., Demetras, N. J., Haaning, S., Monk, C. R., Daniel, R. M., & Arcus, V. L. On the origin and evolution of thermophily: Reconstruction of functional precambrian enzymes from ancestors of Bacillus. Molecular Biology and Evolution (2012) 29(2): 825-835.

Horsfield, J. A., Print, C. G., & Monnich, M. Diverse developmental disorders from the one ring: Distinct molecular pathways underlie the cohesinopathies. Frontiers in Genetics (2012) 3: 171.

Huisman, F. H. A., Koon, N., Bulloch, E. M. M., Baker, H. M., Baker, E. N., Squire, C. J., & Parker, E. J. Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding. Biochemistry (2012) 51(11): 2289- 2297. [pdf]

Hume, P., Furkert, D. P., & Brimble, M. A. Regioselective iridium(I)-catalysed remote borylation of oxygenated naphthalenes. Tetrahedron Letters (2012) 53(29): 3771- 3773.

Hume, P. A., Brimble, M. A., & Reynisson, J. The bioreductive alkylation of DNA by kalafungin: A theoretical investigation. Australian Journal of Chemistry (2012) 65(4): 402-408. [pdf]

Hume, P. A., Brimble, M. A., & Reynisson, J. DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems. Computational and Theoretical Chemistry (2012) 1005: 9-15.

Hung, K. Y., Harris, P. W. R., & Brimble, M. A. Synthesis of the peptaibol framework of the anticancer agent culicinin D: Stereochemical assignment of the AHMOD moiety. Organic Letters (2012) 14(22): 5784-5787.

Hunn, M. K., Farrand, K. J., Broadley, K. W. R., Weinkove, R., Ferguson, P., Miller, R. J., Field, C. S., Petersen, T., McConnell, M. J., & Hermans, I. F. Vaccination with irradiated tumor cells pulsed with an adjuvant that stimulates NKT cells is an effective treatment for glioma. Clinical Cancer Research (2012) 18(23): 6446-6459.

Hunter, F. W., Wang, J., Patel, R., Hsu, H. L., Hickey, A. J. R., Hay, M. P., & Wilson, W. R. Homologous recombination repair-dependent cytotoxicity of the benzotriazine di- N-oxide CEN-209: Comparison with other hypoxia-activated prodrugs. Biochemical Pharmacology (2012) 83(5): 574-585.

Hurley, D., Araki, H., Tamada, Y., Dunmore, B., Sanders, D., Humphreys, S., Affara, M., Imoto, S., Yasuda, K., Tomiyasu, Y., Tashiro, K., Savoie, C., Cho, V., Smith, S., Kuhara, S., Miyano, S., Charnock-Jones, D. S., Crampin, E. J., & Print, C. G. Gene network inference and visualization tools for biologists: Application to new human transcriptome datasets. Nucleic Acids Research (2012) 40(6): 2377-2398.

Jackson, V. J., Yosaatmadja, Y., Flanagan, J. U., & Squire, C. J. Structure of AKR1C3 with 3-phenoxybenzoic acid bound. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2012) 68(4): 409-413.

Jamieson, S. M. F., Brooke, D. G., Heinrich, D., Atwell, G. J., Silva, S., Hamilton, E. J., Turnbull, A. P., Rigoreau, L. J. M., Trivier, E., Soudy, C., Samlal, S. S., Owen, P. J., Schroeder, E., Raynham, T., Flanagan, J. U., & Denny, W. A. 3-(3,4-dihydroisoquinolin-2(1 H)-ylsulfonyl)benzoic acids: Highly potent and selective inhibitors of the type 5 17-beta-hydroxysteroid dehydrogenase AKR1C3. Journal of Medicinal Chemistry (2012) 55(17): 7746-7758.

Jiao, W., Hutton, R. D., Cross, P. J., Jameson, G. B., & Parker, E. J. Dynamic crosstalk among remote binding sites: The molecular basis for unusual synergistic allostery. Journal of Molecular Biology (2012) 415(4): 716-726.

Jiao, W. T., & Parker, E. J. Using a combination of computational and experimental techniques to understand the molecular basis for protein allostery. Structural and Mechanistic Enzymology: Bringing Together Experiments and Computing (2012) 87: 391-413.

Kang, H. J., & Baker, E. N. Structure and assembly of Gram-positive bacterial pili: Unique covalent polymers. Current Opinion in Structural Biology (2012) 22(2): 200-207.

Kaur, H., Heapy, A. M., & Brimble, M. A. Synthesis of the all-l cyclopentapeptides versicoloritides A, B, and C. Synlett (2012) 23(15): 2284-2288.

Kaur, H., Heapy, A. M., & Brimble, M. A. Synthesis of the antifungal cyclic peptides tunicyclins C and D. Synlett (2012) 2: 275-277.

Kendall, J. D., Giddens, A. C., Tsang, K. Y., Frédérick, R., Marshall, E. S., Singh, R., Lill, C. L., Lee, W. J., Kolekar, S., Chao, M., Malik, A., Yu, S., Chaussade, C., Buchanan, C., Rewcastle, G. W., Baguley, B. C., Flanagan, J. U., Jamieson, S. M. F., Denny, W. A., & Shepherd, P. R. Novel pyrazolo[1,5-a]pyridines as p110alpha-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR. Bioorganic and Medicinal Chemistry (2012) 20(1): 58-68.

Kendall, J. D., O’Connor, P. D., Marshall, A. J., Frédérick, R., Marshall, E. S., Lill, C. L., Lee, W. J., Kolekar, S., Chao, M., Malik, A., Yu, S., Chaussade, C., Buchanan, C., Rewcastle, G. W., Baguley, B. C., Flanagan, J. U., Jamieson, S. M. F., Denny, W. A., & Shepherd, P. R. Discovery of pyrazolo[1,5-a]pyridines as p110alpha-selective PI3 kinase inhibitors. Bioorganic and Medicinal Chemistry (2012) 20(1): 69-85. [pdf]

Kowalczyk, R., Brimble, M. A., Callon, K. E., Watson, M., & Cornish, J. How to blast osteoblasts? Novel dicarba analogues of amylin-(1-8) to treat osteoporosis. Bioorganic and Medicinal Chemistry (2012) 20(20): 6011-6018.

Kowalczyk, R., Harris, P. W. R., Brimble, M. A., Callon, K. E., Watson, M., & Cornish, J. Synthesis and evaluation of disulfide bond mimetics of amylin-(1-8) as agents to treat osteoporosis. Bioorganic and Medicinal Chemistry (2012) 20(8): 2661-2668.

Kueh, J. T. B., Choi, K. W., & Brimble, M. A. Enantioselective synthesis of C-linked spiroacetal-triazoles as privileged natural product-like scaffolds. Organic and Biomolecular Chemistry (2012) 10(30): 5993-6002.

Lancaster, G. I., Skiba, B., Yang, C., Nicholls, H. T., Langley, K. G., Chan, M. H., Bruce, C. R., Rewcastle, G. W., Shepherd, P. R., Karin, M., & Febbraio, M. A. IkappaB kinase beta (IKKbeta) does not mediate feedback inhibition of the insulin signalling cascade. Biochemical Journal (2012) 442(3): 723-732. [pdf]

Lasham, A., Samuel, W., Cao, H., Patel, R., Mehta, R., Stern, J. L., Reid, G., Woolley, A. G., Miller, L. D., Black, M. A., Shelling, A. N., Print, C. G., & Braithwaite, A. W. YB-1, the E2F pathway, and regulation of tumor cell growth. Journal of the National Cancer Institute (2012) 104(2): 133-146.

Lee, D. J., Yang, S. H., Williams, G. M., & Brimble, M. A. Synthesis of multivalent neoglyconjugates of MUC1 by the conjugation of carbohydrate-centered, triazolelinked glycoclusters to MUC1 peptides using click chemistry. Journal of Organic Chemistry (2012) 77(17): 7564-7571.

Lim, S. N., Kuhn, S., Hyde, E., & Ronchese, F. Combined TLR stimulation with Pam3Cys and Poly I: C enhances Flt3-ligand dendritic cell activation for tumor immunotherapy. Journal of Immunotherapy (2012) 35(9): 670-679.

Linke, C., Siemens, N., Middleditch, M. J., Kreikemeyer, B., & Baker, E. N. Purification, crystallization and preliminary crystallographic analysis of the adhesion domain of Epf from Streptococcus pyogenes. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2012) 68(7): 793-797.

Linke, C., Siemens, N., Oehmcke, S., Radjainia, M., Law, R. H. P., Whisstock, J. C., Baker, E. N., & Kreikemeyer, B. The extracellular protein factor epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an n-terminal domain containing a carbohydrate-binding module. Journal of Biological Chemistry (2012) 287(45): 38178-38189.

Liu, X., Chia, E., Shaw, O. M., Martin, W. J., & Harper, J. L. Rapid CCL2 release by membrane stromal cells initiates monosodium urate crystal-induced monocyte recruitment in a peritoneal model of gouty inflammation. European Journal of Inflammation (2012) 10(2): 165-174.

McKee, S. J., Young, V. L., Clow, F., Hayman, C. M., Baird, M. A., Hermans, I. F., Young, S. L., & Ward, V. K. Virus-like particles and a-galactosylceramide form a self-adjuvanting composite particle that elicits anti-tumor responses. Journal of Controlled Release (2012) 159(3): 338-345.

McLeod, M. C., Brimble, M. A., Rathwell, D. C. K., Wilson, Z. E., & Yuen, T. Y. Synthetic approaches to [5,6]-benzannulated spiroketal natural products. Pure and Applied Chemistry (2012) 84(6): 1379-1390.

McLeod, M. C., Wilson, Z. E., & Brimble, M. A. Formal synthesis of berkelic acid: A lesson in alpha-alkylation chemistry. Journal of Organic Chemistry (2012) 77(1): 400-416.

Noble, D., Kurachi, Y., Hunter, P., Wang, X., Gordon, M., & Boron, W. Physiology without borders 2. Physiology (2012) 27(1): 2. 

Pantham, P., Rosario, R., Chen, Q., Print, C. G., & Chamley, L. W. Transcriptomic analysis of placenta affected by antiphospholipid antibodies: following the TRAIL of trophoblast death. Journal of Reproductive Immunology (2012) 94(2): 151-154.

Papst, S., Noisier, A., Brimble, M. A., Yang, Y., & Krissansen, G. W. Tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY prepared via Click Chemistry: Synthesis and biological evaluation. Bioorganic and Medicinal Chemistry (2012) 20(8): 2638-2644. [pdf]

Papst, S., Noisier, A. F. M., Brimble, M. A., Yang, Y., Chan, Y. C., & Krissansen, G. W. Synthesis and SAR of a library of cell-permeable biotin-R8ERY*peptidomimetics inhibiting α4β7 integrin mediated adhesion of TK-1 cells to MAdCAM -1-Fc. Australian Journal of Chemistry (2012) 65(9): 1349-1358.

Papst, S., Noisier, A. F. M., Brimble, M. A., Yang, Y., & Krissansen, G. W. Synthesis and biological evaluation of tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY. Bioorganic and Medicinal Chemistry (2012) 20(17): 5139-5149. [pdf]

Peltier, R., Siah, W. R., Williams, G. V. M., Brimble, M. A., Tilley, R. D., & Williams, D. E. Novel phosphopeptides as surface-active agents in iron nanoparticle synthesis. Australian Journal of Chemistry (2012) 65(6): 680-685. [pdf]

Poyner, D. R., & Hay, D. L. Secretin family (Class B) G protein-coupled receptors - From molecular to clinical perspectives. British Journal of Pharmacology (2012) 166(1): 1-3.

Radcliff, F. J., Loh, J. M. S., Ha, B., Schuhbauer, D., McCluskey, J., & Fraser, J. D. Antigen targeting to major histocompatibility complex class II with streptococcal mitogenic exotoxin Z-2 M1, a superantigen-based vaccine carrier. Clinical and Vaccine Immunology (2012) 19(4): 574-586.

Radjainia, M., Huang, B., Bai, B., Schmitz, M., Yang, S. H., Harris, P. W. R., Griffin, M. D. W., Brimble, M. A., Wang, Y., & Mitra, A. K. A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin. FEBS Journal (2012) 279(14): 2495-2507.

Rennison, D., Laita, O., Bova, S., Cavalli, M., Hopkins, B., Linthicum, D. S., & Brimble, M. A. Design and synthesis of prodrugs of the rat selective toxicant norbormide. Bioorganic and Medicinal Chemistry (2012) 20(13): 3997-4011.

Rich, F. J., Kuhn, S., Hyde, E. J., Harper, J. L., Ronchese, F., & Kirman, J. R. Induction of T cell responses and recruitment of an inflammatory dendritic cell subset following tumor immunotherapy with Mycobacterium smegmatis. Cancer Immunology, Immunotherapy (2012) 61(12): 2333-2342.

Richter, S., Richter, J. P., Mehta, S. Y., Gribble, A. M., Sutherland-Smith, A. J., Stowell, K. M., Print, C. G., Ronimus, R. S., & Wilson, W. R. Expression and role in glycolysis of human ADP-dependent glucokinase. Molecular and Cellular Biochemistry (2012) 364(1-2): 131-145. [pdf]

Rosario, R., Araki, H., Print, C. G., & Shelling, A. N. The transcriptional targets of mutant FOXL2 in granulosa cell tumours. PLoS ONE (2012) 7(9): e46270.

Schünemann, K., Connelly, S., Kowalczyk, R., Sperry, J., Wilson, I. A., Fraser, J. D., & Brimble, M. A. A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors. Bioorganic and Medicinal Chemistry Letters (2012) 22(15): 5018-5024.

Shepherd, P. R., & Denny, W. A. Beta-testing of PI3-kinase inhibitors: Is beta better? Cancer Discovery (2012) 2(5): 393-394.

Shepherd, P. R., & Denny, W. A. Drug discovery in the academic environment: The academic model. Biochemist (2012) 34(1): 4-6.

Smith, G. C., Ong, W. K., Rewcastle, G. W., Kendall, J. D., Han, W., & Shepherd, P. R. Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo. Biochemical Journal (2012) 442(1): 161-169.

Sparrow, K., Barker, D., & Brimble, M. A. An efficient synthesis of 3-alkyl-1,5,3- dioxazepanes and their use as electrophiles in double-Mannich reactions. Tetrahedron (2012) 68(4): 1017-1028.

Stubbing, L. A., Li, F. F., Furkert, D. P., Caprio, V. E., & Brimble, M. A. Access to 2-alkyl chromanones via a conjugate addition approach. Tetrahedron (2012) 68(34): 6948-6956.

Swe, P. M., Copp, J. N., Green, L. K., Guise, C. P., Mowday, A. M., Smaill, J. B., Patterson, A. V., & Ackerley, D. F. Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954. Biochemical Pharmacology (2012) 84(6): 775-783. [pdf]

Tang, R. Y., Li, K. Y., Wilson, M., Both, G. W., Taylor, J. A., & Young, S. L. Potent antietumor immunity in mice induced by vaccination with an ovine atadenovirus vector. Journal of Immunotherapy (2012) 35(1): 32-41. [pdf]

Wadsworth, A. D., Furkert, D. P., Sperry, J., & Brimble, M. A. Total synthesis of the initially reported and revised structures of the neuroprotective agent palmyrolide A. Organic Letters (2012) 14(20): 5374-5377.

Wang, L., Hurley, D. G., Watkins, W., Araki, H., Tamada, Y., Muthukaruppan, A., Ranjard, L., Derkac, E., Imoto, S., Miyano, S., Crampin, E. J., & Print, C. G. Cell cycle gene networks are associated with melanoma prognosis. PLoS ONE (2012) 7(4): e34247.

Wang, Y. P., Gjuvsland, A. B., Vik, J. O., Smith, N. P., Hunter, P. J., & Omholt, S. W. Parameters in dynamic models of complex traits are containers of missing heritability. PLoS Computational Biology (2012) 8(4): e1002459.

Watkins, H. A., Au, M., & Hay, D. L. The structure of secretin family GPCR peptide ligands: Implications for receptor pharmacology and drug development. Drug Discovery Today (2012) 17(17-18): 1006-1014.

Watkins, H. A., & Hay, D. L. Recent progress in unraveling the complexities of receptor biology: Towards new therapeutics. Expert Review of Clinical Pharmacology (2012) 5(2): 145-147.

Wilmes, A., Hanna, R., Heathcott, R. W., Northcote, P. T., Atkinson, P. H., Bellows, D. S., & Miller, J. H. Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae. Gene (2012) 497(2): 140-146.

Woods, T. M., Kamalov, M., Harris, P. W. R., Cooper, G. J. S., & Brimble, M. Synthesis of monolysyl advanced glycation endproducts and their incorporation into collagen model peptides. Organic Letters (2012) 14(22): 5740-5743.

Yeung, H., Lee, D. J., Williams, G. M., Harris, P. W. R., Dunbar, R. P., & Brimble, M. A. A method for the generation of Pam(2)Cys-based lipopeptide mimics via CuAAC click chemistry. Synlett (2012) 11: 1617-1620.

Yibmantasiri, P., Leahy, D. C., Busby, B. P., Angermayr, S. A., Sorgo, A. G., Boeger, K., Heathcott, R., Barber, J. M., Moraes, G., Matthews, J. H., Northcote, P. T., Atkinson, P. H., & Bellows, D. S. Molecular basis for fungicidal action of neothyonidioside, a triterpene glycoside from the sea cucumber, Australostichopus mollis. Molecular BioSystems (2012) 8(3): 902-912. [pdf]

Yuen, T. Y., & Brimble, M. A. Total synthesis of 7’,8’-dihydroaigialospirol. Organic Letters (2012) 14(19): 5154-5157.

Zheng, Z. H., Amran, S. I., Zhu, J. X., Schmidt-Kittler, O., Kinzler, K. W., Vogelstein, B., Shepherd, P. R., Thompson, P. E., & Jennings, I. G. Definition of the binding mode of a new class of phosphoinositide 3-kinase alpha-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis. Biochemical Journal (2012) 444(3): 529-535.