Scientific Publications

2022

Ahangarpour, M., Kavianinia, I., Hume, P. A., Harris, P. W. R. & Brimble, M. A. (2022). N-Vinyl Acrylamides: Versatile Heterobifunctional Electrophiles for Thiol-Thiol Bioconjugations. Journal of the American Chemical Society 144(30): 13652-13662.  https://doi.org/10.1021/jacs.2c04146

Al-Zubaidi, A., Cheung, C. Y., Cook, G. M., Taiaroa, G., Mizrahi, V., Lott, J. S. & Dawes, S. S. (2022). RNase HI Depletion Strongly Potentiates Cell Killing by Rifampicin in Mycobacteria. Antimicrobial Agents and Chemotherapy 66(10). https://doi.org/10.1128/aac.02091-21

Alexander, T. I., Tasma, Z., Siow, A., Rees, T. A., Brimble, M. A., Harris, P. W. R., Hay, D. L. & Walker, C. S. (2022). Novel Fluorescently Labeled PACAP and VIP Highlight Differences between Peptide Internalization and Receptor Pharmacology. ACS Pharmacology and Translational Science. https://doi.org/10.1021/acsptsci.2c00124

Banerjee, R., Smith, J., Eccles, M. R., Weeks, R. J. & Chatterjee, A. (2022). Epigenetic basis and targeting of cancer metastasis. Trends in Cancer 8(3): 226-241.  https://doi.org/10.1016/j.trecan.2021.11.008

Brain, S. D., Russo, A. F. & Hay, D. L. (2022). Editorial: Calcitonin Gene-Related Peptide: Novel Biology and Treatments. Frontiers in Physiology 13. https://doi.org/10.3389/fphys.2022.964568

Crystal Chan, S. H., Griffin, J. M., Clemett, C. A., Brimble, M. A., O’Carroll, S. J. & Harris, P. W. R. (2022). Synthesis and Biological Evaluation of Termini-Modified and Cyclic Variants of the Connexin43 Inhibitor Peptide5. Frontiers in Chemistry 10.  https://doi.org/10.3389/fchem.2022.877618

Denny, W. A. (2022). Inhibitors and Activators of the p38 Mitogen-Activated MAP Kinase (MAPK) Family as Drugs to Treat Cancer and Inflammation. Current Cancer Drug Targets 22(3): 209-220. https://doi.org/10.2174/1568009622666220215142837

Denny, W. A. (2022). Nitroaromatic Hypoxia-Activated Prodrugs for Cancer Therapy. Pharmaceuticals 15(2). https://doi.org/10.3390/ph15020187

Garelja, M. L., Bower, R. L., Brimble, M. A., Chand, S., Harris, P. W. R., Jamaluddin, M. A., Petersen, J., Siow, A., Walker, C. S. & Hay, D. L. (2022). Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared with human receptors. British Journal of Pharmacology 179(3): 416-434.  https://doi.org/10.1111/bph.15628

Garelja, M. L. & Hay, D. L. (2022). A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene-related peptide and beyond. Headache 62(9): 1093-1104. https://doi.org/10.1111/head.14388

Garelja, M. L., Walker, C. S. & Hay, D. L. (2022). CGRP receptor antagonists for migraine. Are they also AMY1 receptor antagonists? British Journal of Pharmacology 179(3): 454-459.  https://doi.org/10.1111/bph.15585

Hards, K., Cheung, C. Y., Waller, N., Adolph, C., Keighley, L., Tee, Z. S., Harold, L. K., Menorca, A., Bujaroski, R. S., Buckley, B. J., Tyndall, J. D. A., McNeil, M. B., Rhee, K. Y., Opel-Reading, H. K., Krause, K., Preiss, L., Langer, J. D., Meier, T., Hasenoehrl, E. J., Berney, M., Kelso, M. J. & Cook, G. M. (2022). An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology 5(1).  https://doi.org/10.1038/s42003-022-03110-8

Harold, L. K., Jinich, A., Hards, K., Cordeiro, A., Keighley, L. M., Cross, A., McNeil, M. B., Rhee, K. & Cook, G. M. (2022). Deciphering functional redundancy and energetics of malate oxidation in mycobacteria. Journal of Biological Chemistry 298(5).  https://doi.org/10.1016/j.jbc.2022.101859

Harris, P. W. R., Siow, A., Yang, S. H., Wadsworth, A. D., Tan, L., Hermant, Y., Mao, Y., An, C., Hanna, C. C., Cameron, A. J., Allison, J. R., Chakraborty, A., Ferguson, S. A., Mros, S., Hards, K., Cook, G. M., Williamson, D. A., Carter, G. P., Chan, S. T. S., Painter, G. A., Sander, V., Davidson, A. J. & Brimble, M. A. (2022). Synthesis, Antibacterial Activity, and Nephrotoxicity of Polymyxin B Analogues Modified at Leu-7, d -Phe-6, and the N-Terminus Enabled by S-Lipidation. ACS Infectious Diseases 8(12): 2413-2429. https://doi.org/10.1021/acsinfecdis.1c00347

Hashimi, F. N., Bennett, J., Baker, M. G., Moreland, N. J., Merry, T. L. & Loh, J. M. S. (2022). The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model. Scientific Reports 12(1). https://doi.org/10.1038/s41598-022-22648-5

Hay, D. L., Walker, C. S. & Harris, P. W. R. (2022). Atogepant (Qulipta®) for migraine prevention. Trends in Pharmacological Sciences 43(8): 701-702.  https://doi.org/10.1016/j.tips.2022.03.013

Hendrikse, E. R., Rees, T. A., Tasma, Z., Garelja, M. L., Siow, A., Harris, P. W. R., Pawlak, J. B., Caron, K. M., Blakeney, E. S., Russo, A. F., Sowers, L. P., Lutz, T. A., Le Foll, C., Walker, C. S. & Hay, D. L. (2022). Characterization of Antibodies against Receptor Activity-Modifying Protein 1 (RAMP1): A Cautionary Tale. International Journal of Molecular Sciences 23(24).  https://doi.org/10.3390/ijms232416035

Hendrikse, E. R., Rees, T. A., Tasma, Z., Le Foll, C., Lutz, T. A., Siow, A., Wookey, P. J., Walker, C. S. & Hay, D. L. (2022). Calcitonin receptor antibody validation and expression in the rodent brain. Cephalalgia 42(9): 815-826.  https://doi.org/10.1177/03331024221084029

Hicks, J. L., Oldham, K. E. A., McGarvie, J. & Walker, E. J. (2022). Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens. Bioscience Reports 42(10). https://doi.org/10.1042/bsr20220368

Hossain, S. M., Gimenez, G., Stockwell, P. A., Tsai, P., Print, C. G., Rys, J., Cybulska-Stopa, B., Ratajska, M., Harazin-Lechowska, A., Almomani, S., Jackson, C., Chatterjee, A. & Eccles, M. R. (2022). Innate immune checkpoint inhibitor resistance is associated with melanoma sub-types exhibiting invasive and de-differentiated gene expression signatures. Frontiers in Immunology 13.  https://doi.org/10.338/fimmu.2022.955063

Jamaluddin, A., Chuang, C. L., Williams, E. T., Siow, A., Yang, S. H., Harris, P. W. R., Petersen, J. S. S. M., Bower, R. L., Chand, S., Brimble, M. A., Walker, C. S., Hay, D. L. & Loomes, K. M. (2022). Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo. Frontiers in Pharmacology 13.  https://doi.org/10.3389/fphar.2022.832589

Jiao, W., Mittelstädt, G. & Parker, E. J. (2022). Precise Positioning of Water Is Critical for Hydrolysis Catalyzed by 5′-Methylthioadenosine Nucleosidase. Biochemistry 61(17): 1883-1893. https://doi.org/10.1021/acs.biochem.2c00351

Kobayashi, A., Hamada, M., Yoshida, M. A., Kobayashi, Y., Tsutsui, N., Sekiguchi, T., Matsukawa, Y., Maejima, S., Gingell, J. J., Sekiguchi, S., Hamamoto, A., Hay, D. L., Morris, J. F., Sakamoto, T. & Sakamoto, H. (2022). Vasopressin-oxytocin-type signaling is ancient and has a conserved water homeostasis role in euryhaline marine planarians. Science Advances 8(9).  https://doi.org/10.1126/sciadv.abk0331

Kovalenko, N., Swain, J. A., Howard, G. K., Hermant, Y. O., Cameron, A. J., Stubbing, L. A., Harris, P. W. R. & Brimble, M. A. (2022). Synthetic Studies towards the Calcium-Dependent Lipopeptide Antibiotic Cadaside B. Chemistry - A European Journal 28(70).  https://doi.org/10.1002/chem.202202554

Kurup, H. M., Kvach, M. V., Harjes, S., Barzak, F. M., Jameson, G. B., Harjes, E. & Filichev, V. V. (2022). Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A. Biochemistry 61(22): 2568-2578.  https://doi.org/10.1021/acs.biochem.2c00449

Lee, K., Vakili, S., Burden, H. J., Adams, S., Smith, G. C., Kulatea, B., Wright-McNaughton, M., Sword, D., Watene-O'Sullivan, C., Atiola, R. D., Paul, R. G., Plank, L. D., Kallingappa, P., King, F., Wilcox, P., Merriman, T. R., Krebs, J. D., Hall, R. M., Murphy, R., Merry, T. L. & Shepherd, P. R. (2022). The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition. Molecular Metabolism 59.  https://doi.org/10.1016/j.molmet.2022.101464

Lu, X., Smaill, J. B., Patterson, A. V. & Ding, K. (2022). Discovery of Cysteine-targeting Covalent Protein Kinase Inhibitors. Journal of Medicinal Chemistry 65(1): 58-83.  https://doi.org/10.1021/acs.jmedchem.1c01719

McHugh, A. D., Chase, J. G., Knopp, J. L., Ormsbee, J. J., Kulawiec, D. G., Merry, T. L., Murphy, R., Shepherd, P. R., Burden, H. J. & Docherty, P. D. (2022). The Impact of Exogenous Insulin Input on Calculating Hepatic Clearance Parameters. Journal of Diabetes Science and Technology 16(4): 945-954. https://doi.org/10.1177/1932296820986878

McNeil, M. B., Ryburn, H. W., Tirados, J., Cheung, C. Y. & Cook, G. M. (2022). Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes. iScience 25(1).  https://doi.org/10.1016/j.isci.2021.103573

Metcalfe, L. K., Shepherd, P. R., Smith, G. C. & Turner, N. (2022). Limited Metabolic Effect of the CREBRFR457Q Obesity Variant in Mice. Cells 11(3).  https://doi.org/10.3390/cells11030497

Mulholland, C. V., Gimenez, G., Williamson, A., Steele, M., Thorpe, D., Karalus, N., Cursons, R. T., Playle, V. M., Roberts, S. A., Cook, G. M., Arcus, V. L. & Aung, H. L. (2022). Complete Genome Sequence of a New Zealand Mycobacterium tuberculosis Strain Responsible for Ongoing Transmission over the Past 30 Years. Microbiology Resource Announcements 11(11).  https://doi.org/10.1128/mra.00781-22

Oh, J. K., Przepiorski, A., Chang, H. H., Dodd, R. C., Sander, V., Sorrenson, B., Shih, J. H., Hollywood, J. A., de Zoysa, J. R., Shepherd, P. R., Davidson, A. J. & Holm, T. M. (2022). Derivation of induced pluripotent stem cell lines from New Zealand donors. Journal of the Royal Society of New Zealand 52(1): 54-67. https://doi.org/10.1007/s12015-017-9766-9

Oldham, K. E. A., Prentice, E. J., Summers, E. L. & Hicks, J. L. (2022). Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition. Biochemical Journal 479(1): 57-74. https://doi.org/10.1042/bcj20210564

Ormsbee, J. J., Burden, H. J., Knopp, J. L., Chase, J. G., Murphy, R., Shepherd, P. R. & Merry, T. (2022). Variability in Estimated Modelled Insulin Secretion. Journal of Diabetes Science and Technology 16(3): 732-741. https://doi.org/10.1177/1932296821991120

Peng, Y., Liu, Y., Hu, Y., Chang, F., Wu, Q., Yang, J., Chen, J., Teng, S., Zhang, J., He, R., Wei, Y., Bostina, M., Luo, T., Liu, W., Qu, X. & Li, Y. P. (2022). Monoclonal antibodies constructed from COVID-19 convalescent memory B cells exhibit potent binding activity to MERS-CoV spike S2 subunit and other human coronaviruses. Frontiers in Immunology 13.  https://doi.org/10.3389/fimmu.2022.1056272

Pradhan, S., Williams, M. A. K. & Hale, T. K. (2022). Changes in the properties of membrane tethers in response to HP1α depletion in MCF7 cells. Biochemical and Biophysical Research Communications 587: 126-130. https://doi.org/10.1016/j.bbrc.2021.11.081

Prasit, K. K., Ferrer-Font, L., Burn, O. K., Anderson, R. J., Compton, B. J., Schmidt, A. J., Mayer, J. U., Chen, C. J. J., Dasyam, N., Ritchie, D. S., Godfrey, D. I., Mattarollo, S. R., Dundar, P. R., Painter, G. F. & Hermans, I. F. (2022). Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect. OncoImmunology 11(1). https://doi.org/10.1080/2162402x.2022.2081009

Rees, T. A., Hendrikse, E. R., Hay, D. L. & Walker, C. S. (2022). Beyond CGRP: The calcitonin peptide family as targets for migraine and pain. British Journal of Pharmacology 179(3): 381-399. https://doi.org/10.1111/bph.15605

Rees, T. A., Russo, A. F., O’Carroll, S. J., Hay, D. L. & Walker, C. S. (2022). CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons. Frontiers in Physiology 13. https://doi.org/10.3389/fphys.2022.860037

Shao, M., Chen, X., Yang, F., Song, X., Zhou, Y., Lin, Q., Fu, Y., Ortega, R., Lin, X., Tu, Z., Patterson, A. V., Smaill, J. B., Chen, Y. & Lu, X. (2022). Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. Journal of Medicinal Chemistry 65(6): 5113-5133.  https://doi.org/10.1021/acs.jmedchem.2c00096

Stevenson, L. J., Ackerley, D. F. & Owen, J. G. (2022). Preparation of Soil Metagenome Libraries and Screening for Gene-Specific Amplicons. Methods in Molecular Biology 2397: 3-17.  https://doi.org/10.1007/978-1-0716-1826-4_1

Tasma, Z., Siow, A., Harris, P. W. R., Brimble, M. A., O’Carroll, S. J., Hay, D. L. & Walker, C. S. (2022). PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies. International Journal of Molecular Sciences 23(22). https://doi.org/10.3390/Fijms232213797

Tesfay, B., Karlsson, W. K., Moreno, R. D., Hay, D. L. & Hougaard, A. (2022). Is calcitonin gene-related peptide a reliable biochemical marker of migraine? Current Opinion in Neurology 35(3): 343-352. https://doi.org/10.1097/wco.0000000000001053

Tong, K. K. H., Riisom, M., Leung, E., Hanif, M., Söhnel, T., Jamieson, S. M. F. & Hartinger, C. G. (2022). Impact of Coordination Mode and Ferrocene Functionalization on the Anticancer Activity of N-Heterocyclic Carbene Half-Sandwich Complexes. Inorganic Chemistry 61(43): 17226-17241. https://doi.org/10.1021/acs.inorgchem.2c02832

Truong, D., Lam, N. Y. S., Kamalov, M., Riisom, M., Jamieson, S. M. F., Harris, P. W. R., Brimble, M. A., Metzler-Nolte, N. & Hartinger, C. G. (2022). A Solid Support-Based Synthetic Strategy for the Site-Selective Functionalization of Peptides with Organometallic Half-Sandwich Moieties. Chemistry - A European Journal 28(12). https://doi.org/10.1002/chem.202104049

Tsai, C. J. Y., Loh, J. M. S. & Proft, T. (2022). PilVax: A Novel Platform for the Development of Mucosal Vaccines. Methods in Molecular Biology 2412: 399-410. https://doi.org/10.1007/978-1-0716-1892-9_20

Whitcombe, A. L., Han, F., McAlister, S. M., Kirkham, L. A. S., Young, P. G., Ritchie, S. R., Atatoa Carr, P., Proft, T. & Moreland, N. J. (2022). An eight-plex immunoassay for Group A streptococcus serology and vaccine development. Journal of Immunological Methods 500.  https://doi.org/10.1016/j.jim.2021.113194

Whitcombe, A. L., McGregor, R., Bennett, J., Gurney, J. K., Williamson, D. A., Baker, M. G. & Moreland, N. J. (2022). Increased Breadth of Group A Streptococcus Antibody Responses in Children With Acute Rheumatic Fever Compared to Precursor Pharyngitis and Skin Infections. Journal of Infectious Diseases 226(1): 167-176. https://doi.org/10.1093/infdis/jiac043

Yang, F., Chen, X., Song, X., Ortega, R., Lin, X., Deng, W., Guo, J., Tu, Z., Patterson, A. V., Smaill, J. B., Chen, Y. & Lu, X. (2022). Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. Journal of Medicinal Chemistry 65(21): 14809-14831.  https://doi.org/10.1021/acs.jmedchem.2c01319

2021

Abbattista, M. R., Ashoorzadeh, A., Guise, C. P., Mowday, A. M., Mittra, R., Silva, S., Hicks, K. O., Bull, M. R., Jackson-Patel, V., Lin, X., Prosser, G. A., Lambie, N. K., Dachs, G. U., Ackerley, D. F., Smaill, J. B., & Patterson, A. V.  Restoring tumour selectivity of the bioreductive prodrug pr-104 by developing an analogue resistant to aerobic metabolism by human aldo-keto reductase 1c3. Pharmaceuticals (2021) 14(12): 1231. https://doi.org/10.3390/ph14121231

Ahangarpour, M., Kavianinia, I., Harris, P. W. R., & Brimble, M. A. (2021). Photo-induced radical thiol-ene chemistry: A versatile toolbox for peptide-based drug design. Chemical Society Reviews (2021) 50(2): 898-944. [pdf]

Ahn, A., Rodger, E. J., Motwani, J., Gimenez, G., Stockwell, P. A., Parry, M., Hersey, P., Chatterjee, A., & Eccles, M. R.  Transcriptional reprogramming and constitutive PD-L1 expression in melanoma are associated with dedifferentiation and activation of interferon and tumour necrosis factor signalling pathways. Cancers (2021) 13(17): 4250. https://doi.org/10.3390/cancers13174250

Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Abbracchio, M. P., Alexander, W., Al-hosaini, K., Bäck, M., Barnes, N. M., Bathgate, R., Beaulieu, J. M., Bernstein, K. E., Bettler, B., Birdsall, N. J. M., Blaho, V., Boulay, F., Bousquet, C., Bräuner-Osborne, H., Burnstock, G., Caló, G., Castaño, J. P., Catt, K. J., Ceruti, S., Chazot, P., Chiang, N., Chini, B., Chun, J., Cianciulli, A., Civelli, O., Clapp, L. H., Couture, R., Csaba, Z., Dahlgren, C., Dent, G., Singh, K. D., Douglas, S. D., Dournaud, P., Eguchi, S., Escher, E., Filardo, E. J., Fong, T., Fumagalli, M., Gainetdinov, R. R., Gasparo, M. D., Gerard, C., Gershengorn, M., Gobeil, F., Goodfriend, T. L., Goudet, C., Gregory, K. J., Gundlach, A. L., Hamann, J., Hanson, J., Hauger, R. L., Hay, D. L., Heinemann, A., Hollenberg, M. D., Holliday, N. D., Horiuchi, M., Hoyer, D., Hunyady, L., Husain, A., Ijzerman, A. P., Inagami, T., Jacobson, K. A., Jensen, R. T., Jockers, R., Jonnalagadda, D., Karnik, S., Kaupmann, K., Kemp, J., Kennedy, C., Kihara, Y., Kitazawa, T., Kozielewicz, P., Kreienkamp, H. J., Kukkonen, J. P., Langenhan, T., Leach, K., Lecca, D., Lee, J. D., Leeman, S. E., Leprince, J., Li, X. X., Williams, T. L., Lolait, S. J., Lupp, A., Macrae, R., Maguire, J., Mazella, J., McArdle, C. A., Melmed, S., Michel, M. C., Miller, L. J., Mitolo, V., Mouillac, B., Müller, C. E., Murphy, P., Nahon, J. L., Ngo, T., Norel, X., Nyimanu, D., O’Carroll, A. M., Offermanns, S., Panaro, M. A., Parmentier, M., Pertwee, R. G., Pin, J. P., Prossnitz, E. R., Quinn, M., Ramachandran, R., Ray, M., Reinscheid, R. K., Rondard, P., Rovati, G. E., Ruzza, C., Sanger, G. J., Schöneberg, T., Schulte, G., Schulz, S., Segaloff, D. L., Serhan, C. N., Stoddart, L. A., Sugimoto, Y., Summers, R., Tan, V. P., Thal, D., Thomas, W., Timmermans, P. B. M. W. M., Tirupula, K., Tulipano, G., Unal, H., Unger, T., Valant, C., Vanderheyden, P., Vaudry, D., Vaudry, H., Vilardaga, J. P., Walker, C. S., Wang, J. M., Ward, D. T., Wester, H. J., Willars, G. B., Woodruff, T. M., Yao, C., & Ye, R. D. The concise guide to pharmacology 2021/22: G protein-coupled receptors. British Journal of Pharmacology (2021) 178(S1): S27-S156. https://doi.org/10.1111/bph.15538

Ameratunga, R., Longhurst, H., Steele, R., Lehnert, K., Leung, E., Brooks, A. E. S., & Woon, S.-T.  Common variable immunodeficiency disorders, T-Cell responses to SARS-CoV-2 vaccines, and the risk of chronic COVID-19. The Journal of Allergy and Clinical Immunology: In Practice (2021) 9(10): 3575-3583. https://doi.org/10.1016/j.jaip.2021.06.019

Aoki, M., Gamayun, I., Wyatt, A., Grünewald, R., Simon-Thomas, M., Philipp, S. E., Hummel, O., Wagenpfeil, S., Kattler, K., Gasparoni, G., Walter, J., Qiao, S., Grattan, D. R., & Boehm, U.  Prolactin-sensitive olfactory sensory neurons regulate male preference in female mice by modulating responses to chemosensory cues. Science Advances (2021) 7(41): eabg4074. https://doi.org/10.1126/sciadv.abg4074

Aung, H. L., Nyunt, W. W., Fong, Y., Biggs, P. J., Winkworth, R. C., Lockhart, P. J., Yeo, T. W., Hill, P. C., Cook, G. M., & Aung, S. T.  Genomic profi ling of mycobacterium tuberculosis strains, myanmar. Emerging Infectious Diseases (2021) 27(11): 2847-2855. https://doi.org/10.3201/eid2711.210726

Badii, M., Gaal, O. I., Cleophas, M. C., Klück, V., Davar, R., Habibi, E., Keating, S. T., Novakovic, B., Helsen, M. M., Dalbeth, N., Stamp, L. K., Macartney-Coxson, D., Phipps-Green, A. J., Stunnenberg, H. G., Dinarello, C. A., Merriman, T. R., Netea, M. G., Crişan, T. O., & Joosten, L. A. B.  Urate-induced epigenetic modifications in myeloid cells. Arthritis Research and Therapy (2021) 23(1): 202. https://doi.org/10.1186/s13075-021-02580-1

Barzak, F. M., Ryan, T. M., Kvach, M. V., Kurup, H. M., Aihara, H., Harris, R. S., Filichev, V. V., Harjes, E., Jameson, G. B.  Small-angle x-ray scattering models of apobec3b catalytic domain in a complex with a single-stranded dna inhibitor. Viruses (2021) 13(2): 290.

Blanchett, S., Tsai, C. J. Y., Sandford, S., Loh, J. M. S., Huang, L., Kirman, J. R., & Proft, T.   Intranasal immunization with Ag85B peptide 25 displayed on Lactococcus lactis using the PilVax platform induces antigen-specific B- and T-cell responses. Immunology and Cell Biology (2021) 99: 767-781.

Blumenfeld, A., Durham, P. L., Feoktistov, A., Hay, D. L., Russo, A. F., & Turner, I.  Hypervigilance, allostatic load, and migraine prevention: Antibodies to CGRP or receptor. Neurology and Therapy (2021) 10(2): 469-497. https://doi.org/10.1007/s40120-021-00250-7

Boss, A. L., Chamley, L. W., Brooks, A. E. S., & James, J. L.  Differences in human placental mesenchymal stromal cells may impair vascular function in FGR. Reproduction (2021) 162(4): 319-330. https://doi.org/10.1530/REP-21-0226

Bracegirdle, J., Hou, P., Nowak, V. V., Ackerley, D. F., Keyzers, R. A., & Owen, J. G.  Skyllamycins D and E, non-ribosomal cyclic depsipeptides from lichen-sourced streptomyces anulatus. Journal of Natural Products (2021) 84(9): 2536-2543. https://doi.org/10.1021/acs.jnatprod.1c00547

Burden, H. J., Adams, S., Kulatea, B., Wright-McNaughton, M., Sword, D., Ormsbee, J. J., Watene-O’Sullivan, C., Merriman, T. R., Knopp, J. L., Chase, J. G., Krebs, J. D., Hall, R. M., Plank, L. D., Murphy, R., Shepherd, P. R., & Merry, T. L.  The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry. Diabetologica (2021) 2021.2002.2027.21252567. [medRxiv]

Buss, L. A., Hock, B., Merry, T. L., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U.  Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer. PLoS ONE (2021) 16(10 October): e0258831. https://doi.org/10.1371/journal.pone.0258831

Buss, L. A., Williams, T., Hock, B., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U.  Effects of exercise and anti-PD-1 on the tumour microenvironment. Immunology Letters (2021) 239: 60-71. https://doi.org/10.1016/j.imlet.2021.08.005

Cameron, A. J., Park, C., Howard, G. K., Harris, P. W. R., & Brimble, M. A.  Total Synthesis of Allene-Containing Cyclic Tetrapeptide Pseudoxylallemycin C. Synlett (2021) 32(3): 273-276. 

Daniels, L. J., Annandale, M., Koutsifeli, P., Li, X., Bussey, C. T., van Hout, I., Bunton, R. W., Davis, P. J., Coffey, S., Katare, R., Lamberts, R. R., Delbridge, L. M. D., & Mellor, K. M.  Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro. Nutrition and Diabetes (2021) 11(1): 8.

Denny, W. A., & Flanagan, J. U.  Small-molecule CSF1R kinase inhibitors; review of patents 2015-present. Expert Opinion on Therapeutic Patents (2021) 31(2): 107-117. 

Denny, W. A., & Flanagan, J. U.  Inhibitors of discoidin domain receptor (Ddr) kinases for cancer and inflammation. Biomolecules (2021) 11(11): 1671. https://doi.org/10.3390/biom11111671

Dissanayake, W. C., Oh, J. K., Sorrenson, B., & Shepherd, P. R.  Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12, through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin. Bioscience Reports (2021) 41(7): BSR20211066.

Fu, Z., Mowday, A. M., Smaill, J. B., Hermans, I. F., & Patterson, A. V.  Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy. Cells (2021) 10(5): 1006.

Ghanizada, H., Al-Karagholi, M. A. M., Walker, C. S., Arngrim, N., Rees, T., Petersen, J., Siow, A., Mørch-Rasmussen, M., Tan, S., O'Carroll, S. J., Harris, P., Skovgaard, L. T., Jørgensen, N. R., Brimble, M., Waite, J. S., Rea, B. J., Sowers, L. P., Russo, A. F., Hay, D. L., & Ashina, M.  Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients. Annals of Neurology (2021)  89(6): 1157-1171. 

Grant-Mackie, E. S., Williams, E. T., Harris, P. W. R., & Brimble, M. A.  Aminovinyl cysteine containing peptides: A unique motif that imparts key biological activity. JACS Au (2021) 1(10): 1527-1540. https://doi.org/10.1021/jacsau.1c00308

Grattan, D. R., & Andrews, Z. B.  Insulin as a neuroendocrine hormone. Journal of Neuroendocrinology (2021) 33(4): e12966. 

Hampe, L., Harris, P. W. R., Rushton, B., Radjainia, M., Brimble, M. A., & Mitra, A. K.  Engineering a stable complex of ERp44 with a designed peptide ligand for analyzing the mode of interaction of ERp44 with its clients. Peptide Science (2021) e24230.

Hanna, C. C., Hermant, Y. O., Harris, P. W. R., & Brimble, M. A.  Discovery, Synthesis, and Optimization of Peptide-Based Antibiotics. Accounts of Chemical Research (2021) 54(8): 1878-1890. 

Hermant, Y., Palpal-Latoc, D., Kovalenko, N., Cameron, A. J., Brimble, M. A., & Harris, P. W. R.  The total chemical synthesis and biological evaluation of the cationic antimicrobial peptides, laterocidine and brevicidine. Journal of Natural Products (2021) 84(8): 2165-2174. https://doi.org/10.1021/acs.jnatprod.1c00222

Horne, C. R., Venugopal, H., Panjikar, S., Wood, D. M., Henrickson, A., Brookes, E., North, R. A., Murphy, J. M., Friemann, R., Griffin, M. D. W., Ramm, G., Demeler, B., & Dobson, R. C. J.  Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism. Nature Communications (2021) 12(1): 1988. https://doi.org/10.1038/s41467-021-22253-6

Kasim, J. K., Kavianinia, I., Bull, M., Harris, P. W. R., Smaill, J. B., Patterson, A. V., & Brimble, M. A.  Fourth-Generation Analogues of the Anticancer Peptaibol Culicinin D: Probing the Effects of Hydrophobicity and Halogenation on Cytotoxicity. Synthesis (Germany) (2021) 53: A-G.

Khant Aung, Z., Kokay, I. C., Grattan, D. R., & Ladyman, S. R.  Prolactin-induced adaptation in glucose homeostasis in mouse pregnancy is mediated by the pancreas and not in the forebrain. Frontiers in Endocrinology (2021) 12: 765976. https://doi.org/10.3389/fendo.2021.765976

Kovalenko, N., Howard, G. K., Swain, J. A., Hermant, Y., Cameron, A. J., Cook, G. M., Ferguson, S. A., Stubbing, L. A., Harris, P. W. R., & Brimble, M. A.  A concise synthetic strategy towards the novel calcium-dependent lipopeptide antibiotic, malacidin a and analogues. Frontiers in Chemistry (2021) 9: 687875. https://doi.org/10.3389/fchem.2021.687875

Ladyman, S. R., & Brooks, V. L.  Central actions of insulin during pregnancy and lactation. Journal of Neuroendocrinology (2021) 33(4): e12946.

Ladyman, S. R., Carter, K. M., Gillett, M. L., Aung, Z. K., & Grattan, D. R.  A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin. eLife (2021) 10: e62260. https://doi.org/10.7554/eLife.62260

Ladyman, S. R., Larsen, C. M., Taylor, R. S., Grattan, D. R., & McCowan, L. M. E.  Case–control study of prolactin and placental lactogen in SGA pregnancies. Reproduction and Fertility (2021) 2(4): 244-250. https://doi.org/10.1530/RAF-21-0020

Lasham, A., Knowlton, N., Mehta, S. Y., Braithwaite, A. W., & Print, C. G.  Breast Cancer Patient Prognosis Is Determined by the Interplay between TP53 Mutation and Alternative Transcript Expression: Insights from TP53 Long Amplicon Digital PCR Assays. Cancers (Basel) (2021) 13(7): 1531. 

Lee, B. S., Hards, K., Engelhart, C. A., Hasenoehrl, E. J., Kalia, N. P., Mackenzie, J. S., Sviriaeva, E., Chong, S. M. S., Manimekalai, M. S. S., Koh, V. H., Chan, J., Xu, J., Alonso, S., Miller, M. J., Steyn, A. J. C., Grüber, G., Schnappinger, D., Berney, M., Cook, G. M., Moraski, G. C., & Pethe, K.  Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis. EMBO Molecular Medicine (2021) 13(1): e13207.

Lee, B. Y. T., Sullivan, M. P., Yano, E., Tong, K. K. H., Hanif, M., Kawakubo-Yasukochi, T., Jamieson, S. M. F., Soehnel, T., Goldstone, D. C., & Hartinger, C. G.  Anthracenyl functionalization of half-sandwich carbene complexes: In vitro anticancer activity and reactions with biomolecules. Inorganic Chemistry (2021) 60(19): 14636-14644. https://doi.org/10.1021/acs.inorgchem.1c01675

Lee, K., Vakili, S., Burden, H. J., Adams, S., Smith, G. C., Kulatea, B., Wright-McNaughton, M., Sword, D., Watene-O’Sullivan, C., Atiola, R. D., Paul, R. G., Plank, L. D., Wilcox, P., Kallingappa, P., Merriman, T. R., Krebs, J. D., Hall, R. M., Murphy, R., Merry, T. L., & Shepherd, P. R.  The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition. Molecular Metabolism (2021) 59: 101464. doi.org/10.1016/j.molmet.2022.101464

Li, H., Clarke, G. S., Christie, S., Ladyman, S. R., Kentish, S. J., Young, R. L., Gatford, K. L., & Page, A. J.  Pregnancy-related plasticity of gastric vagal afferent signals in mice. American Journal of Physiology - Gastrointestinal and Liver Physiology (2021) 320(2): G183-G192. 

Loef, E. J., Sheppard, H. M., Birch, N. P., & Dunbar, P. R.  Live-Cell Microscopy Reveals That Human T Cells Primarily Respond Chemokinetically Within a CCL19 Gradient That Induces Chemotaxis in Dendritic Cells. Frontiers in Immunology (2021) 12: 628090.

Loh, J. M. S., Rivera-Hernandez, T., McGregor, R., Khemlani, A. H. J., Tay, M. L., Cork, A. J., M. Raynes, J., Moreland, N. J., Walker, M. J., & Proft, T.  A multivalent T-antigen-based vaccine for Group A Streptococcus. Scientific Report (2021) 11(1): 4353. 

Lorenz, N., Ho, T. K., McGregor, R., Davies, M. R., Williamson, D. A., Gurney, J. K., Smeesters, P. R., Baker, M. G., & Moreland, N. J.  Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever. Clinical Infectious Diseases (2021) ciab180. [pdf]

Lu, B. L., Li, F. F., Kelch, I. D., Williams, G. M., Dunbar, P. R., & Brimble, M. A.  Investigating the individual importance of the Pam2Cys ester motifs on TLR2 activity. European Journal of Organic Chemistry (2021) 2021(39): 5415-5423. https://doi.org/10.1002/ejoc.202101055 [pdf]

Masson, S. W. C., Woodhead, J. S. T., D'Souza, R. F., Broome, S. C., MacRae, C., Cho, H. C., Atiola, R. D., Futi, T., Dent, J. R., Shepherd, P. R., & Merry, T. L.  β-Catenin is required for optimal exercise- and contraction-stimulated skeletal muscle glucose uptake. Journal of Physiology (2021) 599: 3897-3912.

McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R.  Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology (2021) 11: 709540. https://doi.org/10.3389/fonc.2021.709540

McGregor, R., Tay, M. L., Carlton, L. H., Hanson-Manful, P., Raynes, J. M., Forsyth, W. O., Brewster, D. T., Middleditch, M. J., Bennett, J., Martin, W. J., Wilson, N., Atatoa Carr, P., Baker, M. G., & Moreland, N. J.  Mapping Autoantibodies in Children With Acute Rheumatic Fever. Frontiers in Immunology (2021) 12(2883): 702877. 

McHugh, A. D., Chase, J. G., Knopp, J. L., Ormsbee, J. J., Kulawiec, D. G., Merry, T. L., Murphy, R., Shepherd, P. R., Burden, H. J., & Docherty, P. D.  The Impact of Exogenous Insulin Input on Calculating Hepatic Clearance Parameters. Journal of Diabetes Science and Technology (2021) 10.1177/1932296820986878

McNeil, M. B., Keighley, L. M., Cook, J. R., Cheung, C.-Y., & Cook, G. M.  CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis. Molecular Microbiology (2021) 116: 1033-1043. https://doi.org/10.1111/mmi.14790 [bioRxiv]

Mehta, S., Campbell, H., Drummond, C. J., Li, K., Murray, K., Slatter, T., Bourdon, J. C., & Braithwaite, A. W.  Adaptive homeostasis and the p53 isoform network. EMBO Reports (2021) 22(12): e53085. https://doi.org/10.15252/embr.202153085

Mountjoy, K. G.  ELISA versus LUMINEX assay for measuring mouse metabolic hormones and cytokines: sharing the lessons I have learned. Journal of Immunoassay and Immunochemistry (2021) 42(2): 154-173. https://doi.org/10.1080/15321819.2020.1838924

Mowday, A. M., Dubois, L. J., Kubiak, A. M., Chan-Hyams, J. V. E., Guise, C. P., Ashoorzadeh, A., Lambin, P., Ackerley, D. F., Smaill, J. B., Minton, N. P., Theys, J., & Patterson, A. V.  Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours. Cancer Gene Therapy (2021) 10.1038/s41417-021-00296-7 [pdf]

Oliver, M. R., Horne, C. R., Shrestha, S., Keown, J. R., Liang, L. Y., Young, S. N., Sandow, J. J., Webb, A. I., Goldstone, D. C., Lucet, I. S., Kannan, N., Metcalf, P., & Murphy, J. M.  Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix. Nature Communications (2021) 12(1): 1002.

Ormsbee, J. J., Burden, H. J., Knopp, J. L., Chase, J. G., Murphy, R., Shepherd, P. R., & Merry, T.  Variability in Estimated Modelled Insulin Secretion. Journal of Diabetes Science and Technology (2021) 10.1177/1932296821991120

Painter, G. F., Burn, O. K., & Hermans, I. F.  Using agonists for iNKT cells in cancer therapy. Molecular Immunology (2021) 130: 1-6.

Park, S. M., Brooks, A. E. S., Chen, C. J. J., Sheppard, H. M., Loef, E. J., McIntosh, J. D., Angel, C. E., Mansell, C. J., Bartlett, A., Cebon, J., Birch, N. P., & Dunbar, P. R.  Migratory cues controlling B-lymphocyte trafficking in human lymph nodes. Immunology and Cell Biology (2021) 99(1): 49-64. 

Paumann-Page, M., Kienzl, N. F., Motwani, J., Bathish, B., Paton, L. N., Magon, N. J., Sevcnikar, B., Furtmüller, P. G., Traxlmayr, M. W., Obinger, C., Eccles, M. R., & Winterbourn, C. C.  Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential. Redox Biology (2021) 46: 102090. https://doi.org/10.1016/j.redox.2021.102090

Pilapitiya, D. H., Harris, P. W. R., Hanson-Manful, P., McGregor, R., Kowalczyk, R., Raynes, J. M., Carlton, L. H., Dobson, R. C. J., Baker, M. G., Brimble, M., Lukomski, S., & Moreland, N. J.  Antibody responses to collagen peptides and streptococcal collagen-like 1 proteins in acute rheumatic fever patients. Pathogens and Disease (2021) 79(6): ftab033.

Pretz, D., Le Foll, C., Rizwan, M. Z., Lutz, T. A., & Tups, A.  Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity. FASEB Journal (2021) 35(2): e21216.

Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N. A., Benayoun, B. A., Merry, T. L., & Lee, C.  MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications (2021) 12(1): 470.

Safarian, S., Opel-Reading, H. K., Wu, D., Mehdipour, A. R., Hards, K., Harold, L. K., Radloff, M., Stewart, I., Welsch, S., Hummer, G., Cook, G. M., Krause, K. L., & Michel, H.  The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB. Nature Communications (2021) 12(1): 5236. https://doi.org/10.1038/s41467-021-25537-z

Shepperson, O. A., Cameron, A. J., Wang, C. J., Harris, P. W. R., Taylor, J. A., & Brimble, M. A.  Thiol-ene enabled preparation of S -lipidated anti-HBV peptides. Organic and Biomolecular Chemistry (2021) 19(1): 220-232.

Sorrenson, B., Dissanayake, W. C., Hu, F., Lee, K. L., & Shepherd, P. R.  A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion. Biochemical Journal (2021) 478(8): 1605-1615. 

Stevenson, L. J., Bracegirdle, J., Liu, L., Sharrock, A. V., Ackerley, D. F., Keyzers, R. A., & Owen, J. G.  Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway. RSC Chemical Biology (2021) 2(2): 556-567.  

Suresh, V.  Permeability properties of an in vitro model of the alveolar epithelium. Cellular and Molecular Bioengineering (2021) 14(6): 653-659. https://doi.org/10.1007/s12195-021-00690-z [pdf]

Tong, J. T. W., Harris, P. W. R., Brimble, M. A., & Kavianinia, I.  An insight into FDA approved antibody-drug conjugates for cancer therapy. Molecules (2021) 26(19): 5847. https://doi.org/10.3390/molecules26195847

Tong, K. K. H., Hanif, M., Movassaghi, S., Sullivan, M. P., Lovett, J. H., Hummitzsch, K., Söhnel, T., Jamieson, S. M. F., Bhargava, S. K., Harris, H. H., & Hartinger, C. G.  Triazolyl-functionalized N-heterocyclic carbene half-sandwich compounds: Coordination mode, reactivity and in vitro anticancer activity. ChemMedChem (2021) 16(19): 3017-3026. https://doi.org/10.1002/cmdc.202100311

Tran, K. B., Gimenez, G., Tsai, P., Kolekar, S., Rodger, E. J., Chatterjee, A., Jabed, A., Shih, J. H., Joseph, W. R., Marshall, E. S., Wang, Q., Print, C. G., Eccles, M. R., Baguley, B. C., & Shepherd, P. R.  Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma. Pigment Cell and Melanoma Research (2021) 34(1): 136-143.

Tran, K. B., Kolekar, S., Jabed, A., Jaynes, P., Shih, J. H., Wang, Q., Flanagan, J. U., Rewcastle, G. W., Baguley, B. C., & Shepherd, P. R.  Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK. BMC Cancer (2021) 21(1): 136.

Webby, M. N., Herr, N., Bulloch, E. M. M., Schmitz, M., Keown, J. R., Goldstone, D. C., & Kingston, R. L.  Structural analysis of the menangle virus p protein reveals a soft boundary between ordered and disordered regions. Viruses (2021) 13(9): 1737. https://doi.org/10.3390/v13091737

Wilson, Z. E., & Brimble, M. A.  Molecules derived from the extremes of life: A decade later. Natural Product Reports (2021) 38(1): 24-82.

Xiang, S., Song, S., Tang, H., Smaill, J. B., Wang, A., Xie, H., & Lu, X.  TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery. Drug Discovery Today (2021) 26(10): 2445-2455. https://doi.org/10.1016/j.drudis.2021.05.016

Yim, V., Hermant, Y. O., Harris, P. W. R., & Brimble, M. A.  Synthesis of lipopeptides by CLipPA chemistry. In W. M. Hussein, R. J. Stephenson, & I. Toth (Eds.), Peptide Conjugation: Methods and Protocols (2021) pp. 253-263. Springer US. https://doi.org/10.1007/978-1-0716-1617-8_19

Zhang, W., Kaplan, A. R., Davison, E. K., Freeman, J. L., Brimble, M. A., & Wuest, W. M.  Building: Trans -bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: The case for antibiotic development. Natural Product Reports (2021) 38(5): 880-889.

2020

Andrews, E. S. V., & Arcus, V. L. PhoH2 proteins couple RNA helicase and RNAse activities. Protein Science (2020) 29(4): 883-892. 

Andrews, E. S. V., Rzoska-Smith, E., & Arcus, V. L. Post-transcriptional modulation of the SigF regulon in Mycobacterium smegmatis by the PhoH2 toxin-antitoxin. PLoS ONE (2020) 15: e0236551.

Azimi, I., Stevenson, R. J., Zhang, X., Meizoso-Huesca, A., Xin, P., Johnson, M., Flanagan, J. U., Chalmers, S. B., Yoast, R. E., Kapure, J. S., Ross, B. P., Vetter, I., Ashton, M. R., Launikonis, B. S., Denny, W. A., Trebak, M., & Monteith, G. R. A New Selective Pharmacological Enhancer of the Orai1 Ca2+ Channel Reveals Roles for Orai1 in Smooth and Skeletal Muscle Functions. ACS Pharmacology and Translational Science (2020) 3(1): 135-147.

Barad, Z., Khant Aung, Z., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. Impaired prolactin transport into the brain and functional responses to prolactin in aged male mice. Journal of Neuroendocrinology (2020) 32(8): e12889.

Bashiri, G., Nigon, L. V., Jirgis, E. N. M., Ho, N. A. T., Stanborough, T., Dawes, S. S., Baker, E. N., Bulloch, X. E. M. M., &  Johnston, X. J. M. Allosteric regulation of menaquinone (Vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis. Journal of Biological Chemistry (2020) 295(12): 3759-3770. 

Boons, G., Vandamme, T., Ibrahim, J., Roeyen, G., Driessen, A., Peeters, D., Lawrence, B., Print, C., Peeters, M., Van Camp, G., & de Beeck, K. O. PDX1 DNA methylation distinguishes two subtypes of pancreatic neuroendocrine neoplasms with a different prognosis. Cancers (2020) 12(6): 1461.

Bracegirdle, J., Gordon, D. P., Harvey, J. E., & Keyzers, R. A. Kinase-Inhibitory Nucleoside Derivatives from the Pacific Bryozoan Nelliella nelliiformis. Journal of Natural Products (2020) 83(2): 547-551.

Brooks, A. E. S., Iminitoff, M., Williams, E., Damani, T., Jackson-Patel, V., Fan, V., James, J., Dunbar, P. R., Feisst, V. & Sheppard, H. M, Ex Vivo Human Adipose Tissue Derived Mesenchymal Stromal Cells (ASC) Are a Heterogeneous Population That Demonstrate Rapid Culture-Induced Changes. Frontiers in Pharmacology (2020) 10: 1695.

Burn, O. K., Prasit, K. K., & Hermans, I. F. Modulating the tumour microenvironment by intratumoural injection of pattern recognition receptor agonists. Cancers (2020) 12(12): 1-22. 

Busby, B. P., Niktab, E., Roberts, C. A., Sheridan, J. P., Coorey, N. V., Senanayake, D. S., Connor, L. M., Munkacsi, A. B., & Atkinson, P. H. Erratum: Publisher Correction: Genetic interaction networks mediate individual statin drug response in Saccharomyces cerevisiae. NPJ systems biology and applications (2020) 6: 9. 

Calvert, M. B., Furkert, D. P., Cooper, C. B., & Brimble, M. A. Synthetic approaches towards bedaquiline and its derivatives. Bioorganic and Medicinal Chemistry Letters (2020) 30(12): 127172.

Cameron, A. J., Davison, E. K., An, C., Stubbing, L. A., Dunbar, P. R., Harris, P. W. R., & Brimble, M. A. Synthesis and SAR Analysis of Lipovelutibols B and D and Their Lipid Analogues. Journal of Organic Chemistry (2020) 85(3): 1401-1406. 

Cameron, A. J., Harris, P. W. R., & Brimble, M. A. On-Resin Preparation of Allenamidyl Peptides: A Versatile Chemoselective Conjugation and Intramolecular Cyclisation Tool. Angewandte Chemie - International Edition (2020) 59(41): 18054-18061. 

Chung, A. W., Ho, T. K. C., Hanson-Manful, P., Tritscheller, S., Raynes, J. M., Whitcombe, A. L., Tay, M. L., McGregor, R., Lorenz, N., Oliver, J. R., Gurney, J. K., Print, C. G., Wilson, N. J., Martin, W. J., Williamson, D. A., Baker, M. G., & Moreland, N. J.  Systems immunology reveals a linked IgG3–C4 response in patients with acute rheumatic fever. Immunology and Cell Biology (2020) 98(1): 12-21. 

Davison, E. K., Freeman, J. L., Zhang, W., Wuest, W. M., Furkert, D. P., & Brimble, M. A. Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin. Organic Letters (2020) 22(14): 5550-5554. 

Dissanayake, W. C., Sorrenson, B., Lee, K. L., Barre, S., & Shepherd, P. R.  Α-Catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models. Biochemical Journal (2020) 477(4): 763-772.  

Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., Slater, D., Morten, B. C., Avery-Kiejda, K. A., Lasham, A., Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., Reddel, R., Huschtscha, L., Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W.  Intronic TP53 Polymorphisms Are Associated with Increased Δ133TP53 Transcript, Immune Infiltration and Cancer Risk. Cancers (Basel) (2020) 12(9): 2472.

Eom, J., Park, S. M., Feisst, V., Chen, C. J. J., Mathy, J. E., McIntosh, J. D., Angel, C. E., Bartlett, A., Martin, R., Mathy, J. A., Cebon, J. S., Black, M. A., Brooks, A. E. S., & Dunbar, P. R.  Distinctive subpopulations of stromal cells are present in human lymph nodes infiltrated with melanoma. Cancer Immunology Research (2020) 8(8): 990-1003.

Ferrer-Font, L., Mayer, J. U., Old, S., Hermans, I. F., Irish, J., & Price, K. M. High-Dimensional Data Analysis Algorithms Yield Comparable Results for Mass Cytometry and Spectral Flow Cytometry Data. Cytometry Part A (2020) 97(8): 824-831. 

Ferrer-Font, L., Mehta, P., Harmos, P., Schmidt, A. J., Chappell, S., Price, K. M., Hermans, I. F., Ronchese, F., Le Gros, G., & Mayer, J. U. High-dimensional analysis of intestinal immune cells during helminth infection. eLife (2020) 9: e51678.

Freeman, J. L., Li, F. F., Furkert, D. P., & Brimble, M. A.  Synthetic Studies towards Spirocyclic Imine Marine Toxins Using N -Acyl Iminium Ions as Dienophiles in Diels-Alder Reactions. Synlett (2020) 31(7): 657-671. 

Gaar, J., Naffa, R., & Brimble, M. Enzymatic and non-enzymatic crosslinks found in collagen and elastin and their chemical synthesis. Organic Chemistry Frontiers (2020) 7(18): 2789-2814. 

Garelja, M. L., Au, M., Brimble, M. A., Gingell, J. J., Hendrikse, E. R., Lovell, A., Prodan, N., Sexton, P. M., Siow, A., Walker, C. S., Watkins, H. A., Williams, G. M., Wootten, D., Yang, S. H., Harris, P. W. R. & Hay, D. L.  Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors. ACS Pharmacology and Translational Science (2020) 3(2): 246-262. 

Georgescu, T., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse. Journal of Neuroendocrinology (2020) 32(11): e12908. [bioRxiv]

Gingell, J. J., Rees, T. A., Hendrikse, E. R., Siow, A., Rennison, D., Scotter, J., Harris, P. W. R., Brimble, M. A., Walker, C. S., & Hay, D. L.  Distinct Patterns of Internalization of Different Calcitonin Gene-Related Peptide Receptors. ACS Pharmacology and Translational Science (2020) 3(2): 296-304. [pdf]

Grant, P. S., Furkert, D. P., & Brimble, M. A.  Total Synthesis of (±)-Leonuketal. Organic Letters (2020) 22: 8735-8740. [chemRxiv]

Grattan, D. R., & Ladyman, S. R.  Neurophysiological and cognitive changes in pregnancy. Handbook of Clinical Neurology (2020) 171: 25-55.

Guise, C. P., Abbattista, M. R., Anderson, R. F., Li, D., Taghipouran, R., Tsai, A., Lee, S. J., Smaill, J. B., Denny, W. A., Hay, M. P., Wilson, W. R., Hicks, K. O., & Patterson, A. V.  Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity. Molecules (Basel, Switzerland) (2020) 25(21): 4888.

Gustafson, P., Ladyman, S. R., McFadden, S., Larsen, C., Khant Aung, Z., Brown, R. S. E., Bunn, S. J., & Grattan, D. R.  Prolactin receptor-mediated activation of pSTAT5 in the pregnant mouse brain. Journal of Neuroendocrinology (2020) 32(11): e12901. 

Hards, K., Adolph, C., Harold, L. K., McNeil, M. B., Cheung, C. Y., Jinich, A., Rhee, K. Y., & Cook, G. M.  Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents. Progress in Biophysics and Molecular Biology (2020) 152: 35-44. 

Hendrikse, E. R., Liew, L. P., Bower, R. L., Bonnet, M., Jamaluddin, M. A., Prodan, N., Richards, K. D., Walker, C. S., Pairaudeau, G., Smith, D. M., Rujan, R. M., Sudra, R., Reynolds, C. A., Booe, J. M., Pioszak, A. A., Flanagan, J. U., Hay, M. P., & Hay, D. L.  Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors. ACS Pharmacology and Translational Science (2020) 3(2): 305-320. 

Hermant, Y. O., Cameron, A. J., Harris, P. W. R., & Brimble, M. A.  Synthesis of antimicrobial lipopeptides using the “CLipPA” thiol-ene reaction. Methods in Molecular Biology (2020) 2103: 263-274. 

Hollywood, J. A., Przepiorski, A., D'Souza, R. F., Sreebhavan, S., Wolvetang, E. J., Harrison, P. T., Davidson, A. J., & Holm, T. M.  Use of human induced pluripotent stem cells and kidney organoids to develop a cysteamine/mtor inhibition combination therapy for cystinosis. Journal of the American Society of Nephrology (2020) 31(5): 962-982.

Jiao, W., Fan, Y., Blackmore, N. J., & Parker, E. J.  A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis. Journal of Biological Chemistry (2020) 295(19): 6252-6262. 

Jiao, W., Lang, E. J., Bai, Y., Fan, Y., & Parker, E. J.  Diverse allosteric componentry and mechanisms control entry into aromatic metabolite biosynthesis. Current Opinion in Structural Biology (2020) 65: 159-167. 

Kavianinia, I., Stubbing, L. A., Abbattista, M. R., Harris, P. W. R., Smaill, J. B., Patterson, A. V., & Brimble, M. A.  Alanine scan-guided synthesis and biological evaluation of analogues of culicinin D, a potent anticancer peptaibol. Bioorganic and Medicinal Chemistry Letters (2020) 30(11): 127135. 

Keown, J. R., Yang, J., Black, M. M., & Goldstone, D. C.  The RING domain of TRIM69 promotes higher-order assembly. Acta Crystallographica Section D: Structural Biology (2020) 76: 954-961. 

Ketharnathan, S., Labudina, A., & Horsfield, J. A.  Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Frontiers in Cell and Developmental Biology (2020) 8: 617545. 

Khant Aung, Z., Grattan, D. R., & Ladyman, S. R.  Pregnancy-induced adaptation of central sensitivity to leptin and insulin. Molecular and Cellular Endocrinology (2020) 516: 110933.

Khemlani, A. H. J., Proft, T., & Loh, J. M. S.  Assays to Analyze Adhesion of Group A Streptococcus to Host Cells. Methods in Molecular Biology (2020) 2136: 271-278.

Khemlani, A. H. J., Proft, T., & Loh, J. M. S.  A Mouse Nasopharyngeal Colonization Model for Group A Streptococcus. Methods in Molecular Biology (2020) 2136: 303-308.

Kokay, I. C., Grattan, D. R., & Murray, J. F.  Prolactin maintains transient melanin-concentrating hormone expression in the medial preoptic area during established lactation. Journal of Neuroendocrinology (2020) 32(2): e12827. 

Kvach, M. V., Barzak, F. M., Harjes, S., Schares, H. A. M., Kurup, H. M., Jones, K. F., Sutton, L., Donahue, J., D'Aquila, R. T., Jameson, G. B., Harki, D. A., Krause, K. L., Harjes, E., & Filichev, V. V.   Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2′-Deoxyzebularine Embedded in Single-Stranded DNA. ChemBioChem (2020) 21(7): 1028-1035. 

Ladyman, S. R., Hackwell, E. C. R., & Brown, R. S. E.  The role of prolactin in co-ordinating fertility and metabolic adaptations during reproduction. Neuropharmacology (2020) 167: 107911.

Lasham, A., Tsai, P., Fitzgerald, S. J., Mehta, S. Y., Knowlton, N. S., Braithwaite, A. W., & Print, C. G.  Accessing a New Dimension in TP53 Biology: Multiplex Long Amplicon Digital PCR to Specifically Detect and Quantitate Individual TP53 Transcripts. Cancers (Basel) (2020) 12(3): 769.

Le Tissier, P. R., & Grattan, D. R.  Growth hormone and prolactin: So much still to learn. Journal of Neuroendocrinology (2020) 32(11): e12909.

Lee, T. W., Yong, H., Bhatta, S., Singleton, D., Lipert, B., Tsai, P., Bohlander, S., Print, C., Hunter, F., Wilson, W., & Jamieson, S.  Functional genomics screens to identify genes involved in tolerance of tumour microenvironment stress. European Journal of Cancer (2020) 138: S30. 

Li, F. F., Stubbing, L. A., Kavianinia, I., Abbattista, M. R., Harris, P. W. R., Smaill, J. B., Patterson, A. V., & Brimble, M. A.  Synthesis and antiproliferative activity of C- and N-terminal analogues of culicinin D. Bioorganic and Medicinal Chemistry Letters (2020) 30(16): 127331

Loef, E. J., Brooks, A. E. S., Lorenz, N., Birch, N. P., & Dunbar, P. R.  Neuroserpin regulates human T cell-T cell interactions and proliferation through inhibition of tissue plasminogen activator. Journal of Leukocyte Biology (2020) 107(1): 145-158.

Loh, J. M. S., Soh, K. Y., & Proft, T.  Generation of Bioluminescent Group A Streptococcus for Biophotonic Imaging. Methods in Molecular Biology (2020) 2136: 71-77.

Lopez-Vicchi, F., De Winne, C., Brie, B., Sorianello, E., Ladyman, S. R., & Becu-Villalobos, D.  Metabolic functions of prolactin: Physiological and pathological aspects. Journal of Neuroendocrinology (2020) 32(11): e12888.

Lopez-Vicchi, F., Ladyman, S. R., Ornstein, A. M., Gustafson, P., Knowles, P., Luque, G. M., Grattan, D. R., & Becu-Villalobos, D.   Chronic high prolactin levels impact on gene expression at discrete hypothalamic nuclei involved in food intake. FASEB Journal (2020) 34(3): 3902-3914. 

Lu, B. L., Loomes, K. M., Hay, D. L., Harris, P. W. R., & Brimble, M. A.  Synthesis of isotopically labelled αCGRP8-37 and its lipidated analogue. Journal of Labelled Compounds and Radiopharmaceuticals (2020) 63(7): 325-332. [pdf]

Lu, B. L., Williams, G. M., & Brimble, M. A.  TLR2 agonists and their structure-activity relationships. Organic and Biomolecular Chemistry (2020) 18(27): 5073-5094. 

Lu, B. L., Williams, G. M., Verdon, D. J., Dunbar, P. R., & Brimble, M. A.  Synthesis and Evaluation of Novel TLR2 Agonists as Potential Adjuvants for Cancer Vaccines. Journal of Medicinal Chemistry (2020) 63(5): 2282-2291. [pdf]

Masson, S. W. C., Sorrenson, B., Shepherd, P. R., & Merry, T. L. (2020). β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding. Molecular Metabolism (2020) 42, 101091.

McCone, J. A. J., Somarathne, K. K., Orme, C. L., Hewitt, R. J., Grant, E. R., Hall, K. R., Ackerley, D. F., La Flamme, A. C., & Harvey, J. E.  Total Synthesis and Bioactivity Studies of Fungal Metabolite (-)-TAN-2483B. Organic Letters (2020) 22(24): 9427-9432. 

McNeil, M. B., Ryburn, H. W. K., Harold, L. K., Tirados, J. F., & Cook, G. M.  Transcriptional Inhibition of the F(1)F(0)-Type ATP Synthase Has Bactericidal Consequences on the Viability of Mycobacteria. Antimicrobial Agents and Chemotherapy (2020) 64(8): e00492-20.

Mehta, S., Algie, M., Al-Jabry, T., McKinney, C., Kannan, S., Verma, C. S., Ma, W., Zhang, J., Bartolec, T. K., Masamsetti, V. P., Parker, K., Henderson, L., Gould, M. L., Bhatia, P., Harfoot, R., Chircop, M., Kleffmann, T., Cohen, S. B., Woolley, A. G., Cesare, A. J., & Braithwaite, A.  Critical role for cold shock protein YB-1 in cytokinesis. Cancers (2020) 12(9): 1-29.

Mehta, S., McKinney, C., Algie, M., Verma, C. S., Kannan, S., Harfoot, R., Bartolec, T. K., Bhatia, P., Fisher, A. J., Gould, M. L., Parker, K., Cesare, A. J., Cunliffe, H. E., Cohen, S. B., Kleffmann, T., Braithwaite, A. W., & Woolley, A. G.  Dephosphorylation of YB-1 is Required for Nuclear Localisation During G(2) Phase of the Cell Cycle. Cancers (Basel) (2020) 12(2): 315.

Merry, T. L., Brooks, A. E. S., Masson, S. W., Adams, S. E., Jaiswal, J. K., Jamieson, S. M. F., & Shepherd, P. R.  The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice. International Journal of Obesity (London) (2020) 44(1): 245-253. 

Metcalfe, L. K., Krishnan, M., Turner, N., Yaghootkar, H., Merry, T. L., Dewes, O., Hindmarsh, J. H., De Zoysa, J., Dalbeth, N., Stamp, L. K., Merriman, T. R., Smith, G., Shepherd, P., & Murphy, R.  The Māori and Pacific specific CREBRF variant and adult height. International Journal of Obesity (2020) 44(3): 748-752. 

Mowday, A. M., Copp, J. N., Syddall, S. P., Dubois, L. J., Wang, J., Lieuwes, N. G., Biemans, R., Ashoorzadeh, A., Abbattista, M. R., Williams, E. M., Guise, C. P., Lambin, P., Ackerley, D. F., Smaill, J. B., Theys, J., & Patterson, A. V.  E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications. Theranostics (2020) 10(23): 10548-10562.

Munoz-Erazo, L., Rhodes, J. L., Marion, V. C., & Kemp, R. A.  Tertiary lymphoid structures in cancer – considerations for patient prognosis. Cellular and Molecular Immunology (2020) 17(6): 570-575. 

Naismith, J. H., & Parker, E.  Editorial overview: Catalysis and regulation. Current Opinion in Structural Biology (2020) 65: iii-iv. 

Nakatani, Y., Shimaki, Y., Dutta, D., Muench, S. P., Ireton, K., Cook, G. M., & Jeuken, L. J. C.  Unprecedented Properties of Phenothiazines Unraveled by a NDH-2 Bioelectrochemical Assay Platform. Journal of the American Chemical Society (2020) 142(3): 1311-1320. 

Nizi, M. G., Desantis, J., Nakatani, Y., Massari, S., Mazzarella, M. A., Shetye, G., Sabatini, S., Barreca, M. L., Manfroni, G., Felicetti, T., Rushton-Green, R., Hards, K., Latacz, G., Satała, G., Bojarski, A. J., Cecchetti, V., Kolář, M. H., Handzlik, J., Cook, G. M., Franzblau, S. G., & Tabarrini, O.  Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors. European Journal of Medicinal Chemistry (2020) 201: 112420. [PDF]

Oh, J. K., Przepiorski, A., Chang, H. H., Dodd, R. C., Sander, V., Sorrenson, B., Shih, J. H., Hollywood, J. A., de Zoysa, J. R., Shepherd, P. R., Davidson, A. J., & Holm, T. M.  Derivation of induced pluripotent stem cell lines from New Zealand donors. Journal of the Royal Society of New Zealand (2020) 10.1080/03036758.2020.1830808. [pdf]

Paterson, D. L., Flanagan, J. U., Shepherd, P. R., Harris, P. W. R., & Brimble, M. A.  Variable-Length Ester-Based Staples for α-Helical Peptides by Using A Double Thiol-ene Reaction. Chemistry - A European Journal (2020) 26(47): 10826-10833.

Phillipps, H. R., Yip, S. H., & Grattan, D. R.  Patterns of prolactin secretion. Molecular and Cellular Endocrinology (2020) 502: 110679.

Pioszak, A. A., & Hay, D. L.  RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors. Advances in Pharmacology (2020) 88: 115-141.

Prentice, E. J., Hicks, J., Ballerstedt, H., Blank, L. M., Liang, L. L., Schipper, L. A., & Arcus, V. L.  The inflection point hypothesis: The relationship between the temperature dependence of enzyme-catalyzed reaction rates and microbial growth rates. Biochemistry (2020) 59(38): 3562-3569. [pdf]

Raynes, J. M., Tay, M. L., By, S. H., Steemson, J. D., & Moreland, N. J.  Isolation of Monoclonal Antibodies to Group A Streptococcus Antigens Using Phage Display. Methods in Molecular Biology (2020) 2136: 255-268. 

Roach, R. J., Garavís, M., González, C., Jameson, G. B., Filichev, V. V., & Hale, T. K.  Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes. Nucleic Acids Research (2020) 48(2): 682-693.

Routh, E. D., Pullikuth, A. K., Jin, G., Chifman, J., Chou, J. W., D'Agostino, R. B., Seino, K. I., Wada, H., Print, C. G., Zhang, W., Lu, Y., & Miller, L. D.  Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types. Frontiers in Immunology (2020) 11: 57.

Shao, M., McNeil, M., Cook, G. M., & Lu, X.  MmpL3 inhibitors as antituberculosis drugs. European Journal of Medicinal Chemistry (2020) 200: 112390. 

Stagkourakis, S., Smiley, K. O., Williams, P., Kakadellis, S., Ziegler, K., Bakker, J., Brown, R. S. E., Harkany, T., Grattan, D. R., & Broberger, C.  A Neuro-hormonal Circuit for Paternal Behavior Controlled by a Hypothalamic Network Oscillation. Cell (2020) 182(4): 960-975. 

Tong, J. T. W., Kavianinia, I., Ferguson, S. A., Cook, G. M., Harris, P. W. R., & Brimble, M. A.  Synthesis of paenipeptin C′ analogues employing solution-phase CLipPA chemistry. Organic and Biomolecular Chemistry (2020) 18(23): 4381-4385. 

Tong, K. K. H., Hanif, M., Lovett, J. H., Hummitzsch, K., Harris, H. H., Söhnel, T., Jamieson, S. M. F., & Hartinger, C. G.  Thiourea-derived chelating ligands and their organometallic compounds: Investigations into their anticancer activity. Molecules (2020) 25(16): 3661.

Wang, Q., Gavin, W., Masiello, N., Tran, K. B., Laible, G., & Shepherd, P. R.  Cetuximab produced from a goat mammary gland expression system is equally efficacious as innovator cetuximab in animal cancer models. Biotechnology Reports (2020) 28: e00533. 

Wang, Y., Yang, S. H., Brimble, M. A., & Harris, P. W. R.  Recent Progress in the Synthesis of Homogeneous Erythropoietin (EPO) Glycoforms. ChemBioChem (2020) 21(23): 3301-3312. 

Whitcombe, A. L., Hanson-Manful, P., Jack, S., Upton, A., Carr, P. A., Williamson, D. A., Baker, M. G., Proft, T., &  Moreland, N. J.  Development and evaluation of a new triplex immunoassay that detects group a streptococcus antibodies for the diagnosis of rheumatic fever. Journal of Clinical Microbiology (2020) 58(9): e00300-20.

Yang, S. H., Clemett, C. A., Brimble, M. A., O'Carroll, S. J., & Harris, P. W. R.  Synthesis and biological evaluation of: S -lipidated lipopeptides of a connexin 43 channel inhibitory peptide. RSC Medicinal Chemistry (2020) 11(9): 1041-1047. 

Yang, S. H., Hermant, Y. O. J., Harris, P. W. R., & Brimble, M. A.  Replacement of the Acrid tert-Butylthiol and an Improved Isolation Protocol for Cysteine Lipidation on a Peptide or Amino Acid (CLipPA). European Journal of Organic Chemistry (2020) 2020(8): 944-947.

Yim, V., Kavianinia, I., Knottenbelt, M. K., Ferguson, S. A., Cook, G. M., Swift, S., Chakraborty, A., Allison, J. R., Cameron, A. J., Harris, P. W. R., &  Brimble, M. A.  “CLipP”ing on lipids to generate antibacterial lipopeptides. Chemical Science (2020) 11(22): 5759-5765. 

Yim, V. V., Cameron, A. J., Kavianinia, I., Harris, P. W. R., & Brimble, M. A.  Thiol-ene Enabled Chemical Synthesis of Truncated S-Lipidated Teixobactin Analogs. Frontiers in Chemistry (2020) 8(568): 568.

Yim, V. V., Kavianinia, I., Cameron, A. J., Harris, P. W. R., & Brimble, M. A.  Direct synthesis of cyclic lipopeptides using intramolecular native chemical ligation and thiol-ene CLipPA chemistry. Organic and Biomolecular Chemistry (2020) 18(15): 2838-2844. 

Young, P. G., & Baker, E. N.  Engineering of Group A Streptococcus Isopeptide Bonds into Immunoglobulin-Like Protein Domains. Methods in Molecular Biology (2020) 2136: 377-395.

Young, P. G., & Squire, C. J.  Molecular Superglues: Discovery and Engineering Orthogonalization. Methods in Molecular Biology (2020) 2073: 85-99.

2019

Aoki, M., P. Wartenberg, R. Grünewald, H.R. Phillipps, A. Wyatt, D.R. Grattan, and U. Boehm, Widespread cell-specific prolactin receptor expression in multiple murine organs. Endocrinology (2019) 160(11): 2587-2599.

Aquino, N.S.S., I.C. Kokay, C.T. Perez, S.R. Ladyman, P.C. Henriques, J.F. Silva, C. Broberger, D.R. Grattan, and R.E. Szawka, Kisspeptin stimulation of prolactin secretion requires kiss1 receptor but not in tuberoinfundibular dopaminergic neurons. Endocrinology (2019) 160(3): 522-533.

Augustine, R.A., P.J. Knowles, Z. Khant Aung, D.R. Grattan, and S.R. Ladyman, Impaired hypothalamic leptin sensitivity in pseudopregnant rats treated with chronic prolactin to mimic pregnancy. Journal of Neuroendocrinology (2019) 31(9): e12702.

Aung, H.L., T.J. Devine, C.V. Mulholland, V.L. Arcus, and G.M. Cook, Tackling tuberculosis in the indigenous people of New Zealand. The Lancet Public Health (2019) 4(10): e496.

Billington, E.O., R. Murphy, G.D. Gamble, K. Callon, N. Davies, L.D. Plank, M. Booth, and I.R. Reid, Fibroblast growth factor 23 levels decline following sleeve gastrectomy. Clinical Endocrinology (2019) 91(1): 87-93.

Blaser, A., H.S. Sutherland, A.S.T. Tong, P.J. Choi, D. Conole, S.G. Franzblau, C.B. Cooper, A.M. Upton, M. Lotlikar, W.A. Denny, and B.D. Palmer, Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline. Bioorganic and Medicinal Chemistry (2019) 27(7): 1283-1291.

Bridges, R.S. and D.R. Grattan, 30 years after: CNS actions of prolactin: Sources, mechanisms and physiological significance. Journal of Neuroendocrinology (2019) 31(3): e12669.

Brimble, M.A., Organic synthesis: Where to from now? A personal perspective from down under. Organic Letters (2019) 21(15): 5773-5774.

Brown, R.S.E., Z. Khant Aung, H.R. Phillipps, Z. Barad, H.J. Lein, U. Boehm, R.E. Szawka, and D.R. Grattan, Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus. Endocrinology (2019) 160(5): 1323-1332.

Buckley, B.J., H. Majed, A. Aboelela, E. Minaei, L. Jiang, K. Fildes, C.Y. Cheung, D. Johnson, D. Bachovchin, G.M. Cook, M. Huang, M. Ranson, and M.J. Kelso, 6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease. Bioorganic and Medicinal Chemistry Letters (2019) 29(24).

Cameron, A.J., C.J. Squire, A. Gérenton, L.A. Stubbing, P.W.R. Harris, and M.A. Brimble, Investigations of the key macrolactamisation step in the synthesis of cyclic tetrapeptide pseudoxylallemycin A. Organic and Biomolecular Chemistry (2019) 17(16): 3902-3913.

Chen, Y., J. Lu, R. Nemati, L.D. Plank, and R. Murphy, Acute changes of bile acids and FGF19 after sleeve gastrectomy and Roux-en-Y gastric bypass. Obesity Surgery (2019) 29(11): 3605-3621.

Choi, P.J., E. Cooper, P. Schweder, E. Mee, R. Faull, W.A. Denny, M. Dragunow, T.I.H. Park, and J. Jose, The synthesis of a novel Crizotinib heptamethine cyanine dye conjugate that potentiates the cytostatic and cytotoxic effects of Crizotinib in patient-derived glioblastoma cell lines. Bioorganic and Medicinal Chemistry Letters (2019) 29(18): 2617-2621.

Compton, B.J., K.J. Farrand, C.W. Tang, T.L. Osmond, M. Speir, A. Authier-Hall, J. Wang, P.M. Ferguson, S.T.S. Chan, R.J. Anderson, T.R. Cooney, C.M. Hayman, G.M. Williams, M.A. Brimble, C.R. Brooks, L.K. Yong, L.S. Metelitsa, D.M. Zajonc, D.I. Godfrey, O. Gasser, R. Weinkove, G.F. Painter, and I.F. Hermans, Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist. Organic and Biomolecular Chemistry (2019) 17(5): 1225-1237.

Cordero, P.R.F., R. Grinter, K. Hards, M.J. Cryle, C.G. Warr, G.M. Cook, and C. Greening, Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence. Journal of Biological Chemistry (2019) 294(50): 18980-18991.

Daniels, B.J., F.F. Li, D.P. Furkert, and M.A. Brimble, Naturally Occurring Lumazines. Journal of Natural Products (2019) 82(7): 2054-2065. [pdf]

Darnell, R.L., M.K. Knottenbelt, F.O.T. Rose, I.R. Monk, T.P. Stinear, and G.M. Cook, Genomewide profiling of the Enterococcus faecalis transcriptional response to teixobactin reveals CroRS as an essential regulator of antimicrobial tolerance. mSphere (2019) 4(3).

Darnell, R.L., Y. Nakatani, M.K. Knottenbelt, S. Gebhard, and G.M. Cook, Functional characterization of bcrr: A one-component transmembrane signal transduction system for bacitracin resistance. Microbiology (United Kingdom) (2019) 165(4): 475-487.

Davies, N.K., J.M. O'Sullivan, L.D. Plank, and R. Murphy, Altered gut microbiome after bariatric surgery and its association with metabolic benefits: A systematic review. Surgery for Obesity and Related Diseases (2019) 15(4): 656-665.

Davison, E.K. and M.A. Brimble, Natural product derived privileged scaffolds in drug discovery. Current Opinion in Chemical Biology (2019) 52: 1-8.

Davison, E.K., A.J. Cameron, P.W.R. Harris, and M.A. Brimble, Synthesis of endolides A and B: Naturally occurring N-methylated cyclic tetrapeptides. MedChemComm (2019) 10(5): 693-698.

Dimitrov, I.V., M.G. Harvey, L.J. Voss, J.W. Sleigh, M.J. Bickerdike, and W.A. Denny, Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain. Bioorganic and Medicinal Chemistry (2019) 27(7): 1226-1231.

Ding, X.B., D.P. Furkert, and M.A. Brimble, Highly diastereoselective synthesis of syn-1,3-dihydroxyketone motifs from propargylic alcohols via spiroepoxide intermediates. Angewandte Chemie - International Edition (2019) 58(34): 11830-11835.

Field, J.J., A.J. Singh, S. Sinha, M.R. Rowe, W.A. Denny, D.G. Brooke, and J.H. Miller, Synthesis and microtubule-destabilizing activity of N-Cyclopropyl-4-((3,4-dihydroquinolin-1(2H)-yl)sulfonyl)benzamide and its analogs. Chemistry - An Asian Journal (2019) 14(8): 1151-1157.

Freeman, J.L., M.A. Brimble, and D.P. Furkert, A chiral auxiliary-based synthesis of the C5-C17: Trans -decalin framework of anthracimycin. Organic Chemistry Frontiers (2019) 6(16): 2954-2963.

Freeman, J.L., M.A. Brimble, and D.P. Furkert, Convenient access to 5-membered cyclic iminium ions: Evidence for a stepwise [4 + 2] cycloaddition mechanism. Organic and Biomolecular Chemistry (2019) 17(10): 2705-2714.

Gamage, S.A., J.A. Spicer, K.Y. Tsang, P.D. O'Connor, J.U. Flanagan, W.J. Lee, J.M.J. Dickson, P.R. Shepherd, W.A. Denny, and G.W. Rewcastle, Synthesis and evaluation of imidazo[1,2-a]pyridine analogues of the ZSTK474 class of phosphatidylinositol 3-kinase inhibitors. Chemistry - An Asian Journal (2019) 14(8): 1249-1261. [pdf]

Gane, E., D.J. Verdon, A.E. Brooks, A. Gaggar, A.H. Nguyen, G.M. Subramanian, C. Schwabe, and P.R. Dunbar, Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: A pilot study. Journal of Hepatology (2019) 71(5): 900-907.

Giddens, A.C., S.A. Gamage, J.D. Kendall, W.J. Lee, B.C. Baguley, C.M. Buchanan, S.M.F. Jamieson, J.M.J. Dickson, P.R. Shepherd, W.A. Denny, and G.W. Rewcastle, Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474. Bioorganic and Medicinal Chemistry (2019) 27(8): 1529-1545.

Gillard, R.M. and M.A. Brimble, Benzannulated spiroketal natural products: Isolation, biological activity, biosynthesis, and total synthesis. Organic and Biomolecular Chemistry (2019) 17(36): 8272-8307.

Grant, P.S., M.A. Brimble, and D.P. Furkert, Synthesis of the bicyclic lactone core of leonuketal, enabled by a telescoped Diels-Alder reaction sequence. Chemistry - An Asian Journal (2019) 14(8): 1128-1135. [pdf]

Grant, P.S., N. Kahlcke, K. Govindpani, M. Hunter, C. MacDonald, M.A. Brimble, M. Glass, and D.P. Furkert, Divalent cannabinoid-1 receptor ligands: A linker attachment point survey of SR141716A for development of high-affinity CB1R molecular probes. Bioorganic and Medicinal Chemistry Letters (2019) 29(21): 126644.

Grattan, D.R. and R.E. Szawka, Kisspeptin and prolactin. Seminars in Reproductive Medicine (2019) 37(2): 93-104.

Hards, K., S.M. Rodriguez, C. Cairns, and G.M. Cook, Alternate quinone coupling in a new class of succinate dehydrogenase may potentiate mycobacterial respiratory control. FEBS Letters (2019) 593(5): 475-486.

Harold, L.K., J. Antoney, F.H. Ahmed, K. Hards, P.D. Carr, T. Rapson, C. Greening, C.J. Jackson, and G.M. Cook, FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress. Journal of Biological Chemistry (2019) 294(8): 2903-2912.

Harvey, M., J. Sleigh, L. Voss, M. Bickerdike, I. Dimitrov, and W. Denny, KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects. BMC Pharmacology and Toxicology (2019) 20(1): 85.

Hasenoehrl, E.J., D. Rae Sajorda, L. Berney-Meyer, S. Johnson, J.A.M. Tufariello, T. Fuhrer, G.M. Cook, W.R. Jacobs, and M. Berney, Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection. Nature Communications (2019) 10(1): 4215.

Heitz, S.D., D.J. Hamelin, R.M. Hoffmann, N. Greenberg, G. Salloum, Z. Erami, B.D. Khalil, A. Shymanets, E.A. Steidle, G.Q. Gong, B. Nürnberg, J.E. Burke, J.U. Flanagan, A.R. Bresnick, and J.M. Backer, A single discrete Rab5-binding site in phosphoinositide 3-kinase is required for tumor cell invasion. Journal of Biological Chemistry (2019) 294(12): 4621-4633.

Jacobson, G.M., L.J. Voss, A. Klockars, S. Bird, I. Dimitrov, W.A. Denny, P.K. Olszewski, J.W. Sleigh, and M.G. Harvey, Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain. BMC Genomics (2019) 20(1): 281.

Jeong, J.Y., J. Sperry, and M.A. Brimble, Synthesis of the tetracyclic cores of the integrastatins, epicoccolide A and epicocconigrone A. Journal of Organic Chemistry (2019) 84(18): 11935-11944.

Kalyukina, M., Y. Yosaatmadja, M.J. Middleditch, A.V. Patterson, J.B. Smaill, and C.J. Squire, TAS-120 cancer target binding: Defining reactivity and revealing the first fibroblast growth factor receptor 1 (FGFR1) irreversible structure. ChemMedChem (2019) 14(4): 494-500.

Kasim, J.K., I. Kavianinia, P.W.R. Harris, and M.A. Brimble, Three decades of amyloid beta synthesis: Challenges and advances. Frontiers in Chemistry (2019) 7(JUL).

Kasim, J.K., I. Kavianinia, J. Ng, P.W.R. Harris, N.P. Birch, and M.A. Brimble, Efficient synthesis and characterisation of the amyloid beta peptide, Aβ <inf>1-42</inf> , using a double linker system. Organic and Biomolecular Chemistry (2019) 17(1): 30-34.

Kazantseva, M., S. Mehta, R.A. Eiholzer, G. Gimenez, S. Bowie, H. Campbell, A.L. Reily-Bell, I. Roth, S. Ray, C.J. Drummond, G. Reid, S.M. Joruiz, A. Wiles, H.R. Morrin, K.L. Reader, N.A. Hung, M.A. Baird, T.L. Slatter, and A.W. Braithwaite, The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death and Disease (2019) 10(9): 631.

Kelch, I.D., G. Bogle, G.B. Sands, A.R.J. Phillips, I.J. LeGrice, and P.R. Dunbar, High-resolution 3D imaging and topological mapping of the lymph node conduit system. PLoS Biology (2019) 17(12): e3000486.

Khalil, Z.G., T.A. Hill, L.M. De Leon Rodriguez, R.J. Lohman, H.N. Hoang, N. Reiling, D. Hillemann, M.A. Brimble, D.P. Fairlie, A. Blumenthal, and R.J. Capon, Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy (2019) 63(3).

Kirk, S.E., D.R. Grattan, and S.J. Bunn, The median eminence detects and responds to circulating prolactin in the male mouse. Journal of Neuroendocrinology (2019) 31(6): e12733. [pdf]

Lee, D.J., A.J. Cameron, T.H. Wright, P.W.R. Harris, and M.A. Brimble, A synthetic approach to 'click' neoglycoprotein analogues of EPO employing one-pot native chemical ligation and CuAAC chemistry. Chemical Science (2019) 10(3): 815-828.

Lee, K.L., J.F. Aitken, H.L. Hsu, G.M. Williams, M.A. Brimble, and G.J.S. Cooper, Glucoregulatory activity of vesiculin in insulin sensitive and resistant mice. Peptides (2019) 116: 1-7.

Lee, W.G., C.I. Wells, J.L. McCall, R. Murphy, and L.D. Plank, Prevalence of diabetes in liver cirrhosis: A systematic review and meta-analysis. Diabetes/Metabolism Research and Reviews (2019) 35(6).

Li, F.F. and M.A. Brimble, Using chemical synthesis to optimise antimicrobial peptides in the fight against antimicrobial resistance. Pure and Applied Chemistry (2019) 91(2): 181-198.

Liew, L.P., Singleton, D.C., Wong, W.W., Cheng, G.J., Jamieson, S.M. and Hay, M.P. Hypoxia‐activated prodrugs of PERK inhibitors. Chemistry - An Asian Journal (2019) 14(8): 1238-1248.

Lu, X., H. Chen, A. V. Patterson, J. B. Smaill, and K. Ding, Fibroblast growth factor receptor 4 (FGFR4) selective inhibitors as hepatocellular carcinoma therapy: Advances and prospects. Journal of Medicinal Chemistry (2019) 62(6): 2905-2915.

Lu, X., Z. Williams, K. Hards, J. Tang, C.Y. Cheung, H.L. Aung, B. Wang, Z. Liu, X. Hu, A. Lenaerts, L. Woolhiser, C. Hastings, X. Zhang, Z. Wang, K. Rhee, K. Ding, T. Zhang, and G.M. Cook, Pyrazolo[1,5- a]pyridine inhibitor of the respiratory cytochrome bcc complex for the treatment of drug-resistant tuberculosis. ACS Infectious Diseases (2019) 5(2): 239-249. [pdf]

McNeil, M.B. and G.M. Cook, Utilization of CRISPR interference to validate MmpL3 as a drug target in mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy (2019) 63(8).

Momin, M.A.M., B. Rangnekar, S. Sinha, C.Y. Cheung, G.M. Cook, and S.C. Das, Inhalable dry powder of bedaquiline for pulmonary tuberculosis: In vitro physicochemical characterization, antimicrobial activity and safety studies. Pharmaceutics (2019) 11(10).

Mulholland, C.V., A.C. Shockey, H.L. Aung, R.T. Cursons, R.F. O’Toole, S.S. Gautam, D. Brites, S. Gagneux, S.A. Roberts, N. Karalus, G.M. Cook, C.S. Pepperell, and V.L. Arcus, Dispersal of mycobacterium tuberculosis driven by historical European trade in the South Pacific. Frontiers in Microbiology (2019) 10: 2778.

Murphy, R., G.D. Gamble, M. House, B. Pool, A. Horne, T.R. Merriman, and N. Dalbeth, Greater insulin response to acute fructose ingestion among Māori and Pacific people compared to European people living in Aotearoa New Zealand. Internal Medicine Journal (2019) 49(2): 196-202.

Murphy, R., M. Ghafel, G. Beban, M. Booth, K. Bartholomew, and P. Sandiford, Variation in public-funded bariatric surgery intervention rate by New Zealand region. Internal Medicine Journal (2019) 49(3): 391-395.

Murphy, R., X.C. Morgan, X.Y. Wang, K. Wickens, G. Purdie, P. Fitzharris, A. Otal, B. Lawley, T. Stanley, C. Barthow, J. Crane, E.A. Mitchell, and G.W. Tannock, Eczema-protective probiotic alters infant gut microbiome functional capacity but not composition: Sub-sample analysis from a RCT. Beneficial Microbes (2019) 10(1): 5-17. [pdf]

Musa, H., E.R. Hendrikse, M.A. Brimble, M.L. Garelja, H.A. Watkins, P.W.R. Harris, and D.L. Hay, Pharmacological characterization and investigation of N-terminal loop amino acids of adrenomedullin 2 that are important for receptor activation. Biochemistry (2019) 58(32): 3468-3474.

Ng, J., H. Kaur, T. Collier, K. Chang, A.E.S. Brooks, J.R. Allison, M.A. Brimble, A. Hickey, and N.P. Birch, Site-specific glycation of A1- 42 affects fibril formation and is neurotoxic. Journal of Biological Chemistry (2019) 294(22): 8806-8818.

Okesene-Gafa, K.A.M., M. Li, C.J.D. McKinlay, R.S. Taylor, E.C. Rush, C.R. Wall, J. Wilson, R. Murphy, R. Taylor, J.M.D. Thompson, C.A. Crowther, and L.M.E. McCowan, Effect of antenatal dietary interventions in maternal obesity on pregnancy weight-gain and birthweight: Healthy Mums and Babies (HUMBA) randomized trial. American Journal of Obstetrics and Gynecology (2019) 221(2): 152.e1-152.e13. [pdf]

Patil, M., S. Belugin, J. Mecklenburg, A. Wangzhou, C. Paige, P.A. Barba-Escobedo, J.T. Boyd, V. Goffin, D. Grattan, U. Boehm, G. Dussor, T.J. Price, and A.N. Akopian, Prolactin regulates pain responses via a female-selective nociceptor-specific mechanism. iScience (2019) 20: 449-465.

Patil, M., A.H. Hovhannisyan, A. Wangzhou, J. Mecklenburg, W. Koek, V. Goffin, D. Grattan, U. Boehm, G. Dussor, T.J. Price, and A.N. Akopian, Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent. Journal of Neuroendocrinology (2019) 31(8): e12759.

Petri, J., Y. Nakatani, M.G. Montgomery, S.A. Ferguson, D. Aragão, A.G.W. Leslie, A. Heikal, J.E. Walker, and G.M. Cook, Structure of F1-ATPase from the obligate anaerobe Fusobacterium nucleatum. Open Biology (2019) 9(6): 190066.

Phillipps, H.R., C.J. Rand, R.S.E. Brown, I.C. Kokay, J.A. Stanton, and D.R. Grattan, Prolactin regulation of insulin-like growth factor 2 gene expression in the adult mouse choroid plexus. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology (2019) 33(5): 6115-6128.

Pilkington, L.I., X. Yang, M.W. Liu, Y. Hemar, M.A. Brimble, and J. Reynisson, A chemometric analysis of compounds from native New Zealand medicinal flora. Chemistry - An Asian Journal (2019) 14(8): 1117-1127.

Ramke, J., V. Jordan, A.L. Vincent, M. Harwood, R. Murphy, and S. Ameratunga, Diabetic eye disease and screening attendance by ethnicity in New Zealand: A systematic review. Clinical and Experimental Ophthalmology (2019) 47(7): 937-947.

Rushton-Green, R., R.L. Darnell, G. Taiaroa, G.P. Carter, G.M. Cook, and X.C. Morgan, Agricultural origins of a highly persistent lineage of vancomycin-resistant Enterococcus faecalis in New Zealand. Applied and Environmental Microbiology (2019) 85(13).

Santoso, K.T., C.Y. Cheung, K. Hards, G.M. Cook, B.L. Stocker, and M.S.M. Timmer, Synthesis and investigation of Phthalazinones as antitubercular agents. Chemistry - An Asian Journal (2019) 14(8): 1278-1285.

Santoso, K.T., A. Menorca, C.Y. Cheung, G.M. Cook, B.L. Stocker, and M.S.M. Timmer, The synthesis and evaluation of quinolinequinones as anti-mycobacterial agents. Bioorganic and Medicinal Chemistry (2019) 27(16): 3532-3545.

Saponara, S., F. Fusi, O. Spiga, A. Trezza, B. Hopkins, M.A. Brimble, D. Rennison, and S. Bova, The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells. Frontiers in Pharmacology (2019) 10(MAY).

Sarojini, V., A.J. Cameron, K.G. Varnava, W.A. Denny, and G. Sanjayan, Cyclic tetrapeptides from nature and design: A review of synthetic methodologies, structure, and function. Chemical Reviews (2019) 119(17): 10318-10359.

Saw, W.G., M.L. Wu, P. Ragunathan, G. Biuković, A.M. Lau, J. Shin, A. Harikishore, C.Y. Cheung, K. Hards, J.P. Sarathy, R.W. Bates, G.M. Cook, T. Dick, and G. Grüber, Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis. Scientific Reports (2019) 9(1): 16759.

Skinner, N.J., M.Z. Rizwan, D.R. Grattan, and A. Tups, Chronic light cycle disruption alters central insulin and leptin signaling as well as metabolic markers in male mice. Endocrinology (2019) 160(10): 2257-2270.

Slykerman, R.F., M.V. Joglekar, A.A. Hardikar, S.N. Satoor, J.M.D. Thompson, A. Jenkins, E.A. Mitchell, and R. Murphy, Maternal stress during pregnancy and small for gestational age birthweight are not associated with telomere length at 11 years of age. Gene (2019) 694: 97-101.

Smith, R.J., R.L. Bower, S.A. Ferguson, R.J. Rosengren, G.M. Cook, and B.C. Hawkins, The synthesis of (±)-oxyisocyclointegrin. European Journal of Organic Chemistry (2019) 2019(7): 1571-1573.

Spicer, J.A., C.K. Miller, P.D. O'Connor, J. Jose, A.C. Giddens, J.K. Jaiswal, S.M.F. Jamieson, M.R. Bull, W.A. Denny, H. Akhlaghi, J.A. Trapani, G.R. Hill, K. Chang, and K.H. Gartlan, Inhibition of the cytolytic protein perforin prevents rejection of transplanted bone marrow stem cells in vivo. Journal of Medicinal Chemistry (Epub 2019) DOI: 10.1021/acs.jmedchem.9b00881.

Stevenson, L.J., J.G. Owen, and D.F. Ackerley, Metagenome driven discovery of nonribosomal peptides. ACS Chemical Biology (2019) 14(10): 2115-2126.

Stubbing, L.A., I. Kavianinia, M.R. Abbattista, P.W.R. Harris, J.B. Smaill, A.V. Patterson, and M.A. Brimble, Synthesis and antiproliferative activity of culicinin D analogues containing simplified AHMOD-based residues. European Journal of Medicinal Chemistry (2019) 177: 235-246.

Sutherland, H.S., A.S.T. Tong, P.J. Choi, A. Blaser, D. Conole, S.G. Franzblau, M.U. Lotlikar, C.B. Cooper, A.M. Upton, W.A. Denny, and B.D. Palmer, 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel. Bioorganic and Medicinal Chemistry (2019) 27(7): 1292-1307.

Svendsen, J.S.M., T.M. Grant, D. Rennison, M.A. Brimble, and J. Svenson, Very short and stable lactoferricin-derived antimicrobial peptides: Design principles and potential uses. Accounts of Chemical Research (2019) 52(3): 749-759.

Thompson, A.M. and W.A. Denny, Inhibitors of enzymes in the electron transport chain of Mycobacterium tuberculosis. in Annual Reports in Medicinal Chemistry (2019) 52: 97-130.

Trevarton, A., Y. Zhou, D. Yang, G.W. Rewcastle, J.U. Flanagan, A. Braithwaite, P.R. Shepherd, C.G. Print, M.W. Wang, and A. Lasham, Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1. Acta Pharmaceutica Sinica B (2019) 9(5): 997-1007.

Vennin, C., P. Mélénec, R. Rouet, M. Nobis, A.S. Cazet, K.J. Murphy, D. Herrmann, D.A. Reed, M.C. Lucas, S.C. Warren, Z. Elgundi, M. Pinese, G. Kalna, D. Roden, M. Samuel, A. Zaratzian, S.T. Grey, A. Da Silva, W. Leung, A.L. Johns, L.A. Chantrill, A. Chou, A. Steinmann, M. Arshi, T. Dwarte, D. Froio, B. Pereira, S. Ritchie, C.R. Chambers, X. Metcalf, N. Waddell, J.V. Pearson, A.M. Patch, K. Nones, F. Newell, P. Mukhopadhyay, V. Addala, S. Kazakoff, O. Holmes, C. Leonard, S. Wood, S.M. Grimmond, O. Hofmann, A. Christ, T. Bruxner, J.S. Samra, N. Pavlakis, H.A. High, R. Asghari, N.D. Merrett, D. Pavey, A. Das, P.H. Cosman, K. Ismail, C. O’Connnor, A. Stoita, D. Williams, A. Spigellman, V.W. Lam, D. McLeod, J. Kirk, J.G. Kench, P. Grimison, C.L. Cooper, C. Sandroussi, A. Goodwin, R.S. Mead, K. Tucker, L. Andrews, M. Texler, C. Forest, K.P. Epari, M. Ballal, D.R. Fletcher, S. Mukhedkar, N. Zeps, M. Beilin, K. Feeney, N.Q. Nguyen, A.R. Ruszkiewicz, C. Worthley, J. Chen, M.E. Brooke-Smith, V. Papangelis, A.D. Clouston, A.P. Barbour, T.J. O’Rourke, J.W. Fawcett, K. Slater, M. Hatzifotis, P. Hodgkinson, M. Nikfarjam, J.R. Eshleman, R.H. Hruban, C.L. Wolfgang, R.T. Lawlor, S. Beghelli, V. Corbo, M. Scardoni, C. Bassi, A.V. Biankin, J. Dixon, N.B. Jamieson, D.K. Chang, S. Mathivanan, Y. Wang, A.W. Braithwaite, D. Christ, A. Benda, A. Parkin, P.A. Phillips, J.M. Whitelock, A.J. Gill, O.J. Sansom, D.R. Croucher, B.L. Parker, M. Pajic, J.P. Morton, T.R. Cox and P. Timpson, CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nature Communications (2019) 10(1): 3637.

Wood, J.M., D.P. Furkert, and M.A. Brimble, 2-Formylpyrrole natural products: Origin, structural diversity, bioactivity and synthesis. Natural Product Reports (2019) 36(2): 289-306.

Xu, B., Y. Hermant, S.H. Yang, P.W.R. Harris, and M.A. Brimble, A versatile Boc solid phase synthesis of daptomycin and analogues using site specific, on-resin ozonolysis to install the kynurenine residue. Chemistry - A European Journal (2019) 25(62): 14101-14107.

Yip, S.H., N. Romanò, P. Gustafson, D.J. Hodson, E.J. Williams, I.C. Kokay, A.O. Martin, P. Mollard, D.R. Grattan, and S.J. Bunn, Elevated prolactin during pregnancy drives a phenotypic switch in mouse hypothalamic dopaminergic neurons. Cell Reports (2019) 26(7): 1787-1799.e5.

 Yule, L.R., Garelja, M.L., Hendrikse, E.R., Gingell, J.J., Poyner, D.R., Harris, P.W., Brimble, M.A. and Hay, D.L. A potent fluorescent calcitonin gene‐related peptide analogue enables visualization of receptor internalization. Peptide Science (2019) 111(6): e24126.

Zhang, A.T., M.G. Montgomery, A.G.W. Leslie, G.M. Cook, and J.E. Walker, The structure of the catalytic domain of the ATP synthase from Mycobacterium smegmatis is a target for developing antitubercular drugs. Proceedings of the National Academy of Sciences of the United States of America (2019) 116(10): 4206-4211.

Zhang, S., I. Kavianinia, and M.A. Brimble, Naturally occurring antitubercular cyclic peptides. Tetrahedron Letters (2019) 60(50): 151339.

2018

Agostini, M., E. Schoenmakers, J. Beig, L. Fairall, I. Szatmari, O. Rajanayagam, F. W. Muskett, C. Adams, A. D. Marais, S. O’Rahilly, R. K. Semple, L. Nagy, A. R. Majithia, J. W. R. Schwabe, D. J. Blom, R. Murphy, K. Chatterjee, and D. B. Savage, A pharmacogenetic approach to the treatment of patients with PPARG mutations. Diabetes (2018) 67(6): 1086-1092.

Alexander, S. R., G. M. Williams, M. A. Brimble, and A. J. Fairbanks, A double-click approach to the protecting group free synthesis of glycoconjugates. Organic and Biomolecular Chemistry (2018) 16(8): 1258-1262.

Amso, Z., S. W. Bisset, S. H. Yang, P. W. R. Harris, T. H. Wright, C. D. Navo, M. L. Patchett, G. E. Norris, and M. A. Brimble, Total chemical synthesis of glycocin F and analogues: S-glycosylation confers improved antimicrobial activity. Chemical Science (2018) 9(6): 1686-1691.

Augustine, R. A., A. J. Seymour, R. E. Campbell, D. R. Grattan, and C. H. Brown, Integrative neurohumoural regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Neuroendocrinology (2018) 30(8).

Aung, H. L., T. Tun, W. W. Nyunt, Y. Fong, J. A. Crump, K. K. Thinn, S. T. Aung, and G. M. Cook, Association between anti-tuberculosis drug resistance-conferring mutations and treatment outcomes in Myanmar. Infectious Diseases (2018) 50(5): 388-390.

Bisset, S. W., S. H. Yang, Z. Amso, P. W. R. Harris, M. L. Patchett, M. A. Brimble, and G. E. Norris, Using chemical synthesis to probe structure-activity relationships of the glycoactive bacteriocin glycocin F. ACS Chemical Biology (2018) 13(5): 1270-1278.

Bower, R. L., L. Yule, T. A. Rees, G. Deganutti, E. R. Hendrikse, P. W. Harris, R. Kowalczyk, Z. Ridgway, A. G. Wong, and K. Swierkula, Molecular signature for receptor engagement in the metabolic peptide hormone amylin. ACS Pharmacology & Translational Science (2018) 1(1): 32-49.

Britto, D. D., B. Wyroba, W. Chen, R. A. Lockwood, K. B. Tran, P. R. Shepherd, C. J. Hall, K. E. Crosier, P. S. Crosier, and J. W. Astin, Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model. Disease Models & Mechanisms (2018) 11(12).

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Nicholson, M. J., K. C. Van de Bittner, A. Ram, L. Y. Bustamante, B. Scott, and E. J. Parker, Draft genome sequence of the filamentous fungus Hypoxylon pulicicidum ATCC 74245. Genome Announcements (2018) 6(2).

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Petri, J., Y. Shimaki, W. Jiao, H. R. Bridges, E. R. Russell, E. J. Parker, D. Aragão, G. M. Cook, and Y. Nakatani, Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors. Biochimica et Biophysica Acta - Bioenergetics (2018) 1859(7): 482-490.

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Prendergast, K. A., N. J. Daniels, T. R. Petersen, I. F. Hermans, and J. R. Kirman, Langerin+ CD8α+ dendritic cells drive early CD8+ T cell activation and IL-12 production during systemic bacterial infection. Frontiers in Immunology (2018) 9(MAY).

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Shirley, H. J., M. L. Jamieson, M. A. Brimble, and C. D. Bray, A new family of sesterterpenoids isolated around the Pacific Rim. Natural Product Reports (2018) 35(3): 210-219.

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Siow, A., G. Opiyo, I. Kavianinia, F. F. Li, D. P. Furkert, P. W. R. Harris, and M. A. Brimble, Total synthesis of the highly N-methylated acetylene-containing anticancer peptide jahanyne. Organic Letters (2018) 20(3): 788-791.

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Sterritt, O. W., E. J. M. Lang, S. A. Kessans, T. M. Ryan, B. Demeler, G. B. Jameson, and E. J. Parker, Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase subclass. Bioscience Reports (2018) 38(5).

Stevenson, R. J., I. Azimi, J. U. Flanagan, M. Inserra, I. Vetter, G. R. Monteith, and W. A. Denny, An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay. Bioorganic and Medicinal Chemistry (2018) 26(12): 3406-3413. [pdf]

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Williams, E. T., P. W. R. Harris, M. A. Jamaluddin, K. M. Loomes, D. L. Hay, and M. A. Brimble, Solid-phase thiol-ene lipidation of peptides for the synthesis of a potent CGRP receptor antagonist. Angewandte Chemie - International Edition (2018) 57(36): 11640-11643.

Xiang, Q., C. Wang, Y. Zhang, X. Xue, M. Song, C. Zhang, C. Li, C. Wu, K. Li, X. Hui, Y. Zhou, J. B. Smaill, A. V. Patterson, D. Wu, K. Ding, and Y. Xu, Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer. European Journal of Medicinal Chemistry (2018) 147: 238-252.

Xu, B., E. J. Aitken, B. P. Baker, C. A. Turner, J. E. Harvey, M. B. Stott, J. F. Power, P. W. R. Harris, R. A. Keyzers, and M. A. Brimble, Genome mining, isolation, chemical synthesis and biological evaluation of a novel lanthipeptide, tikitericin, from the extremophilic microorganism: Thermogemmatispora strain T81. Chemical Science (2018) 9(37): 7311-7317.

Yip, S. H., J. York, B. Hyland, S. J. Bunn, and D. R. Grattan, Incomplete concordance of dopamine transporter Cre (DATIREScre)-mediated recombination and tyrosine hydroxylase immunoreactivity in the mouse forebrain. Journal of Chemical Neuroanatomy (2018) 90: 40-48.

Zafar, A., L. I. Pilkington, N. A. Haverkate, M. Van Rensburg, E. Leung, S. Kumara, W. A. Denny, D. Barker, A. Alsuraifi, C. Hoskins, and J. Reynisson, Investigation into improving the aqueous solubility of the thieno[2,3-b]pyridine anti-proliferative agents. Molecules (2018) 23(1).

Zhang, J., C. Burn, K. Young, M. Wilson, K. Ly, M. Budhwani, A. Tschirley, A. Braithwaite, M. Baird, and M. Hibma, Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response. Scientific Reports (2018) 8(1).

Zhang, S., L. M. De Leon Rodriguez, I. K. H. Leung, G. M. Cook, P. W. R. Harris, and M. A. Brimble, Total synthesis and conformational study of callyaerin A: Anti-Tubercular cyclic peptide bearing a rare rigidifying (Z)-2,3- diaminoacrylamide moiety. Angewandte Chemie - International Edition (2018) 57(14): 3631-3635. [pdf]

2017

Ahn, A., A. Chatterjee and M. R. Eccles, The slow cycling phenotype: A growing problem for treatment resistance in melanoma. Molecular Cancer Therapeutics (2017) 16(6): 1002-1009.

Aitken, J. F., Loomes, K. M., Riba-Garcia, I., Unwin, R. D., Prijic, G., Phillips, A. S., Phillips, A. R. J., Wu, D., Poppitt, S. D., Ding, K., Barran, P. E., Dowsey, A. W. and Cooper, G. J. S. Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human amylin/hIAPP transgenic mice. Biochemical and Biophysical Research Communications (2017) 482(4): 625-631. [pdf]

Alexander, S. R., D. Lim, Z. Amso, M. A. Brimble and A. J. Fairbanks, Protecting group free synthesis of glycosyl thiols from reducing sugars in water; application to the production of N-glycan glycoconjugates. Organic and Biomolecular Chemistry (2017) 15(10): 2152-2156.

Anderson, R. J., J. Li, L. Kedzierski, B. J. Compton, C. M. Hayman, T. L. Osmond, C. W. Tang, K. J. Farrand, H. F. Koay, C. F. D. S. E. Almeida, L. R. Holz, G. M. Williams, M. A. Brimble, Z. F. Wang, M. Koutsakos, K. Kedzierska, D. I. Godfrey, I. F. Hermans, S. J. Turner and G. F. Painter, Augmenting influenza-specific T Cell memory generation with a natural killer T Cell-dependent glycolipid-peptide vaccine. ACS Chemical Biology (2017) 12(11): 2898-2905.

Aung, H. L., W. W. Nyunt, Y. Fong, G. M. Cook and S. T. Aung, First 2 extensively drug-resistant tuberculosis cases from Myanmar treated with Bedaquiline. Clinical Infectious Diseases (2017) 65(3): 531-532.

Badrinarayanan, S., C. J. Squire, J. Sperry and M. A. Brimble, Bioinspired total synthesis and stereochemical revision of the fungal metabolite pestalospirane B. Organic Letters (2017) 19(13): 3414-3417.

Blaza, J. N., H. R. Bridges, D. Aragao, E. A. Dunn, A. Heikal, G. M. Cook, Y. Nakatani and J. Hirst, The mechanism of catalysis by type-II NADH: Quinone oxidoreductases. Scientific Reports (2017) 7: 40165.

Booker, C. S. and D. R. Grattan, IL1R9 is evolutionarily related to IL18BP and may function as an IL-18 receptor. Journal of Immunology (2017) 198(1): 270-278.

Brown, R. S. E., M. Aoki, S. R. Ladyman, H. R. Phillipps, A. Wyatt, U. Boehm and D. R. Grattan, Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior. Proceedings of the National Academy of Sciences of the United States of America (2017) 114(40): 10779-10784.

Chatterjee, A., E. C. MacAulay, A. Ahn, J. L. Ludgate, P. A. Stockwell, R. J. Weeks, M. F. Parry, T. J. Foster, I. M. Knarston, M. R. Eccles and I. M. Morison, Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics (2017) 9(6): 823-832.

Chatterjee, A., P. A. Stockwell, A. Ahn, E. J. Rodger, A. L. Leichter and M. R. Eccles, Genome-wide methylation sequencing of paired primary and metastatic cell lines identifies common DNA methylation changes and a role for EBF3 as a candidate epigenetic driver of melanoma metastasis. Oncotarget (2017) 8(4): 6085-6101.

Choi, H., H. J. Shirley, P. A. Hume, M. A. Brimble and D. P. Furkert, Unexpected direct synthesis of N-Vinyl amides through Vinyl Azide–Enolate [3+2] Cycloaddition. Angewandte Chemie - International Edition (2017) 56(26): 7420-7424.

Choi, P. J., H. S. Sutherland, A. S. T. Tong, A. Blaser, S. G. Franzblau, C. B. Cooper, M. U. Lotlikar, A. M. Upton, J. Guillemont, M. Motte, L. Queguiner, K. Andries, W. Van den Broeck, W. A. Denny and B. D. Palmer, Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units. Bioorganic & Medicinal Chemistry Letters (2017) 27(23): 5190-5196.

Chowdhury, M. K. H., N. Turner, N. L. Bentley, A. Das, L. E. Wu, D. Richani, S. Bustamante, R. B. Gilchrist, M. J. Morris, P. R. Shepherd and G. C. Smith, Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes. Scientific Reports (2017) 7: 40159.

Cook, G. M., K. Hards, E. Dunn, A. Heikal, Y. Nakatani, C. Greening, D. C. Crick, F. L. Fontes, K. Pethe, E. Hasenoehrl and M. Berney, Oxidative phosphorylation as a target space for tuberculosis: Success, caution, and future directions. Microbiology Spectrum (2017) 5(3). 

Cooper, A., S. Singh, S. Hook, J. D. A. Tyndall and A. J. Vernall, Chemical tools for studying lipid-binding class a g protein–coupled receptors. Pharmacological Reviews (2017) 69(3): 316-353.

Copp, J. N., A. M. Mowday, E. M. Williams, C. P. Guise, A. Ashoorzadeh, A. V. Sharrock, J. U. Flanagan, J. B. Smaill, A. V. Patterson, and D. F. Ackerley, Engineering a multifunctional nitroreductase for improved activation of prodrugs and PET probes for cancer gene therapy. Cell Chemical Biology (2017) 24(3): 391-403.

da Silva, K. S., P. R. Pinto, N. T. Fabre, D. J. Gomes, K. Thieme, L. S. Okuda, R. T. Iborra, V. G. Freitas, M. H. M. Shimizu, W. R. Teodoro, S. K. N. Marie, T. Woods, M. A. Brimble, R. Pickford, K.-A. Rye, M. Okamoto, S. Catanozi, M. L. Correa-Giannela, U. F. Machado and M. Passarelli, N-acetylcysteine counteracts adipose tissue macrophage infiltration and insulin resistance elicited by advanced glycated albumin in healthy rats. Frontiers in Physiology (2017) 8: 723.

Dalton, J. P., B. Uy, K. S. Okuda, C. J. Hall, W. A. Denny, P. S. Crosier, S. Swift and S. Wiles, Screening of anti-mycobacterial compounds in a naturally infected zebrafish larvae model. Journal of Antimicrobial Chemotherapy (2017) 72(2): 421-427.

De Leon-Rodriguez, L. M., Y. Hemar, A. K. Mitra and M. A. Brimble, Understanding the metal mediated assembly and hydrogel formation of a [small beta]-hairpin peptide. Biomaterials Science (2017) 5(10): 1993-1997.

De Leon-Rodriguez, L. M., Y. Hemar, G. Mo, A. K. Mitra, J. Cornish and M. A. Brimble, Multifunctional thermoresponsive designer peptide hydrogels. Acta Biomaterialia (2017) 47: 40-49.

Ding, X. B., D. P. Furkert and M. A. Brimble, General synthesis of the nitropyrrolin family of natural products via regioselective CO<inf>2</inf>-mediated alkyne hydration. Organic Letters (2017) 19(19): 5418-5421. [pdf]

Dissanayake, S., W. A. Denny, S. Gamage and V. Sarojini, Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides. Journal of Controlled Release (2017) 250: 62-76.

Evans, G. L., D. P. Furkert, N. Abermil, P. Kundu, K. M. de Lange, E. J. Parker, M. A. Brimble, E. N. Baker and J. S. Lott, Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups. Data in Brief (2017) 15: 1019-1029.

Field, C. S., M. K. Hunn, P. M. Ferguson, C. Ruedl, L. R. Ancelet and I. F. Hermans, Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model. OncoImmunology (2017) 7(1): e1376154.

Gamage, S. A., A. C. Giddens, K. Y. Tsang, J. U. Flanagan, J. D. Kendall, W. J. Lee, B. C. Baguley, C. M. Buchanan, S. M. F. Jamieson, P. R. Shepherd, W. A. Denny and G. W. Rewcastle, Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474. Bioorganic & Medicinal Chemistry (2017) 25(20): 5859-5874.

Gong, G. Q., J. D. Kendall, J. M. J. Dickson, G. W. Rewcastle, C. M. Buchanan, W. A. Denny, P. R. Shepherd and J. U. Flanagan, Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity. Biochemical Journal (2017) 474(13): 2261-2276.

Gustafson, P., S. J. Bunn and G. D. R., The role of prolactin in the suppression of Crh mRNA expression during pregnancy and lactation in the mouse. Journal of Neuroendocrinology (2017) 29(9): e12511.

Gustafson, P., I. Kokay, T. Sapsford, S. Bunn and D. Grattan, Prolactin regulation of the HPA axis is not mediated by a direct action upon CRH neurons: evidence from the rat and mouse. Brain Structure and Function (2017) 222(7): 3191-3204

Harris, P. W. R., G. M. Cook, I. K. H. Leung and M. A. Brimble, An efficient chemical synthesis of lassomycin enabled by an on-resin lactamisation-off-resin methanolysis strategy and preparation of chemical variants. Australian Journal of Chemistry (2017) 70(2): 172-183.

Hobbs, J. K., W. T. Jiao, A. D. Easter, E. J. Parker, L. A. Schipper and V. L. Arcus, Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates. ACS Chemical Biology (2017) 12(3): 868-868.

Hung, K. Y., P. W. R. Harris, A. Desai, J. F. Marshall and M. A. Brimble, Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality. European Journal of Medicinal Chemistry (2017) 136: 154-164.

Jamieson, M. L., N. Z. Brant, M. A. Brimble and D. P. Furkert, Remarkable influence of cobalt catalysis on epoxide ring-opening with sulfoxonium ylides. Synthesis (Germany) (2017) 49(17): 3952-3956.

Jayasinghe, T. N., C. Hilton, P. Tsai, B. Apple, P. Shepherd, W. S. Cutfield and J. M. O'Sullivan, Long-term stability in the gut microbiome over 46 years in the life of Billy Apple®. Human Microbiome Journal (2017) 5-6: 7-10.

Jiao, W., N. J. Blackmore, A. R. Nazmi and E. J. Parker, Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis. PLoS ONE (2017) 12(6): e0180052.

Kalia, N. P., E. J. Hasenoehrl, N. B. Ab Rahman, V. H. Koh, M. L. T. Ang, D. R. Sajorda, K. Hards, G. Grüber, S. Alonso, G. M. Cook, M. Berney and K. Pethe, Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection. Proceedings of the National Academy of Sciences of the United States of America (2017) 114(28): 7426-7431.

Kamato, D., P. Mitra, F. Davis, N. Osman, R. Chaplin, P. J. Cabot, R. Afroz, W. Thomas, W. Zheng, H. Kaur, M. Brimble and P. J. Little, Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences (2017) 74(8): 1379-1390. [pdf]

Kavianinia, I., S. H. Yang, H. Kaur, P. W. R. Harris, R. C. J. Dobson, A. J. Fairbanks and M. A. Brimble, Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides. Chemical Communications (2017) 53(60): 8459-8462.

Kazantseva, M., N. A. Hung, S. Mehta, I. Roth, R. Eiholzer, A. M. Rich, B. Seo, M. A. Baird, A. W. Braithwaite and T. L. Slatter, Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports (2017) 7(1): 1566.

Kendall, J. D., A. C. Giddens, K. Y. Tsang, E. S. Marshall, C. L. Lill, W. J. Lee, S. Kolekar, M. Chao, A. Malik, S. Yu, C. Chaussade, C. Buchanan, S. M. F. Jamieson, G. W. Rewcastle, B. C. Baguley, W. A. Denny and P. R. Shepherd, Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors. Bioorganic and Medicinal Chemistry Letters (2017) 27(2): 187-190.

Kim, Y., J. M. Griffin, P. W. R. Harris, S. H. C. Chan, L. F. B. Nicholson, M. A. Brimble, S. J. O'Carroll and C. R. Green, Characterizing the mode of action of extracellular Connexin43 channel blocking mimetic peptides in an in vitro ischemia injury model. Biochimica et Biophysica Acta - General Subjects (2017) 1861(2): 68-78.

Kueh, J. T. B., N. J. Stanley, R. J. Hewitt, L. M. Woods, L. Larsen, J. C. Harrison, D. Rennison, M. A. Brimble, I. A. Sammut and D. S. Larsen, Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science (2017) 8(8): 5454-5459.

Kwon, H., P. G. Young, C. J. Squire and E. N. Baker, Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability. Scientific Reports (2017) 7: 42753.

Ladyman, S. R. and D. R. Grattan, Region-specific suppression of hypothalamic responses to insulin to adapt to elevated maternal insulin secretion during pregnancy. Endocrinology (2017) 158(12): 4257-4269.

Ladyman, S. R., M. A. MacLeod, Z. Khant Aung, P. Knowles, H. R. Phillipps, R. S. E. Brown and D. R. Grattan, Prolactin receptors in Rip-cre cells, but not in AgRP neurones, are involved in energy homeostasis. J Neuroendocrinol (2017) 29(10): e12474.

Langley, R. J., Y. T. Ting, F. Clow, P. G. Young, F. J. Radcliff, J. M. Choi, R. P. Sequeira, S. Holtfreter, H. Baker and J. D. Fraser, Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors. PLoS Pathogens (2017) 13(9): e1006549.

Leichter, A. L., M. J. Sullivan, M. R. Eccles and A. Chatterjee, MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours. Molecular Cancer (2017) 16(1): 15.

Leroy, B., M. L. Ballinger, F. Baran-Marszak, G. L. Bond, A. Braithwaite, N. Concin, L. A. Donehower, W. S. El-Deiry, P. Fenaux, G. Gaidano, A. Langerød, E. Hellstrom-Lindberg, R. Iggo, J. Lehmann-Che, P. L. Mai, D. Malkin, U. M. Moll, J. N. Myers, K. E. Nichols, S. Pospisilova, P. Ashton-Prolla, D. Rossi, S. A. Savage, L. C. Strong, P. N. Tonin, R. Zeillinger, T. Zenz, J. F. Fraumeni, P. E. M. Taschner, P. Hainaut and T. Soussi, Recommended guidelines for validation, quality control, and reporting of TP53 variants in clinical practice. Cancer Research (2017) 77(6): 1250-1260.

Li, X., C. P. Guise, R. Taghipouran, Y. Yosaatmadja, A. Ashoorzadeh, W. K. Paik, C. J. Squire, S. Jiang, J. Luo, Y. Xu, Z. C. Tu, X. Lu, X. Ren, A. V. Patterson, J. B. Smaill and K. Ding, 2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors. European Journal of Medicinal Chemistry (2017) 135: 531-543.

Lorenz, N., J. M. S. Loh, N. J. Moreland and T. Proft, Development of a high-throughput opsonophagocytic assay for the determination of functional antibody activity against Streptococcus pyogenes using bioluminescence. Journal of Microbiological Methods (2017) 134: 58-61. [pdf]

Ludgate, J. L., J. Wright, P. A. Stockwell, I. M. Morison, M. R. Eccles and A. Chatterjee, A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA. BMC Medical Genomics (2017) 10: 54.

Lutteroth, K. R., P. W. R. Harris, T. H. Wright, H. Kaur, K. Sparrow, S. H. Yang, G. J. S. Cooper and M. A. Brimble, Incorporation of 'click' chemistry glycomimetics dramatically alters triple-helix stability in an adiponectin model peptide. Organic and Biomolecular Chemistry (2017) 15(26): 5602-5608.

Mason, J. M., H. Yuan, G. B. Evans, P. C. Tyler, Q. Du and V. L. Schramm, Oligonucleotide transition state analogues of saporin L3. Eur J Med Chem (2017) 127: 793-809.

McGrath, A. J., C. Dolan, S. Cheong, D. A. J. Herman, B. Naysmith, F. Zong, P. Galvosas, K. J. Farrand, I. F. Hermans, M. Brimble, D. E. Williams, J. Jin and R. D. Tilley, Stability of polyelectrolyte-coated iron nanoparticles for T2-weighted magnetic resonance imaging. Journal of Magnetism and Magnetic Materials (2017) 439: 251-258.

Medini, K., B. West, D. E. Williams, M. A. Brimble and J. A. Gerrard, MALDI-imaging enables direct observation of kinetic and thermodynamic products of mixed peptide fiber assembly. Chemical Communications (2017) 53(10): 1715-1718.

Mo, C., Z. Zhang, C. P. Guise, X. Li, J. Luo, Z. Tu, Y. Xu, A. V. Patterson, J. B. Smaill, X. Ren, X. Lu and K. Ding, 2-aminopyrimidine derivatives as new selective fibroblast growth factor receptor 4 (FGFR4) inhibitors. ACS Medicinal Chemistry Letters (2017) 8(5): 543-548.

Moggre, G. J., M. B. Poulin, P. C. Tyler, V. L. Schramm and E. J. Parker, Transition state analysis of adenosine triphosphate phosphoribosyltransferase. ACS Chemical Biology (2017) 12(10): 2662-2670.

Mulholland, C. V., A. Ruthe, R. T. Cursons, R. Durrant, N. Karalus, K. Coley, J. Bower, E. Permina, M. J. Coleman, S. A. Roberts, V. L. Arcus, G. M. Cook and H. L. Aung, Rapid molecular diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand. Diagnostic Microbiology and Infectious Disease (2017) 88(2): 138-140.

Murphy, R., P. Tsai, M. Jüllig, A. Liu, L. Plank and M. Booth, Differential changes in gut microbiota after gastric bypass and sleeve gastrectomy bariatric surgery vary according to diabetes remission. Obesity Surgery (2017) 27(4): 917-925.

Nakatani, Y., W. T. Jiao, D. Aragao, Y. Shimaki, J. Petri, E. J. Parker and G. M. Cook, Crystal structure of type II NADH: Quinone oxidoreductase from Caldalkalibacillus thermarum with an improved resolution of 2.15 angstrom. Acta Crystallographica Section F-Structural Biology Communications (2017) 73: 541-549.

Nakatani, Y., H. K. Opel-Reading, M. Merker, D. Machado, S. Andres, S. S. Kumar, D. Moradigaravand, F. Coll, J. Perdigão, I. Portugal, T. Schön, D. Nair, K. R. U. Devi, T. A. Kohl, P. Beckert, T. G. Clark, G. Maphalala, D. Khumalo, R. Diel, K. Klaos, H. L. Aung, G. M. Cook, J. Parkhill, S. J. Peacock, S. Swaminathan, M. Viveiros, S. Niemann, K. L. Krause and C. U. Köser, Role of Alanine racemase mutations in Mycobacterium tuberculosis d-Cycloserine resistance. Antimicrobial Agents and Chemotherapy (2017) 61(12): e01575-01517.

Namanja-Magliano, H. A., G. B. Evans, R. K. Harijan, P. C. Tyler and V. L. Schramm, Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis. Biochemistry (2017) 56(38): 5090-5098.

Naysmith, B. J., P. A. Hume, J. Sperry and M. A. Brimble, Pyranonaphthoquinones-isolation, biology and synthesis: An update. Natural Product Reports (2017) 34(1): 25-61.

Nyunt, W. W., S. T. Aung, G. M. Cook and H. L. Aung, Evaluation of the genotype MTBDRsl test for detection of second-line drug resistance in drug-resistant Mycobacterium tuberculosis strains in Myanmar. Infectious Diseases (2017) 49(11-12): 865-866.

Nyunt, W. W., S. T. Aung, T. Lwin, G. M. Cook and H. L. Aung, First- and second-line antituberculosis drug resistance patterns among previous treatment failure patients in Myanmar. Journal of Global Antimicrobial Resistance (2017) 9: 34-35.

Pantin, M., J. G. Hubert, T. Söhnel, M. A. Brimble and D. P. Furkert, Stereochemical characterization of Polyketide stereotriads synthesized via hydrogen-mediated asymmetric syn-Crotylation. Journal of Organic Chemistry (2017) 82(20): 11225-11229.

Quach, R., D. P. Furkert and M. A. Brimble, Gold catalysis: synthesis of spiro, bridged, and fused ketal natural products. Organic and Biomolecular Chemistry (2017) 15(15): 3098-3104.

Radcliff, F. J., F. Clow, M. Mahadevan, J. Johnston, T. Proft, R. G. Douglas and J. D. Fraser, A potential role for staphylococcal and streptococcal superantigens in driving skewing of TCR Vbeta subsets in tonsillar hyperplasia. Med Microbiol Immunol (2017) 206(4): 337-346.

Rewcastle, G. W., S. Kolekar, C. M. Buchanan, S. A. Gamage, A. C. Giddens, K. Y. Tsang, J. D. Kendall, R. Singh, W. J. Lee, G. C. Smith, W. Han, D. J. Matthews, W. A. Denny, P. R. Shepherd and S. M. F. Jamieson, Biological characterization of SN32976, a selective inhibitor of PI3κ and mTOR with preferential activity to PI3κα, in comparison to established pan PI3κ inhibitors. Oncotarget (2017) 8(29): 47725-47740.

Rizwan, M. Z., S. Mehlitz, D. R. Grattan and A. Tups, Temporal and regional onset of leptin resistance in diet-induced obese mice. Journal of Neuroendocrinology (2017) 29(10): e12481.

Roberts, C. A., J. H. Miller and P. H. Atkinson, The genetic architecture in Saccharomyces cerevisiae that contributes to variation in drug response to the antifungals benomyl and ketoconazole. FEMS Yeast Research (2017) 17(3). 

Salio, M., O. Gasser, C. Gonzalez-Lopez, A. Martens, N. Veerapen, U. Gileadi, J. G. Verter, G. Napolitani, R. Anderson, G. Painter, G. S. Besra, I. F. Hermans and V. Cerundolo, Activation of human mucosal-associated invariant T Cells induces CD40L-dependent maturation of monocyte-derived and primary Dendritic Cells. J Immunol (2017) 199(8): 2631-2638.

Schumacher, C. E., P. W. R. Harris, X. B. Ding, B. Krause, T. H. Wright, G. M. Cook, D. P. Furkert and M. A. Brimble, Synthesis and biological evaluation of novel teixobactin analogues. Organic and Biomolecular Chemistry (2017) 15(41): 8755-8760.

Siow, A., K. y. Hung, P. W. R. Harris and M. A. Brimble, Solid-phase synthesis of the Peptaibol Alamethicin U-22324 by using a double-linker strategy. European Journal of Organic Chemistry (2017) 2017(2): 350-354.

Speir, M., A. Authier-Hall, C. R. Brooks, K. J. Farrand, B. J. Compton, R. J. Anderson, A. Heiser, T. L. Osmond, C. W. Tang, J. A. Berzofsky, M. Terabe, G. F. Painter, I. F. Hermans and R. Weinkove, Glycolipid-peptide conjugate vaccines enhance CD8(+) T cell responses against human viral proteins. Scientific Reports (2017) 7(1): 14273.

Speir, M., I. F. Hermans and R. Weinkove, Engaging natural killer T Cells as ‘Universal Helpers’ for vaccination. Drugs (2017) 77(1): 1-15.

Spicer, J. A., C. K. Miller, P. D. O'Connor, J. Jose, K. M. Huttunen, J. K. Jaiswal, W. A. Denny, H. Akhlaghi, K. A. Browne and J. A. Trapani, Benzenesulphonamide inhibitors of the cytolytic protein perforin. Bioorganic & Medicinal Chemistry Letters (2017) 27(4): 1050-1054.

Spicer, J. A., C. K. Miller, P. D. O'Connor, J. Jose, K. M. Huttunen, J. K. Jaiswal, W. A. Denny, H. Akhlaghi, K. A. Browne and J. A. Trapani, Substituted arylsulphonamides as inhibitors of perforin-mediated lysis. European Journal of Medicinal Chemistry (2017) 137: 139-155.

Strauss, O., A. Phillips, K. Ruggiero, A. Bartlett and P. R. Dunbar, Immunofluorescence identifies distinct subsets of endothelial cells in the human liver. Scientific Reports (2017) 7: 44356.

Stubbing, L. A., I. Kavianinia and M. A. Brimble, Synthesis of AHMOD-containing aminolipopeptides, unique bioactive peptaibiotics. Organic and Biomolecular Chemistry (2017) 15(17): 3542-3549.

Thompson, A. M., A. Blaser, B. D. Palmer, R. F. Anderson, S. S. Shinde, D. Launay, E. Chatelain, L. Maes, S. G. Franzblau, B. Wan, Y. Wang, Z. Ma and W. A. Denny, 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases. Bioorganic and Medicinal Chemistry Letters (2017) 27(11):2583-2589.

Thompson, A. M., P. D. O’Connor, A. J. Marshall, V. Yardley, L. Maes, S. Gupta, D. Launay, S. Braillard, E. Chatelain, S. G. Franzblau, B. Wan, Y. Wang, Z. Ma, C. B. Cooper and W. A. Denny, 7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel antitubercular agents lead to a new preclinical candidate for visceral leishmaniasis. Journal of Medicinal Chemistry (2017) 60(10): 4212-4233.

Tong, A. S. T., P. J. Choi, A. Blaser, H. S. Sutherland, S. K. Y. Tsang, J. Guillemont, M. Motte, C. B. Cooper, K. Andries, W. Van den Broeck, S. G. Franzblau, A. M. Upton, W. A. Denny, B. D. Palmer and D. Conole, 6-Cyano analogues of Bedaquiline as less lipophilic and potentially safer Diarylquinolines for tuberculosis. ACS Medicinal Chemistry Letters (2017) 8(10): 1019-1024.

Tun, T., K. S. Aye, W. W. Nyunt, J. A. Crump, C. Nakajima, Y. Suzuki, K. K. Thinn, G. M. Cook and H. L. Aung, Genotypic diversity of Mycobacterium tuberculosis strains in Myanmar. Infectious Diseases (2017) 49(3): 237-239. [pdf]

Wang, S. E., A. E. S. Brooks, B. Cann and A. Simoes-Barbosa, The fluorescent protein iLOV outperforms eGFP as a reporter gene in the microaerophilic protozoan Trichomonas vaginalis. Molecular and Biochemical Parasitology (2017) 216: 1-4.

Wood, J. M., D. P. Furkert and M. A. Brimble, Total synthesis and stereochemical revision of the 2-Formylpyrrole alkaloid hemerocallisamine I. Journal of Natural Products (2017) 80(6): 1926-1929.

Xu, J., S. J. Church, S. Patassini, P. Begley, H. J. Waldvogel, M. A. Curtis, R. L. M. Faull, R. D. Unwin and G. J. S. Cooper, Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia. Metallomics (2017) 9(8): 1106-1119.

Zhang, S., L. M. De Leon Rodriguez, E. Lacey, A. M. Piggott, I. K. H. Leung and M. A. Brimble, Cyclization of linear tetrapeptides containing N-Methylated amino acids by using 1-Propanephosphonic acid anhydride. European Journal of Organic Chemistry (2017) 2017(1): 149-158. [pdf]

Zhang, S., L. M. D. L. Rodriguez, P. W. R. Harris and M. A. Brimble, Synthesis of enediamino amino acid analogues and peptides. Asian Journal of Organic Chemistry (2017) 6(9): 1180-1190.

2016

Amso, Z., Cornish, J. and Brimble, M. A. Short anabolic peptides for bone growth. Medicinal Research Reviews (2016) 36(4): 579-640. [pdf]

Amso, Z., Kowalczyk, R., Watson, M., Park, Y. E., Callon, K. E., Musson, D. S., Cornish, J. and Brimble, M. A. Structure activity relationship study on the peptide hormone preptin, a novel bone-anabolic agent for the treatment of osteoporosis. Organic and Biomolecular Chemistry (2016) 14(39): 9225-9238.

Amso, Z., Kowalczyk, R., Park, Y. E., Watson, M., Lin, J. M., Musson, D. S., Cornish, J. and Brimble, M. A. Synthesis and in vitro bone cell activity of analogues of the cyclohexapeptide dianthin G. Organic and Biomolecular Chemistry (2016) 14(26): 6231-6243. [pdf]

Ankisettypalli, K., Cheng, J. J. Y., Baker, E. N. and Bashiri, G. PdxH proteins of mycobacteria are typical members of the classical pyridoxine/pyridoxamine 5′-phosphate oxidase family. FEBS Letters (2016) 590(4): 453-460.

Atkinson, D. J., Naysmith, B. J., Furkert, D. P. and Brimble, M. A. Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis. Beilstein Journal of Organic Chemistry (2016) 12: 2325-2342.

Aung, H. L., Tun, T., Moradigaravand, D., Koser, C. U., Nyunt, W. W., Aung, S. T., Lwin, T., Thinn, K. K., Crump, J. A., Parkhill, J., Peacock, S. J., Cook, G. M. and Hill, P. C. Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar. J Glob Antimicrob Resist (2016) 6: 113-117.

Aung, H. L., Tun, T., Permina, E., Nyunt, W. W., Aung, S. T., Thinn, K. K., Crump, J. A. and Cook, G. M. Draft genome sequences of two drug-resistant Mycobacterium tuberculosis isolates from Myanmar. Genome Announc (2016) 4(5).

Bashiri, G., Rehan, A. M., Sreebhavan, S., Baker, H. M., Baker, E. N. and Squire, C. J. Elongation of the poly-γ-glutamate tail of F<inf>420</inf> requires both domains of the F<inf>420</inf>:γ-Glutamyl ligase (FbiB) of Mycobacterium tuberculosis. Journal of Biological Chemistry (2016) 291(13): 6882-6894.

Blenkiron, C., Simonov, D., Muthukaruppan, A., Tsai, P., Dauros, P., Green, S., Hong, J., Print, C. G., Swift, S. and Phillips, A. R. Uropathogenic Escherichia coli releases extracellular vesicles that are associated with RNA. PLoS ONE (2016) 11(8).

Chorley, D. F., Furkert, D. P. and Brimble, M. A. Synthesis of the spiroketal core of the pinnatifinoside family of natural products. European Journal of Organic Chemistry (2016) 2016(2): 314-319.

Chowdhury, M. K. H., Wu, L. E., Coleman, J. L. J., Smith, N. J., Morris, M. J., Shepherd, P. R. and Smith, G. C. Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling. Biochemical Journal (2016) 473(9): 1247-1255.

Chua, E. W., Cree, S. L., Ton, K. N. T., Lehnert, K., Shepherd, P., Helsby, N. and Kennedy, M. A. Cross-comparison of exome analysis, next-generation sequencing of amplicons, and the iPLEX® ADME PGx panel for pharmacogenomic profiling. Frontiers in Pharmacology (2016) 7(JAN).

Cook, G. M. and Poole, R. K. A bacterial oxidase like no other? Science (2016) 352(6285): 518-519. [pdf]

Cooling, M. T., Nickerson, D. P., Nielsen, P. M. F. and Hunter, P. J. Modular modelling with Physiome standards. Journal of Physiology (2016) 594(23): 6817-6831.

Cottam Jones, J. M., Harris, P. W. R., Scanlon, D. B., Forbes, B. E., Brimble, M. A. and Abell, A. D. Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R. Organic and Biomolecular Chemistry (2016) 14(9): 2698-2705.

Cross, P. J., Heyes, L. C., Zhang, S., Nazmi, A. R. and Parker, E. J. The functional unit of neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase is dimeric. PLoS ONE (2016) 11(2).

Dalton, J. P., Uy, B., Phummarin, N., Copp, B. R., Denny, W. A., Swift, S. and Wiles, S. Effect of common and experimental anti- tuberculosis treatments on Mycobacterium tuberculosis growing as biofilms. PeerJ (2016) 2016(11).

De Leon Rodriguez, L. M., Hemar, Y., Cornish, J. and Brimble, M. A. Structure-mechanical property correlations of hydrogel forming β-sheet peptides. Chemical Society Reviews (2016) 45(17): 4797-4824.

De Leon Rodriguez, L. M., Kaur, H. and Brimble, M. A. Synthesis and bioactivity of antitubercular peptides and peptidomimetics: An update. Organic and Biomolecular Chemistry (2016) 14(4): 1177-1187.

De Leon-Rodriguez, L. M., Kamalov, M., Hemar, Y., Mitra, A. K., Castelletto, V., Hermida-Merino, D., Hamley, I. W. and Brimble, M. A. A peptide hydrogel derived from a fragment of human cardiac troponin C. Chemical Communications (2016) 52(21): 4056-4059.

Ding, X. B., Brimble, M. A. and Furkert, D. P. Nitropyrrole natural products: Isolation, biosynthesis and total synthesis. Organic and Biomolecular Chemistry (2016) 14(24): 5390-5401.

Ding, X. B., Furkert, D. P. and Brimble, M. A. 2-Nitropyrrole cross-coupling enables a second generation synthesis of the heronapyrrole antibiotic natural product family. Chemical Communications (2016) 52(85): 12638-12641. [pdf]

Donovan, K. A., Zhu, S., Liuni, P., Peng, F., Kessans, S. A., Wilson, D. J. and Dobson, R. C. J. Conformational dynamics and allostery in pyruvate kinase. Journal of Biological Chemistry (2016) 291(17): 9244-9256.

Dunn, E. A., Cook, G. M. and Heikal, A. Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening. Data Brief (2016) 6: 275-278.

Dunn, E. A., Cook, G. M. and Heikal, A. Comparison of lipid and detergent enzyme environments for identifying inhibitors of membrane-bound energy-transducing proteins. J Microbiol Methods (2016) 120: 41-43.

Field, J. J., Kanakkanthara, A., Brooke, D. G., Sinha, S., Pillai, S. D., Denny, W. A., Butt, A. J. and Miller, J. H. Microtubule-stabilizing properties of the avocado-derived toxins (+)-(R)-persin and (+)-(R)-tetrahydropersin in cancer cells and activity of related synthetic analogs. Investigational New Drugs (2016) 34(3): 277-289.

Fromm, P. D., Kupresanin, F., Brooks, A. E. S., Dunbar, P. R., Haniffa, M., Hart, D. N. J. and Clark, G. J. A multi-laboratory comparison of blood dendritic cell populations. Clinical & Translational Immunology (2016) 5(4): e68.

Gingell, J., Simms, J., Barwell, J., Poyner, D. R., Watkins, H. A., Pioszak, A. A., Sexton, P. M. and Hay, D. L. An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology. Cell Discovery (2016) 2: 16012.

Gomes, D. J., Velosa, A. P., Okuda, L. S., Fusco, F. B., da Silva, K. S., Pinto, P. R., Nakandakare, E. R., Correa-Giannella, M. L., Woods, T., Brimble, M. A., Pickford, R., Rye, K. A., Teodoro, W. R., Catanozi, S. and Passarelli, M. Glycated albumin induces lipid infiltration in mice aorta independently of DM and RAS local modulation by inducing lipid peroxidation and inflammation. Journal of Diabetes and its Complications (2016) 30(8): 1614-1621.

Heikal, A., Hards, K., Cheung, C. Y., Menorca, A., Timmer, M. S. M., Stocker, B. L. and Cook, G. M. Activation of type II NADH dehydrogenase by Quinolinequinones mediates antitubercular cell death. Journal of Antimicrobial Chemotherapy (2016) 71(10): 2840-2847.

Hemi Cumming, A., Brown, S. L., Tao, X., Cuyamendous, C., Field, J. J., Miller, J. H., Harvey, J. E. and Teesdale-Spittle, P. H. Synthesis of a simplified triazole analogue of pateamine A. Organic and Biomolecular Chemistry (2016) 14(22): 5117-5127.

Ho, N. A. T., Dawes, S. S., Crowe, A. M., Casabon, I., Gao, C., Kendall, S. L., Baker, E. N., Eltis, L. D. and Lott, J. S. The structure of the transcriptional repressor kstr in complex with coa thioester cholesterol metabolites sheds light on the regulation of cholesterol catabolism in mycobacterium tuberculosis. Journal of Biological Chemistry (2016) 291(14): 7256-7266.

Huttunen, K. M., Huttunen, J., Aufderhaar, I., Gynther, M., Denny, W. A. and Spicer, J. A. L-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors. International Journal of Pharmaceutics (2016) 498(1-2): 205-216.

Jamieson, M. L., Hume, P. A., Furkert, D. P. and Brimble, M. A. Divergent reactivity via cobalt catalysis: An epoxide olefination. Organic Letters (2016) 18(3): 468-471.

Jirgis, E. N. M., Bashiri, G., Bulloch, E. M. M., Johnston, J. M. and Baker, E. N. Structural views along the Mycobacterium tuberculosis MenD reaction pathway illuminate key aspects of thiamin diphosphate-dependent enzyme mechanisms. Structure (2016) 24(7): 1167-1177.

Jones, A. M, Ferguson, P., Gardner, J., Rooker, S., Sutton, T., Ahn, A., Chatterjee, A., Bickley, V. M., Sarwar, M., Emanuel, P., Kenwright, D., Shepherd P. R., and Eccles M. R. NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand. Oncotarget (2016) 7(27): 41017-41030.

Jones, N. M., Rowe, M. R., Shepherd, P. R. and McConnell, M. J. Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models. International Journal of Oncology (2016) 49(1): 207-216.

Jung, J., Bashiri, G., Johnston, J. M. and Baker, E. N. Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis. FEBS Open Bio (2016) 6(12): 1220-1226.

Kamalov, M., Kaur, H. and Brimble, M. A. Intermolecular peptide cross-linking by using diaminodicarboxylic acids. Chemistry - A European Journal (2016) 22(11): 3622-3631.

Kaur, H., Kamalov, M. and Brimble, M. A. Chemical synthesis of peptides containing site-specific advanced glycation endproducts. Accounts of Chemical Research (2016) 49(10): 2199-2208.

Kavianinia, I., Kunalingam, L., Harris, P. W. R., Cook, G. M. and Brimble, M. A. Total synthesis and stereochemical revision of the anti-tuberculosis peptaibol trichoderin A. Organic Letters (2016) 18(15): 3878-3881.

Keown, J. R. and Goldstone, D. C. Crystal structure of the Trim5α Bbox2 domain from rhesus macaques describes a plastic oligomerisation interface. Journal of Structural Biology (2016) 195(3): 282-285.

Ladyman, S. R., Augustine, R. A., Scherf, E., Phillipps, H. R., Brown, C. H. and Grattan, D. R. Attenuated hypothalamic responses to α-melanocyte stimulating hormone during pregnancy in the rat. Journal of Physiology (2016) 594(4): 1087-1101.

Ladyman, S. R. and Grattan, D. R. Central effects of leptin on glucose homeostasis are modified during pregnancy in the rat. Journal of Neuroendocrinology (2016) 28(10).

Lang, E. J. M., Heyes, L. C., Jameson, G. B. and Parker, E. J. Calculated pK<inf>a</inf> variations expose dynamic allosteric communication networks. Journal of the American Chemical Society (2016) 138(6): 2036-2045.

Li, F. F., Atkinson, D. J., Furkert, D. P. and Brimble, M. A. A convergent synthesis of gonytolide c using an intramolecular oxa-Michael addition. European Journal of Organic Chemistry (2016) 2016(6): 1145-1155.

Lorenz, N., Loef, E. J., Kelch, I. D., Verdon, D. J., Black, M. M., Middleditch, M. J., Greenwood, D. R., Graham, E. S., Brooks, A. E. S., Dunbar, P. R. and Birch, N. P. Plasmin and regulators of plasmin activity control the migratory capacity and adhesion of human T cells and dendritic cells by regulating cleavage of the chemokine CCL21. Immunology and Cell Biology (2016) 94(10): 955-963. [pdf]

Macdonald, J. R., Huang, A. D. and Loomes, K. M. Cellular degradation of 4-hydroxy-2-oxoglutarate aldolase leads to absolute deficiency in primary hyperoxaluria type 3. FEBS Letters (2016) 590(10): 1467-1476.

McEwen, H. J. L., Inglis, M. A., Quennell, J. H., Grattan, D. R. and Anderson, G. M. Deletion of suppressor of cytokine signaling 3 from forebrain neurons delays infertility and onset of hypothalamic leptin resistance in response to a high caloric diet. Journal of Neuroscience (2016) 36(27): 7142-7153.

Medini, K., Harris, P. W. R., Menorca, A., Hards, K., Cook, G. M. and Brimble, M. A. Synthesis and activity of a diselenide bond mimetic of the antimicrobial protein caenopore-5. Chemical Science (2016) 7(3): 2005-2010.

Mowday, A. M., Ashoorzadeh, A., Williams, E. M., Copp, J. N., Silva, S., Bull, M. R., Abbattista, M. R., Anderson, R. F., Flanagan, J. U., Guise, C. P., Ackerley, D. F., Smaill, J. B. and Patterson, A. V. Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy. Biochemical Pharmacology (2016) 116: 176-187.

Mowday, A. M., Guise, C. P., Ackerley, D. F., Minton, N. P., Lambin, P., Dubois, L. J., Theys, J., Smaill, J. B. and Patterson, A. V. Advancing clostridia to clinical trial: Past lessons and recent progress. Cancers (2016) 8(7).

Naylor, R. W., McGhee, C. N. J., Cowan, C. A., Davidson, A. J., Holm, T. M. and Sherwin, T. Derivation of corneal keratocyte-like cells from human induced pluripotent stem cells. PLoS ONE (2016) 11(10): e0165464.

Ngen, S. T. Y., Kaur, H., Hume, P. A., Furkert, D. P. and Brimble, M. A. Synthesis of psychrophilin e. Journal of Organic Chemistry (2016) 81(17): 7635-7643.

Panwalkar, V., Neudecker, P., Schmitz, M., Lecher, J., Schulte, M., Medini, K., Stoldt, M., Brimble, M. A., Willbold, D. and Dingley, A. J. The Nedd4-1 WW domain recognizes the PY motif peptide through coupled folding and binding equilibria. Biochemistry (2016) 55(4): 659-674.

Park, T. I. H., Feisst, V., Brooks, A. E. S., Rustenhoven, J., Monzo, H. J., Feng, S. X., Mee, E. W., Bergin, P. S., Oldfield, R., Graham, E. S., Curtis, M. A., Faull, R. L. M., Dunbar, P. R. and Dragunow, M. Cultured pericytes from human brain show phenotypic and functional differences associated with differential CD90 expression. Scientific Reports (2016) 6.

Petridis, M., Vickers, C., Robson, J., McKenzie, J. L., Bereza, M., Sharrock, A., Aung, H. L., Arcus, V. L. and Cook, G. M. Structure and function of AmtR in Mycobacterium smegmatis: Implications for post-transcriptional regulation of urea metabolism through a small antisense RNA. Journal of Molecular Biology (2016) 428(21): 4315-4329.

Quach, R., Furkert, D. P. and Brimble, M. A. Total synthesis of the resorcyclic acid lactone spiroketal citreoviranol. Journal of Organic Chemistry (2016) 81(18): 8343-8350.

Raynes, J. M., Frost, H. R. C., Williamson, D. A., Young, P. G., Baker, E. N., Steemson, J. D., Loh, J. M., Proft, T., Dunbar, P. R., Atatoa Carr, P. E., Bell, A. and Moreland, N. J. Serological evidence of immune priming by group a streptococci in patients with acute rheumatic fever. Frontiers in Microbiology (2016) 7(JUL).

Read, H. M., Mills, G., Johnson, S., Tsai, P., Dalton, J., Barquist, L., Print, C. G., Patrick, W. M. and Wiles, S. The in vitro and in vivo effects of constitutive light expression on a bioluminescent strain of the mouse enteropathogen Citrobacter rodentium. PeerJ (2016) 2016(6).

Reed, J. E. and Smaill, J. B. The discovery of dacomitinib, a potent irreversible EGFR inhibitor. ACS Symposium Series (2016) 1239: 207-233.

Ren, H., Birch, N. P. and Suresh, V. An optimised human cell culture model for alveolar epithelial transport. PLoS One (2016) 11(10): e0165225.

Rendle, P. M., Kassibawi, F., Johnston, K. A., Hart, J. B., Cameron, S. A., Falshaw, A., Painter, G. F. and Loomes, K. M. Synthesis and biological activities of D-chiro-inositol analogues with insulin-like actions. European Journal of Medicinal Chemistry (2016) 122: 442-451.

Roth, I., Campbell, H., Rubio, C., Vennin, C., Wilson, M., Wiles, A., Williams, G., Woolley, A., Timpson, P., Berridge, M. V., Fleming, N., Baird, M. and Braithwaite, A. W. The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene (2016) 35(38): 4981-4989. [pdf]

Safaei, S., Bradley, C. P., Suresh, V., Mithraratne, K., Muller, A., Ho, H., Ladd, D., Hellevik, L. R., Omholt, S. W., Chase, J. G., Müller, L. O., Watanabe, S. M., Blanco, P. J., de Bono, B. and Hunter, P. J. Roadmap for cardiovascular circulation model. Journal of Physiology (2016) 594(23): 6909-6928.

Sheppard, H. M., Feisst, V., Chen, J., Print, C. and Dunbar, P. R. AHNAK is downregulated in melanoma, predicts poor outcome, and may be required for the expression of functional cadherin-1. Melanoma Research (2016) 26(2): 108-116.

Slatter, T. L., Wilson, M., Tang, C., Campbell, H. G., Ward, V. K., Young, V. L., Van Ly, D., Fleming, N. I., Braithwaite, A. W. and Baird, M. A. Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12. OncoImmunology (2016) 5(3).

Smaill, J. B., Gonzales, A. J., Spicer, J. A., Lee, H., Reed, J. E., Sexton, K., Althaus, I. W., Zhu, T., Black, S. L., Blaser, A., Denny, W. A., Ellis, P. A., Fakhoury, S., Harvey, P. J., Hook, K., McCarthy, F. O. J., Palmer, B. D., Rivault, F., Schlosser, K., Ellis, T., Thompson, A. M., Trachet, E., Winters, R. T., Tecle, H. and Bridges, A. Tyrosine kinase inhibitors. 20. Optimization of substituted quinazoline and pyrido[3,4-d]pyrimidine derivatives as orally active, irreversible inhibitors of the epidermal growth factor receptor family. Journal of Medicinal Chemistry (2016) 59(17): 8103-8124.

Son, S. J., Harris, P. W. R., Squire, C. J., Baker, E. N. and Brimble, M. A. Synthesis and structural insight into ESX-1 Substrate Protein C, an immunodominant Mycobacterium tuberculosis-secreted antigen. Biopolymers (2016): 267-274.

Sorrenson, B., Cognard, E., Lee, K. L., Dissanayake, W. C., Fu, Y., Han, W., Hughes, W. E. and Shepherd, P. R. A critical role for β-catenin in modulating levels of insulin secretion from β-cells by regulating actin cytoskeleton and insulin vesicle localization. Journal of Biological Chemistry (2016) 291(50): 25888-25900.

Sun, W., Lai, Y., Li, H., Nie, T., Kuang, Y., Tang, X., Li, K., Dunbar, P. R., Xu, A., Li, P. and Wu, D. High level expression and purification of active recombinant human interleukin-15 in Pichia pastoris. Journal of Immunological Methods (2016) 428: 50-57.

Thompson, A.M., O’Connor, P.D., Blaser, A., Yardley, V., Maes, L., Puri, S., Mattin, D., Franzblau, S.G., Wan, B., Wang, Y., Ma, Z., Denny, W.A. Repositioning antitubercular 6-nitro-2,3-dihydroimidazo[2,1-b][1,3]-thiazoles and -oxazoles for neglected diseases: structure-activity studies on a potential clinical candidate for visceral leishmaniasis. Journal of Medicinal Chemistry (2016) 59: 2530-2550.

Ting, Y. T., Harris, P. W. R., Batot, G., Brimble, M. A., Baker, E. N. and Young, P. G. Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization. IUCrJ (2016) 3: 10-19.

Tun, T., Nyunt, W. W., Latt, K. Z., Samaranayaka, A., Crump, J. A., Thinn, K. K., Cook, G. M. and Aung, H. L. Drug-resistant tuberculosis among previously treated patients in Yangon, Myanmar. International Journal of Mycobacteriol (2016) 5(3): 366-367.

Wang, Z., Krogsgaard-Larsen, N., Daniels, B., Furkert, D. P. and Brimble, M. A. Cyclic enecarbamates as precursors of α,β-unsaturated iminium ions: Reactivity and synthesis of 6,6-spirocyclic ring systems. Journal of Organic Chemistry (2016) 81(21): 10366-10375.

Watkins, H. A., Chakravarthy, M., Abhayawardana, R. S., Gingell, J. J., Garelja, M., Pardamwar, M., McElhinney, J. M. W. R., Lathbridge, A., Constantine, A., Harris, P. W. R., Yuen, T. Y., Brimble, M. A., Barwell, J., Poyner, D. R., Woolley, M. J., Conner, A. C., Pioszak, A. A., Reynolds, C. A. and Hay, D. L. Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties. Journal of Biological Chemistry (2016) 291(22): 11657-11675.

Wood, J. M., Furkert, D. P. and Brimble, M. A. Synthesis of the 2-formylpyrrole spiroketal pollenopyrroside A and structural elucidation of xylapyrroside A, shensongine A and capparisine B. Organic and Biomolecular Chemistry (2016) 14(32): 7659-7664. [pdf]

Xu, J., Begley, P., Church, S. J., Patassini, S., Hollywood, K. A., Jüllig, M., Curtis, M. A., Waldvogel, H. J., Faull, R. L. M., Unwin, R. D. and Cooper, G. J. S. Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder. Biochimica et Biophysica Acta - Molecular Basis of Disease (2016) 1862(6): 1084-1092.

Xu, J., Begley, P., Church, S. J., Patassini, S., McHarg, S., Kureishy, N., Hollywood, K. A., Waldvogel, H. J., Liu, H., Zhang, S., Lin, W., Herholz, K., Turner, C., Synek, B. J., Curtis, M. A., Rivers-Auty, J., Lawrence, C. B., Kellett, K. A. B., Hooper, N. M., Vardy, E. R. L. C., Wu, D., Unwin, R. D., Faull, R. L. M., Dowsey, A. W. and Cooper, G. J. S. Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: Metabolic basis for dementia. Scientific Reports (2016) 6: 27524.

Yang, S. H., Harris, P. W. R., Williams, G. M. and Brimble, M. A. Lipidation of cysteine or cysteine-containing peptides using the thiol-ene reaction (CLipPA). European Journal of Organic Chemistry (2016) 2016(15): 2608-2616.

Yeung, H., Squire, C. J., Yosaatmadja, Y., Panjikar, S., López, G., Molina, A., Baker, E. N., Harris, P. W. R. and Brimble, M. A. Radiation damage and racemic protein crystallography reveal the unique structure of the GASA/snakin protein superfamily. Angewandte Chemie - International Edition (2016) 55(28): 7930-7933.

Yim, V., Noisier, A. F. M., Hung, K. Y., Bartsch, J. W., Schlomann, U. and Brimble, M. A. Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis. Bioorganic and Medicinal Chemistry (2016) 24(18): 4032-4037.

Yule, L. R., Bower, R. L., Kaur, H., Kowalczyk, R., Hay, D. L. and Brimble, M. A. Synthesis and amylin receptor activity of glycomimetics of pramlintide using click chemistry. Organic and Biomolecular Chemistry (2016) 14(23): 5238-5245.

Zhang, S., Amso, Z., De Leon Rodriguez, L. M., Kaur, H. and Brimble, M. A. Synthesis of natural cyclopentapeptides isolated from Dianthus chinensis. Journal of Natural Products (2016) 79(7): 1769-1774.

2015

Ahmed, F. H., Carr, P. D., Lee, B. M., Afriat-Jurnou, L., Mohamed, A. E., Hong, N. S., Flanagan, J., Taylor, M. C., Greening, C., & Jackson, C. J. Sequence-structure-function classification of a catalytically diverse oxidoreductase superfamily in mycobacteria. Journal of Molecular Biology (2015) 427(22): 3554-3571. [pdf]

Anderson, R. J., Compton, B. J., Tang, C. W., Authier-Hall, A., Hayman, C. M., Swinerd, G. W., Kowalczyk, R., Harris, P., Brimble, M. A., Larsen, D. S., Gasser, O., Weinkove, R., Hermans, I. F., & Painter, G. F. NKT cell-dependent glycolipid-peptide vaccines with potent anti-tumour activity. Chemical Science (2015) 6(9): 5120-5127.

Andrews, E. S. V., & Arcus, V. L. The mycobacterial PhoH2 proteins are type II toxin antitoxins coupled to RNA helicase domains. Tuberculosis (2015) 95(4): 385-394.

Atkinson, D. J., & Brimble, M. A. Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products. Natural Product Reports (2015) 32(6): 811-840. [pdf]

Aung, H. L., Dey, D., Janssen, P. H., Ronimus, R. S., & Cook, G. M. A high-throughput screening assay for identification of inhibitors of the A1AO-ATP synthase of the rumen methanogen Methanobrevibacter ruminantium M1. Journal of Microbiological Methods (2015) 110: 15-17. [pdf]

Aung, H. L., Dixon, L. L., Smith, L. J., Sweeney, N. P., Robson, J. R., Berney, M., Buxton, R. S., Green, J., & Cook, G. M. Novel regulatory roles of cAMP receptor proteins in fast-growing environmental mycobacteria. Microbiology (United Kingdom) (2015) 161(3): 648-661.

Bashiri, G., & Baker, E. N. Production of recombinant proteins in Mycobacterium smegmatis for structural and functional studies. Protein Science (2015) 24(1): 1-10.

Bashiri, G., Johnston, J. M., Evans, G. L., Bulloch, E. M. M., Goldstone, D. C., Jirgis, E. N. M., Kleinboelting, S., Castell, A., Ramsay, R. J., Manos-Turvey, A., Payne, R. J., Lott, J. S., & Baker, E. N. Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex. Acta Crystallographica Section D: Biological Crystallography (2015) 71: 2297-2308. [pdf]

Blackmore, N. J., Nazmi, A. R., Hutton, R. D., Webby, M. N., Baker, E. N., Jameson, G. B., & Parker, E. J. Complex formation between two biosynthetic enzymes modifies the allosteric regulatory properties of both: An example of molecular symbiosis. Journal of Biological Chemistry (2015) 290(29): 18187-18198.

Blenkiron, C., Tsai, P., Brown, L. A., Tintinger, V., Askelund, K. J., Windsor, J. A., & Phillips, A. R. Characterisation of the small RNAs in the biomedically important green-bottle blowfly Lucilia sericata. PLoS ONE (2015) 10(3).

Booe, J. M., Walker, C. S., Barwell, J., Kuteyi, G., Simms, J., Jamaluddin, M. A., Warner, M. L., Bill, R. M., Harris, P. W., Brimble, M. A., Poyner, D. R., Hay, D. L., & Pioszak, A. A. Structural basis for receptor activity-nodifying protein-dependent selective peptide recognition by a G protein-coupled receptor. Molecular Cell (2015) 58(6): 1040-1052.

Brimble, M. A., Edwards, P. J., Harris, P. W. R., Norris, G. E., Patchett, M. L., Wright, T. H., Yang, S. H., & Carley, S. E. Synthesis of the antimicrobial S-Linked glycopeptide, glycocin F. Chemistry - A European Journal (2015) 21(9): 3556-3561.

Brings, S., Zhang, S., Choong, Y. S., Hogl, S., Middleditch, M., Kamalov, M., Brimble, M. A., Gong, D., & Cooper, G. J. S. Diabetes-induced alterations in tissue collagen and carboxymethyllysine in rat kidneys: Association with increased collagen-degrading proteinases and amelioration by Cu(II)-selective chelation. Biochimica et Biophysica Acta - Molecular Basis of Disease (2015) 1852(8): 1610-1618.

Bull, M. R., Spicer, J. A., Huttunen, K. M., Denny, W. A., Ciccone, A., Browne, K. A., Trapani, J. A., & Helsby, N. A. The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents. European Journal of Drug Metabolism and Pharmacokinetics (2015) 40(4): 417-425. [pdf]

Bunker, R. D., Mandal, K., Bashiri, G., Chaston, J. J., Pentelute, B. L., Lott, J. S., Kent, S. B. H., Baker, E. N., & Petsko, G. A. A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Proceedings of the National Academy of Sciences of the United States of America (2015) 112(14): 4310-4315.

Campen, R. L., Ackerley, D. F., Cook, G. M., & O'Toole, R. F. Development of a Mycobacterium smegmatis transposon mutant array for characterising the mechanism of action of tuberculosis drugs: Findings with isoniazid and its structural analogues. Tuberculosis (2015) 95(4): 432-439.

Chai, A. F., Bulloch, E. M. M., Evans, G. L., Lott, J. S., Baker, E. N., & Johnston, J. M. A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket. Acta Crystallographica Section D: Biological Crystallography (2015) 71: 862-872. [pdf]

Chan, S., Han, K., Qu, R., Tong, L., Li, Y., Zhang, Z., Cheng, H., Lu, X., Patterson, A., Smaill, J., Ren, X., Ding, J., Xie, H., & Ding, K. 2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFRL858R/T790M. Bioorganic and Medicinal Chemistry Letters (2015) 25(19): 4277-4281.

Cheung, C. C. H., Soon, C. Y., Chuang, C.-L., Phillips, A. R. J., Zhang, S. and Cooper, G. J. S. Low-dose copper infusion into the coronary circulation induces acute heart failure in diabetic rats: New mechanism of heart disease. Biochemical Pharmacology (2015) 97(1): 62-76.

Chowdhury, M. K. H., Montgomery, M. K., Morris, M. J., Cognard, E., Shepherd, P. R., & Smith, G. C. Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver. Archives of Physiology and Biochemistry (2015) 121(3): 88-96. [pdf]

Chu, M. J. J., Vather, R., Hickey, A. J. R., Phillips, A. R. J., & Bartlett, A. S. J. R. Impact of ischaemic preconditioning on experimental steatotic livers following hepatic ischaemia-reperfusion injury: A systematic review. HPB (2015) 17(1): 1-10.

Chua, E. W., Cree, S., Barclay, M. L., Doudney, K., Lehnert, K., Aitchison, A., & Kennedy, M. A. Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers. Pharmacogenomics Journal (2015) 15(5): 414-421. [pdf]

Cookson, T. V. M., Evans, G. L., Castell, A., Baker, E. N., Lott, J. S., & Parker, E. J. Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry (2015) 54(39): 6082-6092.

Cooling, M. T., & Yu, T. (2015) Distributed model construction with virtual parts. Vol. 1244. Methods in Molecular Biology (pp. 301-322): Humana Press Inc. [pdf]

Cursons, J., Angel, C. E., Hurley, D. G., Print, C. G., Dunbar, P. R., Jacobs, M. D., & Crampin, E. J. Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis. GigaScience (2015) 4(1): 1-6.

Cursons, J., Gao, J., Hurley, D. G., Print, C. G., Dunbar, P. R., Jacobs, M. D., & Crampin, E. J. Regulation of ERK-MAPK signaling in human epidermis. BMC Systems Biology (2015) 9(1).

De Bono, B., Safaei, S., Grenon, P., Nickerson, D. P., Alexander, S., Helvensteijn, M., Kok, J. N., Kokash, N., Wu, A., Yu, T., Hunter, P., & Baldock, R. A. The open physiology workflow: Modeling processes over physiology circuitboards of interoperable tissue units. Frontiers in Physiology (2015) 6(FEB).

De Leon Rodriguez, L. M., Weidkamp, A. J., & Brimble, M. A. An update on new methods to synthesize cyclotetrapeptides. Organic and Biomolecular Chemistry (2015) 13(25): 6906-6921. [pdf]

Grattan, D. R. The hypothalamo-prolactin axis. Journal of Endocrinology (2015) 226(2): T101-T122.

Guan, J., Harris, P., Brimble, M., Lei, Y., Lu, J., Yang, Y., & Gunn, A. J. The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders. Expert Opinion on Therapeutic Targets (2015) 19(6): 785-793.

Hampe, L., Radjainia, M., Xu, C., Harris, P. W. R., Bashiri, G., Goldstone, D. C., Brimble, M. A., Wang, Y., & Mitra, A. K. Regulation and quality control of adiponectin assembly by endoplasmic reticulum chaperone ERp44. Journal of Biological Chemistry (2015) 290(29): 18111-18123.

Hand, L. E., Usan, P., Cooper, G. J. S., Xu, L. Y., Ammori, B., Cunningham, P. S., Aghamohammadzadeh, R., Soran, H., Greenstein, A., Loudon, A. S. I., Bechtold, D. A., & Ray, D. W. Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit. Diabetes (2015) 64(1): 128-136.

Hards, K., Robson, J. R., Berney, M., Shaw, L., Bald, D., Koul, A., Andries, K., & Cook, G. M. Bactericidal mode of action of bedaquiline. Journal of Antimicrobial Chemotherapy (2015) 70(7): 2028-2037.

Harris, P. W. R., & Brimble, M. A. Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines. Peptide Science (2015) 104(2): 116-127.

Harris, P. W. R., Squire, C., Young, P. G., & Brimble, M. A. Chemical synthesis of γ-secretase activating protein using pseudo-glutamines as ligation sites. Biopolymers - Peptide Science Section (2015) 104(1): 37-45.

Hassan, N. P. S., Naysmith, B. J., Sperry, J., & Brimble, M. A. Formal synthesis of nanaomycin D via a Hauser-Kraus annulation using a chiral enone-lactone. Tetrahedron (2015) 71(39): 7137-7143.

Hubert, J. G., Furkert, D. P., & Brimble, M. A. Preparation of cis-γ-hydroxycarvone derivatives for synthesis of sesterterpenoid natural products: Total synthesis of phorbin A. Journal of Organic Chemistry (2015a) 80(4): 2231-2239.

Hubert, J. G., Furkert, D. P., & Brimble, M. A. Synthesis of the spirocyclic framework of sesterterpenoid natural products. Journal of Organic Chemistry (2015b) 80(5): 2715-2723.

Hunn, M. K., Bauer, E., Wood, C. E., Gasser, O., Dzhelali, M., Ancelet, L. R., Mester, B., Sharples, K.J., Findlay, M.P., Hamilton, D.A. & Hermans, I. F. Dendritic cell vaccination combined with temozolomide retreatment: Results of a phase I trial in patients with recurrent glioblastoma multiforme. Journal of Neuro-Oncology (2015) 121(2): 319-329. [pdf]

Hussan, J.R., Hunter, P.J., Gladding, P.A., Greenberg, N., Christie, R., Wu, A., Sorby, H., Thomas, J.D. ICMA: An integrated cardiac modeling and analysis platform. Bioinformatics (2015) 31(8): 1331-1333.

Kamalov, M., Harris, P. W. R., Hartinger, C. G., Miskelly, G. M., Cooper, G. J. S., & Brimble, M. A. Physicochemical studies on the copper(ii) binding by glycated collagen telopeptides. Organic and Biomolecular Chemistry (2015) 13(10): 3058-3063. [pdf]

Kamalov, M., Harris, P. W. R., Wood, J. M., & Brimble, M. A. On resin synthesis and cross-linking of collagen peptides containing the advanced glycation end-product pyrraline via Maillard condensation. Chemical Communications (2015) 51(46): 9475-9478. [pdf]

Kamato, D., Thach, L., Bernard, R., Chan, V., Zheng, W., Kaur, H., Brimble, M., Osman, N., & Little, P. J. Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Galpha/q,11. Frontiers in Cardiovascular Medicine (2015) 2:14.

Kaur, H., Harris, P. W. R., Little, P. J., & Brimble, M. A. Total synthesis of the cyclic depsipeptide YM-280193, a platelet aggregation inhibitor. Organic Letters (2015) 17(3): 492-495.

Kay, E. I., Botha, R., Montgomery, J. M., & Mountjoy, K. G. HMRAPα, but not hMRAP2, enhances hMC4R constitutive activity in HEK293 cells and this is not dependent on hMRAPα induced changes in hMC4R complex N-linked glycosylation. PLoS ONE (2015) 10(10).

Kelch, I. D., Bogle, G., Sands, G. B., Phillips, A. R. J., LeGrice, I. J. and Dunbar, P. R. Corrigendum: Organ-wide 3D-imaging and topological analysis of the continuous microvascular network in a murine lymph node. Scientific Reports (2015) 5: 16534.

Ko, K. Y., Wagner, S., Yang, S. H., Furkert, D. P., & Brimble, M. A. Improved Synthesis of the Unnatural Amino Acids AHMOD and AMD, Components of the Anticancer Peptaibol Culicinin D. Journal of Organic Chemistry (2015) 80(17): 8631-8636.

Lagautriere, T., Bashiri, G., & Baker, E. N. Use of a "silver bullet" to resolve crystal lattice dislocation disorder: A cobalamin complex of δ1-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis. Journal of Structural Biology (2015) 189(2): 153-157.

Lee, K. L., Middleditch, M. J., Williams, G. M., Brimble, M. A., & Cooper, G. J. S. Using mass spectrometry to detect, differentiate, and semiquantitate closely related peptide hormones in complex milieu: Measurement of IGF-II and vesiculin. Endocrinology (2015) 156(3): 1194-1199.

Li, Y., Cheng, H., Zhang, Z., Zhuang, X., Luo, J., Long, H., Zhou, Y., Xu, Y., Taghipouran, R., Li, D., Patterson, A., Smaill, J., Tu, Z., Wu, D., Ren, X., & Ding, K. N-(3-ethynyl-2,4-difluorophenyl)sulfonamide derivatives as selective Raf inhibitors. ACS Medicinal Chemistry Letters (2015) 6(5): 543-547.

Lorenz, N., Loef, E. J., Verdon, D. J., Chen, C. J. J., Mansell, C. J., Angel, C. E., Brooks, A. E. S., Dunbar, P. R., & Birch, N. P. Human T cell activation induces synaptic translocation and alters expression of the serine protease inhibitor neuroserpin and its target protease. Journal of Leukocyte Biology (2015) 97(4): 699-710.

Lu, P., Heineke, M. H., Koul, A., Andries, K., Cook, G. M., Lill, H., Van Spanning, R., & Bald, D. The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress. Scientific Reports (2015) 5.

Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. Bridging small molecules to modified bacterial microparticles using a disulphide linkage: MIS416 as a cargo delivery system. PLoS ONE (2015) 10(12).

Marshall, A. J., Lill, C. L., Chao, M., Kolekar, S. V., Lee, W. J., Marshall, E. S., Baguley, B. C., Shepherd, P. R., Denny, W. A., Flanagan, J. U., & Rewcastle, G. W. Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: Synthesis, biological evaluation and molecular modelling. Bioorganic and Medicinal Chemistry (2015) 23(13): 3796-3808.

McIntosh, J. D., Brimble, M. A., Brooks, A. E. S., Dunbar, P. R., Kowalczyk, R., Tomabechi, Y., & Fairbanks, A. J. Convergent chemo-enzymatic synthesis of mannosylated glycopeptides; targeting of putative vaccine candidates to antigen presenting cells. Chemical Science (2015) 6(8): 4636-4642.

Medini, K., Harris, P. W. R., Hards, K., Dingley, A. J., Cook, G. M., & Brimble, M. A. Chemical synthesis of a pore-forming antimicrobial protein, caenopore-5, by using native chemical ligation at a Glu-Cys site. ChemBioChem (2015) 16(2): 328-336.

Murphy, R., Jiang, Y., Booth, M., Babor, R., Maccormick, A., Hammodat, H., Beban, G., Barnes, R. M., & Vincent, A. L. Progression of diabetic retinopathy after bariatric surgery. Diabetic Medicine (2015) 32(9): 1212-1220.

Musson, D. S., Naot, D., Chhana, A., Matthews, B. G., McIntosh, J. D., Lin, S. T. C., Choi, A. J., Callon, K. E., Dunbar, P. R., Lesage, S., Coleman, B., & Cornish, J. In vitro evaluation of a novel non-mulberry silk scaffold for use in tendon regeneration. Tissue Engineering - Part A (2015) 21(9-10): 1539-1551.

Neumann, S., Young, K., Compton, B., Anderson, R., Painter, G., & Hook, S. Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8+ T-cell responses and prevent tumour progression. Vaccine (2015) 33(43): 5838-5844.

Newman, T. A. C., Carleton, C. R., Leeke, B., Hampton, M. B., & Horsfield, J. A. Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biology (2015) 6: 648-655.

Newton, M. S., Arcus, V. L., & Patrick, W. M. Rapid bursts and slow declines: On the possible evolutionary trajectories of enzymes. Journal of the Royal Society Interface (2015) 12(107).

Palmer, B. D., Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., Denny, W. A., & Thompson, A. M. Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6 S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2015) 58(7): 3036-3059.

Papst, S., Brimble, M. A., Evans, C. W., Verdon, D. J., Feisst, V., Dunbar, P. R., Tilley, R. D., & Williams, D. E. Cell-targeted platinum nanoparticles and nanoparticle clusters. Organic and Biomolecular Chemistry (2015) 13(23): 6567-6572. [pdf]

Parker, E. J. The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3. Structure (2015) 23(4): 608-609.

Patassini, S., Begley, P., Reid, S. J., Xu, J., Church, S. J., Curtis, M., Dragunow, M., Waldvogel, H. J., Unwin, R. D., Snell, R. G., Faull, R. L. M., & Cooper, G. J. S. Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease. Biochemical and Biophysical Research Communications (2015) 468(1-2): 161-166.

Petridis, M., Benjak, A., & Cook, G. M. Defining the nitrogen regulated transcriptome of Mycobacterium smegmatis using continuous culture. BMC Genomics (2015) 16(1): 1-13.

Poral, V. L., Furkert, D. P., & Brimble, M. A. Total synthesis and structural confirmation of the antimalarial naphthopyrone lasionectrin. Organic Letters (2015) 17(24): 6214-6217.

Radcliff, F. J., Fraser, J. D., & Proft, T. Vaccination with Streptococcus pyogenes nuclease A stimulates a high antibody response but no protective immunity in a mouse model of infection. Medical Microbiology and Immunology (2015) 204(2): 185-191. [pdf]

Sawhney, S., Hood, K., Shaw, A., Braithwaite, A. W., Stubbs, R., Hung, N. A., Royds, J. A., & Slatter, T. L. Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a Δ133p53α mimic. PLoS ONE (2015) 10(2).

Sparrow, K. J., Carley, S., Söhnel, T., Barker, D., & Brimble, M. A. Studies towards development of asymmetric double-Mannich reactions of chiral 2-oxocyclohexanecarboxylate derivatives with bis(aminol)ethers. Tetrahedron (2015) 71(15): 2210-2221.

Stach, M., Weidkamp, A. J., Yang, S. H., Hung, K. Y., Furkert, D. P., Harris, P. W. R., Smaill, J. B., Patterson, A. V., & Brimble, M. A. Improved strategy for the synthesis of the anticancer agent culicinin D. European Journal of Organic Chemistry (2015) 2015(28): 6341-6350.

Strauss, O., Dunbar, P. R., Bartlett, A., & Phillips, A. The immunophenotype of antigen presenting cells of the mononuclear phagocyte system in normal human liver - A systematic review. Journal of Hepatology (2015) 62(2): 458-468.

Street, M., Thambyah, A., Dray, M., Amirapu, S., Tuari, D., Callon, K. E., McIntosh, J. D., Burkert, K., Dunbar, P. R., Coleman, B., Cornish, J., & Musson, D. S. Augmentation with an ovine forestomach matrix scaffold improves histological outcomes of rotator cuff repair in a rat model. Journal of Orthopaedic Surgery and Research (2015) 10(1).

Stubbing, L. A., Lott, J. S., Dawes, S. S., Furkert, D. P., & Brimble, M. A. Synthesis of DOHNAA, a Mycobacterium tuberculosis cholesterol CD ring catabolite and FadD3 substrate. European Journal of Organic Chemistry (2015) 2015(27): 6075-6083.

Sun, Y., Bell, J. L., Carter, D., Gherardi, S., Poulos, R. C., Milazzo, G., Wong, J. W. H., Al-Awar, R., Tee, A. E., Liu, P. Y., Liu, B., Atmadibrata, B., Wong, M., Trahair, T., Zhao, Q., Shohet, J. M., Haupt, Y., Schulte, J. H., Brown, P. J., Arrowsmith, C. H., Vedadi, M., MacKenzie, K. L., Hüttelmaier, S., Perini, G., Marshall, G. M., Braithwaite, A., & Liu, T. WDR5 supports an N-myc transcriptional complex that drives a protumorigenic gene expression signature in neuroblastoma. Cancer Research (2015) 75(23): 5143-5154.

Sweetlove, M., Wrightson, E., Kolekar, S., Rewcastle, G. W., Baguley, B. C., Shepherd, P. R., & Jamieson, S. M. F. Inhibitors of pan-PI3K signaling synergize with BRAF or MEK inhibitors to prevent BRAF-mutant melanoma cell growth. Frontiers in Oncology (2015) 5(JUN).

Thompson, A. M., Blaser, A., Palmer, B. D., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., & Denny, W. A. Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy. Bioorganic and Medicinal Chemistry Letters (2015) 25(18): 3804-3809.

Ting, Y. T., Batot, G., Baker, E. N., & Young, P. G. Expression, purification and crystallization of a membrane-associated, catalytically active type I signal peptidase from Staphylococcus aureus. Acta Crystallographica Section F: Structural Biology Communications (2015) 71: 61-65.

Tomek, P., Palmer, B. D., Kendall, J. D., Flanagan, J. U., & Ching, L. M. Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine. Biochimica et Biophysica Acta - General Subjects (2015) 1850(9): 1772-1780.

Tran, T. T., Palmer, H. R., Weimar, M. R., Arias, C. A., Cook, G. M., & Murray, B. E. Oral bacitracin: A consideration for suppression of intestinal vancomycin-resistant enterococci (VRE) and for VRE bacteremia from an apparent gastrointestinal tract source. Clinical Infectious Diseases (2015) 60(11): 1726-1728.

Wadsworth, A. D., Naysmith, B. J., & Brimble, M. A. A review of the synthesis of α-carbolines. European Journal of Medicinal Chemistry (2015) 97(1): 816-829.

Whiting, L., Stewart, K. W., Hay, D. L., Harris, P. W., Choong, Y. S., Phillips, A. R. J., Brimble, M. A., & Cooper, G. J. S. Glicentin‐related pancreatic polypeptide inhibits glucose‐stimulated insulin secretion from the isolated pancreas of adult male rats. Physiological Reports (2015) 3(12): e12638.

Williams, E. M., Little, R. F., Mowday, A. M., Rich, M. H., Chan-Hyams, J. V. E., Copp, J. N., Smaill, J. B., Patterson, A. V., & Ackerley, D. F. Nitroreductase gene-directed enzyme prodrug therapy: Insights and advances toward clinical utility. Biochemical Journal (2015) 471(2): 131-153.

Williamson, D. A., Smeesters, P. R., Steer, A. C., Steemson, J. D., Ng, A. C. H., Proft, T., Fraser, J. D., Baker, M. G., Morgan, J., Carter, P. E., & Moreland, N. J. M-protein analysis of streptococcus pyogenes isolates associated with acute rheumatic fever in New Zealand. Journal of Clinical Microbiology (2015) 53(11): 3618-3620.

Xu, J., Jüllig, M., Middleditch, M. J., & Cooper, G. J. S. Modelling atherosclerosis by proteomics: Molecular changes in the ascending aortas of cholesterol-fed rabbits. Atherosclerosis (2015) 242(1): 268-276.

Xu, S., Mao, L., Ding, P., Zhuang, X., Zhou, Y., Yu, L., Liu, Y., Nie, T., Xu, T., Xu, Y., Liu, J., Smaill, J., Ren, X., Wu, D., & Ding, K. 1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose. Bioorganic and Medicinal Chemistry (2015) 23(13): 3751-3760.

Yosaatmadja, Y., Patterson, A. V., Smaill, J. B., & Squire, C. J. The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition. Acta Crystallographica Section D: Biological Crystallography (2015) 71: 525-533. [pdf]

Yosaatmadja, Y., Silva, S., Dickson, J. M., Patterson, A. V., Smaill, J. B., Flanagan, J. U., McKeage, M. J., & Squire, C. J. Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed. Journal of Structural Biology (2015) 192(3): 539-544.

Zhang, L., Li, M. M., Corcoran, M., Zhang, S., & Cooper, G. J. S. Essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin. Molecular and Cellular Endocrinology (2015) 399: 164-177. [pdf]

2014

Abendroth, J., Ollodart, A., Andrews, E. S. V., Myler, P. J., Staker, B. L., Edwards, T. E., Arcus, V.L. & Grundner, C. Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution. Journal of Biological Chemistry (2014) 289(4): 2139-2147.

Ahmadi, O., Stringer, M. D., Black, M. A., & McCall, J. L. Influence of age and site of disease on lymph node yield in colorectal cancer. The New Zealand Medical Journal  (2014) 127 (1395): 31-40.

Ameratunga, R., Chen, C. J., Koopmans, W., Dunbar, P. R., Brewerton, M., Lloydd, R.,
Mansell, C., van Vliet, C., & Woon, S. T. Identification of germinal centres in the lymph node of a patient with hyperimmunoglobulin M syndrome associated with congenital rubella. Journal of Clinical Immunology (2014) 34(7): 796-803.

Anderson, R.J., Tang, C.W., Daniels, N.J., Compton, B.J., Hayman, C.M., Johnston, K.A., Knight, D.A., Gasser, O., Poyntz, H.C., Ferguson, P.M., Larsen, D.S., Ronchese, F., Painter, G.F., & Hermans, I.F. A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy. Nature Chemical Biology (2014) 10(11): 943-949.

Aung, H. L., Berney, M., & Cook, G. M.  Hypoxia-activated cytochrome bd expression in Mycobacterium smegmatis is cyclic AMP receptor protein dependent. Journal of Bacteriology (2014) 196(17): 3091-3097.

Bouchery, T., Kyle, R., Ronchese, F. & Le Gos, G.. The differentiation of CD4+ T-helper cell subsets in the context of helminth parasite infection. Frontiers of Immunology (2014) 5: 487.

Bulloch, E. M. M., & Kingston, R. L. Identifying protein domains by global analysis of soluble fragment data. Analytical Biochemistry (2014) 465: 53-62.

Chu, M. J. J., Hickey, A. J. R., Tagaloa, S., Zhang, L., Dare, A. J., MacDonald, J. R., Yeong, M-L., Adam, S.J., Bartlett, R. & Phillips, A. R. J. Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia. PLoS ONE (2014) 9(6).

Commons, R. J., Smeesters, P. R., Proft, T., Fraser, J. D., Robins-Browne, R., & Curtis, N. Streptococcal superantigens: Categorization and clinical associations. Trends in Molecular Medicine (2014) 20(1): 48-62. [pdf]

Connor, L.M., Tang, S.C., Camberis, M., Le Gros, G. & Ronchese, F.. Helminth–conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo. Journal of Immunology (2014) 193(6): 2709-2717.

Cookson, T. V. M., Castell, A., Bulloch, E. M. M., Evans, G. L., Short, F. L., Baker, E. N., Lott, J. S.& Parker, E. J.  Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochemical Journal (2014) 461: (1)

Cotton, T. R., Joseph, D. D. A., Jiao, W., & Parker, E. J.  Probing the determinants of phosphorylated sugar-substrate binding for human sialic acid synthase. Biochimica et Biophysica Acta - Proteins and Proteomics (2014) 1844 (12): 2257-2264.

Dawes, S., Kendall, S., Baker, E.N. & Lott, J.S. Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (keto-steroid regulatory protein) from Mycobacterium tuberculosis. Acta Crystallographica (2014) 70: 1643-1645.

Dunn, E. A., Roxburgh, M., Larsen, L., Smith, R. A. J., McLellan, A. D., Heikal, A., Murphy, M.P. & Cook, G. M. Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis. Bioorganic and Medicinal Chemistry (2014) 22(19): 5320-5328.

Evans, G. L., Gamage, S. A., Bulloch, E. M. M., Baker, E. N., Denny, W. A., & Lott, J. S.  Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis. ChemBioChem (2014) 15(6): 852-864.

Feisst, V., Brooks, A. E., Chen, C. -J., & Dunbar, P. R. (2014). Characterization of mesenchymal progenitor cell populations directly derived from human dermis. Stem Cells and Development (2014) 23(6): 631-642. [pdf]

Flanagan, J. U., & Shepherd, P. R. Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme. Biochemical Society Transactions (2014) 42(1): 120-124.

Flanagan, J. U., Atwell, G. J., Heinrich, D. M., Brooke, D. G., Silva, S., Rigoreau, L. J. M., Trivier, E., Turnbull, A.P., Raynham, T., Jamieson, S.M.F. & Denny, W. A. Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3). Bioorganic and Medicinal Chemistry (2014) 22(3): 967-977.

Furkert, D. P., Breitenbach, B., Juen, L., Sroka, I., Pantin, M., & Brimble, M. A. Nonsymmetrical azocarbonamide carboxylates as effective Mitsunobu reagents. European Journal of Organic Chemistry (2014) 2014(35): 7806-7809.

Gebhard, S., Busby, J. N., Fritz, G., Moreland, N. J., Cook, G. M., Lott, J. S., Baker, E.N. & Money, V. A. Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis. Journal of Bacteriology (2014) 196(19): 3472-3481.

Gibbins, J.D., Ancelet, L.R., Weinkove, R., Compton, B.J., Painter, G.F., Petersen, T.R. & Hermans, I.F. An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment. Blood (2014) 124(19): 2953.

Gingell, J. J., Burns, E. R., & Hay, D. L.  Activity of Pramlintide, Rat and Human Amylin but not Aβ1-42 at Human Amylin Receptors. Endocrinology (2014) 155(1): 21-26.

Guise, C. P., Mowday, A. M., Ashoorzadeh, A., Yuan, R., Lin, W. H., Wu, D. H., Smaill, J. B., Patterson, A. V., & Ding, K. Bioreductive prodrugs as cancer therapeutics: Targeting tumor hypoxia. Chinese Journal of Cancer (2014) 33(2): 80-86.

Harris, P. W. R., Kowalczyk, R., Yang, S. H., Williams, G. M., & Brimble, M. A. An important side reaction using the thiol, 3,6-dioxa-1,8-octanedithiol (DODT), in 9-fluorenylmethoxycarbonyl-based solid phase peptide synthesis. Journal of Peptide Science (2014) 20(3): 186-190.

Harris, P. W. R., Yang, S. H., Molina, A., Lõpez, G., Middleditch, M., & Brimble, M. A. Plant antimicrobial peptides snakin-1 and snakin-2: Chemical synthesis and insights into the disulfide connectivity. Chemistry - A European Journal (2014) 20(17): 5102-5110.

Harris, P. W., Hampe, L., Radjainia, M., Brimble, M. A., & Mitra, A. K. An investigation of the role of the adiponectin variable domain on the stability of the collagen-like domain. Biopolymers (2014) 101(4): 313-321.

Harris, P., Molenaar, G. T., Amso, Z., Savage, G. P., & Brimble, M. A. An efficient Fmoc solid-phase synthesis of an amphiphile of the neuroprotective agent glycyl-prolyl-glutamic acid. Synlett (2014) 25(15): 2221-2224.

Harris, P.W.R., Hampe, Radjainia, L.M., Brimble, M.A. & Mitra, A.K. An investigation of the role of the adiponectin variable domain on the stability of the collagen-like domain. Biopolymers (Peptide Science) (2014) 102: 313-321.

Hartman, T., Weinrick, B., Vilchèze, C., Berney, M., Tufariello, J., Cook, G. M., & Jacobs, W. R., Jr.  Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis. PLoS Pathogens (2014) 10(11).

Hay, D. L., Harris, P. W. R., Kowalczyk, R., Brimble, M. A., Rathbone, D. L., Barwell, J. & Poyner, D. R.  Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: Key roles of alanine-5 and threonine-6 in receptor activation. British Journal of Pharmacology (2014) 171(2): 415-426.

Heikal, A., Nakatani, Y., Dunn, E., Weimar, M. R., Day, C. L., Baker, E. N., Lott, J. S., Sazanov, L. A., & Cook, G. M. Structure of the bacterial type II NADH dehydrogenase: A monotopic membrane protein with an essential role in energy generation. Molecular Microbiology (2014) 91(5): 950-964.

Huang, A., Baker, E.N. & Loomes, K.M.  Use of a novel micro-titration protocol to obtain diffraction quality crystals of 4-hydroxy-2-oxoglutarate aldolase from Bos taurus. Acta Crystallographica Section F: Structural Biology Communications (2014) 70: 1546-1549.

Hume, P. A., Furkert, D. P., & Brimble, M. A.  Total synthesis of virgatolide b via exploitation of intramolecular hydrogen bonding. Journal of Organic Chemistry (2014) 79(11): 5269-5281.

Jamieson, S.M.F., Gu, Y., Manesh, D.M., El-Hoss, J., Jing, D., Mackenzie, K.L., Guise, C.P., Foehrenbacher, A., Pullen, S., Benito, J., Smaill, J.B., Patterson, A.V., Mulaw, M.A., Konopleva, M., Bohlander, S.K., Lock, R.B. & Wilson, W.R., A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells. Biochemical Pharmacology (2014) 88(1): 36-45.

Joseph, D. D. A., Jiao, W., Kessans, S. A., & Parker, E. J. Substrate-mediated control of the conformation of an ancillary domain delivers a competent catalytic site for N-acetylneuraminic acid synthase. Proteins: Structure, Function and Bioinformatics (2014) 82(9): 2054-2066.

Jüllig, M., Yip, S., Xu, A., Smith, G., Middleditch, M., Booth, M., Babor, R., Beban, G. & Murphy, R.  Lower Fetuin-A, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes. PLoS ONE (2014) 9(5): e96489.

Jung, J., Bashiri, G., Johnston, J. M., Brown, A. S., Ackerley, D. F., & Baker, E. N. Crystal structure of the essential mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein. Journal of Structural Biology (2014) 188(3): 274-278.

Kamalov, M., Harris, P. W. R., Cooper, G. J. S., & Brimble, M. A. Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts. Chemical Communications (2014) 50(38): 4944-4946.[pdf]

Kamalov, M., Yang, S., Harris, P. W. R., Cooper, G. J. S., & Brimble, M. A.  Expedient synthesis of peptides containing Nε- carboxymethyllysine. Synlett (2014) 25(13): 1835-1838.

Kang, H. J., Paterson, N. G., Kim, C. U., Middleditch, M., Chang, C., Ton-That, H., & Baker, E. N.  A slow-forming isopeptide bond in the structure of the major pilin SpaD from Corynebacterium diphtheriae has implications for pilus assembly. Acta Crystallographica Section D: Biological Crystallography (2014) 70(5): 1190-1201.

Kaur, H., Heapy, A. M., Kowalczyk, R., Amso, Z., Watson, M., Cornish, J., & Brimble, M. A.  Synthesis and biological evaluation of the osteoblast proliferating cyclic peptides dianthins G and H. Tetrahedron (2014) 70(42): 7788-7794.

Kendall, J. D., Marshall, A. J., Giddens, A. C., Tsang, K. Y., Boyd, M., Frédérick, R., Lill, C.L., Woo-Jeong, L., Kolekar, S., Chaor, M., Malik, A., Yu, S., Chaussade, C., Buchanan, C., Rewcastle, G.W., Baguley, B.C., Flanagan, J.U., Denny, W.A. & Shepherd, P. R.  Novel pyrazolo[1,5-a]pyridines as PI3K inhibitors: Variation of the central linker group. MedChemComm (2014) 5(1): 41-46.

Kowalczyk, R., Brimble, M. A., Tomabechi, Y., Fairbanks, A. J., Fletcher, M., & Hay, D. L.  Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: Structure-activity relationships for amylin receptor agonism. Organic and Biomolecular Chemistry (2014) 12(41): 8142-8151. [pdf]

Kwon, H., Squire, C.J., Young, P.G. & Baker, E.N. Autocatalytically-generated Thr-Gln ester bond crosslinks stabilize the repetitive Ig-domain shaft of a bacterial cell-surface adhesin. Proceedings of the National Academy of Sciences of the United States of America (2014) 111: 1367-1372.

Lagautriere, T., Bashiri, G., Paterson, N. G., Berney, M., Cook, G. M., & Baker, E. N.  Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies. Acta Crystallographica Section D: Biological Crystallography (2014) 70(4): 968-980. [pdf]

Li, Y., Mortuza, R., Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. Investigation of the essentiality of glutamate racemase in mycobacterium smegmatis. Journal of Bacteriology (2014) 196(24): 4239-4244.

Linke-Winnebeck, C., Paterson, N. G., Young, P. G., Middleditch, M. J., Greenwood, D. R., Witte, G., & Baker, E. N.  Structural model for covalent adhesion of the Streptococcus pyogenes pilus through a thioester bond. Journal of Biological Chemistry (2014) 289(1): 177-189.

Low, Y. S., Bircham, P. W., Maass, D. R., & Atkinson, P. H. Kinetochore genes are required to fully activate secretory pathway expansion in S. cerevisiae under induced ER stress. Molecular BioSystems (2014) 10(7): 1790-1802.

McIntosh, J. D., Manning, K., Chokshi, S., Naoumov, N. V., Fraser, J. D., Dunbar, P. R., & Taylor, J. A. An engineered non-toxic superantigen increases cross presentation of hepatitis B virus nucleocapsids by human dendritic cells. PLoS One (2014) 9(4): e93598.

Moreland, N. J., Waddington, C. S., Williamson, D. A., Sriskandan, S., Smeesters, P. R., Proft, T., Street, A.C., Walker, M.J., Baker, E.N., Baker, M.G., Dunbar, R., Carapetis, J., & Fraser, J. D. Working towards a group A streptococcal vaccine: report of a collaborative Trans-Tasman workshop. Vaccine (2014) 32(30): 3713-3720.

Nazmi, A. R., Schofield, L. R., Dobson, R. C. J., Jameson, G. B., & Parker, E. J. Destabilization of the homotetrameric assembly of 3-deoxy-d-arabino- heptulosonate-7-phosphate synthase from the hyperthermophile pyrococcus furiosus enhances enzymatic activity. Journal of Molecular Biology (2014) 426(3): 656-673.

Neal, M. L., Cooling, M. T., Smith, L. P., Thompson, C. T., Sauro, H. M., Carlson, B. E., Cook, D. L. & Gennari, J. H. A reappraisal of how to build modular, reusable models of biological systems. PLoS Computational Biology (2014) 10(10): e1003849.

Neumann, S., Burkert, K., Kemp, R., Rades, T., Dunbar, P. R., & Hook, S. Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunology and Cell Biology (2014) 92(6): 535-542.

Nyanhanda, T., Gould, E.M., McGhie, T., Shaw, O.M., Harper, J.L., & Hurst, R.D. Blackcurrant polyphenolic cultivar extracts suppress CCL26 secretion from alveolar epithelial cells. Food and Function (2014) 26 5(4): 671-7. [pdf]

Ochiai, S., Roediger, B., Abtin, A., Shklovskaya, E., Fazekas de St Groth, B., Yamane, H., Weninger, W., Le Gros, G. & Ronchese, F.. CD326loCD103loCD11blo dermal dendritic cells are activated by Thymic Stromal Lymphopoietin during contact sensitization in mice. Journal of Immunology (2014) 193(5): 2504-2511.

Park, S. M., Angel, C. E., McIntosh, J. D., Brooks, A. E., Middleditch, M., Chen, C. J., Ruggiero, K., Cebon, J., & Dunbar, P. R. Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes. European Journal of Immunology (2014) 44(8): 2425-2436.

Park, S. M., Angel, C. E., McIntosh, J. D., Mansell, C. M., Chen, C. J., Cebon, J., & Dunbar, P. R. Mapping the distinctive populations of lymphatic endothelial cells in different zones of human lymph nodes. PLoS One (2014) 9(4): e94781.

Parker, H. A., Magon, N. J., Green, J. N., Hampton, M. B., & Winterbourn, C. C.  Analysis of neutrophil bactericidal activity. Methods in Molecular Biology (2014) 1124: 291-306.

Patrick, W. M., & Gerth, M. L. ITCHY: Incremental truncation for the creation of hybrid enzymes. Methods in Molecular Biology (2014) 1179: 225-244. [pdf]

Petersen, T. R., Knight, D. A., Tang, C. W., Osmond, T. L., & Hermans, I. F. Batf3-independent langerin-CX3CR1-CD8α +splenic DCs represent a precursor for classical cross-presenting CD8α +DCs. Journal of Leukocyte Biology (2014) 96(6): 1001-1010.

Pham, T., Loiselle, D., Power, A., & Hickey, A. J. R. Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart. American Journal of Physiology - Cell Physiology (2014) 307(6): C499-C507.

Prendergast, K.A., Osmond, T.L., Ochiai, S., Hermans, I.F. & Kirman, J.R. Sustained in vivo depletion of splenic langerin+ CD8<alpha>+ dendritic cells is well-tolerated by lang-DTREGFP mice. Journal of Immunological Methods (2014) 406: 104-109. [pdf]

Rattanapak, T., Birchall, J. C., Young, K., Kubo, A., Fujimori, S., Ishii, M., & Hook, S.  Dynamic visualization of dendritic cell-antigen interactions in the skin following transcutaneous immunization. PLoS ONE (2014) 9(2): e89503.

Schünemann, K., Furkert, D. P., Choi, E. C., Connelly, S., Fraser, J. D., Sperry, J., & Brimble, M. A. Synthesis of the 2-methylene analogue of the HRV 3C protease inhibitor thysanone (2-carbathysanone). Organic and Biomolecular Chemistry (2014) 12(6): 905-912.

Schünemann, K., Furkert, D. P., Connelly, S., Fraser, J. D., Sperry, J., & Brimble, M. A. Iridium-catalysed C-H borylation facilitates a total synthesis of the HRV 3C protease inhibitor (±)-thysanone. Synlett (2014) 25(4): 556-558.

Shaw, O.M., Pool, B., Dalbeth, N. & Harper, J.L. The effect of diet-induced obesity on the inflammatory phenotype of non-adipose-resident macrophages in an in vivo model of gout. Rheumatology (2014) 53(10): 1901-1905.

Shaw, O.M., Steiger, S., Liu, X., Hamilton, J.A., ^ Harper, J.L. Granulocyte-Macrophage Colony-Stimulating factor drives monosodium urate monohydrate crystal-induced inflammatory macrophage differentiation and NLRP3 inflammasome up-regulation in an in vivo mouse model. Arthritis & Rheumatology (2014) 66(9): 2423-2428.

Sheppard HM, Verdon D, Brooks AE, Feisst V, Ho YY, Lorenz N, Fan V, Birch NP, Didsbury A, Dunbar PR. MicroRNA regulation in human CD8+ T cell subsets - cytokine exposure alone drives miR-146a expression. Journal of Translational Medicine (2014) 12(1):292-303.

Smith, G.C., McEwen, H., Steinberg, J.D. & Shepherd, P. R. The activation of the Akt/PKB signalling pathway in the brains of clozapine-exposed rats is linked to hyperinsulinemia and not a direct drug effect. Psychopharmacology (2014) 231(23): 4553-4560.

Son, S. J., Harris, P. W. R., Squire, C. J., Baker, E. N., Kent, S. B. H., & Brimble, M. A.  Total chemical synthesis of an Orf virus protein, ORFV002, an inhibitor of the master gene regulator NF-κB. Biopolymers (2014) 102(2): 137-144.

Steemson, J. D., Moreland, N. J., Williamson, D., Morgan, J., Carter, P. E., & Proft, T.  Survey of the bp/tee genes from clinical group A streptococcus isolates in New Zealand - Implications for vaccine development. Journal of Medical Microbiology (2014) 63: 1670-1678.

Steemson, J. D., Baake, M., Rakonjac, J., Arcus, V.L., & Liddament, M.T. Tracking molecular recognition at the atomic level with a new protein scaffold based on the OB-fold. PLoS ONE (2014) 9(1): e86050.

Williams, E. M., Copp, J. N., & Ackerley, D. F.  Site-saturation mutagenesis by overlap extension. Methods in Molecular Biology (2014) 1179: 83-101.

Williamson, D. A., Mills, G., Johnson, J. R., Porter, S., & Wiles, S. In vivo correlates of molecularly inferred virulence among extraintestinal pathogenic Escherichia coli (ExPEC) in the wax moth Galleria mellonella model system. Virulence (2014) 5(3): 388-393.

Williamson, D. A., Monecke, S., Heffernan, H., Ritchie, S. R., Roberts, S. A., Upton, A.,  & Fraser, J. D. High usage of topical fusidic acid and rapid clonal expansion of fusidic acid-resistant Staphylococcus aureus: A cautionary tale. Clinical Infectious Diseases (2014) 59(10): 1451-1454.

Williamson, D. A., Moreland, N. J., Carter, P., Upton, A., Morgan, J., Proft, T., Lennon, D., Baker, M.G., Dunbar, R. & Fraser, J. D. Molecular epidemiology of group a streptococcus from pharyngeal isolates in Auckland, New Zealand, 2013. New Zealand Medical Journal (2014) 127(1388): 55-60.

Yeung, H., Harris, P. W. R., Squire, C. J., Baker, E. N., & Brimble, M. A. Preparation of truncated orf virus entry fusion complex proteins by chemical synthesis. Journal of Peptide Science (2014) 20(6): 398-405.

Yin, Y. D., Fu, M., Brooke, D. G., Heinrich, D. M., Denny, W. A., & Jamieson, S. M. F. The activity of SN33638, an inhibitor of AKR1C3, on testosterone and 17β-estradiol production and function in castration-resistant prostate cancer and ER-positive breast cancer. Frontiers in Oncology (2014) 4: 159.

Young Jeong, J., Sperry, J., Taylor, J. A., & Brimble, M. A. Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease. European Journal of Medicinal Chemistry (2014) 87: 220-227.

Young, P. G., Proft, T., Harris, P. W. R., Brimble, M. A., & Baker, E. N.  Structure and activity of Streptococcus pyogenes SipA: A signal peptidase-like protein essential for pilus polymerisation. PLoS ONE (2014) 9(6).

Young, P. G., Moreland, N. J., Loh, J. M., Bell, A., Atatoa-Carr, P., Proft, T. & Baker, E. N. Structural conservation, variability and immunogenicity of the T6 backbone pilin of serotype M6 Streptococcus pyogenes. Infection and Immunity (2014) 82: 2949-2957.

Zhang, S., Liu, H.,  Amarsingh, G.,  Cheung, C.,  Hogl, S., Narayanan, U., Zhang, L.,  McHarg, S.,  Xu, J.,  Gong, D.,  Kennedy, J., Barry, B., Soon Choong, Y., Phillips, A. R., Cooper, G. Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation. Cardiovascular Diabetology (2014) 13(1): 100. 

Zhang, S., Liu, H., Chuang, C.L., Li, X., Au, M., Zhang, L., Phillips, A.R., Scott, D.W., & Cooper, G.J. The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet β cells. The FASEB Journal (2014) 28(12): 5083-5096.

2013

Affara, M., Sanders, D., Araki, H., Tamada, Y., Dunmore, B. J., Humphreys, S., Imoto, S., Savoie, C., Miyano, S., Kuhara, S., Jeffries, D., Print, C., & Charnock-Jones, D. S. Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis. BMC Genomics (2013) 14(1).

Aitken, H. R. M., Furkert, D. P., Hubert, J. G., Wood, J. M., & Brimble, M. A. Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary. Organic and Biomolecular Chemistry (2013) 11(31): 5147-5155.

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Weinkove, R., Brooks, C. R., Carter, J. M., Hermans, I. F., & Ronchese, F. Efficient depletion of chronic lymphocytic leukemia B cells using serial rounds of immunomagnetic depletion. Journal of Immunological Methods (2013) 396(1-2): 152-156.

Weinkove, R., Brooks, C. R., Carter, J. M., Hermans, I. F., & Ronchese, F. Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: Implications for immunotherapy. Haematologica (2013) 98(3): 376-384.

Whiting, L., Danaher, R. N., Ruggiero, K., Lee, C. C., Chaussade, C., Mulvey, T., Phillips, A., & Loomes, K. M. D-chiro-inositol attenuates epinephrine-stimulated hepatic glucose output in the isolated perfused liver independently of insulin. Hormone and Metabolic Research (2013) 45(5): 394-397. [pdf]

Williams, G. M., Cooper, G. J., Lee, K., Whiting, L., & Brimble, M. A. Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds. Organic and Biomolecular Chemistry (2013) 11(19): 3145-3150.

Woods, T. M., Cooper, G. J., & Brimble, M. A. Synthesis of stable isotope-labelled monolysyl advanced glycation endproducts. Amino Acids (2013) 45(2): 319-325.

Wright, T. H., Brooks, A. E., Didsbury, A. J., Williams, G. M., Harris, P. W., Dunbar, P. R., & Brimble, M. A. Direct peptide lipidation through thiol-ene coupling enables rapid synthesis and evaluation of self-adjuvanting vaccine candidates. Angewandte Chemie - International Edition (2013) 52(40): 10616-10619.

Xiong, X., Xu, Z., Yang, Z., Liu, Y., Wang, D., Dong, M., Parker, E. J., & Zhu, W. Key targets and relevant inhibitors for the drug discovery of tuberculosis. Curr Drug Targets (2013) 14(6): 676-699. [pdf]

Yang, S. H., Wojnar, J. M., Harris, P. W., DeVries, A. L., Evans, C. W., & Brimble, M. A. Chemical synthesis of a masked analogue of the fish antifreeze potentiating protein (AFPP). Organic and Biomolecular Chemistry (2013) 11(30): 4935-4942.

Young, P. G., Kang, H. J., & Baker, E. N. An arm-swapped dimer of the Streptococcus pyogenes pilin specific assembly factor SipA. Journal of Structural Biology (2013) 183(1): 99-104.

Yuen, T. Y., Ng, Y. P., Ip, F. C. F., Chen, J. L. Y., Atkinson, D. J., Sperry, J., Ip, N. Y., & Brimble, M. A. Telomerase inhibition studies of novel spiroketal-containing rubromycin derivatives. Australian Journal of Chemistry (2013) 66(5): 530-533.

Zeng, I. S. L., Lumley, T., Ruggiero, K., Middleditch, M., Woon, S. T., & Stewart, R. A. H. Two optimization strategies of multi-stage design in clinical proteomic studies. Statistical Applications in Genetics and Molecular Biology (2013) 12(2): 263-283. [pdf]

Zhang, L., Ward, M. L., Phillips, A. R., Zhang, S., Kennedy, J., Barry, B., Cannell, M. B., & Cooper, G. J. Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats. Cardiovascular Diabetology (2013) 12: 123.

2012

Ancelet, L. R., Aldwell, F. E., Rich, F. J., & Kirman, J. R. Oral vaccination with lipid formulated BCG induces a long-lived, multifunctional CD4+ T cell memory immune response. PLoS ONE (2012) 7(9): e45888.

Ancelet, L., Rich, F. J., Delahunt, B., & Kirman, J. R. Dissecting memory T cell responses to TB: Concerns using adoptive transfer into immunodeficient mice. Tuberculosis (2012) 92(5): 422-433.

Araki, H., Knapp, C., Tsai, P., & Print, C. GeneSetDB: A comprehensive metadatabase, statistical and visualisation framework for gene set analysis. FEBS Open Bio (2012) 2: 76-82.

Araki H, Hurley D, Crampin E, Print C, Kuhara S. Gene network analysis and application. Seibutsu Butsuri - the Biophysical Society of Japan (2012) 51: 182-185 (in Japanese).

Bailey, R. J., Walker, C. S., Ferner, A. H., Loomes, K. M., Prijic, G., Halim, A., Whiting, L., Phillips, A. R. J., & Hay, D. L. Pharmacological characterization of rat amylin receptors: Implications for the identification of amylin receptor subtypes. British Journal of Pharmacology (2012) 166(1): 151-167.

Baker, H. M., & Baker, E. N. A structural perspective on lactoferrin function. Biochemistry and Cell Biology (2012) 90(3): 320-328. [pdf]

Barwell, J., Gingell, J. J., Watkins, H. A., Archbold, J. K., Poyner, D. R., & Hay, D. L. Calcitonin and calcitonin receptor-like receptors: Common themes with family B GPCRs? British Journal of Pharmacology (2012) 166(1): 51-65.

Bashiri, G., Perkowski, E. F., Turner, A. P., Feltcher, M. E., Braunstein, M., & Baker, E. N. Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis. PLoS ONE (2012) 7(10): e45003.

Benzler, J., Ganjam, G. K., Kruger, M., Pinkenburg, O., Kutschke, M., Stohr, S., Steger, J., Koch, C. E., Olkrug, R., Schwartz, M. W., Shepherd, P. R., Grattan, D. R., & Tups, A. Hypothalamic glycogen synthase kinase 3beta has a central role in the regulation of food intake and glucose metabolism. Biochemical Journal (2012) 447: 175-184.

Berney, M., Weimar, M. R., Heikal, A., & Cook, G. M. Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia. Molecular Microbiology (2012) 84(4): 664-681.

Blumenstein, M., McCowan, L. M. E., Wu, S., Cooper, G. J. S., & North, R. A. Plasma clusterin increased prior to small for gestational age (SGA) associated with preeclampsia and decreased prior to SGA in normotensive pregnancies. Reproductive Sciences (2012) 19(6): 650-657.

Bogle, G., & Dunbar, P. R. On-lattice simulation of T cell motility, chemotaxis, and trafficking in the lymph node paracortex. PLoS ONE (2012) 7(9): e45258.

Brimble, M. A., Haym, I., Sperry, J., & Furkert, D. P. Synthesis of the tetracyclic core of berkelic acid using gold(I)-catalyzed hydroarylation and oxidative radical cyclizations. Organic Letters (2012) 14(23): 5820-5823.

Broadbent, E., Kahokehr, A., Booth, R. J., Thomas, J., Windsor, J. A., Buchanan, C. M., Wheeler, B. R. L., Sammour, T., & Hill, A. G. A brief relaxation intervention reduces stress and improves surgical wound healing response: A randomised trial. Brain, Behavior, and Immunity (2012) 26(2): 212-217. [pdf]

Buchanan, C. M., Shih, J. H., Astin, J. W., Rewcastle, G. W., Flanagan, J. U., Crosier, P. S., & Shepherd, P. R. DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. Clinical Science (2012) 122(10): 449-457. [pdf]

Bunker, R. D., Dickson, J. M. J., Caradoc-Davies, T. T., Loomes, K. M., & Baker, E. N. Use of a repetitive seeding protocol to obtain diffraction-quality crystals of a putative human D-xylulokinase. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2012) 68(10): 1259-1262.

Busby, J. N., Landsberg, M. J., Simpson, R. M., Jones, S. A., Hankamer, B., Hurst, M. R. H., & Lott, J. S. Structural analysis of Chi1 chitinase from Yen-Tc: The multisubunit insecticidal ABC toxin complex of Yersinia entomophaga. Journal of Molecular Biology (2012) 415(2): 359-371.

Caldon, C. E., Sergio, C. M., Kang, J., Muthukaruppan, A., Boersma, M. N., Stone, A., Barraclough, J., Lee, C. S., Black, M. A., Miller, L. D., Gee, J. M., Nicholson, R. I., Sutherland, R. L., Print, C. G., & Musgrove, E. A. Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells. Molecular Cancer Therapeutics (2012) 11(7): 1488-1499.

Chi, G., Manos-Turvey, A., O’Connor, P. D., Johnston, J. M., Evans, G. L., Baker, E. N., Payne, R. J., Lott, J. S., & Bulloch, E. M. M. Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry (2012) 51(24): 4868-4879.

Chiu, E., Coulibaly, F., & Metcalf, P. Insect virus polyhedra, infectious protein crystals that contain virus particles. Current Opinion in Structural Biology (2012) 22(2): 234- 240.

Chorley, D. F., Chen, J. L. Y., Furkert, D. P., Sperry, J., & Brimble, M. A. Total synthesis of danshenspiroketallactone. Synlett (2012) 1: 128-130.

Clark, G. R., Pytel, P. D., & Squire, C. J. The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages. Nucleic Acids Research (2012) 40(12): 5731-5738.

Cook, G. M., & Heikal, A. Bridging the gap between a TB drug and its target. Science Translational Medicine (2012) 4(150): 150fs33.

Cooper, G. J. S. Selective divalent copper chelation for the treatment of diabetes mellitus. Current Medicinal Chemistry (2012) 19(17): 2828-2860.

Coulibaly, F., Lassalle, E., Baker, H. M., & Baker, E. N. Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis. Acta Crystallographica Section D: Biological Crystallography (2012) 68(5): 553-563.

Dangerfield, E. M., Cheng, J. M. H., Knight, D. A., Weinkove, R., Dunbar, P. R., Hermans, I. F., Timmer, M. S. M., & Stocker, B. L. Species-specific activity of glycolipid ligands for invariant NKT cells. ChemBioChem (2012) 13(9): 1349-1356.

Dbouk, H. A., Vadas, O., Shymanets, A., Burke, J. E., Salamon, R. S., Khalil, B. D., Barrett, M. O., Waldo, G. L., Surve, C., Hsueh, C., Perisic, O., Harteneck, C., Shepherd, P. R., Harden, T. K., Smrcka, A. V., Taussig, R., Bresnick, A. R., Nurnberg, B., Williams, R. L., & Backer, J. M. G protein-coupled receptor-mediated activation of p110 beta by G beta gamma is required for cellular transformation and invasiveness. Science Signaling (2012) 5(253): ra89.

De Bono, B., & Hunter, P. Integrating knowledge representation and quantitative modelling in physiology. Biotechnology Journal (2012) 7(8): 958-972. [pdf]

Dimitrov, I., Furkert, D. P., Fraser, J. D., Radcliff, F. J., Finch, O., & Brimble, M. A. Synthesis and anti-Helicobacter pylori activity of analogues of spirolaxine methyl ether. MedChemComm (2012) 3(8): 944-949.

Donges, C. E., Burd, N. A., Duffield, R., Smith, G. C., West, D. W. D., Short, M. J., Mackenzie, R., Plank, L. D., Shepherd, P. R., Phillips, S. M., & Edge, J. A. Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men. Journal of Applied Physiology (2012) 112(12): 1992-2001.

Enomoto, N., Hyde, E., Ma, J. Z. I., Yang, J., Forbes-Blom, E., Delahunt, B., Le Gros, G., & Ronchese, F. Allergen-specific CTL require perforin expression to suppress allergic airway inflammation. Journal of Immunology (2012) 188(4): 1734-1741.

Evans, C. W., Hellman, L., Middleditch, M., Wojnar, J. M., Brimble, M. A., & Devries, A. L. Synthesis and recycling of antifreeze glycoproteins in polar fishes. Antarctic Science (2012) 24(3): 259-268. [pdf]

Evans, C. W., Williams, D. E., Vacchi, M., Brimble, M. A., & DeVries, A. L. Metabolic and behavioural adaptations during early development of the Antarctic silverfish, Pleuragramma antarcticum. Polar Biology (2012) 35(6): 891-898.

Evans, G. E., Martinez-Conejero, J. A., Phillipson, G. T. M., Simon, C., Mcnoe, L. A., Sykes, P. H., Horcajadas, J. A., Lam, E. Y. N., Print, C. G., Sin, I. L., & Evans, J. J. Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. Fertility and Sterility (2012) 97(6): 1365-1373.

Fernandez, J. W., Haque, M. Z. U., Hunter, P. J., & Mithraratne, K. Mechanics of the foot Part 1: A continuum framework for evaluating soft tissue stiffening in the pathologic foot. International Journal for Numerical Methods in Biomedical Engineering (2012) 28(10): 1056-1070.

Fernandez, J. W., Shim, V. B., & Hunter, P. J. Integrating degenerative mechanisms in bone and cartilage: A multiscale approach. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) (2012): 6616-6619.

Flanagan, J. U., Yosaatmadja, Y., Teague, R. M., Chai, M. Z. L., Turnbull, A. P., & Squire, C. J. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PLoS ONE (2012) 7(8): e43965.

Forbes-Blom, E., Camberis, M., Prout, M., Tang, S. C., & Le Gros, G. Staphylococcalderived superantigen enhances peanut induced Th2 responses in the skin. Clinical and Experimental Allergy (2012) 42(2): 305-314.

Ge, Q., Moir, L. M., Trian, T., Niimi, K., Poniris, M., Shepherd, P. R., Black, J. L., Oliver, B. G., & Burgess, J. K. The phosphoinositide 3'-kinase p110delta modulates contractile protein production and IL-6 release in human airway smooth muscle. Journal of Cellular Physiology (2012) 227(8): 3044-3052.

Geng, H., Chen, J. Y., Furkert, D., Jiang, S., & Brimble, M. A. A convergent synthesis of the 2-formylpyrrole spiroketal natural product acortatarin A. Synlett (2012) 23(6): 855-858. [pdf]

Goodall, K. J., Brimble, M. A., & Barker, D. A tandem Diels-Alder/Mannich approach to the synthesis of AE and ABE ring analogues of Delphinium alkaloids. Tetrahedron (2012) 68(29): 5759-5778.

Han, J. C., Taberner, A. J., Tran, K., Goo, S., Nickerson, D. P., Nash, M. P., Nielsen, P. M. F., Crampin, E. J., & Loiselle, D. S. Comparison of the Gibbs and Suga formulations of cardiac energetics: The demise of “isoefficiency”. Journal of Applied Physiology (2012) 113(7): 996-1003.

Han, J. C., Taberner, A. J., Tran, K., Nickerson, D. P., Nash, M. P., Nielsen, P. M. F., Crampin, E. J., & Loiselle, D. S. Relating components of pressure-volume area in Suga’s formulation of cardiac energetics to components of the stress-time integral. Journal of Applied Physiology (2012) 113(7): 988-995.

Han, J. C., Tran, K., Taberner, A. J., Nickerson, D. P., Kirton, R. S., Nielsen, P. M. F., Ward, M. L., Nash, M. P., Crampin, E. J., & Loiselle, D. S. Myocardial twitch duration and the dependence of oxygen consumption on pressure-volume area: Experiments and modelling. Journal of Physiology (2012) 590(18): 4603-4622.

Harris, P. W., Lee, D. J., & Brimble, M. A. A slow gradient approach for the purification of synthetic polypeptides by reversed phase high performance liquid chromatography. Journal of Peptide Science (2012) 18(9): 549-555.

Harris, P. W. R., & Brimble, M. A. The chemical synthesis of the collagenous domain of the hormone adiponectin. International Journal of Peptide Research and Therapeutics (2012) 18(1): 63-70.

Harrison, A. N., Reichau, S., & Parker, E. J. Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Bioorganic and Medicinal Chemistry Letters (2012) 22(2): 907-911.

Haym, I., & Brimble, M. A. The Kulinkovich hydroxycyclopropanation reaction in natural product synthesis. Organic & Biomolecular Chemistry (2012) 10(38): 7649- 7665.

Heapy, A. M., Williams, G. M., Fraser, J. D., & Brimble, M. A. Synthesis of a dicarba analogue of human beta-defensin-1 using a combined ring closing metathesis-native chemical ligation strategy. Organic Letters (2012) 14(3): 878-881.

Henare, K., Wang, L., Wang, L. C., Thomsen, L., Tijono, S., Chen, C. J., Winkler, S., Dunbar, P. R., Print, C., & Ching, L. M. Dissection of stromal and cancer cell-derived signals in melanoma xenografts before and after treatment with DMXAA. British Journal of Cancer (2012) 106(6): 1134-1147.

Herbert, K. R., Williams, G. M., Cooper, G. J. S., & Brimble, M. A. Synthesis of glycosylated 5-hydroxylysine, an important amino acid present in collagen-like proteins such as adiponectin. Organic and Biomolecular Chemistry (2012) 10(6): 1137-1144. [pdf]

Herbst, T., Esser, J., Prati, M., Kulagin, M., Stettler, R., Zaiss, M. M., Hewitson, J. P., Merky, P., Verbeek, J. S., Bourquin, C., Camberis, M., Prout, M., Maizels, R. M., Le Gros, G., & Harris, N. L. Antibodies and IL-3 support helminth-induced basophil expansion. Proceedings of the National Academy of Sciences of the United States of America (2012) 109(37): 14954-14959

Hermans, S. J., Baker, H. M., Sequeira, R. P., Langley, R. J., Baker, E. N., & Fraser, J. D. Structural and functional properties of staphylococcal superantigen-like protein 4. Infection and Immunity (2012) 80(11): 4004-4013.

Hickey, A. J. R., Jüllig, M., Aitken, J., Loomes, K., Hauber, M. E., & Phillips, A. R. J. Birds and longevity: Does flight driven aerobicity provide an oxidative sink? Ageing Research Reviews (2012) 11(2): 242-253.

Hobbs, J. K., Shepherd, C., Saul, D. J., Demetras, N. J., Haaning, S., Monk, C. R., Daniel, R. M., & Arcus, V. L. On the origin and evolution of thermophily: Reconstruction of functional precambrian enzymes from ancestors of Bacillus. Molecular Biology and Evolution (2012) 29(2): 825-835.

Horsfield, J. A., Print, C. G., & Monnich, M. Diverse developmental disorders from the one ring: Distinct molecular pathways underlie the cohesinopathies. Frontiers in Genetics (2012) 3: 171.

Huisman, F. H. A., Koon, N., Bulloch, E. M. M., Baker, H. M., Baker, E. N., Squire, C. J., & Parker, E. J. Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding. Biochemistry (2012) 51(11): 2289- 2297. [pdf]

Hume, P., Furkert, D. P., & Brimble, M. A. Regioselective iridium(I)-catalysed remote borylation of oxygenated naphthalenes. Tetrahedron Letters (2012) 53(29): 3771- 3773.

Hume, P. A., Brimble, M. A., & Reynisson, J. The bioreductive alkylation of DNA by kalafungin: A theoretical investigation. Australian Journal of Chemistry (2012) 65(4): 402-408. [pdf]

Hume, P. A., Brimble, M. A., & Reynisson, J. DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems. Computational and Theoretical Chemistry (2012) 1005: 9-15.

Hung, K. Y., Harris, P. W. R., & Brimble, M. A. Synthesis of the peptaibol framework of the anticancer agent culicinin D: Stereochemical assignment of the AHMOD moiety. Organic Letters (2012) 14(22): 5784-5787.

Hunn, M. K., Farrand, K. J., Broadley, K. W. R., Weinkove, R., Ferguson, P., Miller, R. J., Field, C. S., Petersen, T., McConnell, M. J., & Hermans, I. F. Vaccination with irradiated tumor cells pulsed with an adjuvant that stimulates NKT cells is an effective treatment for glioma. Clinical Cancer Research (2012) 18(23): 6446-6459.

Hunter, F. W., Wang, J., Patel, R., Hsu, H. L., Hickey, A. J. R., Hay, M. P., & Wilson, W. R. Homologous recombination repair-dependent cytotoxicity of the benzotriazine di- N-oxide CEN-209: Comparison with other hypoxia-activated prodrugs. Biochemical Pharmacology (2012) 83(5): 574-585.

Hurley, D., Araki, H., Tamada, Y., Dunmore, B., Sanders, D., Humphreys, S., Affara, M., Imoto, S., Yasuda, K., Tomiyasu, Y., Tashiro, K., Savoie, C., Cho, V., Smith, S., Kuhara, S., Miyano, S., Charnock-Jones, D. S., Crampin, E. J., & Print, C. G. Gene network inference and visualization tools for biologists: Application to new human transcriptome datasets. Nucleic Acids Research (2012) 40(6): 2377-2398.

Jackson, V. J., Yosaatmadja, Y., Flanagan, J. U., & Squire, C. J. Structure of AKR1C3 with 3-phenoxybenzoic acid bound. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2012) 68(4): 409-413.

Jamieson, S. M. F., Brooke, D. G., Heinrich, D., Atwell, G. J., Silva, S., Hamilton, E. J., Turnbull, A. P., Rigoreau, L. J. M., Trivier, E., Soudy, C., Samlal, S. S., Owen, P. J., Schroeder, E., Raynham, T., Flanagan, J. U., & Denny, W. A. 3-(3,4-dihydroisoquinolin-2(1 H)-ylsulfonyl)benzoic acids: Highly potent and selective inhibitors of the type 5 17-beta-hydroxysteroid dehydrogenase AKR1C3. Journal of Medicinal Chemistry (2012) 55(17): 7746-7758.

Jiao, W., Hutton, R. D., Cross, P. J., Jameson, G. B., & Parker, E. J. Dynamic crosstalk among remote binding sites: The molecular basis for unusual synergistic allostery. Journal of Molecular Biology (2012) 415(4): 716-726.

Jiao, W. T., & Parker, E. J. Using a combination of computational and experimental techniques to understand the molecular basis for protein allostery. Structural and Mechanistic Enzymology: Bringing Together Experiments and Computing (2012) 87: 391-413.

Kang, H. J., & Baker, E. N. Structure and assembly of Gram-positive bacterial pili: Unique covalent polymers. Current Opinion in Structural Biology (2012) 22(2): 200-207.

Kaur, H., Heapy, A. M., & Brimble, M. A. Synthesis of the all-l cyclopentapeptides versicoloritides A, B, and C. Synlett (2012) 23(15): 2284-2288.

Kaur, H., Heapy, A. M., & Brimble, M. A. Synthesis of the antifungal cyclic peptides tunicyclins C and D. Synlett (2012) 2: 275-277.

Kendall, J. D., Giddens, A. C., Tsang, K. Y., Frédérick, R., Marshall, E. S., Singh, R., Lill, C. L., Lee, W. J., Kolekar, S., Chao, M., Malik, A., Yu, S., Chaussade, C., Buchanan, C., Rewcastle, G. W., Baguley, B. C., Flanagan, J. U., Jamieson, S. M. F., Denny, W. A., & Shepherd, P. R. Novel pyrazolo[1,5-a]pyridines as p110alpha-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR. Bioorganic and Medicinal Chemistry (2012) 20(1): 58-68.

Kendall, J. D., O’Connor, P. D., Marshall, A. J., Frédérick, R., Marshall, E. S., Lill, C. L., Lee, W. J., Kolekar, S., Chao, M., Malik, A., Yu, S., Chaussade, C., Buchanan, C., Rewcastle, G. W., Baguley, B. C., Flanagan, J. U., Jamieson, S. M. F., Denny, W. A., & Shepherd, P. R. Discovery of pyrazolo[1,5-a]pyridines as p110alpha-selective PI3 kinase inhibitors. Bioorganic and Medicinal Chemistry (2012) 20(1): 69-85. [pdf]

Kowalczyk, R., Brimble, M. A., Callon, K. E., Watson, M., & Cornish, J. How to blast osteoblasts? Novel dicarba analogues of amylin-(1-8) to treat osteoporosis. Bioorganic and Medicinal Chemistry (2012) 20(20): 6011-6018.

Kowalczyk, R., Harris, P. W. R., Brimble, M. A., Callon, K. E., Watson, M., & Cornish, J. Synthesis and evaluation of disulfide bond mimetics of amylin-(1-8) as agents to treat osteoporosis. Bioorganic and Medicinal Chemistry (2012) 20(8): 2661-2668.

Kueh, J. T. B., Choi, K. W., & Brimble, M. A. Enantioselective synthesis of C-linked spiroacetal-triazoles as privileged natural product-like scaffolds. Organic and Biomolecular Chemistry (2012) 10(30): 5993-6002.

Lancaster, G. I., Skiba, B., Yang, C., Nicholls, H. T., Langley, K. G., Chan, M. H., Bruce, C. R., Rewcastle, G. W., Shepherd, P. R., Karin, M., & Febbraio, M. A. IkappaB kinase beta (IKKbeta) does not mediate feedback inhibition of the insulin signalling cascade. Biochemical Journal (2012) 442(3): 723-732. [pdf]

Lasham, A., Samuel, W., Cao, H., Patel, R., Mehta, R., Stern, J. L., Reid, G., Woolley, A. G., Miller, L. D., Black, M. A., Shelling, A. N., Print, C. G., & Braithwaite, A. W. YB-1, the E2F pathway, and regulation of tumor cell growth. Journal of the National Cancer Institute (2012) 104(2): 133-146.

Lee, D. J., Yang, S. H., Williams, G. M., & Brimble, M. A. Synthesis of multivalent neoglyconjugates of MUC1 by the conjugation of carbohydrate-centered, triazolelinked glycoclusters to MUC1 peptides using click chemistry. Journal of Organic Chemistry (2012) 77(17): 7564-7571.

Lim, S. N., Kuhn, S., Hyde, E., & Ronchese, F. Combined TLR stimulation with Pam3Cys and Poly I: C enhances Flt3-ligand dendritic cell activation for tumor immunotherapy. Journal of Immunotherapy (2012) 35(9): 670-679.

Linke, C., Siemens, N., Middleditch, M. J., Kreikemeyer, B., & Baker, E. N. Purification, crystallization and preliminary crystallographic analysis of the adhesion domain of Epf from Streptococcus pyogenes. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2012) 68(7): 793-797.

Linke, C., Siemens, N., Oehmcke, S., Radjainia, M., Law, R. H. P., Whisstock, J. C., Baker, E. N., & Kreikemeyer, B. The extracellular protein factor epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an n-terminal domain containing a carbohydrate-binding module. Journal of Biological Chemistry (2012) 287(45): 38178-38189.

Liu, X., Chia, E., Shaw, O. M., Martin, W. J., & Harper, J. L. Rapid CCL2 release by membrane stromal cells initiates monosodium urate crystal-induced monocyte recruitment in a peritoneal model of gouty inflammation. European Journal of Inflammation (2012) 10(2): 165-174.

McKee, S. J., Young, V. L., Clow, F., Hayman, C. M., Baird, M. A., Hermans, I. F., Young, S. L., & Ward, V. K. Virus-like particles and a-galactosylceramide form a self-adjuvanting composite particle that elicits anti-tumor responses. Journal of Controlled Release (2012) 159(3): 338-345.

McLeod, M. C., Brimble, M. A., Rathwell, D. C. K., Wilson, Z. E., & Yuen, T. Y. Synthetic approaches to [5,6]-benzannulated spiroketal natural products. Pure and Applied Chemistry (2012) 84(6): 1379-1390.

McLeod, M. C., Wilson, Z. E., & Brimble, M. A. Formal synthesis of berkelic acid: A lesson in alpha-alkylation chemistry. Journal of Organic Chemistry (2012) 77(1): 400-416.

Noble, D., Kurachi, Y., Hunter, P., Wang, X., Gordon, M., & Boron, W. Physiology without borders 2. Physiology (2012) 27(1): 2. 

Pantham, P., Rosario, R., Chen, Q., Print, C. G., & Chamley, L. W. Transcriptomic analysis of placenta affected by antiphospholipid antibodies: following the TRAIL of trophoblast death. Journal of Reproductive Immunology (2012) 94(2): 151-154.

Papst, S., Noisier, A., Brimble, M. A., Yang, Y., & Krissansen, G. W. Tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY prepared via Click Chemistry: Synthesis and biological evaluation. Bioorganic and Medicinal Chemistry (2012) 20(8): 2638-2644. [pdf]

Papst, S., Noisier, A. F. M., Brimble, M. A., Yang, Y., Chan, Y. C., & Krissansen, G. W. Synthesis and SAR of a library of cell-permeable biotin-R8ERY*peptidomimetics inhibiting α4β7 integrin mediated adhesion of TK-1 cells to MAdCAM -1-Fc. Australian Journal of Chemistry (2012) 65(9): 1349-1358.

Papst, S., Noisier, A. F. M., Brimble, M. A., Yang, Y., & Krissansen, G. W. Synthesis and biological evaluation of tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY. Bioorganic and Medicinal Chemistry (2012) 20(17): 5139-5149. [pdf]

Peltier, R., Siah, W. R., Williams, G. V. M., Brimble, M. A., Tilley, R. D., & Williams, D. E. Novel phosphopeptides as surface-active agents in iron nanoparticle synthesis. Australian Journal of Chemistry (2012) 65(6): 680-685. [pdf]

Poyner, D. R., & Hay, D. L. Secretin family (Class B) G protein-coupled receptors - From molecular to clinical perspectives. British Journal of Pharmacology (2012) 166(1): 1-3.

Radcliff, F. J., Loh, J. M. S., Ha, B., Schuhbauer, D., McCluskey, J., & Fraser, J. D. Antigen targeting to major histocompatibility complex class II with streptococcal mitogenic exotoxin Z-2 M1, a superantigen-based vaccine carrier. Clinical and Vaccine Immunology (2012) 19(4): 574-586.

Radjainia, M., Huang, B., Bai, B., Schmitz, M., Yang, S. H., Harris, P. W. R., Griffin, M. D. W., Brimble, M. A., Wang, Y., & Mitra, A. K. A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin. FEBS Journal (2012) 279(14): 2495-2507.

Rennison, D., Laita, O., Bova, S., Cavalli, M., Hopkins, B., Linthicum, D. S., & Brimble, M. A. Design and synthesis of prodrugs of the rat selective toxicant norbormide. Bioorganic and Medicinal Chemistry (2012) 20(13): 3997-4011.

Rich, F. J., Kuhn, S., Hyde, E. J., Harper, J. L., Ronchese, F., & Kirman, J. R. Induction of T cell responses and recruitment of an inflammatory dendritic cell subset following tumor immunotherapy with Mycobacterium smegmatis. Cancer Immunology, Immunotherapy (2012) 61(12): 2333-2342.

Richter, S., Richter, J. P., Mehta, S. Y., Gribble, A. M., Sutherland-Smith, A. J., Stowell, K. M., Print, C. G., Ronimus, R. S., & Wilson, W. R. Expression and role in glycolysis of human ADP-dependent glucokinase. Molecular and Cellular Biochemistry (2012) 364(1-2): 131-145. [pdf]

Rosario, R., Araki, H., Print, C. G., & Shelling, A. N. The transcriptional targets of mutant FOXL2 in granulosa cell tumours. PLoS ONE (2012) 7(9): e46270.

Schünemann, K., Connelly, S., Kowalczyk, R., Sperry, J., Wilson, I. A., Fraser, J. D., & Brimble, M. A. A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors. Bioorganic and Medicinal Chemistry Letters (2012) 22(15): 5018-5024.

Shepherd, P. R., & Denny, W. A. Beta-testing of PI3-kinase inhibitors: Is beta better? Cancer Discovery (2012) 2(5): 393-394.

Shepherd, P. R., & Denny, W. A. Drug discovery in the academic environment: The academic model. Biochemist (2012) 34(1): 4-6.

Smith, G. C., Ong, W. K., Rewcastle, G. W., Kendall, J. D., Han, W., & Shepherd, P. R. Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo. Biochemical Journal (2012) 442(1): 161-169.

Sparrow, K., Barker, D., & Brimble, M. A. An efficient synthesis of 3-alkyl-1,5,3- dioxazepanes and their use as electrophiles in double-Mannich reactions. Tetrahedron (2012) 68(4): 1017-1028.

Stubbing, L. A., Li, F. F., Furkert, D. P., Caprio, V. E., & Brimble, M. A. Access to 2-alkyl chromanones via a conjugate addition approach. Tetrahedron (2012) 68(34): 6948-6956.

Swe, P. M., Copp, J. N., Green, L. K., Guise, C. P., Mowday, A. M., Smaill, J. B., Patterson, A. V., & Ackerley, D. F. Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954. Biochemical Pharmacology (2012) 84(6): 775-783. [pdf]

Tang, R. Y., Li, K. Y., Wilson, M., Both, G. W., Taylor, J. A., & Young, S. L. Potent antietumor immunity in mice induced by vaccination with an ovine atadenovirus vector. Journal of Immunotherapy (2012) 35(1): 32-41. [pdf]

Wadsworth, A. D., Furkert, D. P., Sperry, J., & Brimble, M. A. Total synthesis of the initially reported and revised structures of the neuroprotective agent palmyrolide A. Organic Letters (2012) 14(20): 5374-5377.

Wang, L., Hurley, D. G., Watkins, W., Araki, H., Tamada, Y., Muthukaruppan, A., Ranjard, L., Derkac, E., Imoto, S., Miyano, S., Crampin, E. J., & Print, C. G. Cell cycle gene networks are associated with melanoma prognosis. PLoS ONE (2012) 7(4): e34247.

Wang, Y. P., Gjuvsland, A. B., Vik, J. O., Smith, N. P., Hunter, P. J., & Omholt, S. W. Parameters in dynamic models of complex traits are containers of missing heritability. PLoS Computational Biology (2012) 8(4): e1002459.

Watkins, H. A., Au, M., & Hay, D. L. The structure of secretin family GPCR peptide ligands: Implications for receptor pharmacology and drug development. Drug Discovery Today (2012) 17(17-18): 1006-1014.

Watkins, H. A., & Hay, D. L. Recent progress in unraveling the complexities of receptor biology: Towards new therapeutics. Expert Review of Clinical Pharmacology (2012) 5(2): 145-147.

Wilmes, A., Hanna, R., Heathcott, R. W., Northcote, P. T., Atkinson, P. H., Bellows, D. S., & Miller, J. H. Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae. Gene (2012) 497(2): 140-146.

Woods, T. M., Kamalov, M., Harris, P. W. R., Cooper, G. J. S., & Brimble, M. Synthesis of monolysyl advanced glycation endproducts and their incorporation into collagen model peptides. Organic Letters (2012) 14(22): 5740-5743.

Yeung, H., Lee, D. J., Williams, G. M., Harris, P. W. R., Dunbar, R. P., & Brimble, M. A. A method for the generation of Pam(2)Cys-based lipopeptide mimics via CuAAC click chemistry. Synlett (2012) 11: 1617-1620.

Yibmantasiri, P., Leahy, D. C., Busby, B. P., Angermayr, S. A., Sorgo, A. G., Boeger, K., Heathcott, R., Barber, J. M., Moraes, G., Matthews, J. H., Northcote, P. T., Atkinson, P. H., & Bellows, D. S. Molecular basis for fungicidal action of neothyonidioside, a triterpene glycoside from the sea cucumber, Australostichopus mollis. Molecular BioSystems (2012) 8(3): 902-912. [pdf]

Yuen, T. Y., & Brimble, M. A. Total synthesis of 7’,8’-dihydroaigialospirol. Organic Letters (2012) 14(19): 5154-5157.

Zheng, Z. H., Amran, S. I., Zhu, J. X., Schmidt-Kittler, O., Kinzler, K. W., Vogelstein, B., Shepherd, P. R., Thompson, P. E., & Jennings, I. G. Definition of the binding mode of a new class of phosphoinositide 3-kinase alpha-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis. Biochemical Journal (2012) 444(3): 529-535.

2011

Affara, M., Dunmore, B. J., Sanders, D. A., Johnson, N., Print, C. G., & Charnock- Jones, D. S. MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms. BMC Genomics (2011) 12:43.

Allison, T. M., Hutton, R. D., Cochrane, F. C., Yeoman, J. A., Jameson, G. B., & Parker, E. J. Targeting the role of a key conserved motif for substrate selection and catalysis by 3-Deoxy-D-Manno-octulosonate 8-Phosphate synthase. Biochemistry (2011) 50(18): 3686-3695.

Allison, T. M., Hutton, R. D., Jiao, W., Gloyne, B. J., Nimmo, E. B., Jameson, G. B., & Parker, E. J. An extended beta7alpha7 substrate-binding loop is essential for efficient catalysis by 3-deoxy-d-Manno-octulosonate 8-Phosphate synthase. Biochemistry (2011) 50(43): 9318-9327.

Archbold, J. K., Flanagan, J. U., Watkins, H. A., Gingell, J. J., & Hay, D. L. Structural insights into RAMP modification of secretin family G protein-coupled receptors: Implications for drug development. Trends in Pharmacological Sciences (2011) 32(10): 591-600.

Arcus, V. L., McKenzie, J. L., Robson, J., & Cook, G. M. The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array. Protein Engineering, Design and Selection (2011) 24(1-2): 33-40.

Atkinson, D. J., Sperry, J., & Brimble, M. A. Synthesis of benzotriazole analogues of the helicobactericidal agents CJ-13,015, CJ-13,102, CJ-13,108, and CJ-13,104 using a regioselective 1,3-dipolar cycloaddition. Synlett (2011) 1: 99-103.

Benson, M. A., Lilo, S., Wasserman, G. A., Thoendel, M., Smith, A., Horswill, A. R., Fraser, J., Novick, R. P., Shopsin, B., & Torres, V. J. Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner. Molecular Microbiology (2011) 81(3): 659-675.

Best, N., Fraser, J. D., Rainey, P. B., Roberts, S. A., Thomas, M. G., & Ritchie, S. R. Nasal carriage of Staphylococcus aureus in healthy Aucklanders. New Zealand Medical Journal (2011) 124(1332): 30-39.

Bircham, P. W., Maass, D. R., Roberts, C. A., Kiew, P. Y., Low, Y. S., Yegambaram, M., Matthews, J., Jack, C. A., & Atkinson, P. H. Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Molecular BioSystems (2011) 7(9): 2589-2598.[pdf]

Bonnet, M., Flanagan, J. U., Chan, D. A., Lai, E. W., Nguyen, P., Giaccia, A. J., & Hay, M. P. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells. Bioorganic and Medicinal Chemistry (2011) 19(11): 3347-3356.

Bradley, C., Bowery, A., Britten, R., Budelmann, V., Camara, O., Christie, R., Cookson, A., Frangi, A. F., Gamage, T. B., Heidlauf, T., Krittian, S., Ladd, D., Little, C., Mithraratne, K., Nash, M., Nickerson, D., Nielsen, P., Nordbo, O., Omholt, S., Pashaei, A., Paterson, D., Rajagopal, V., Reeve, A., Rohrle, O., Safaei, S., Sebastian, R., Steghofer, M., Wu, T., Yu, T., Zhang, H. Y., & Hunter, P. OpenCMISS: A multi-physics & multi-scale computational infrastructure for the VPH/Physiome project. Progress in Biophysics & Molecular Biology (2011) 107(1): 32-47. [pdf]

Brimble, M. A., Finch, O. C., Heapy, A. M., Fraser, J. D., Furkert, D. P., & O’Connor, P. D. A convergent synthesis of the [4.4]-Spiroacetal-gamma-lactones cephalosporolides E and F. Tetrahedron (2011) 67(5): 995-1001.

Broadley, K., Larsen, L., Herst, P. M., Smith, R. A. J., Berridge, M. V., & McConnell, M. J. The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress. Journal of Cellular Biochemistry (2011) 112(7): 1869-1879.

Broadley, K. W. R., Hunn, M. K., Farrand, K. J., Price, K. M., Grasso, C., Miller, R. J., Hermans, I. F., & McConnell, M. J. Side population is not necessary or sufficient for a cancer stem cell phenotype in glioblastoma multiforme. Stem Cells (2011) 29(3): 452-461.

Chan, D. A., Sutphin, P. D., Nguyen, P., Turcotte, S., Lai, E. W., Banh, A., Reynolds, G. E., Chi, J. T., Wu, J., Solow-Cordero, D. E., Bonnet, M., Flanagan, J. U., Bouley, D. M., Graves, E. E., Denny, W. A., Hay, M. P., & Giaccia, A. J. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Science Translational Medicine (2011) 3(94): 94ra70.

Chang, A., Khemlani, A., Kang, H., & Proft, T. Functional analysis of Streptococcus pyogenes nuclease A (SpnA), a novel group A streptococcal virulence factor. Molecular Microbiology (2011) 79(6): 1629-1642.

Chen, J. L. Y., & Brimble, M. A. Synthesis of the bis-spiroacetal core of the antimitotic agent spirastrellolide B. Journal of Organic Chemistry (2011) 76(22): 9417-9428.

Chen, J. L. Y., Sperry, J., Ip, N. Y., & Brimble, M. A. Natural products targeting telomere maintenance. MedChemComm (2011) 2(4): 229-245.

Cheng, J. M. H., Chee, S. H., Knight, D. A., Acha-Orbea, H., Hermans, I. F., Timmer, M. S. M., & Stocker, B. L. An improved synthesis of dansylated alpha-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells. Carbohydrate Research (2011) 346(7): 914-926.

Chim, N., Habel, J. E., Johnston, J. M., Krieger, I., Miallau, L., Sankaranarayanan, R., Morse, R. P., Bruning, J., Swanson, S., Kim, H., Kim, C. Y., Li, H., Bulloch, E. M., Payne, R. J., Manos-Turvey, A., Hung, L. W., Baker, E. N., Lott, J. S., James, M. N. G., Terwilliger, T. C., Eisenberg, D. S., Sacchettini, J. C., & Goulding, C. W. The TB Structural Genomics Consortium: A decade of progress. Tuberculosis (2011) 91(2): 155-172.

Cooper, G. J. S. Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer’s disease. Drugs (2011) 71(10): 1281- 1320. [pdf]

Costa, J. L., Smith, G., Watson, M., Lin, J. M., Callon, K., Gamble, G., Cheng, A., Vickers, M. H., Shepherd, P. R., Cornish, J., & Grey, A. The atypical anti-psychotic clozapine decreases bone mass in rats in vivo. Schizophrenia Research (2011) 126(1-3): 291-297.

Cross, P. J., Dobson, R. C. J., Patchett, M. L., & Parker, E. J. Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis. Journal of Biological Chemistry (2011) 286(12): 10216-10224.

Didsbury, A., Wang, C., Verdon, D., Sewell, M., McIntosh, J., & Taylor, J. Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells. Virology Journal (2011) 8(1): 551.

Dogra, M., Palmer, B. D., Bashiri, G., Tingle, M. D., Shinde, S. S., Anderson, R. F., O’Toole, R., Baker, E. N., Denny, W. A., & Helsby, N. A. Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver. British Journal of Pharmacology (2011) 162(1): 226-236.

Flanagan, J. U., & Smythe, M. L. Sigma-class glutathione transferases. Drug Metabolism Reviews (2011) 43(2): 194-214.

Fraser, J. D. Clarifying the mechanism of superantigen toxicity. PLoS Biology (2011) 9(9): e1001145.

Girvan, R. C., Knight, D. A., O’Loughlin, C. J., Hayman, C. M., Hermans, I. F., & Webster, G. A. MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity. Vaccine (2011) 29(3): 545-557. [pdf]

Guéret, S. M., & Brimble, M. A. Synthetic studies toward the spiroimine unit of the spirolides. Pure and Applied Chemistry (2011) 83(3): 425-433.

Hagbom, M., Istrate, C., Engblom, D., Karlsson, T., Rodriguez-Diaz, J., Buesa, J., Taylor, J. A., Loitto, V. M., Magnusson, K. E., Ahlman, H., Lundgren, O., & Svensson, L. Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting. PLoS Pathogens (2011) 7(7): e1002115.

Harris, P. W. R., Yang, S. H., & Brimble, M. A. An improved procedure for the preparation of aminomethyl polystyrene resin and its use in solid phase (peptide) synthesis. Tetrahedron Letters (2011) 52(45): 6024-6026.

Hay, D. L., Walker, C. S., & Poyner, D. R. Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: Opportunities and challenges. Endocrine-Related Cancer (2011) 18(1): C1-C14.

Ho, H., Suresh, V., Kang, W., Cooling, M. T., Watton, P. N., & Hunter, P. J. Multiscale modeling of intracranial aneurysms: Cell signaling, hemodynamics, and remodeling. IEEE Transactions on Biomedical Engineering (2011) 58(10 PART 2): 2974-2977.

Hume, P. A., Sperry, J., & Brimble, M. A. Enantioselective synthesis of pyranonaphthoquinone antibiotics using a CBS reduction/cross-metathesis/oxa- Michael strategy. Organic and Biomolecular Chemistry (2011) 9(15): 5423-5430. [pdf]

Hung, K. Y., Harris, P. W. R., Heapy, A. M., & Brimble, M. A. Synthesis and assignment of stereochemistry of the antibacterial cyclic peptide xenematide. Organic and Biomolecular Chemistry (2011) 9(1): 236-242.

Hurley, D., Araki, H., Tamada, Y., Dunmore, B., Sanders, D., Humphreys, S., Affara, M., Imoto, S., Yasuda, K., Tomiyasu, Y., Tashiro, K., Savoie, C., Cho, V., Smith, S., Kuhara, S., Miyano, S., Charnock-Jones, D. S., Crampin, E. J., & Print, C. G. Gene network inference and visualization tools for biologists: application to new human transcriptome datasets. Nucleic Acids Research (2011): 1-22.

Jamieson, S., Flanagan, J. U., Kolekar, S., Buchanan, C., Kendall, J. D., Lee, W. J., Rewcastle, G. W., Denny, W. A., Singh, R., Dickson, J., Baguley, B. C., & Shepherd, P. R. A drug targeting only p110 alpha can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochemical Journal (2011) 438: 53-62.

Jullig, M., Browett, P., Middleditch, M. M. J., Prijic, G., Kilfoyle, D., Angelo, N., & Cooper, G. J. S. A unique case of neural amyloidoma diagnosed by mass spectrometry of formalin-fixed tissue using a novel preparative technique. Amyloid (2011) 18(3): 147-155.

Kang, H. J., & Baker, E. N. Intramolecular isopeptide bonds: Protein crosslinks built for stress? Trends in Biochemical Sciences (2011) 36(4): 229-237.

Kang, H. J., Coulibaly, F., Proft, T., & Baker, E. N. Crystal structure of spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly. PLoS ONE (2011) 6(1): e15969.

Kaur, H., Heapy, A. M., & Brimble, M. A. The synthesis of dehydrotryptophan and dehydrotryptophan-containing peptides. Organic and Biomolecular Chemistry (2011) 9(17): 5897-5907. [pdf]

Le Nours, J., Bulloch, E. M. M., Zhang, Z., Greenwood, D. R., Middleditch, M. J., Dickson, J. M. J., & Baker, E. N. Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide. Journal of Biological Chemistry (2011) 286(47): 40706-40716.

Lee, D. J., Harris, P. W. R., & Brimble, M. A. Synthesis of MUC1 Neoglycopeptides using efficient microwave-enhanced chaotrope-assisted click chemistry. Organic and Biomolecular Chemistry (2011) 9(5): 1621-1626. [pdf]

Leung, E., Kim, J. E., Rewcastle, G. W., Finlay, G. J., & Baguley, B. C. Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifenresistant breast cancer cells. Cancer Biology & Therapy (2011) 11(11): 938-946.

Locke, M., Feisst, V., & Dunbar, P. R. Concise review: Human adipose-derived stem cells: Separating promise from clinical need. Stem Cells (2011) 29(3): 404-411.

Locke, M., Ussher, J. E., Mistry, R., Taylor, J. A., & Dunbar, P. R. Transduction of human adipose-derived mesenchymal stem cells by recombinant adeno-associated virus vectors. Tissue Engineering - Part C: Methods (2011) 17(9): 949-959.

Loomes, K. M. Survival of an islet beta-cell in type 2 diabetes Curbing the effects of amyloid cytotoxicity. Islets (2011) 3(1): 38-39.

Lu, G. L., Stevenson, R. J., Chang, J. Y. C., Brothers, P. J., Ware, D. C., Wilson, W. R., Denny, W. A., & Tercel, M. N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7- trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f] quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs. Bioorganic and Medicinal Chemistry (2011) 19(16): 4861-4867.

MacDonald, J. R., Oellermann, M., Rynbeck, S., Chang, G., Ruggiero, K., Cooper, G. J. S., & Hickey, A. J. R. Transmural differences in respiratory capacity across the rat left ventricle in health, aging, and streptozotocin-induced diabetes mellitus: Evidence that mitochondrial dysfunction begins in the subepicardium. American Journal of Physiology - Cell Physiology (2011) 300(2): C246-C255.

McLeod, M. C., Wilson, Z. E., & Brimble, M. A. An enantioselective formal synthesis of berkelic acid. Organic Letters (2011) 13(19): 5382-5385.  

McMillan, D. G. G., Ferguson, S. A., Dey, D., Schröder, K., Aung, H. L., Carbone, V., Attwood, G. T., Ronimus, R. S., Meier, T., Janssen, P. H., & Cook, G. M. A 1A o-ATP synthase of Methanobrevibacter ruminantium couples sodium ions for ATP synthesis under physiological conditions. Journal of Biological Chemistry (2011) 286(46): 39882- 39892.

Miller, A. K., Yu, T., Britten, R., Cooling, M. T., Lawson, J., Cowan, D., Garny, A., Halstead, M. D. B., Hunter, P. J., Nickerson, D. P., Nunns, G., Wimalaratne, S. M., & F Nielsen, P. M. Revision history aware repositories of computational models of biological systems. BMC Bioinformatics (2011) 12: 22.

Misirli, G., Hallinan, J. S., Yu, T., Lawson, J. R., Wimalaratne, S. M., Cooling, M. T., & Wipat, A. Model annotation for synthetic biology: Automating model to nucleotide sequence conversion. Bioinformatics (2011) 27(7): 973-979.

Mittal, A., Hickey, A. J. R., Chai, C. C., Loveday, B. P. T., Thompson, N., Dare, A., Delahunt, B., Cooper, G. J. S., Windsor, J. A., & Phillips, A. R. J. Early organ-specific mitochondrial dysfunction of jejunum and lung found in rats with experimental acute pancreatitis. HPB (Oxford) (2011) 13(5): 332-341.

Moir, L. M., Trian, T., Ge, Q., Shepherd, P. R., Burgess, J. K., Oliver, B. G. G., & Black, J. L. Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function. Journal of Pharmacology and Experimental Therapeutics (2011) 337(2): 557-566.

Mönnich, M., Kuriger, Z., Print, C. G., & Horsfield, J. A. A zebrafish model of roberts syndrome reveals that esco2 depletion interferes with development by disrupting the cell cycle. PLoS ONE (2011) 6(5): e20051.

Negron, L., & Parker, E. J. Fluorinated substrates result in variable leakage of a reaction intermediate during catalysis by dehydroquinate synthase. Organic and Biomolecular Chemistry (2011) 9(8): 2861-2867. [pdf]

Paterson, N. G., & Baker, E. N. Structure of the full-length major pilin from Streptococcus pneumoniae: Implications for isopeptide bond formation in grampositive bacterial pili. PLoS ONE (2011) 6(7): e22095.

Pather, K., Helsby, N.A., Palmer, B.D. & Ching, L.M. Development and validation of a high performance liquid chromatography assay for the determination of a fluorinated analogue of thalidomide, N-(2,6-dioxopiperidin-3-yl)-3,4,5,6- tetrafluorophthalamic acid and lenalidomide. Journal of Liquid Chromatography & Related Technologies (2011) 34(2): 83-92.

Pearce, F. G., Dobson, R. C. J., Jameson, G. B., Perugini, M. A., & Gerrard, J. A. Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization. Biochimica Et Biophysica Acta-Proteins and Proteomics (2011) 1814(12): 1900-1909.

Petersen, T. R., Sika-Paotonu, D., Knight, D. A., Simkins, H. M. A., & Hermans, I. F. Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines. PLoS ONE (2011) 6(3): e17657.

Qi, T., Ly, K., Poyner, D. R., Christopoulos, G., Sexton, P. M., & Hay, D. L. Structurefunction analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors. Peptides (2011) 32(5): 1060-1067.

Rehan, A. M., Bashiri, G., Paterson, N. G., Baker, E. N., & Squire, C. J. Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2011) 67(10): 1274-1277.

Reichau, S., Jiao, W., Walker, S. R., Hutton, R. D., Baker, E. N., & Parker, E. J. Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: Combining mechanism- and modeling-based design. Journal of Biological Chemistry (2011) 286(18): 16197-16207.

Rewcastle, G. W., Gamage, S. A., Flanagan, J. U., Frederick, R., Denny, W. A., Baguley, B. C., Kestell, P., Singh, R., Kendall, J. D., Marshall, E. S., Lill, C. L., Lee, W. J., Kolekar, S., Buchanan, C. M., Jamieson, S. M. F., & Shepherd, P. R. Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(Difluoromethyl)-1-[4,6-di(4- morpholinyl)-1,3,5-triazin-2- yl]-1 H -benzimidazole (ZSTK474). Journal of Medicinal Chemistry (2011) 54(20): 7105-7126.

Ritchie, S. R., Fraser, J. D., Libby, E., Morris, A. J., Rainey, P. B., & Thomas, M. G. Demographic variation in community-based MRSA skin and soft tissue infection in Auckland, New Zealand. New Zealand Medical Journal (2011) 124(1332): 21-30.

Shaw, O. M., & Harper, J. L. Bradykinin receptor 2 extends inflammatory cell recruitment in a model of acute gouty arthritis. Biochemical and Biophysical Research Communications (2011) 416(3–4): 266-269.

Simkins, H. M. A., Hyde, E., Farrand, K. J., Ong, M. L., Degli-Esposti, M. A., Hermans, I. F., & Ronchese, F. Administration of alpha-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo. Journal of Leukocyte Biology (2011) 89(5): 753-762.

Smith, G. C., Vickers, M. H., & Shepherd, P. R. Olanzapine effects on body composition, food preference, glucose metabolism and insulin sensitivity in the rat. Archives of Physiology and Biochemistry (2011) 117(4): 241-249.

Sparrow, K., Barker, D., & Brimble, M. A. The enantioselective synthesis of tetracyclic methyllycaconitine analogues. Tetrahedron (2011) 67(41): 7989-7999.

Sperry, J., Liu, Y. C., Wilson, Z. E., Hubert, J. G., & Brimble, M. A. Synthesis of benzannulated spiroketals using an oxidative radical cyclization. Synthesis (2011) (9): 1383-1398.

Stevenson, R. J., Denny, W. A., Ashoorzadeh, A., Pruijn, F. B., Van Leeuwen, W. F., & Tercel, M. The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy. Bioorganic and Medicinal Chemistry (2011) 19(20): 5989-5998.

Stewart, K. W., Phillips, A. R. J., Whiting, L., Jüllig, M., Middleditch, M. J., & Cooper, G. J. S. A simple and rapid method for identifying and semi-quantifying peptide hormones in isolated pancreatic islets by direct-tissue matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry (2011) 25(22): 3387-3395.

Szwergold, B. S., Bunker, R. D., & Loomes, K. M. The physiological substrates of fructosamine-3-kinase-related-protein (FN3KRP) are intermediates of nonenzymatic reactions between biological amines and ketose sugars (fructation products). Medical Hypotheses (2011) 77(5): 739-744.

Tercel, M., Atwell, G. J., Yang, S., Ashoorzadeh, A., Stevenson, R. J., Botting, K. J., Gu, Y., Mehta, S. Y., Denny, W. A., Wilson, W. R., & Pruijn, F. B. Selective treatment of hypoxic tumor cells in vivo: Phosphate pre-prodrugs of nitro analogues of the duocarmycins. Angewandte Chemie - International Edition (2011) 50(11): 2606-2609.

Thompson, A. M., Sutherland, H. S., Palmer, B. D., Kmentova, I., Blaser, A., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., & Denny, W. A. Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6 S)-2-nitro- 6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2011) 54(19): 6563-6585. [pdf]

Tran, D., Pietersma, A. L., Schofield, L. R., Rost, M., Jameson, G. B., & Parker, E. J. Investigating the role of the hydroxyl groups of substrate erythrose 4-phosphate in the reaction catalysed by the first enzyme of the shikimate pathway. Bioorganic & Medicinal Chemistry Letters (2011) 21 (22): 6838-6841.

Vaghefi, E., Pontre, B. P., Jacobs, M. D., & Donaldson, P. J. Visualizing ocular lens fluid dynamics using MRI: Manipulation of steady state water content and water fluxes. American Journal of Physiology - Regulatory Integrative and Comparative Physiology (2011) 301(2): R335-R342.

Waardenberg, A. J., Bernardo, B. C., Ng, D. C. H., Shepherd, P. R., Cemerlang, N., Sbroggio, M., Wells, C. A., Dalrymple, B. P., Brancaccio, M., Lin, R. C. Y., & McMullen, J. R. Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure. Journal of Biological Chemistry (2011) 286(35): 30837-30846.

Walker, S. R., Jiao, W., & Parker, E. J. Synthesis and evaluation of dual site inhibitors of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase. Bioorganic and Medicinal Chemistry Letters (2011) 21(17): 5092-5097.

Waltemath, D., Adams, R., Beard, D. A., Bergmann, F. T., Bhalla, U. S., Britten, R., Chelliah, V., Cooling, M. T., Cooper, J., Crampin, E. J., Garny, A., Hoops, S., Hucka, M., Hunter, P., Klipp, E., Laibe, C., Miller, A. K., Moraru, I., Nickerson, D., Nielsen, P., Nikolski, M., Sahle, S., Sauro, H. M., Schmidt, H., Snoep, J. L., Tolle, D., Wolkenhauer, O., & le Novère, N. Minimum information about a simulation experiment (MIASE). PLoS Computational Biology (2011) 7(4): e1001122.

Wilson, W. R., & Hay, M. P. Targeting hypoxia in cancer therapy. Nature Reviews Cancer (2011) 11(6): 393-410. [pdf]

Wilson, Z. E., Hubert, J. G., & Brimble, M. A. A flexible approach to 6,5-benzannulated spiroketals. European Journal of Organic Chemistry (2011) (20-21): 3938-3945.

Win, S. J., Ward, V. K., Dunbar, P. R., Young, S. L., & Baird, M. A. Cross-presentation of epitopes on virus-like particles via the MHC I receptor recycling pathway. Immunology and Cell Biology (2011) 89(6): 681-688. [pdf]

Wines, B. D., Ramsland, P. A., Trist, H. M., Gardam, S., Brink, R., Fraser, J. D., & Hogarth, P. M. Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor. Journal of Biological Chemistry (2011) 286(38): 33118-33124.

Wojnar, J. M., Evans, C. W., Devries, A. L., & Brimble, M. A. Synthesis of an isotopically-labelled antarctic fish antifreeze glycoprotein probe. Australian Journal of Chemistry (2011) 64(6): 723-731. [pdf]

Wood AJ, Fraser J, Swift S, Amirapu S, Douglas RG. Are biofilms associated with an inflammatory response in chronic rhinosinusitis? International Forum of Allergy and Rhinology (2011) 1(5): 335-339.

Yang, S. H., Lee, D. J., & Brimble, M. A. Synthesis of an NDPK phosphocarrier domain peptide containing a novel triazolylalanine analogue of phosphohistidine using click chemistry. Organic Letters (2011) 13(20): 5604-5607.

Yu, T., Lloyd, C. M., Nickerson, D. P., Cooling, M. T., Miller, A. K., Garny, A., Terkildsen, J. R., Lawson, J., Britten, R. D., Hunter, P. J., & Nielsen, P. M. The physiome model repository 2. Bioinformatics (2011) 27(5): 743-744.

Yuen, T. Y., Yang, S. H., & Brimble, M. A. Total synthesis of paecilospirone. Angewandte Chemie - International Edition (2011) 50(36): 8350-8353.

Zhang, Y. C., Furkert, D. P., Guéret, S. M., Lombard, F., & Brimble, M. A. Gold(I)- catalysed intramolecular hydroamination of alpha-quaternary alkynes: synthetic studies towards spiroimine marine toxins. Tetrahedron Letters (2011) 52(38): 4896-4898.

Zulian, A., Šileikyte, J., Petronilli, V., Bova, S., Dabbeni-Sala, F., Cargnelli, G., Rennison, D., Brimble, M. A., Hopkins, B., Bernardi, P., & Ricchelli, F. The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide. Biochimica et Biophysica Acta - Bioenergetics (2011) 1807(12): 1600-1605.

2010

Aitken, J. F., Loomes, K. M., Scott, D. W., Reddy, S., Phillips, A. R. J., Prijic, G., Fernando, C., Zhang, S., Broadhurst, R., L’Huillier, P., & Cooper, G. J. S. Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/ islet amyloid polypeptide transgenic mice. Diabetes (2010) 59(1): 161-171.

Atkinson, D. J., Sperry, J., & Brimble, M. A. Improved synthesis of the benzyne precursor 2-(trimethylsilyl) phenyl trifluoromethane sulfonate. Synthesis (2010) (6): 911- 913.

Bashiri, G., Rehan, A. M., Greenwood, D. R., Dickson, J. M. J., & Baker, E. N. Metabolic engineering of cofactor F420 production in mycobacterium smegmatis. PLoS ONE (2010) 5(12).

Brauer, R., Wang, L. C., Woon, S. T., Bridewell, D. J., Henare, K., Malinger, D., Palmer, B. D., Vogel, S. N., Kieda, C., Tijono, S. M., & Ching, L. M. Labeling of oxidizable proteins with a photoactivatable analog of the antitumor agent DMXAA: evidence for redox signaling in its mode of action. Neoplasia (2010) 12(9): 755-765.

Bogle, G., & Dunbar, P. R. Agent-based simulation of T-cell activation and proliferation within a lymph node. Immunology and Cell Biology (2010) 88(2): 172-179. [pdf]

 

Bogle, G. & Dunbar, P. R. T cell responses in lymph nodes. Wiley Interdisciplinary Reviews: Systems Biology & Medicine (2010) 2: 107-116.

Buchanan, C. M., Phillips, A. R. J., & Cooper, G. J. S. A novel two-chain IGF-II-derived peptide from purified b-cell granules. Growth Hormone and IGF Research (2010) 20(5): 360-366.

Chan, Y., Balle, J., Kevin Sparrow, J., Boyd, P. D. W., Brimble, M. A., & Barker, D. A double Mannich approach to the synthesis of substituted piperidones - Application to the synthesis of substituted E-ring analogues of methyllycaconitine. Tetrahedron (2010) 66(35): 7179-7191.

Chang, J. Y. C., Stevenson, R. J., Lu, G. L., Brothers, P. J., Clark, G. R., Denny, W. A., & Ware, D. C. Syntheses of 8-quinolinolatocobalt(III) complexes containing cyclen based auxiliary ligands as models for hypoxia-activated prodrugs. Dalton Transactions (2010) 39(48): 11535-11550.

Chen, J. L. Y., & Brimble, M. A. Synthesis of the bis-spiroacetal C25-C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence. Chemical Communications (2010) 46(22): 3967-3969. [pdf]

Chien, V., Aitken, J. F., Zhang, S., Buchanan, C. M., Hickey, A., Brittain, T., Cooper, G. J. S., & Loomes, K. M. The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of beta-sheet-containing aggregates by human amylin: A potential role for defective chaperone biology in Type 2 diabetes. Biochemical Journal (2010) 432(1): 113-121. [pdf]

Choi, P. J., Sperry, J., & Brimble, M. A. Heteroatom-directed reverse Wacker oxidations. Synthesis of the reported structure of (-)-herbaric acid. Journal of Organic Chemistry (2010) 75(21): 7388-7392. [pdf]

Cooper, G. J. S., Aitken, J. F., & Zhang, S. Is type 2 diabetes an amyloidosis and does it really matter (to patients)? Diabetologia (2010) 53(6): 1011-1016.

Denny, W. A. Hypoxia-activated prodrugs in cancer therapy: Progress to the clinic. Future Oncology (2010) 6(3): 419-428.

Denny, W. A., & Palmer, B. D. The nitroimidazooxazines (PA-824 and analogs): Structure-activity relationship and mechanistic studies. Future Medicinal Chemistry (2010) 2(8): 1295-1304. [pdf]

Garny, A., Cooper, J., & Hunter, P. J. Toward a VPH/Physiome ToolKit. Wiley Interdisciplinary Reviews. Systems Biology and Medicine (2010) 2(2): 134-147.

Gianni, D., McKeever, S., Yu, T., Britten, R., Delingette, H., Frangi, A., Hunter, P., & Smith, N. Sharing and reusing cardiovascular anatomical models over the Web: A step towards the implementation of the virtual physiological human project. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (2010) 368(1921): 3039-3056. [pdf]

Graham, E. S., Angel, C. E., Schwarcz, L. E., Dunbar, P. R., & Glass, M. Detailed characterisation of CB2 receptor protein expression in peripheral blood immune cells from healthy human volunteers using flow cytometry. International Journal of Immunopathology and Pharmacology (2010) 23(1): 25-34.

Grey, A., Chaussade, C., Empson, V., Lin, J. M., Watson, M., O’Sullivan, S., Rewcastle, G., Naot, D., Cornish, J., & Shepherd, P. Evidence for a role for the p110-alpha isoform of PI3K in skeletal function. Biochemical and Biophysical Research Communications (2010) 391(1): 564-569.

Guéret, S. M., Boyd, P. D. W., & Brimble, M. A. (1R,6R,13R,18R)-(Z,Z)-1,18-Bis[(4R)- 2,2-dimethyl-1,3-dioxolan-4-yl]-3, 16-dimethylene-8,20-diazadispiro-[5.6.5.6]tetracosa- 7,19-diene. Acta Crystallographica Section E: Structure Reports Online (2010) 66(7).

Guéret, S. M., & Brimble, M. A. Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: Isolation, structure, biological activity and synthesis. Natural Product Reports (2010) 27(9): 1350-1366.

Guéret, S. M., Furkert, D. P., & Brimble, M. A. Synthesis of a functionalized 7,6-bicyclic spiroimine ring fragment of the spirolides. Organic Letters (2010) 12(22): 5226-5229.

Harris, P. W., & Brimble, M. A. Toward the total chemical synthesis of the cancer protein NY-ESO-1. Biopolymers (2010) 94(4): 542-550. 

Hay, M. P., Turcotte, S., Flanagan, J. U., Bonnet, M., Chan, D. A., Sutphin, P. D., Nguyen, P., Giaccia, A. J., & Denny, W. A. 4-Pyridylanilinothiazoles that selectively target von Hippel - Lindau deficient renal cell carcinoma cells by inducing autophagic cell death. Journal of Medicinal Chemistry (2010) 53(2): 787-797.

Heapy, A. M., & Brimble, M. A. Synthesis of the FG ring fragment of pectenotoxins 1-9. Tetrahedron (2010) 66(29): 5424-5431.

Hicks, K. O., Siim, B. G., Jaiswal, J. K., Pruijn, F. B., Fraser, A. M., Patel, R., Hogg, A., Liyanage, H. D. S., Dorie, M. J., Brown, J. M., Denny, W. A., Hay, M. P., & Wilson, W. R. Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors. Clinical Cancer Research (2010) 16(20): 4946-4957.

Ho, H., Mithraratne, K., Schmid, H., Sands, G., & Hunter, P. Computer simulation of vertebral artery occlusion in endovascular procedures. International Journal of Computer Assisted Radiology and Surgery (2010) 5(1): 29-37. [pdf]

Hung, K. Y., Harris, P. W. R., & Brimble, M. A. Synthesis of methyl N-Boc-(2 S,4 R)-4- methylpipecolate. Journal of Organic Chemistry (2010) 75(24): 8728-8731.

Hunter, P., Coveney, P. V., De Bono, B., Diaz, V., Fenner, J., Frangi, A. F., Harris, P., Hose, R., Kohl, P., Lawford, P., McCormack, K., Mendes, M., Omholt, S., Quarteroni, A., Skår, J., Tegner, J., Thomas, S. R., Tollis, I., Tsamardinos, I., Van Beek, J. H. G. M., & Viceconti, M. A vision and strategy for the virtual physiological human in 2010 and beyond. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (2010) 368(1920): 2595-2614.

Jameson, M. B., Rischin, D., Pegram, M., Gutheil, J., Patterson, A. V., Denny, W. A., & Wilson, W. R. A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors. Cancer Chemotherapy and Pharmacology (2010) 65(4): 791-801.

Johnston, J. M., Jiang, M., Guo, Z., & Baker, E. N. Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: Testing a putative role in menaquinone biosynthesis. Acta Crystallographica Section D: Biological Crystallography (2010) 66(8): 909-917. [pdf]

Jongbloed, S. L., Kassianos, A. J., McDonald, K. J., Clark, G. J., Ju, X., Angel, C. E., Chen, C. J. J., Dunbar, P. R., Wadley, R. B., Jeet, V., Vulink, A. J. E., Hart, D. N. J., & Radford, K. J. Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. Journal of Experimental Medicine (2010) 207(6): 1247-1260.

Jor, J. W. Y., Nash, M. P., Nielsen, P. M. F., & Hunter, P. J. Estimating material parameters of a structurally based constitutive relation for skin mechanics. Biomechanics and Modeling in Mechanobiology (2010): 1-12. [pdf]

Jüllig, M., Chen, X., Middleditch, M. J., Vazhoor, G., Hickey, A. J., Gong, D., Lu, J., Zhang, S., Phillips, A. R. J., & Cooper, G. J. S. Illuminating the molecular basis of diabetic arteriopathy: A proteomic comparison of aortic tissue from diabetic and healthy rats. Proteomics (2010) 10(18): 3367-3378. [pdf]

Kenny, L. C., Broadhurst, D. I., Dunn, W., Brown, M., North, R. A., McCowan, L., Roberts, C., Cooper, G. J. S., Kell, D. B., & Baker, P. N. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension (2010) 56(4): 741-749.

 

Kim, N., Cannell, M. B., & Hunter, P. J. Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart. Progress in Biophysics and Molecular Biology (2010) 103(1): 28-34.

Kmentova, I., Sutherland, H. S., Palmer, B. D., Blaser, A., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., Denny, W. A., & Thompson, A. M. Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6 S)-2- nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H-imidazo[2,1-b][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2010) 53(23): 8421-8439.

Koch, C., Augustine, R. A., Steger, J., Ganjam, G. K., Benzler, J., Pracht, C., Lowe, C., Schwartz, M. W., Shepherd, P. R., Anderson, G. M., Grattan, D. R., & Tups, A. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. Journal of Neuroscience (2010) 30(48): 16180-16187.

Kolnes, A. J., Ingvaldsen, A., Bolling, A., Stuenæs, J. T., Kreft, M., Zorec, R., Shepherd, P. R., & Jensen, J. Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles. Acta Physiologica (2010) 200(1): 65-74.

Langley, R., Patel, D., Jackson, N., Clow, F., & Fraser, J. D. Staphylococcal superantigen super-domains in immune evasion. Critical Reviews in Immunology (2010) 30(2): 149-165.

Laursen, N. S., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Wines, B., Spillner, E., Christensen, J. B., Jensen, M., Fredslund, F., Bjerre, M., Sottrup-Jensen, L., Fraser, J. D., & Andersen, G. R. Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America (2010) 107(8): 3681-3686.

Lee, D. J., Harris, P. W. R., Kowalczyk, R., Dunbar, P. R., & Brimble, M. A. Microwaveassisted synthesis of fluorescein-labelled GalNAca1-O-Ser/ Thr (Tn) glycopeptides as immunological probes. Synthesis (2010) 5: 763-769.

 

Linke, C., Young, P. G., Kang, H. J., Bunker, R. D., Middleditch, M. J., Caradoc- Davies, T. T., Proft, T., & Baker, E. N. Crystal structure of the minor pilin FctB reveals determinants of group A streptococcal pilus anchoring. Journal of Biological Chemistry (2010) 285(26): 20381-20389.

Linke, C., Young, P. G., Kang, H. J., Proft, T., & Baker, E. N. Purification, crystallization and preliminary crystallographic analysis of the minor pilin FctB from Streptococcus pyogenes. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2010) 66(2): 177-179.

Lu, J., Gong, D., Choong, S. Y., Xu, H., Chan, Y. K., Chen, X., Fitzpatrick, S., Glyn- Jones, S., Zhang, S., Nakamura, T., Ruggiero, K., Obolonkin, V., Poppitt, S. D., Phillips, A. R. J., & Cooper, G. J. S. Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: Comparisons between triethylenetetramine and three less copper-selective transitionmetal- targeted treatments. Diabetologia (2010) 53(6): 1217-1226.

Lu, J., Poppitt, S. D., Othman, A. A., Sunderland, T., Ruggiero, K., Willett, M. S., Diamond, L. E., Garcia, W. D., Roesch, B. G., & Cooper, G. J. S. Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: An open-label trial. Journal of Clinical Pharmacology (2010) 50(6): 647-658. [pdf]

Manos-Turvey, A., Bulloch, E. M. M., Rutledge, P. J., Baker, E. N., Lott, J. S., & Payne, R. J. Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI). ChemMedChem (2010) 5(7): 1067-1079. 

Maroz, A., Shinde, S. S., Franzblau, S. G., Ma, Z., Denny, W. A., Palmer, B. D., & Anderson, R. F. Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent. Organic and Biomolecular Chemistry (2010) 8(2): 413-418. [pdf]

Martin, S. K., Fitter, S., Bong, L. F., Drew, J. J., Gronthos, S., Shepherd, P. R., & Zannettino, A. C. W. NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells. Journal of Bone and Mineral Research (2010) 25(10): 2126-2137.

McKay, V. A., Thompson, S. J., Tran, P. M., Goodall, K. J., Brimble, M. A., & Barker, D. Stereoselective synthesis of 4-substituted 4-hydroxypiperidines via epoxidation-ring opening of 4-methylenepiperidines. Synlett (2010) 17: 2631-2635.

Miller, N., Williams, G. M., & Brimble, M. A. Synthesis of Neoglycopeptides via Click Chemistry. International Journal of Peptide Research and Therapeutics (2010): 1-8.

Mittal, A., Göke, F., Flint, R., Loveday, B. P. T., Thompson, N., Delahunt, B., Kilmartin, P. A., Cooper, G. J. S., MacDonald, J., Hickey, A., Windsor, J. A., & Phillips, A. R. J. The redox status of experimental hemorrhagic shock as measured by cyclic voltammetry. Shock (2010) 33(5): 460-466.

Mittal, A., Middleditch, M., Ruggiero, K., Loveday, B., Delahunt, B., Jüllig, M., Cooper, G. J. S., Windsor, J. A., & Phillips, A. R. J. Changes in the mesenteric lymph proteome induced by hemorrhagic shock. Shock (2010) 34(2): 140-149.

Nikac, M., Brimble, M. A., Crumbie, R. L., & Bailey, T. D. Metal binding studies using spiroacetal thiacrown ethers. Tetrahedron Letters (2010) 51(7): 1072-1074.

Palmer, B. D., Thompson, A. M., Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., & Denny, W. A. Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro- 5H-imidazo[2,1-b][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2010) 53(1): 282-294. [pdf]

Patel, D., Wines, B. D., Langley, R. J., & Fraser, J. D. Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain. Journal of Immunology (2010) 184(11): 6283-6292.

Peltier, R., Brimble, M. A., Wojnar, J. M., Williams, D. E., Evans, C. W., & DeVries, A. L. Synthesis and antifreeze activity of fish antifreeze glycoproteins and their analogues. Chemical Science (2010) 1(5): 538-551.

Peltier, R., Evans, C. W., Devries, A. L., Brimble, M. A., Dingley, A. J., & Williams, D. E. Growth habit modification of ice crystals using antifreeze glycoprotein (AFGP) analogues. Crystal Growth and Design (2010) 10(12): 5066-5077.

Prosser, G. A., Copp, J. N., Syddall, S. P., Williams, E. M., Smaill, J. B., Wilson, W. R., Patterson, A. V., & Ackerley, D. F. Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochemical Pharmacology (2010) 79(5): 678-687.

Prosser, G. A., Patterson, A. V., & Ackerley, D. F. uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954. Journal of Biotechnology (2010) 150(1): 190-194.

Rathwell, K., Sperry, J., & Brimble, M. A. Synthesis of triazole analogues of the nanaomycin antibiotics using ‘click chemistry’. Tetrahedron (2010) 66(23): 4002-4009.

Reynolds, H. M., Walker, C. G., Dunbar, P. R., O’Sullivan, M. J., Uren, R. F., Thompson, J. F., & Smith, N. P. Functional anatomy of the lymphatics draining the skin: A detailed statistical analysis. Journal of Anatomy (2010) 216(3): 344-355.

Shinde, S. S., Maroz, A., Hay, M. P., Patterson, A. V., Denny, W. A., & Anderson, R. F. Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4- benzotriazine 1,4-dioxide (tirapazamine). Journal of the American Chemical Society (2010) 132(8): 2591-2599.

Smith, W. D., Pointon, J. A., Abbot, E., Kang, H. J., Baker, E. N., Hirst, B. H., Wilson, J. A., Banfield, M. J., & Kehoe, M. A. Roles of minor pilin subunits Spy0125 and Spy0130 in the serotype M1 Streptococcus pyogenes strain SF370. Journal of Bacteriology (2010) 192(18): 4651-4659.

Sperry, J., Harris, E. B. J., & Brimble, M. A. Total synthesis and absolute configuration of (-)-berkeleyamide A. Organic Letters (2010) 12(3): 420-423.

Sperry, J., Liu, Y. C., & Brimble, M. A. Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction. Organic and Biomolecular Chemistry (2010) 8(1): 29-38.

Sperry, J., Wilson, Z. E., Rathwell, D. C. K., & Brimble, M. A. Isolation, biological activity and synthesis of benzannulated spiroketal natural products. Natural Product Reports (2010) 27(8): 1117-1137. [pdf]

Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., Palmer, B. D., Denny, W. A., & Thompson, A. M. Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains. Journal of Medicinal Chemistry (2010) 53(2): 855-866. [pdf]

Tercel, M., Yang, S., Atwell, G. J., Smith, E., Gu, Y., Anderson, R. F., Denny, W. A., Wilson, W. R., & Pruijn, F. B. Hypoxic selectivity and solubility - Investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e] indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy. Bioorganic and Medicinal Chemistry (2010) 18(14): 4997-5006.

Tups, A., Anderson, G. M., Rizwan, M., Augustine, R. A., Chaussade, C., Shepherd, P. R., & Grattan, D. R. Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of Neuroendocrinology (2010) 22(6): 534-542.

Ussher, J. E., & Taylor, J. A. Optimized transduction of human monocyte-derived dendritic cells by recombinant adeno-associated virus serotype 6. Human Gene Therapy (2010) 21(12): 1675-1686.

Wadsworth, A. D., Sperry, J., & Brimble, M. A. Synthesis of the pyranonaphthoquinones dehydroherbarin, (+)-astropaquinone B and (+)-astropaquinone C en route to ascomycones A and B. Synthesis (2010) 15: 2604-2608.

Walker, C. S., Li, X., Whiting, L., Glyn-Jones, S., Zhang, S., Hickey, A. J., Sewell, M. A., Ruggiero, K., Phillips, A. R. J., Kraegen, E. W., Hay, D. L., Cooper, G. J. S., & Loomes, K. M. Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity. Endocrinology (2010) 151(9): 4257-4269.

Watkins, H. A., & Baker, E. N. Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis. Journal of Bacteriology (2010) 192(11): 2878-2886.

Webby, C. J., Jiao, W., Hutton, R. D., Blackmore, N. J., Baker, H. M., Baker, E. N., Jameson, G. B., & Parker, E. J. Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis. Journal of Biological Chemistry (2010) 285(40): 30567-30576.

Wilson, Z. E., & Brimble, M. A. A flexible asymmetric synthesis of the tetracyclic core of berkelic acid using a Horner-Wadsworth-Emmons/oxa-Michael cascade. Organic and Biomolecular Chemistry (2010) 8(6): 1284-1286. [pdf]

Zhang, H., Li, B., Young, A. A., & Hunter, P. J. Recovery of myocardial kinematic function without the time history of external loads. EURASIP Journal on Advances in Signal Processing (2010) 2010: 1-9.