Scientific Publications
Every year Maurice Wilkins Centre investigators produce a large number of peer-reviewed scientific papers and reviews published in international journals. Research directly supported by the Maurice Wilkins Centre generated the following scientific papers.
2022
Ahangarpour, M., Kavianinia, I., Hume, P. A., Harris, P. W. R. & Brimble, M. A. (2022). N-Vinyl Acrylamides: Versatile Heterobifunctional Electrophiles for Thiol-Thiol Bioconjugations. Journal of the American Chemical Society 144(30): 13652-13662. https://doi.org/10.1021/jacs.2c04146
Al-Zubaidi, A., Cheung, C. Y., Cook, G. M., Taiaroa, G., Mizrahi, V., Lott, J. S. & Dawes, S. S. (2022). RNase HI Depletion Strongly Potentiates Cell Killing by Rifampicin in Mycobacteria. Antimicrobial Agents and Chemotherapy 66(10). https://doi.org/10.1128/aac.02091-21
Alexander, T. I., Tasma, Z., Siow, A., Rees, T. A., Brimble, M. A., Harris, P. W. R., Hay, D. L. & Walker, C. S. (2022). Novel Fluorescently Labeled PACAP and VIP Highlight Differences between Peptide Internalization and Receptor Pharmacology. ACS Pharmacology and Translational Science. https://doi.org/10.1021/acsptsci.2c00124
Banerjee, R., Smith, J., Eccles, M. R., Weeks, R. J. & Chatterjee, A. (2022). Epigenetic basis and targeting of cancer metastasis. Trends in Cancer 8(3): 226-241. https://doi.org/10.1016/j.trecan.2021.11.008
Brain, S. D., Russo, A. F. & Hay, D. L. (2022). Editorial: Calcitonin Gene-Related Peptide: Novel Biology and Treatments. Frontiers in Physiology 13. https://doi.org/10.3389/fphys.2022.964568
Crystal Chan, S. H., Griffin, J. M., Clemett, C. A., Brimble, M. A., O’Carroll, S. J. & Harris, P. W. R. (2022). Synthesis and Biological Evaluation of Termini-Modified and Cyclic Variants of the Connexin43 Inhibitor Peptide5. Frontiers in Chemistry 10. https://doi.org/10.3389/fchem.2022.877618
Denny, W. A. (2022). Inhibitors and Activators of the p38 Mitogen-Activated MAP Kinase (MAPK) Family as Drugs to Treat Cancer and Inflammation. Current Cancer Drug Targets 22(3): 209-220. https://doi.org/10.2174/1568009622666220215142837
Denny, W. A. (2022). Nitroaromatic Hypoxia-Activated Prodrugs for Cancer Therapy. Pharmaceuticals 15(2). https://doi.org/10.3390/ph15020187
Garelja, M. L., Bower, R. L., Brimble, M. A., Chand, S., Harris, P. W. R., Jamaluddin, M. A., Petersen, J., Siow, A., Walker, C. S. & Hay, D. L. (2022). Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared with human receptors. British Journal of Pharmacology 179(3): 416-434. https://doi.org/10.1111/bph.15628
Garelja, M. L. & Hay, D. L. (2022). A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene-related peptide and beyond. Headache 62(9): 1093-1104. https://doi.org/10.1111/head.14388
Garelja, M. L., Walker, C. S. & Hay, D. L. (2022). CGRP receptor antagonists for migraine. Are they also AMY1 receptor antagonists? British Journal of Pharmacology 179(3): 454-459. https://doi.org/10.1111/bph.15585
Hards, K., Cheung, C. Y., Waller, N., Adolph, C., Keighley, L., Tee, Z. S., Harold, L. K., Menorca, A., Bujaroski, R. S., Buckley, B. J., Tyndall, J. D. A., McNeil, M. B., Rhee, K. Y., Opel-Reading, H. K., Krause, K., Preiss, L., Langer, J. D., Meier, T., Hasenoehrl, E. J., Berney, M., Kelso, M. J. & Cook, G. M. (2022). An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology 5(1). https://doi.org/10.1038/s42003-022-03110-8
Harold, L. K., Jinich, A., Hards, K., Cordeiro, A., Keighley, L. M., Cross, A., McNeil, M. B., Rhee, K. & Cook, G. M. (2022). Deciphering functional redundancy and energetics of malate oxidation in mycobacteria. Journal of Biological Chemistry 298(5). https://doi.org/10.1016/j.jbc.2022.101859
Harris, P. W. R., Siow, A., Yang, S. H., Wadsworth, A. D., Tan, L., Hermant, Y., Mao, Y., An, C., Hanna, C. C., Cameron, A. J., Allison, J. R., Chakraborty, A., Ferguson, S. A., Mros, S., Hards, K., Cook, G. M., Williamson, D. A., Carter, G. P., Chan, S. T. S., Painter, G. A., Sander, V., Davidson, A. J. & Brimble, M. A. (2022). Synthesis, Antibacterial Activity, and Nephrotoxicity of Polymyxin B Analogues Modified at Leu-7, d -Phe-6, and the N-Terminus Enabled by S-Lipidation. ACS Infectious Diseases 8(12): 2413-2429. https://doi.org/10.1021/acsinfecdis.1c00347
Hashimi, F. N., Bennett, J., Baker, M. G., Moreland, N. J., Merry, T. L. & Loh, J. M. S. (2022). The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model. Scientific Reports 12(1). https://doi.org/10.1038/s41598-022-22648-5
Hay, D. L., Walker, C. S. & Harris, P. W. R. (2022). Atogepant (Qulipta®) for migraine prevention. Trends in Pharmacological Sciences 43(8): 701-702. https://doi.org/10.1016/j.tips.2022.03.013
Hendrikse, E. R., Rees, T. A., Tasma, Z., Garelja, M. L., Siow, A., Harris, P. W. R., Pawlak, J. B., Caron, K. M., Blakeney, E. S., Russo, A. F., Sowers, L. P., Lutz, T. A., Le Foll, C., Walker, C. S. & Hay, D. L. (2022). Characterization of Antibodies against Receptor Activity-Modifying Protein 1 (RAMP1): A Cautionary Tale. International Journal of Molecular Sciences 23(24). https://doi.org/10.3390/ijms232416035
Hendrikse, E. R., Rees, T. A., Tasma, Z., Le Foll, C., Lutz, T. A., Siow, A., Wookey, P. J., Walker, C. S. & Hay, D. L. (2022). Calcitonin receptor antibody validation and expression in the rodent brain. Cephalalgia 42(9): 815-826. https://doi.org/10.1177/03331024221084029
Hicks, J. L., Oldham, K. E. A., McGarvie, J. & Walker, E. J. (2022). Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens. Bioscience Reports 42(10). https://doi.org/10.1042/bsr20220368
Hossain, S. M., Gimenez, G., Stockwell, P. A., Tsai, P., Print, C. G., Rys, J., Cybulska-Stopa, B., Ratajska, M., Harazin-Lechowska, A., Almomani, S., Jackson, C., Chatterjee, A. & Eccles, M. R. (2022). Innate immune checkpoint inhibitor resistance is associated with melanoma sub-types exhibiting invasive and de-differentiated gene expression signatures. Frontiers in Immunology 13. https://doi.org/10.338/fimmu.2022.955063
Jamaluddin, A., Chuang, C. L., Williams, E. T., Siow, A., Yang, S. H., Harris, P. W. R., Petersen, J. S. S. M., Bower, R. L., Chand, S., Brimble, M. A., Walker, C. S., Hay, D. L. & Loomes, K. M. (2022). Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo. Frontiers in Pharmacology 13. https://doi.org/10.3389/fphar.2022.832589
Jiao, W., Mittelstädt, G. & Parker, E. J. (2022). Precise Positioning of Water Is Critical for Hydrolysis Catalyzed by 5′-Methylthioadenosine Nucleosidase. Biochemistry 61(17): 1883-1893. https://doi.org/10.1021/acs.biochem.2c00351
Kobayashi, A., Hamada, M., Yoshida, M. A., Kobayashi, Y., Tsutsui, N., Sekiguchi, T., Matsukawa, Y., Maejima, S., Gingell, J. J., Sekiguchi, S., Hamamoto, A., Hay, D. L., Morris, J. F., Sakamoto, T. & Sakamoto, H. (2022). Vasopressin-oxytocin-type signaling is ancient and has a conserved water homeostasis role in euryhaline marine planarians. Science Advances 8(9). https://doi.org/10.1126/sciadv.abk0331
Kovalenko, N., Swain, J. A., Howard, G. K., Hermant, Y. O., Cameron, A. J., Stubbing, L. A., Harris, P. W. R. & Brimble, M. A. (2022). Synthetic Studies towards the Calcium-Dependent Lipopeptide Antibiotic Cadaside B. Chemistry - A European Journal 28(70). https://doi.org/10.1002/chem.202202554
Kurup, H. M., Kvach, M. V., Harjes, S., Barzak, F. M., Jameson, G. B., Harjes, E. & Filichev, V. V. (2022). Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A. Biochemistry 61(22): 2568-2578. https://doi.org/10.1021/acs.biochem.2c00449
Lee, K., Vakili, S., Burden, H. J., Adams, S., Smith, G. C., Kulatea, B., Wright-McNaughton, M., Sword, D., Watene-O'Sullivan, C., Atiola, R. D., Paul, R. G., Plank, L. D., Kallingappa, P., King, F., Wilcox, P., Merriman, T. R., Krebs, J. D., Hall, R. M., Murphy, R., Merry, T. L. & Shepherd, P. R. (2022). The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition. Molecular Metabolism 59. https://doi.org/10.1016/j.molmet.2022.101464
Lu, X., Smaill, J. B., Patterson, A. V. & Ding, K. (2022). Discovery of Cysteine-targeting Covalent Protein Kinase Inhibitors. Journal of Medicinal Chemistry 65(1): 58-83. https://doi.org/10.1021/acs.jmedchem.1c01719
McHugh, A. D., Chase, J. G., Knopp, J. L., Ormsbee, J. J., Kulawiec, D. G., Merry, T. L., Murphy, R., Shepherd, P. R., Burden, H. J. & Docherty, P. D. (2022). The Impact of Exogenous Insulin Input on Calculating Hepatic Clearance Parameters. Journal of Diabetes Science and Technology 16(4): 945-954. https://doi.org/10.1177/1932296820986878
McNeil, M. B., Ryburn, H. W., Tirados, J., Cheung, C. Y. & Cook, G. M. (2022). Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes. iScience 25(1). https://doi.org/10.1016/j.isci.2021.103573
Metcalfe, L. K., Shepherd, P. R., Smith, G. C. & Turner, N. (2022). Limited Metabolic Effect of the CREBRFR457Q Obesity Variant in Mice. Cells 11(3). https://doi.org/10.3390/cells11030497
Mulholland, C. V., Gimenez, G., Williamson, A., Steele, M., Thorpe, D., Karalus, N., Cursons, R. T., Playle, V. M., Roberts, S. A., Cook, G. M., Arcus, V. L. & Aung, H. L. (2022). Complete Genome Sequence of a New Zealand Mycobacterium tuberculosis Strain Responsible for Ongoing Transmission over the Past 30 Years. Microbiology Resource Announcements 11(11). https://doi.org/10.1128/mra.00781-22
Oh, J. K., Przepiorski, A., Chang, H. H., Dodd, R. C., Sander, V., Sorrenson, B., Shih, J. H., Hollywood, J. A., de Zoysa, J. R., Shepherd, P. R., Davidson, A. J. & Holm, T. M. (2022). Derivation of induced pluripotent stem cell lines from New Zealand donors. Journal of the Royal Society of New Zealand 52(1): 54-67. https://doi.org/10.1007/s12015-017-9766-9
Oldham, K. E. A., Prentice, E. J., Summers, E. L. & Hicks, J. L. (2022). Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition. Biochemical Journal 479(1): 57-74. https://doi.org/10.1042/bcj20210564
Ormsbee, J. J., Burden, H. J., Knopp, J. L., Chase, J. G., Murphy, R., Shepherd, P. R. & Merry, T. (2022). Variability in Estimated Modelled Insulin Secretion. Journal of Diabetes Science and Technology 16(3): 732-741. https://doi.org/10.1177/1932296821991120
Peng, Y., Liu, Y., Hu, Y., Chang, F., Wu, Q., Yang, J., Chen, J., Teng, S., Zhang, J., He, R., Wei, Y., Bostina, M., Luo, T., Liu, W., Qu, X. & Li, Y. P. (2022). Monoclonal antibodies constructed from COVID-19 convalescent memory B cells exhibit potent binding activity to MERS-CoV spike S2 subunit and other human coronaviruses. Frontiers in Immunology 13. https://doi.org/10.3389/fimmu.2022.1056272
Pradhan, S., Williams, M. A. K. & Hale, T. K. (2022). Changes in the properties of membrane tethers in response to HP1α depletion in MCF7 cells. Biochemical and Biophysical Research Communications 587: 126-130. https://doi.org/10.1016/j.bbrc.2021.11.081
Prasit, K. K., Ferrer-Font, L., Burn, O. K., Anderson, R. J., Compton, B. J., Schmidt, A. J., Mayer, J. U., Chen, C. J. J., Dasyam, N., Ritchie, D. S., Godfrey, D. I., Mattarollo, S. R., Dundar, P. R., Painter, G. F. & Hermans, I. F. (2022). Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect. OncoImmunology 11(1). https://doi.org/10.1080/2162402x.2022.2081009
Rees, T. A., Hendrikse, E. R., Hay, D. L. & Walker, C. S. (2022). Beyond CGRP: The calcitonin peptide family as targets for migraine and pain. British Journal of Pharmacology 179(3): 381-399. https://doi.org/10.1111/bph.15605
Rees, T. A., Russo, A. F., O’Carroll, S. J., Hay, D. L. & Walker, C. S. (2022). CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons. Frontiers in Physiology 13. https://doi.org/10.3389/fphys.2022.860037
Shao, M., Chen, X., Yang, F., Song, X., Zhou, Y., Lin, Q., Fu, Y., Ortega, R., Lin, X., Tu, Z., Patterson, A. V., Smaill, J. B., Chen, Y. & Lu, X. (2022). Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. Journal of Medicinal Chemistry 65(6): 5113-5133. https://doi.org/10.1021/acs.jmedchem.2c00096
Stevenson, L. J., Ackerley, D. F. & Owen, J. G. (2022). Preparation of Soil Metagenome Libraries and Screening for Gene-Specific Amplicons. Methods in Molecular Biology 2397: 3-17. https://doi.org/10.1007/978-1-0716-1826-4_1
Tasma, Z., Siow, A., Harris, P. W. R., Brimble, M. A., O’Carroll, S. J., Hay, D. L. & Walker, C. S. (2022). PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies. International Journal of Molecular Sciences 23(22). https://doi.org/10.3390/Fijms232213797
Tesfay, B., Karlsson, W. K., Moreno, R. D., Hay, D. L. & Hougaard, A. (2022). Is calcitonin gene-related peptide a reliable biochemical marker of migraine? Current Opinion in Neurology 35(3): 343-352. https://doi.org/10.1097/wco.0000000000001053
Tong, K. K. H., Riisom, M., Leung, E., Hanif, M., Söhnel, T., Jamieson, S. M. F. & Hartinger, C. G. (2022). Impact of Coordination Mode and Ferrocene Functionalization on the Anticancer Activity of N-Heterocyclic Carbene Half-Sandwich Complexes. Inorganic Chemistry 61(43): 17226-17241. https://doi.org/10.1021/acs.inorgchem.2c02832
Truong, D., Lam, N. Y. S., Kamalov, M., Riisom, M., Jamieson, S. M. F., Harris, P. W. R., Brimble, M. A., Metzler-Nolte, N. & Hartinger, C. G. (2022). A Solid Support-Based Synthetic Strategy for the Site-Selective Functionalization of Peptides with Organometallic Half-Sandwich Moieties. Chemistry - A European Journal 28(12). https://doi.org/10.1002/chem.202104049
Tsai, C. J. Y., Loh, J. M. S. & Proft, T. (2022). PilVax: A Novel Platform for the Development of Mucosal Vaccines. Methods in Molecular Biology 2412: 399-410. https://doi.org/10.1007/978-1-0716-1892-9_20
Whitcombe, A. L., Han, F., McAlister, S. M., Kirkham, L. A. S., Young, P. G., Ritchie, S. R., Atatoa Carr, P., Proft, T. & Moreland, N. J. (2022). An eight-plex immunoassay for Group A streptococcus serology and vaccine development. Journal of Immunological Methods 500. https://doi.org/10.1016/j.jim.2021.113194
Whitcombe, A. L., McGregor, R., Bennett, J., Gurney, J. K., Williamson, D. A., Baker, M. G. & Moreland, N. J. (2022). Increased Breadth of Group A Streptococcus Antibody Responses in Children With Acute Rheumatic Fever Compared to Precursor Pharyngitis and Skin Infections. Journal of Infectious Diseases 226(1): 167-176. https://doi.org/10.1093/infdis/jiac043
Yang, F., Chen, X., Song, X., Ortega, R., Lin, X., Deng, W., Guo, J., Tu, Z., Patterson, A. V., Smaill, J. B., Chen, Y. & Lu, X. (2022). Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. Journal of Medicinal Chemistry 65(21): 14809-14831. https://doi.org/10.1021/acs.jmedchem.2c01319