Publications //

Scientific Publications

Every year Maurice Wilkins Centre investigators produce a large number of peer-reviewed scientific papers and reviews published in international journals. Research directly supported by the Maurice Wilkins Centre generated the following scientific papers.

    2021

    Ahangarpour, M., Kavianinia, I., Harris, P. W. R., & Brimble, M. A. (2021). Photo-induced radical thiol-ene chemistry: A versatile toolbox for peptide-based drug design. Chemical Society Reviews (2021) 50(2): 898-944. 

    Barzak, F. M., Ryan, T. M., Kvach, M. V., Kurup, H. M., Aihara, H., Harris, R. S., Filichev, V. V., Harjes, E., Jameson, G. B.  Small-angle x-ray scattering models of apobec3b catalytic domain in a complex with a single-stranded dna inhibitor. Viruses (2021) 13(2): 290.

    Blanchett, S., Tsai, C. J. Y., Sandford, S., Loh, J. M. S., Huang, L., Kirman, J. R., & Proft, T.   Intranasal immunization with Ag85B peptide 25 displayed on Lactococcus lactis using the PilVax platform induces antigen-specific B- and T-cell responses. Immunology and Cell Biology (2021) 99: 767-781.

    Burden, H. J., Adams, S., Kulatea, B., Wright-McNaughton, M., Sword, D., Ormsbee, J. J., Watene-O’Sullivan, C., Merriman, T. R., Knopp, J. L., Chase, J. G., Krebs, J. D., Hall, R. M., Plank, L. D., Murphy, R., Shepherd, P. R., & Merry, T. L.  The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry. Diabetologica (2021) 2021.2002.2027.21252567.

    Cameron, A. J., Park, C., Howard, G. K., Harris, P. W. R., & Brimble, M. A.  Total Synthesis of Allene-Containing Cyclic Tetrapeptide Pseudoxylallemycin C. Synlett (2021) 32(3): 273-276. 

    Daniels, L. J., Annandale, M., Koutsifeli, P., Li, X., Bussey, C. T., van Hout, I., Bunton, R. W., Davis, P. J., Coffey, S., Katare, R., Lamberts, R. R., Delbridge, L. M. D., & Mellor, K. M.  Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro. Nutrition and Diabetes (2021) 11(1): 8.

    Denny, W. A., & Flanagan, J. U.  Small-molecule CSF1R kinase inhibitors; review of patents 2015-present. Expert Opinion on Therapeutic Patents (2021) 31(2): 107-117. 

    Dissanayake, W. C., Oh, J. K., Sorrenson, B., & Shepherd, P. R.  Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12, through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin. Bioscience Reports (2021) 41(7): BSR20211066.

    Fu, Z., Mowday, A. M., Smaill, J. B., Hermans, I. F., & Patterson, A. V.  Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy. Cells (2021) 10(5): 1006.

    Ghanizada, H., Al-Karagholi, M. A. M., Walker, C. S., Arngrim, N., Rees, T., Petersen, J., Siow, A., Mørch-Rasmussen, M., Tan, S., O'Carroll, S. J., Harris, P., Skovgaard, L. T., Jørgensen, N. R., Brimble, M., Waite, J. S., Rea, B. J., Sowers, L. P., Russo, A. F., Hay, D. L., & Ashina, M.  Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients. Annals of Neurology (2021)  89(6): 1157-1171. 

    Grattan, D. R., & Andrews, Z. B.  Insulin as a neuroendocrine hormone. Journal of Neuroendocrinology (2021) 33(4): e12966. 

    Hampe, L., Harris, P. W. R., Rushton, B., Radjainia, M., Brimble, M. A., & Mitra, A. K.  Engineering a stable complex of ERp44 with a designed peptide ligand for analyzing the mode of interaction of ERp44 with its clients. Peptide Science (2021) e24230.

    Hanna, C. C., Hermant, Y. O., Harris, P. W. R., & Brimble, M. A.  Discovery, Synthesis, and Optimization of Peptide-Based Antibiotics. Accounts of Chemical Research (2021) 54(8): 1878-1890. 

    Horne, C. R., Venugopal, H., Panjikar, S., Wood, D. M., Henrickson, A., Brookes, E., North, R. A., Murphy, J. M., Friemann, R., Griffin, M. D. W., Ramm, G., Demeler, B., & Dobson, R. C. J.  Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism. Nature Communications (2021) 12(1): 1988.

    Kasim, J. K., Kavianinia, I., Bull, M., Harris, P. W. R., Smaill, J. B., Patterson, A. V., & Brimble, M. A.  Fourth-Generation Analogues of the Anticancer Peptaibol Culicinin D: Probing the Effects of Hydrophobicity and Halogenation on Cytotoxicity. Synthesis (Germany) (2021) 53: A-G.

    Ladyman, S. R., & Brooks, V. L.  Central actions of insulin during pregnancy and lactation. Journal of Neuroendocrinology (2021) 33(4): e12946.

    Lasham, A., Knowlton, N., Mehta, S. Y., Braithwaite, A. W., & Print, C. G.  Breast Cancer Patient Prognosis Is Determined by the Interplay between TP53 Mutation and Alternative Transcript Expression: Insights from TP53 Long Amplicon Digital PCR Assays. Cancers (Basel) (2021) 13(7): 1531. 

    Lee, B. S., Hards, K., Engelhart, C. A., Hasenoehrl, E. J., Kalia, N. P., Mackenzie, J. S., Sviriaeva, E., Chong, S. M. S., Manimekalai, M. S. S., Koh, V. H., Chan, J., Xu, J., Alonso, S., Miller, M. J., Steyn, A. J. C., Grüber, G., Schnappinger, D., Berney, M., Cook, G. M., Moraski, G. C., & Pethe, K.  Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis. EMBO Molecular Medicine (2021) 13(1): e13207.

    Lee, K., Vakili, S., Burden, H. J., Adams, S., Smith, G. C., Kulatea, B., Wright-McNaughton, M., Sword, D., Watene-O’Sullivan, C., Atiola, R. D., Paul, R. G., Plank, L. D., Wilcox, P., Kallingappa, P., Merriman, T. R., Krebs, J. D., Hall, R. M., Murphy, R., Merry, T. L., & Shepherd, P. R.  The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition. medRxiv (2021) 2021.2007.2013.21260462. 

    Li, H., Clarke, G. S., Christie, S., Ladyman, S. R., Kentish, S. J., Young, R. L., Gatford, K. L., & Page, A. J.  Pregnancy-related plasticity of gastric vagal afferent signals in mice. American Journal of Physiology - Gastrointestinal and Liver Physiology (2021) 320(2): G183-G192. 

    Loef, E. J., Sheppard, H. M., Birch, N. P., & Dunbar, P. R.  Live-Cell Microscopy Reveals That Human T Cells Primarily Respond Chemokinetically Within a CCL19 Gradient That Induces Chemotaxis in Dendritic Cells. Frontiers in Immunology (2021) 12: 628090.

    Loh, J. M. S., Rivera-Hernandez, T., McGregor, R., Khemlani, A. H. J., Tay, M. L., Cork, A. J., M. Raynes, J., Moreland, N. J., Walker, M. J., & Proft, T.  A multivalent T-antigen-based vaccine for Group A Streptococcus. Scientific Report (2021) 11(1): 4353. 

    Lorenz, N., Ho, T. K., McGregor, R., Davies, M. R., Williamson, D. A., Gurney, J. K., Smeesters, P. R., Baker, M. G., & Moreland, N. J.  Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever. Clinical Infectious Diseases (2021) ciab180.

    Masson, S. W. C., Woodhead, J. S. T., D'Souza, R. F., Broome, S. C., MacRae, C., Cho, H. C., Atiola, R. D., Futi, T., Dent, J. R., Shepherd, P. R., & Merry, T. L.  β-Catenin is required for optimal exercise- and contraction-stimulated skeletal muscle glucose uptake. Journal of Physiology (2021) 599: 3897-3912.

    McGregor, R., Tay, M. L., Carlton, L. H., Hanson-Manful, P., Raynes, J. M., Forsyth, W. O., Brewster, D. T., Middleditch, M. J., Bennett, J., Martin, W. J., Wilson, N., Atatoa Carr, P., Baker, M. G., & Moreland, N. J.  Mapping Autoantibodies in Children With Acute Rheumatic Fever. Frontiers in Immunology (2021) 12(2883): 702877. 

    McHugh, A. D., Chase, J. G., Knopp, J. L., Ormsbee, J. J., Kulawiec, D. G., Merry, T. L., Murphy, R., Shepherd, P. R., Burden, H. J., & Docherty, P. D.  The Impact of Exogenous Insulin Input on Calculating Hepatic Clearance Parameters. Journal of Diabetes Science and Technology (2021) 10.1177/1932296820986878

    McNeil, M. B., Keighley, L. M., Cook, J. R., Cheung, C.-Y., & Cook, G. M.  CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis. bioRxiv (2021) 2021.2002.2004.429736. 

    Mountjoy, K. G.  ELISA versus LUMINEX assay for measuring mouse metabolic hormones and cytokines: sharing the lessons I have learned. Journal of Immunoassay and Immunochemistry (2021) 42(2): 154-173. 

    Mowday, A. M., Dubois, L. J., Kubiak, A. M., Chan-Hyams, J. V. E., Guise, C. P., Ashoorzadeh, A., Lambin, P., Ackerley, D. F., Smaill, J. B., Minton, N. P., Theys, J., & Patterson, A. V.  Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours. Cancer Gene Therapy (2021) 10.1038/s41417-021-00296-7

    Oliver, M. R., Horne, C. R., Shrestha, S., Keown, J. R., Liang, L. Y., Young, S. N., Sandow, J. J., Webb, A. I., Goldstone, D. C., Lucet, I. S., Kannan, N., Metcalf, P., & Murphy, J. M.  Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix. Nature Communications (2021) 12(1): 1002.

    Ormsbee, J. J., Burden, H. J., Knopp, J. L., Chase, J. G., Murphy, R., Shepherd, P. R., & Merry, T.  Variability in Estimated Modelled Insulin Secretion. Journal of Diabetes Science and Technology (2021) 10.1177/1932296821991120

    Painter, G. F., Burn, O. K., & Hermans, I. F.  Using agonists for iNKT cells in cancer therapy. Molecular Immunology (2021) 130: 1-6.

    Park, S. M., Brooks, A. E. S., Chen, C. J. J., Sheppard, H. M., Loef, E. J., McIntosh, J. D., Angel, C. E., Mansell, C. J., Bartlett, A., Cebon, J., Birch, N. P., & Dunbar, P. R.  Migratory cues controlling B-lymphocyte trafficking in human lymph nodes. Immunology and Cell Biology (2021) 99(1): 49-64. 

    Pilapitiya, D. H., Harris, P. W. R., Hanson-Manful, P., McGregor, R., Kowalczyk, R., Raynes, J. M., Carlton, L. H., Dobson, R. C. J., Baker, M. G., Brimble, M., Lukomski, S., & Moreland, N. J.  Antibody responses to collagen peptides and streptococcal collagen-like 1 proteins in acute rheumatic fever patients. Pathogens and Disease (2021) 79(6): ftab033.

    Pretz, D., Le Foll, C., Rizwan, M. Z., Lutz, T. A., & Tups, A.  Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity. FASEB Journal (2021) 35(2): e21216.

    Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N. A., Benayoun, B. A., Merry, T. L., & Lee, C.  MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications (2021) 12(1): 470.

    Shepperson, O. A., Cameron, A. J., Wang, C. J., Harris, P. W. R., Taylor, J. A., & Brimble, M. A.  Thiol-ene enabled preparation of S -lipidated anti-HBV peptides. Organic and Biomolecular Chemistry (2021) 19(1): 220-232. 

    Sorrenson, B., Dissanayake, W. C., Hu, F., Lee, K. L., & Shepherd, P. R.  A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion. Biochemical Journal (2021) 478(8): 1605-1615. 

    Stevenson, L. J., Bracegirdle, J., Liu, L., Sharrock, A. V., Ackerley, D. F., Keyzers, R. A., & Owen, J. G.  Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway. RSC Chemical Biology (2021) 2(2): 556-567.  

    Tran, K. B., Gimenez, G., Tsai, P., Kolekar, S., Rodger, E. J., Chatterjee, A., Jabed, A., Shih, J. H., Joseph, W. R., Marshall, E. S., Wang, Q., Print, C. G., Eccles, M. R., Baguley, B. C., & Shepherd, P. R.  Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma. Pigment Cell and Melanoma Research (2021) 34(1): 136-143.

    Tran, K. B., Kolekar, S., Jabed, A., Jaynes, P., Shih, J. H., Wang, Q., Flanagan, J. U., Rewcastle, G. W., Baguley, B. C., & Shepherd, P. R.  Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK. BMC Cancer (2021) 21(1): 136.

    Wilson, Z. E., & Brimble, M. A.  Molecules derived from the extremes of life: A decade later. Natural Product Reports (2021) 38(1): 24-82.

    Zhang, W., Kaplan, A. R., Davison, E. K., Freeman, J. L., Brimble, M. A., & Wuest, W. M.  Building: Trans -bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: The case for antibiotic development. Natural Product Reports (2021) 38(5): 880-889.

    2020

    Andrews, E. S. V., & Arcus, V. L. PhoH2 proteins couple RNA helicase and RNAse activities. Protein Science (2020) 29(4): 883-892. 

    Andrews, E. S. V., Rzoska-Smith, E., & Arcus, V. L. Post-transcriptional modulation of the SigF regulon in Mycobacterium smegmatis by the PhoH2 toxin-antitoxin. PLoS ONE (2020) 15: e0236551.

    Azimi, I., Stevenson, R. J., Zhang, X., Meizoso-Huesca, A., Xin, P., Johnson, M., Flanagan, J. U., Chalmers, S. B., Yoast, R. E., Kapure, J. S., Ross, B. P., Vetter, I., Ashton, M. R., Launikonis, B. S., Denny, W. A., Trebak, M., & Monteith, G. R. A New Selective Pharmacological Enhancer of the Orai1 Ca2+ Channel Reveals Roles for Orai1 in Smooth and Skeletal Muscle Functions. ACS Pharmacology and Translational Science (2020) 3(1): 135-147.

    Barad, Z., Khant Aung, Z., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. Impaired prolactin transport into the brain and functional responses to prolactin in aged male mice. Journal of Neuroendocrinology (2020) 32(8): e12889.

    Bashiri, G., Nigon, L. V., Jirgis, E. N. M., Ho, N. A. T., Stanborough, T., Dawes, S. S., Baker, E. N., Bulloch, X. E. M. M., &  Johnston, X. J. M. Allosteric regulation of menaquinone (Vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis. Journal of Biological Chemistry (2020) 295(12): 3759-3770. 

    Boons, G., Vandamme, T., Ibrahim, J., Roeyen, G., Driessen, A., Peeters, D., Lawrence, B., Print, C., Peeters, M., Van Camp, G., & de Beeck, K. O. PDX1 DNA methylation distinguishes two subtypes of pancreatic neuroendocrine neoplasms with a different prognosis. Cancers (2020) 12(6): 1461.

    Bracegirdle, J., Gordon, D. P., Harvey, J. E., & Keyzers, R. A. Kinase-Inhibitory Nucleoside Derivatives from the Pacific Bryozoan Nelliella nelliiformis. Journal of Natural Products (2020) 83(2): 547-551.

    Brooks, A. E. S., Iminitoff, M., Williams, E., Damani, T., Jackson-Patel, V., Fan, V., James, J., Dunbar, P. R., Feisst, V. & Sheppard, H. M, Ex Vivo Human Adipose Tissue Derived Mesenchymal Stromal Cells (ASC) Are a Heterogeneous Population That Demonstrate Rapid Culture-Induced Changes. Frontiers in Pharmacology (2020) 10: 1695.

    Burn, O. K., Prasit, K. K., & Hermans, I. F. Modulating the tumour microenvironment by intratumoural injection of pattern recognition receptor agonists. Cancers (2020) 12(12): 1-22. 

    Busby, B. P., Niktab, E., Roberts, C. A., Sheridan, J. P., Coorey, N. V., Senanayake, D. S., Connor, L. M., Munkacsi, A. B., & Atkinson, P. H. Erratum: Publisher Correction: Genetic interaction networks mediate individual statin drug response in Saccharomyces cerevisiae. NPJ systems biology and applications (2020) 6: 9. 

    Calvert, M. B., Furkert, D. P., Cooper, C. B., & Brimble, M. A. Synthetic approaches towards bedaquiline and its derivatives. Bioorganic and Medicinal Chemistry Letters (2020) 30(12): 127172.

    Cameron, A. J., Davison, E. K., An, C., Stubbing, L. A., Dunbar, P. R., Harris, P. W. R., & Brimble, M. A. Synthesis and SAR Analysis of Lipovelutibols B and D and Their Lipid Analogues. Journal of Organic Chemistry (2020) 85(3): 1401-1406. 

    Cameron, A. J., Harris, P. W. R., & Brimble, M. A. On-Resin Preparation of Allenamidyl Peptides: A Versatile Chemoselective Conjugation and Intramolecular Cyclisation Tool. Angewandte Chemie - International Edition (2020) 59(41): 18054-18061. 

    Chung, A. W., Ho, T. K. C., Hanson-Manful, P., Tritscheller, S., Raynes, J. M., Whitcombe, A. L., Tay, M. L., McGregor, R., Lorenz, N., Oliver, J. R., Gurney, J. K., Print, C. G., Wilson, N. J., Martin, W. J., Williamson, D. A., Baker, M. G., & Moreland, N. J.  Systems immunology reveals a linked IgG3–C4 response in patients with acute rheumatic fever. Immunology and Cell Biology (2020) 98(1): 12-21. 

    Davison, E. K., Freeman, J. L., Zhang, W., Wuest, W. M., Furkert, D. P., & Brimble, M. A. Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin. Organic Letters (2020) 22(14): 5550-5554. 

    Dissanayake, W. C., Sorrenson, B., Lee, K. L., Barre, S., & Shepherd, P. R.  Α-Catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models. Biochemical Journal (2020) 477(4): 763-772.  

    Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., Slater, D., Morten, B. C., Avery-Kiejda, K. A., Lasham, A., Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., Reddel, R., Huschtscha, L., Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W.  Intronic TP53 Polymorphisms Are Associated with Increased Δ133TP53 Transcript, Immune Infiltration and Cancer Risk. Cancers (Basel) (2020) 12(9): 2472.

    Eom, J., Park, S. M., Feisst, V., Chen, C. J. J., Mathy, J. E., McIntosh, J. D., Angel, C. E., Bartlett, A., Martin, R., Mathy, J. A., Cebon, J. S., Black, M. A., Brooks, A. E. S., & Dunbar, P. R.  Distinctive subpopulations of stromal cells are present in human lymph nodes infiltrated with melanoma. Cancer Immunology Research (2020) 8(8): 990-1003.

    Ferrer-Font, L., Mayer, J. U., Old, S., Hermans, I. F., Irish, J., & Price, K. M. High-Dimensional Data Analysis Algorithms Yield Comparable Results for Mass Cytometry and Spectral Flow Cytometry Data. Cytometry Part A (2020) 97(8): 824-831. 

    Ferrer-Font, L., Mehta, P., Harmos, P., Schmidt, A. J., Chappell, S., Price, K. M., Hermans, I. F., Ronchese, F., Le Gros, G., & Mayer, J. U. High-dimensional analysis of intestinal immune cells during helminth infection. eLife (2020) 9: e51678.

    Freeman, J. L., Li, F. F., Furkert, D. P., & Brimble, M. A.  Synthetic Studies towards Spirocyclic Imine Marine Toxins Using N -Acyl Iminium Ions as Dienophiles in Diels-Alder Reactions. Synlett (2020) 31(7): 657-671. 

    Gaar, J., Naffa, R., & Brimble, M. Enzymatic and non-enzymatic crosslinks found in collagen and elastin and their chemical synthesis. Organic Chemistry Frontiers (2020) 7(18): 2789-2814. 

    Garelja, M. L., Au, M., Brimble, M. A., Gingell, J. J., Hendrikse, E. R., Lovell, A., Prodan, N., Sexton, P. M., Siow, A., Walker, C. S., Watkins, H. A., Williams, G. M., Wootten, D., Yang, S. H., Harris, P. W. R. & Hay, D. L.  Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors. ACS Pharmacology and Translational Science (2020) 3(2): 246-262. 

    Georgescu, T., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse. Journal of Neuroendocrinology (2020) 32(11): e12908. 

    Gingell, J. J., Rees, T. A., Hendrikse, E. R., Siow, A., Rennison, D., Scotter, J., Harris, P. W. R., Brimble, M. A., Walker, C. S., & Hay, D. L.  Distinct Patterns of Internalization of Different Calcitonin Gene-Related Peptide Receptors. ACS Pharmacology and Translational Science (2020) 3(2): 296-304. 

    Grant, P. S., Furkert, D. P., & Brimble, M. A.  Total Synthesis of (±)-Leonuketal. Organic Letters (2020) 22: 8735-8740.

    Grattan, D. R., & Ladyman, S. R.  Neurophysiological and cognitive changes in pregnancy. Handbook of Clinical Neurology (2020) 171: 25-55.

    Guise, C. P., Abbattista, M. R., Anderson, R. F., Li, D., Taghipouran, R., Tsai, A., Lee, S. J., Smaill, J. B., Denny, W. A., Hay, M. P., Wilson, W. R., Hicks, K. O., & Patterson, A. V.  Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity. Molecules (Basel, Switzerland) (2020) 25(21): 4888.

    Gustafson, P., Ladyman, S. R., McFadden, S., Larsen, C., Khant Aung, Z., Brown, R. S. E., Bunn, S. J., & Grattan, D. R.  Prolactin receptor-mediated activation of pSTAT5 in the pregnant mouse brain. Journal of Neuroendocrinology (2020) 32(11): e12901. 

    Hards, K., Adolph, C., Harold, L. K., McNeil, M. B., Cheung, C. Y., Jinich, A., Rhee, K. Y., & Cook, G. M.  Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents. Progress in Biophysics and Molecular Biology (2020) 152: 35-44. 

    Hendrikse, E. R., Liew, L. P., Bower, R. L., Bonnet, M., Jamaluddin, M. A., Prodan, N., Richards, K. D., Walker, C. S., Pairaudeau, G., Smith, D. M., Rujan, R. M., Sudra, R., Reynolds, C. A., Booe, J. M., Pioszak, A. A., Flanagan, J. U., Hay, M. P., & Hay, D. L.  Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors. ACS Pharmacology and Translational Science (2020) 3(2): 305-320. 

    Hermant, Y. O., Cameron, A. J., Harris, P. W. R., & Brimble, M. A.  Synthesis of antimicrobial lipopeptides using the “CLipPA” thiol-ene reaction. Methods in Molecular Biology (2020) 2103: 263-274. 

    Hollywood, J. A., Przepiorski, A., D'Souza, R. F., Sreebhavan, S., Wolvetang, E. J., Harrison, P. T., Davidson, A. J., & Holm, T. M.  Use of human induced pluripotent stem cells and kidney organoids to develop a cysteamine/mtor inhibition combination therapy for cystinosis. Journal of the American Society of Nephrology (2020) 31(5): 962-982.

    Jiao, W., Fan, Y., Blackmore, N. J., & Parker, E. J.  A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis. Journal of Biological Chemistry (2020) 295(19): 6252-6262. 

    Jiao, W., Lang, E. J., Bai, Y., Fan, Y., & Parker, E. J.  Diverse allosteric componentry and mechanisms control entry into aromatic metabolite biosynthesis. Current Opinion in Structural Biology (2020) 65: 159-167. 

    Kavianinia, I., Stubbing, L. A., Abbattista, M. R., Harris, P. W. R., Smaill, J. B., Patterson, A. V., & Brimble, M. A.  Alanine scan-guided synthesis and biological evaluation of analogues of culicinin D, a potent anticancer peptaibol. Bioorganic and Medicinal Chemistry Letters (2020) 30(11): 127135. 

    Keown, J. R., Yang, J., Black, M. M., & Goldstone, D. C.  The RING domain of TRIM69 promotes higher-order assembly. Acta Crystallographica Section D: Structural Biology (2020) 76: 954-961. 

    Ketharnathan, S., Labudina, A., & Horsfield, J. A.  Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Frontiers in Cell and Developmental Biology (2020) 8: 617545. 

    Khant Aung, Z., Grattan, D. R., & Ladyman, S. R.  Pregnancy-induced adaptation of central sensitivity to leptin and insulin. Molecular and Cellular Endocrinology (2020) 516: 110933.

    Khemlani, A. H. J., Proft, T., & Loh, J. M. S.  Assays to Analyze Adhesion of Group A Streptococcus to Host Cells. Methods in Molecular Biology (2020) 2136: 271-278.

    Khemlani, A. H. J., Proft, T., & Loh, J. M. S.  A Mouse Nasopharyngeal Colonization Model for Group A Streptococcus. Methods in Molecular Biology (2020) 2136: 303-308.

    Kokay, I. C., Grattan, D. R., & Murray, J. F.  Prolactin maintains transient melanin-concentrating hormone expression in the medial preoptic area during established lactation. Journal of Neuroendocrinology (2020) 32(2): e12827. 

    Kvach, M. V., Barzak, F. M., Harjes, S., Schares, H. A. M., Kurup, H. M., Jones, K. F., Sutton, L., Donahue, J., D'Aquila, R. T., Jameson, G. B., Harki, D. A., Krause, K. L., Harjes, E., & Filichev, V. V.   Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2′-Deoxyzebularine Embedded in Single-Stranded DNA. ChemBioChem (2020) 21(7): 1028-1035. 

    Ladyman, S. R., Hackwell, E. C. R., & Brown, R. S. E.  The role of prolactin in co-ordinating fertility and metabolic adaptations during reproduction. Neuropharmacology (2020) 167: 107911.

    Lasham, A., Tsai, P., Fitzgerald, S. J., Mehta, S. Y., Knowlton, N. S., Braithwaite, A. W., & Print, C. G.  Accessing a New Dimension in TP53 Biology: Multiplex Long Amplicon Digital PCR to Specifically Detect and Quantitate Individual TP53 Transcripts. Cancers (Basel) (2020) 12(3): 769.

    Le Tissier, P. R., & Grattan, D. R.  Growth hormone and prolactin: So much still to learn. Journal of Neuroendocrinology (2020) 32(11): e12909.

    Lee, T. W., Yong, H., Bhatta, S., Singleton, D., Lipert, B., Tsai, P., Bohlander, S., Print, C., Hunter, F., Wilson, W., & Jamieson, S.  Functional genomics screens to identify genes involved in tolerance of tumour microenvironment stress. European Journal of Cancer (2020) 138: S30. 

    Li, F. F., Stubbing, L. A., Kavianinia, I., Abbattista, M. R., Harris, P. W. R., Smaill, J. B., Patterson, A. V., & Brimble, M. A.  Synthesis and antiproliferative activity of C- and N-terminal analogues of culicinin D. Bioorganic and Medicinal Chemistry Letters (2020) 30(16): 127331

    Loef, E. J., Brooks, A. E. S., Lorenz, N., Birch, N. P., & Dunbar, P. R.  Neuroserpin regulates human T cell-T cell interactions and proliferation through inhibition of tissue plasminogen activator. Journal of Leukocyte Biology (2020) 107(1): 145-158.

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    Lopez-Vicchi, F., Ladyman, S. R., Ornstein, A. M., Gustafson, P., Knowles, P., Luque, G. M., Grattan, D. R., & Becu-Villalobos, D.   Chronic high prolactin levels impact on gene expression at discrete hypothalamic nuclei involved in food intake. FASEB Journal (2020) 34(3): 3902-3914. 

    Lu, B. L., Loomes, K. M., Hay, D. L., Harris, P. W. R., & Brimble, M. A.  Synthesis of isotopically labelled αCGRP8-37 and its lipidated analogue. Journal of Labelled Compounds and Radiopharmaceuticals (2020) 63(7): 325-332.

    Lu, B. L., Williams, G. M., & Brimble, M. A.  TLR2 agonists and their structure-activity relationships. Organic and Biomolecular Chemistry (2020) 18(27): 5073-5094. 

    Lu, B. L., Williams, G. M., Verdon, D. J., Dunbar, P. R., & Brimble, M. A.  Synthesis and Evaluation of Novel TLR2 Agonists as Potential Adjuvants for Cancer Vaccines. Journal of Medicinal Chemistry (2020) 63(5): 2282-2291. 

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    McNeil, M. B., Ryburn, H. W. K., Harold, L. K., Tirados, J. F., & Cook, G. M.  Transcriptional Inhibition of the F(1)F(0)-Type ATP Synthase Has Bactericidal Consequences on the Viability of Mycobacteria. Antimicrobial Agents and Chemotherapy (2020) 64(8): e00492-20.

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    Merry, T. L., Brooks, A. E. S., Masson, S. W., Adams, S. E., Jaiswal, J. K., Jamieson, S. M. F., & Shepherd, P. R.  The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice. International Journal of Obesity (London) (2020) 44(1): 245-253. 

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    Munoz-Erazo, L., Rhodes, J. L., Marion, V. C., & Kemp, R. A.  Tertiary lymphoid structures in cancer – considerations for patient prognosis. Cellular and Molecular Immunology (2020) 17(6): 570-575. 

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    Roach, R. J., Garavís, M., González, C., Jameson, G. B., Filichev, V. V., & Hale, T. K.  Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes. Nucleic Acids Research (2020) 48(2): 682-693.

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    Shao, M., McNeil, M., Cook, G. M., & Lu, X.  MmpL3 inhibitors as antituberculosis drugs. European Journal of Medicinal Chemistry (2020) 200: 112390. 

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    Tong, J. T. W., Kavianinia, I., Ferguson, S. A., Cook, G. M., Harris, P. W. R., & Brimble, M. A.  Synthesis of paenipeptin C′ analogues employing solution-phase CLipPA chemistry. Organic and Biomolecular Chemistry (2020) 18(23): 4381-4385. 

    Tong, K. K. H., Hanif, M., Lovett, J. H., Hummitzsch, K., Harris, H. H., Söhnel, T., Jamieson, S. M. F., & Hartinger, C. G.  Thiourea-derived chelating ligands and their organometallic compounds: Investigations into their anticancer activity. Molecules (2020) 25(16): 3661.

    Wang, Q., Gavin, W., Masiello, N., Tran, K. B., Laible, G., & Shepherd, P. R.  Cetuximab produced from a goat mammary gland expression system is equally efficacious as innovator cetuximab in animal cancer models. Biotechnology Reports (2020) 28: e00533. 

    Wang, Y., Yang, S. H., Brimble, M. A., & Harris, P. W. R.  Recent Progress in the Synthesis of Homogeneous Erythropoietin (EPO) Glycoforms. ChemBioChem (2020) 21(23): 3301-3312. 

    Whitcombe, A. L., Hanson-Manful, P., Jack, S., Upton, A., Carr, P. A., Williamson, D. A., Baker, M. G., Proft, T., &  Moreland, N. J.  Development and evaluation of a new triplex immunoassay that detects group a streptococcus antibodies for the diagnosis of rheumatic fever. Journal of Clinical Microbiology (2020) 58(9): e00300-20.

    Yang, S. H., Clemett, C. A., Brimble, M. A., O'Carroll, S. J., & Harris, P. W. R.  Synthesis and biological evaluation of: S -lipidated lipopeptides of a connexin 43 channel inhibitory peptide. RSC Medicinal Chemistry (2020) 11(9): 1041-1047. 

    Yang, S. H., Hermant, Y. O. J., Harris, P. W. R., & Brimble, M. A.  Replacement of the Acrid tert-Butylthiol and an Improved Isolation Protocol for Cysteine Lipidation on a Peptide or Amino Acid (CLipPA). European Journal of Organic Chemistry (2020) 2020(8): 944-947.

    Yim, V., Kavianinia, I., Knottenbelt, M. K., Ferguson, S. A., Cook, G. M., Swift, S., Chakraborty, A., Allison, J. R., Cameron, A. J., Harris, P. W. R., &  Brimble, M. A.  “CLipP”ing on lipids to generate antibacterial lipopeptides. Chemical Science (2020) 11(22): 5759-5765. 

    Yim, V. V., Cameron, A. J., Kavianinia, I., Harris, P. W. R., & Brimble, M. A.  Thiol-ene Enabled Chemical Synthesis of Truncated S-Lipidated Teixobactin Analogs. Frontiers in Chemistry (2020) 8(568): 568.

    Yim, V. V., Kavianinia, I., Cameron, A. J., Harris, P. W. R., & Brimble, M. A.  Direct synthesis of cyclic lipopeptides using intramolecular native chemical ligation and thiol-ene CLipPA chemistry. Organic and Biomolecular Chemistry (2020) 18(15): 2838-2844. 

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    Young, P. G., & Squire, C. J.  Molecular Superglues: Discovery and Engineering Orthogonalization. Methods in Molecular Biology (2020) 2073: 85-99.