Publications //

Scientific Publications

Every year Maurice Wilkins Centre investigators produce a large number of peer-reviewed scientific papers and reviews published in international journals. Research directly supported by the Maurice Wilkins Centre generated the following scientific papers.

    2018

    Agostini, M., E. Schoenmakers, J. Beig, L. Fairall, I. Szatmari, O. Rajanayagam, F. W. Muskett, C. Adams, A. D. Marais, S. O’Rahilly, R. K. Semple, L. Nagy, A. R. Majithia, J. W. R. Schwabe, D. J. Blom, R. Murphy, K. Chatterjee, and D. B. Savage, A pharmacogenetic approach to the treatment of patients with PPARG mutations. Diabetes (2018) 67(6): 1086-1092.

    Alexander, S. R., G. M. Williams, M. A. Brimble, and A. J. Fairbanks, A double-click approach to the protecting group free synthesis of glycoconjugates. Organic and Biomolecular Chemistry (2018) 16(8): 1258-1262.

    Amso, Z., S. W. Bisset, S. H. Yang, P. W. R. Harris, T. H. Wright, C. D. Navo, M. L. Patchett, G. E. Norris, and M. A. Brimble, Total chemical synthesis of glycocin F and analogues: S-glycosylation confers improved antimicrobial activity. Chemical Science (2018) 9(6): 1686-1691.

    Augustine, R. A., A. J. Seymour, R. E. Campbell, D. R. Grattan, and C. H. Brown, Integrative neurohumoural regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Neuroendocrinology (2018) 30(8).

    Aung, H. L., T. Tun, W. W. Nyunt, Y. Fong, J. A. Crump, K. K. Thinn, S. T. Aung, and G. M. Cook, Association between anti-tuberculosis drug resistance-conferring mutations and treatment outcomes in Myanmar. Infectious Diseases (2018) 50(5): 388-390.

    Bisset, S. W., S. H. Yang, Z. Amso, P. W. R. Harris, M. L. Patchett, M. A. Brimble, and G. E. Norris, Using Chemical Synthesis to Probe Structure-Activity Relationships of the Glycoactive Bacteriocin Glycocin F. ACS Chemical Biology (2018) 13(5): 1270-1278.

    Bower, R. L., L. Yule, T. A. Rees, G. Deganutti, E. R. Hendrikse, P. W. Harris, R. Kowalczyk, Z. Ridgway, A. G. Wong, and K. Swierkula, Molecular signature for receptor engagement in the metabolic peptide hormone amylin. ACS Pharmacology & Translational Science (2018) 1(1): 32-49.

    Britto, D. D., B. Wyroba, W. Chen, R. A. Lockwood, K. B. Tran, P. R. Shepherd, C. J. Hall, K. E. Crosier, P. S. Crosier, and J. W. Astin, Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model. Disease models & mechanisms (2018) 11(12).

    Campbell, H., N. Fleming, I. Roth, S. Mehta, A. Wiles, G. Williams, C. Vennin, N. Arsic, A. Parkin, M. Pajic, F. Munro, L. McNoe, M. Black, J. McCall, T. L. Slatter, P. Timpson, R. Reddel, P. Roux, C. Print, M. A. Baird, and A. W. Braithwaite, Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signaling. Nature Communications (2018) 9(1).

    Chan-Hyams, J. V. E., J. N. Copp, J. B. Smaill, A. V. Patterson, and D. F. Ackerley, Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy. Biochemical Pharmacology (2018) 158: 192-200.

    Chatterjee, A., E. J. Rodger, A. Ahn, P. A. Stockwell, M. Parry, J. Motwani, S. J. Gallagher, E. Shklovskaya, J. Tiffen, and M. R. Eccles, Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma. iScience (2018) 4: 312-325.

    Cooper, A. G., C. MacDonald, M. Glass, S. Hook, J. D. A. Tyndall, and A. J. Vernall, Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment. European Journal of Medicinal Chemistry (2018) 145: 770-789.

    Cooper, A. G., C. R. M. Oyagawa, J. J. Manning, S. Singh, S. Hook, N. L. Grimsey, M. Glass, J. D. A. Tyndall, and A. J. Vernall, Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1,8-naphthyridin-2-(1: H)-one-3-carboxamide scaffold. MedChemComm (2018) 9(12): 2055-2067.

    D'Amore, C., G. Orso, A. Forgiarini, G. Ceolotto, D. Rennison, G. Ribaudo, M. Jay-Smith, B. Hopkins, M. A. Brimble, and S. Bova, Synthesis and biological characterization of a new norbormide derived bodipy FL-conjugated fluorescent probe for cell imaging. Frontiers in Pharmacology (2018) 9(SEP).

    De Leon Rodriguez, L. M., E. T. Williams, and M. A. Brimble, Chemical Synthesis of Bioactive Naturally Derived Cyclic Peptides Containing Ene-Like Rigidifying Motifs. Chemistry - A European Journal (2018) 24(68): 17869-17880.

    DeSouza, S. V., R. G. Singh, H. D. Yoon, R. Murphy, L. D. Plank, and M. S. Petrov, Pancreas volume in health and disease: a systematic review and meta-analysis. Expert Review of Gastroenterology and Hepatology (2018) 12(8): 757-766.

    Ding, X. B., M. A. Brimble, and D. P. Furkert, Reactivity of 2-Nitropyrrole Systems: Development of Improved Synthetic Approaches to Nitropyrrole Natural Products. Journal of Organic Chemistry (2018) 83(20): 12460-12470.

    Dissanayake, W. C., B. Sorrenson, E. Cognard, W. E. Hughes, and P. R. Shepherd, β-catenin is important for the development of an insulin responsive pool of GLUT4 glucose transporters in 3T3-L1 adipocytes. Experimental Cell Research (2018) 366(1): 49-54.

    Dissanayake, W. C., B. Sorrenson, and P. R. Shepherd, The role of adherens junction proteins in the regulation of insulin secretion. Bioscience Reports (2018) 38(2).

    Dobson, R., R. Whittaker, Y. Jiang, R. Maddison, M. Shepherd, C. McNamara, R. Cutfield, M. Khanolkar, and R. Murphy, Effectiveness of text message based, diabetes self management support programme (SMS4BG): Two arm, parallel randomised controlled trial. BMJ (Online) (2018) 361.

    Eom, J., V. Feisst, L. Ranjard, K. Loomes, T. Damani, V. Jackson-Patel, M. Locke, H. Sheppard, P. Narayan, and P. R. Dunbar, Visualization and Quantification of Mesenchymal Cell Adipogenic Differentiation Potential with a Lineage Specific Marker. Journal of visualized experiments : JoVE (2018)(133).

    Evans, G. L., D. P. Furkert, N. Abermil, P. Kundu, K. M. de Lange, E. J. Parker, M. A. Brimble, E. N. Baker, and J. S. Lott, Anthranilate phosphoribosyltransferase: Binding determinants for 5′-phospho-alpha-D-ribosyl-1′-pyrophosphate (PRPP) and the implications for inhibitor design. Biochimica et Biophysica Acta - Proteins and Proteomics (2018) 1866(2): 264-274.

    Fan, Y., P. J. Cross, G. B. Jameson, and E. J. Parker, Exploring modular allostery via interchangeable regulatory domains. Proceedings of the National Academy of Sciences of the United States of America (2018) 115(12): 3006-3011.

    Field, J. J., A. J. Singh, S. Sinha, M. R. Rowe, W. A. Denny, D. G. Brooke, and J. H. Miller, Synthesis and Microtubule-Destabilizing Activity of N-Cyclopropyl-4-((3,4-dihydroquinolin-1(2H)-yl)sulfonyl)benzamide and its Analogs. Chemistry - An Asian Journal (2018).

    Garelja, M. L., C. A. Walker, A. Siow, S. H. Yang, P. W. R. Harris, M. A. Brimble, H. A. Watkins, J. J. Gingell, and D. L. Hay, Receptor Activity Modifying Proteins Have Limited Effects on the Class B G Protein-Coupled Receptor Calcitonin Receptor-Like Receptor Stalk. Biochemistry (2018) 57(8): 1410-1422.

    Gasser, O., K. J. Sharples, C. Barrow, G. M. Williams, E. Bauer, C. E. Wood, B. Mester, M. Dzhelali, G. Caygill, J. Jones, C. M. Hayman, V. A. Hinder, J. Macapagal, M. McCusker, R. Weinkove, G. F. Painter, M. A. Brimble, M. P. Findlay, P. R. Dunbar, and I. F. Hermans, A phase I vaccination study with dendritic cells loaded with NY-ESO-1 and α-galactosylceramide: induction of polyfunctional T cells in high-risk melanoma patients. Cancer Immunology, Immunotherapy (2018) 67(2): 285-298.

    Gong, G. Q., K. Wang, X. C. Dai, Y. Zhou, R. Basnet, Y. Chen, D. H. Yang, W. J. Lee, C. M. Buchanan, J. U. Flanagan, P. R. Shepherd, Y. Chen, and M. W. Wang, Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds. Acta Pharmacologica Sinica (2018) 39(12): 1902-1912.

    Grant, P. S., M. A. Brimble, and D. P. Furkert, Synthesis of the Bicyclic Lactone Core of Leonuketal, Enabled by a Telescoped Diels–Alder Reaction Sequence. Chemistry - An Asian Journal (2018).

    Grattan, D. R., Coordination or Coincidence? The Relationship between Prolactin and Gonadotropin Secretion. Trends in Endocrinology and Metabolism (2018) 29(1): 3-5.

    Guan, J., G. Singh-Mallah, K. Liu, E. Thorstensen, P. Shorten, E. A. Mitchell, R. Taylor, P. Harris, M. Brimble, J. M. D. Thompson, and R. Murphy, The role for cyclic glycine-proline, a biological regulator of insulin-like growth factor-1 in pregnancy-related obesity and weight changes. Journal of Biological Regulators and Homeostatic Agents (2018) 32(3): 465-478.

    Hanson-Manful, P., A. L. Whitcombe, P. G. Young, P. E. Atatoa Carr, A. Bell, A. Didsbury, E. A. Mitchell, P. R. Dunbar, T. Proft, and N. J. Moreland, The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. Journal of Infection (2018) 76(4): 361-368.

    Hards, K. and G. M. Cook, Targeting bacterial energetics to produce new antimicrobials. Drug Resistance Updates (2018) 36: 1-12.

    Hards, K., D. G. G. McMillan, L. A. Schurig-Briccio, R. B. Gennis, H. Lill, D. Bald, and G. M. Cook, Ionophoric effects of the antitubercular drug bedaquiline. Proceedings of the National Academy of Sciences of the United States of America (2018) 115(28): 7326-7331.

    Hauptstein, N., L. M. De Leon-Rodriguez, A. K. Mitra, Y. Hemar, I. Kavianinia, N. Li, V. Castelletto, I. W. Hamley, and M. A. Brimble, Supramolecular Threading of Peptide Hydrogel Fibrils. ACS Biomaterials Science and Engineering (2018) 4(8): 2733-2738.

    Healey, G., R. Murphy, C. Butts, L. Brough, K. Whelan, and J. Coad, Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: A randomised, double-blind, placebo-controlled, cross-over, human intervention study. British Journal of Nutrition (2018) 119(2): 176-189.

    Heikal, A., Y. Nakatani, W. Jiao, C. Wilson, D. Rennison, M. R. Weimar, E. J. Parker, M. A. Brimble, and G. M. Cook, ‘Tethering’ fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase. Bioorganic and Medicinal Chemistry Letters (2018) 28(13): 2239-2243.

    Iborra, R. T., A. Machado-Lima, L. S. Okuda, P. R. Pinto, E. R. Nakandakare, U. F. Machado, M. L. Correa-Giannella, R. Pickford, T. Woods, M. A. Brimble, K. A. Rye, R. Lu, S. Yokoyama, and M. Passarelli, AGE-albumin enhances ABCA1 degradation by ubiquitin-proteasome and lysosomal pathways in macrophages. Journal of Diabetes and its Complications (2018) 32(1): 1-10.

    Jamieson, S. M., P. Tsai, M. K. Kondratyev, P. Budhani, A. Liu, N. N. Senzer, E. G. Chiorean, S. I. Jalal, J. J. Nemunaitis, and D. Kee, Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma. JCI insight (2018) 3(16).

    Janssens, J. V., B. Ma, M. A. Brimble, J. E. Van Eyk, L. M. D. Delbridge, and K. M. Mellor, Cardiac troponins may be irreversibly modified by glycation: novel potential mechanisms of cardiac performance modulation. Scientific Reports (2018) 8(1).

    Kazantseva, M., R. A. Eiholzer, S. Mehta, A. Taha, S. Bowie, I. Roth, J. Zhou, S. M. Joruiz, J. A. Royds, N. A. Hung, T. L. Slatter, and A. W. Braithwaite, Elevation of the TP53 isoform Δ133p53β in glioblastomas: an alternative to mutant p53 in promoting tumor development. Journal of Pathology (2018) 246(1): 77-88.

    Kazantseva, M., S. Mehta, R. A. Eiholzer, N. Hung, A. Wiles, T. L. Slatter, and A. W. Braithwaite, A mouse model of the Δ133p53 isoform: roles in cancer progression and inflammation. Mammalian Genome (2018) 29(11-12): 831-842.

    Keown, J. R., M. M. Black, A. Ferron, M. Yap, M. J. Barnett, F. G. Pearce, J. P. Stoye, and D. C. Goldstone, A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins. The Journal of biological chemistry (2018) 293(47): 18378-18386.

    Ketharnathan, S., M. Leask, J. Boocock, A. J. Phipps-Green, J. Antony, J. M. O'Sullivan, T. R. Merriman, and J. A. Horsfield, A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression. Human Molecular Genetics (2018) 27(22): 3964-3973.

    Kokay, I. C., A. Wyatt, H. R. Phillipps, M. Aoki, F. Ectors, U. Boehm, and D. R. Grattan, Analysis of prolactin receptor expression in the murine brain using a novel prolactin receptor reporter mouse. Journal of Neuroendocrinology (2018) 30(9).

    Krishnan, M., T. J. Major, R. K. Topless, O. Dewes, L. Yu, J. M. D. Thompson, L. McCowan, J. de Zoysa, L. K. Stamp, N. Dalbeth, J. Harré Hindmarsh, N. Rapana, R. Deka, W. W. H. Eng, D. E. Weeks, R. L. Minster, S. T. McGarvey, S. Viali, T. Naseri, M. Sefuiva Reupena, P. Wilcox, D. Grattan, P. R. Shepherd, A. N. Shelling, R. Murphy, and T. R. Merriman, Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. Diabetologia (2018) 61(7): 1603-1613.

    Krishnan, M., A. N. Shelling, C. R. Wall, E. A. Mitchell, R. Murphy, L. M. E. McCowan, J. M. D. Thompson, W. Cutfield, Y. Huang, A. Stewart, R. Taylor, K. M. Godfrey, L. Poston, and P. Taylor, Gene-by-activity interactions on obesity traits of 6-year-old New Zealand European children: A children of SCOPE study. Pediatric Exercise Science (2018) 30(1): 71-82.

    Ladyman, S. R., K. M. Carter, and D. R. Grattan, Energy homeostasis and running wheel activity during pregnancy in the mouse. Physiology and Behavior (2018) 194: 83-94.

    Ladyman, S. R., Z. Khant Aung, and D. R. Grattan, Impact of Pregnancy and Lactation on the Long-Term Regulation of Energy Balance in Female Mice. Endocrinology (2018) 159(6): 2324-2336.

    Lawrence, B., C. Blenkiron, K. Parker, P. Tsai, S. Fitzgerald, P. Shields, T. Robb, M. L. Yeong, N. Kramer, S. James, M. Black, V. Fan, N. Poonawala, P. Yap, E. Coats, B. Woodhouse, R. Ramsaroop, M. Yozu, B. Robinson, K. Henare, J. Koea, P. Johnston, R. Carroll, S. Connor, H. Morrin, M. Elston, C. Jackson, P. Reid, J. Windsor, A. MacCormick, R. Babor, A. Bartlett, D. Damianovich, N. Knowlton, S. Grimmond, M. Findlay, and C. Print, Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer. npj Genomic Medicine (2018) 3(1).

    Lu, X., H. Chen, A. V. Patterson, J. B. Smaill, and K. Ding, Fibroblast Growth Factor Receptor 4 (FGFR4) Selective Inhibitors as Hepatocellular Carcinoma Therapy: Advances and Prospects. Journal of Medicinal Chemistry (2018).

    Lu, X., Z. Williams, K. Hards, J. Tang, C.-Y. Cheung, H. L. Aung, B. Wang, Z. Liu, X. Hu, and A. Lenaerts, Pyrazolo [1, 5-a] pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis. ACS infectious diseases (2018).

    Lu, X., L. Yu, Z. Zhang, X. Ren, J. B. Smaill, and K. Ding, Targeting EGFRL858R/T790M and EGFRL858R/T790M/C797S resistance mutations in NSCLC: Current developments in medicinal chemistry. Medicinal Research Reviews (2018) 38(5): 1550-1581.

    Mainini, F., D. S. Larsen, G. A. Webster, S. L. Young, and M. R. Eccles, MIS416 as a siRNA Delivery System with the Ability to Target Antigen-Presenting Cells. Nucleic Acid Therapeutics (2018) 28(4): 225-232.

    Manning, P. J., D. Grattan, T. Merriman, T. Manning, S. Williams, and W. Sutherland, Pharmaceutical interventions for weight-loss maintenance: no effect from cabergoline. International Journal of Obesity (2018) 42(11): 1871-1879.

    McEwen, H. J. L., E. Cognard, S. R. Ladyman, Z. Khant-Aung, A. Tups, P. R. Shepherd, and D. R. Grattan, Feeding and glucagon-like peptide-1 receptor activation stabilise β-catenin in specific hypothalamic nuclei in male rats. Journal of Neuroendocrinology (2018) 30(6).

    Mehta, S. Y., B. C. Morten, J. Antony, L. Henderson, A. Lasham, H. Campbell, H. Cunliffe, J. A. Horsfield, R. R. Reddel, and K. A. Avery-Kiejda, Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. Oncotarget (2018) 9(49): 29146.

    Mitchell, E. A., A. W. Stewart, I. Braithwaite, R. Murphy, R. J. Hancox, C. Wall, and R. Beasley, Factors associated with body mass index in children and adolescents: An international cross-sectional study. PLoS ONE (2018) 13(5).

    Mittelstädt, G., W. Jiao, E. K. Livingstone, G. J. Moggre, A. R. Nazmi, and E. J. Parker, A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase. Biochemical Journal (2018) 475(1): 247-260.

    Mortuza, R., H. L. Aung, G. Taiaroa, H. K. Opel-Reading, T. Kleffmann, G. M. Cook, and K. L. Krause, Overexpression of a newly identified d-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion. Molecular Microbiology (2018) 107(2): 198-213.

    Mountjoy, K. G., A. Caron, K. Hubbard, A. Shome, A. C. Grey, B. Sun, S. Bould, M. Middleditch, B. Pontré, A. McGregor, P. W. R. Harris, R. Kowalczyk, M. A. Brimble, R. Botha, K. M. L. Tan, S. J. Piper, C. Buchanan, S. Lee, A. P. Coll, and J. K. Elmquist, Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance. Molecular Metabolism (2018) 9: 207-216.

    Murphy, R., M. G. Clarke, N. J. Evennett, S. John Robinson, M. Lee Humphreys, H. Hammodat, B. Jones, D. D. Kim, R. Cutfield, M. H. Johnson, L. D. Plank, and M. W. C. Booth, Laparoscopic Sleeve Gastrectomy Versus Banded Roux-en-Y Gastric Bypass for Diabetes and Obesity: a Prospective Randomised Double-Blind Trial. Obesity Surgery (2018) 28(2): 293-302.

    Murphy, R., A. W. Stewart, R. J. Hancox, C. R. Wall, I. Braithwaite, R. Beasley, E. A. Mitchell, and I. P. T. S. Group, Obesity, underweight and BMI distribution characteristics of children by gross national income and income inequality: results from an international survey. Obesity science & practice (2018) 4(3): 216-228.

    Nemati, R., J. Lu, D. Dokpuang, M. Booth, L. D. Plank, and R. Murphy, Increased Bile Acids and FGF19 After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Correlate with Improvement in Type 2 Diabetes in a Randomized Trial. Obesity Surgery (2018) 28(9): 2672-2686.

    Nicholson, M. J., K. C. Van de Bittner, A. Ram, L. Y. Bustamante, B. Scott, and E. J. Parker, Draft genome sequence of the filamentous fungus Hypoxylon pulicicidum ATCC 74245. Genome Announcements (2018) 6(2).

    Nie, T., S. Zhao, L. Mao, Y. Yang, W. Sun, X. Lin, S. Liu, K. Li, Y. Sun, and P. Li, The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity. British Journal of Pharmacology (2018) 175(9): 1439-1450.

    North, R. A., C. R. Horne, J. S. Davies, D. M. Remus, A. C. Muscroft-Taylor, P. Goyal, W. Y. Wahlgren, S. Ramaswamy, R. Friemann, and R. C. J. Dobson, “Just a spoonful of sugar..”: import of sialic acid across bacterial cell membranes. Biophysical Reviews (2018) 10(2): 219-227.

    Pearson, H. B., J. Li, V. S. Meniel, C. M. Fennell, P. Waring, K. G. Montgomery, R. J. Rebello, A. A. Macpherson, S. Koushyar, L. Furic, C. Cullinane, R. W. Clarkson, M. J. Smalley, K. J. Simpson, T. J. Phesse, P. R. Shepherd, P. O. Humbert, O. J. Sansom, and W. A. Phillips, Identification of pik3ca mutation as a genetic driver of prostate cancer that cooperates with pten loss to accelerate progression and castration-resistant growth. Cancer Discovery (2018) 8(6): 764-779.

    Petri, J., Y. Shimaki, W. Jiao, H. R. Bridges, E. R. Russell, E. J. Parker, D. Aragão, G. M. Cook, and Y. Nakatani, Structure of the NDH-2 – HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors. Biochimica et Biophysica Acta - Bioenergetics (2018) 1859(7): 482-490.

    Pilkington, L. I., X. Yang, M. W. Liu, Y. Hemar, M. A. Brimble, and J. Reynisson, A Chemometric Analysis of Compounds from Native New Zealand Medicinal Flora. Chemistry - An Asian Journal (2018).

    Prendergast, K. A., N. J. Daniels, T. R. Petersen, I. F. Hermans, and J. R. Kirman, Langerin+CD8α+dendritic cells drive early CD8+T cell activation and IL-12 production during systemic bacterial infection. Frontiers in Immunology (2018) 9(MAY).

    Przepiorski, A., V. Sander, T. Tran, J. A. Hollywood, B. Sorrenson, J. H. Shih, E. J. Wolvetang, A. P. McMahon, T. M. Holm, and A. J. Davidson, A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells. Stem Cell Reports (2018) 11(2): 470-484.

    Raynes, J. M., P. G. Young, T. Proft, D. A. Williamson, E. N. Baker, and N. J. Moreland, Protein adhesins as vaccine antigens for Group A Streptococcus. Pathogens and disease (2018) 76(2).

    Schwabe, C., B. Rosenstock, T. Doan, P. Hamilton, P. R. Dunbar, A. G. Eleftheraki, D. Joseph, J. Hilbert, C. Schoelch, S. J. Padula, and J. Steffgen, Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Rising Doses of BI 655064, an Antagonistic Anti-CD40 Antibody, in Healthy Subjects: A Potential Novel Treatment for Autoimmune Diseases. Journal of Clinical Pharmacology (2018) 58(12): 1566-1577.

    Shirley, H. J., M. L. Jamieson, M. A. Brimble, and C. D. Bray, A new family of sesterterpenoids isolated around the Pacific Rim. Natural Product Reports (2018) 35(3): 210-219.

    Simms, J., R. Uddin, T. P. Sakmar, J. J. Gingell, M. L. Garelja, D. L. Hay, M. A. Brimble, P. W. Harris, C. A. Reynolds, and D. R. Poyner, Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex. Biochemistry (2018) 57(32): 4915-4922.

    Siow, A., G. Opiyo, I. Kavianinia, F. F. Li, D. P. Furkert, P. W. R. Harris, and M. A. Brimble, Total Synthesis of the Highly N-Methylated Acetylene-Containing Anticancer Peptide Jahanyne. Organic Letters (2018) 20(3): 788-791.

    Sterritt, O. W., S. A. Kessans, G. B. Jameson, and E. J. Parker, A Pseudoisostructural Type II DAH7PS Enzyme from Pseudomonas aeruginosa: Alternative Evolutionary Strategies to Control Shikimate Pathway Flux. Biochemistry (2018) 57(18): 2667-2678.

    Sterritt, O. W., E. J. M. Lang, S. A. Kessans, T. M. Ryan, B. Demeler, G. B. Jameson, and E. J. Parker, Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase subclass. Bioscience Reports (2018) 38(5).

    Stevenson, R. J., I. Azimi, J. U. Flanagan, M. Inserra, I. Vetter, G. R. Monteith, and W. A. Denny, An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay. Bioorganic and Medicinal Chemistry (2018) 26(12): 3406-3413.

    Sutherland, H. S., A. S. T. Tong, P. J. Choi, D. Conole, A. Blaser, S. G. Franzblau, C. B. Cooper, A. M. Upton, M. U. Lotlikar, W. A. Denny, and B. D. Palmer, Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles. Bioorganic and Medicinal Chemistry (2018) 26(8): 1797-1809.

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