Publications //

Scientific Publications

Every year Maurice Wilkins Centre investigators produce a large number of peer-reviewed scientific papers and reviews published in international journals. Research directly supported by the Maurice Wilkins Centre generated the following scientific papers.

    2011

    Affara, M., Dunmore, B. J., Sanders, D. A., Johnson, N., Print, C. G., & Charnock- Jones, D. S. MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms. BMC Genomics (2011) 12:43.

    Allison, T. M., Hutton, R. D., Cochrane, F. C., Yeoman, J. A., Jameson, G. B., & Parker, E. J. Targeting the role of a key conserved motif for substrate selection and catalysis by 3-Deoxy-D-Manno-octulosonate 8-Phosphate synthase. Biochemistry (2011) 50(18): 3686-3695.

    Allison, T. M., Hutton, R. D., Jiao, W., Gloyne, B. J., Nimmo, E. B., Jameson, G. B., & Parker, E. J. An extended beta7alpha7 substrate-binding loop is essential for efficient catalysis by 3-deoxy-d-Manno-octulosonate 8-Phosphate synthase. Biochemistry (2011) 50(43): 9318-9327.

    Archbold, J. K., Flanagan, J. U., Watkins, H. A., Gingell, J. J., & Hay, D. L. Structural insights into RAMP modification of secretin family G protein-coupled receptors: Implications for drug development. Trends in Pharmacological Sciences (2011) 32(10): 591-600.

    Arcus, V. L., McKenzie, J. L., Robson, J., & Cook, G. M. The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array. Protein Engineering, Design and Selection (2011) 24(1-2): 33-40.

    Atkinson, D. J., Sperry, J., & Brimble, M. A. Synthesis of benzotriazole analogues of the helicobactericidal agents CJ-13,015, CJ-13,102, CJ-13,108, and CJ-13,104 using a regioselective 1,3-dipolar cycloaddition. Synlett (2011) 1: 99-103.

    Benson, M. A., Lilo, S., Wasserman, G. A., Thoendel, M., Smith, A., Horswill, A. R., Fraser, J., Novick, R. P., Shopsin, B., & Torres, V. J. Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner. Molecular Microbiology (2011) 81(3): 659-675.

    Best, N., Fraser, J. D., Rainey, P. B., Roberts, S. A., Thomas, M. G., & Ritchie, S. R. Nasal carriage of Staphylococcus aureus in healthy Aucklanders. New Zealand Medical Journal (2011) 124(1332): 30-39.

    Bircham, P. W., Maass, D. R., Roberts, C. A., Kiew, P. Y., Low, Y. S., Yegambaram, M., Matthews, J., Jack, C. A., & Atkinson, P. H. Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Molecular BioSystems (2011) 7(9): 2589-2598.

    Bonnet, M., Flanagan, J. U., Chan, D. A., Lai, E. W., Nguyen, P., Giaccia, A. J., & Hay, M. P. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells. Bioorganic and Medicinal Chemistry (2011) 19(11): 3347-3356.

    Bradley, C., Bowery, A., Britten, R., Budelmann, V., Camara, O., Christie, R., Cookson, A., Frangi, A. F., Gamage, T. B., Heidlauf, T., Krittian, S., Ladd, D., Little, C., Mithraratne, K., Nash, M., Nickerson, D., Nielsen, P., Nordbo, O., Omholt, S., Pashaei, A., Paterson, D., Rajagopal, V., Reeve, A., Rohrle, O., Safaei, S., Sebastian, R., Steghofer, M., Wu, T., Yu, T., Zhang, H. Y., & Hunter, P. OpenCMISS: A multi-physics & multi-scale computational infrastructure for the VPH/Physiome project. Progress in Biophysics & Molecular Biology (2011) 107(1): 32-47.

    Brimble, M. A., Finch, O. C., Heapy, A. M., Fraser, J. D., Furkert, D. P., & O’Connor, P. D. A convergent synthesis of the [4.4]-Spiroacetal-gamma-lactones cephalosporolides E and F. Tetrahedron (2011) 67(5): 995-1001.

    Broadley, K., Larsen, L., Herst, P. M., Smith, R. A. J., Berridge, M. V., & McConnell, M. J. The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress. Journal of Cellular Biochemistry (2011) 112(7): 1869- 1879.

    Broadley, K. W. R., Hunn, M. K., Farrand, K. J., Price, K. M., Grasso, C., Miller, R. J., Hermans, I. F., & McConnell, M. J. Side population is not necessary or sufficient for a cancer stem cell phenotype in glioblastoma multiforme. Stem Cells (2011) 29(3): 452-461.

    Chan, D. A., Sutphin, P. D., Nguyen, P., Turcotte, S., Lai, E. W., Banh, A., Reynolds, G. E., Chi, J. T., Wu, J., Solow-Cordero, D. E., Bonnet, M., Flanagan, J. U., Bouley, D. M., Graves, E. E., Denny, W. A., Hay, M. P., & Giaccia, A. J. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Science Translational Medicine (2011) 3(94): 94ra70.

    Chang, A., Khemlani, A., Kang, H., & Proft, T. Functional analysis of Streptococcus pyogenes nuclease A (SpnA), a novel group A streptococcal virulence factor. Molecular Microbiology (2011) 79(6): 1629-1642.

    Chen, J. L. Y., & Brimble, M. A. Synthesis of the bis-spiroacetal core of the antimitotic agent spirastrellolide B. Journal of Organic Chemistry (2011) 76(22): 9417-9428.

    Chen, J. L. Y., Sperry, J., Ip, N. Y., & Brimble, M. A. Natural products targeting telomere maintenance. MedChemComm (2011) 2(4): 229-245.

    Cheng, J. M. H., Chee, S. H., Knight, D. A., Acha-Orbea, H., Hermans, I. F., Timmer, M. S. M., & Stocker, B. L. An improved synthesis of dansylated alpha-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells. Carbohydrate Research (2011) 346(7): 914-926.

    Chim, N., Habel, J. E., Johnston, J. M., Krieger, I., Miallau, L., Sankaranarayanan, R., Morse, R. P., Bruning, J., Swanson, S., Kim, H., Kim, C. Y., Li, H., Bulloch, E. M., Payne, R. J., Manos-Turvey, A., Hung, L. W., Baker, E. N., Lott, J. S., James, M. N. G., Terwilliger, T. C., Eisenberg, D. S., Sacchettini, J. C., & Goulding, C. W. The TB Structural Genomics Consortium: A decade of progress. Tuberculosis (2011) 91(2): 155-172.

    Cooper, G. J. S. Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer’s disease. Drugs (2011) 71(10): 1281- 1320.

    Costa, J. L., Smith, G., Watson, M., Lin, J. M., Callon, K., Gamble, G., Cheng, A., Vickers, M. H., Shepherd, P. R., Cornish, J., & Grey, A. The atypical anti-psychotic clozapine decreases bone mass in rats in vivo. Schizophrenia Research (2011) 126(1-3): 291-297.

    Cross, P. J., Dobson, R. C. J., Patchett, M. L., & Parker, E. J. Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis. Journal of Biological Chemistry (2011) 286(12): 10216-10224.

    Didsbury, A., Wang, C., Verdon, D., Sewell, M., McIntosh, J., & Taylor, J. Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells. Virology Journal (2011) 8(1): 551.

    Dogra, M., Palmer, B. D., Bashiri, G., Tingle, M. D., Shinde, S. S., Anderson, R. F., O’Toole, R., Baker, E. N., Denny, W. A., & Helsby, N. A. Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver. British Journal of Pharmacology (2011) 162(1): 226-236.

    Flanagan, J. U., & Smythe, M. L. Sigma-class glutathione transferases. Drug Metabolism Reviews (2011) 43(2): 194-214.

    Fraser, J. D. Clarifying the mechanism of superantigen toxicity. PLoS Biology (2011) 9(9):e1001145.

    Girvan, R. C., Knight, D. A., O’Loughlin, C. J., Hayman, C. M., Hermans, I. F., & Webster, G. A. MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity. Vaccine (2011) 29(3): 545-557.

    Guéret, S. M., & Brimble, M. A. Synthetic studies toward the spiroimine unit of the spirolides. Pure and Applied Chemistry (2011) 83(3): 425-433.

    Hagbom, M., Istrate, C., Engblom, D., Karlsson, T., Rodriguez-Diaz, J., Buesa, J., Taylor, J. A., Loitto, V. M., Magnusson, K. E., Ahlman, H., Lundgren, O., & Svensson, L. Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting. PLoS Pathogens (2011) 7(7): e1002115.

    Harris, P. W. R., Yang, S. H., & Brimble, M. A. An improved procedure for the preparation of aminomethyl polystyrene resin and its use in solid phase (peptide) synthesis. Tetrahedron Letters (2011) 52(45): 6024-6026.

    Hay, D. L., Walker, C. S., & Poyner, D. R. Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: Opportunities and challenges. Endocrine-Related Cancer (2011) 18(1): C1-C14.

    Ho, H., Suresh, V., Kang, W., Cooling, M. T., Watton, P. N., & Hunter, P. J. Multiscale modeling of intracranial aneurysms: Cell signaling, hemodynamics, and remodeling. IEEE Transactions on Biomedical Engineering (2011) 58(10 PART 2): 2974-2977.

    Hume, P. A., Sperry, J., & Brimble, M. A. Enantioselective synthesis of pyranonaphthoquinone antibiotics using a CBS reduction/cross-metathesis/oxa- Michael strategy. Organic and Biomolecular Chemistry (2011) 9(15): 5423-5430.

    Hung, K. Y., Harris, P. W. R., Heapy, A. M., & Brimble, M. A. Synthesis and assignment of stereochemistry of the antibacterial cyclic peptide xenematide. Organic and Biomolecular Chemistry (2011) 9(1): 236-242.

    Hurley, D., Araki, H., Tamada, Y., Dunmore, B., Sanders, D., Humphreys, S., Affara, M., Imoto, S., Yasuda, K., Tomiyasu, Y., Tashiro, K., Savoie, C., Cho, V., Smith, S., Kuhara, S., Miyano, S., Charnock-Jones, D. S., Crampin, E. J., & Print, C. G. Gene network inference and visualization tools for biologists: application to new human transcriptome datasets. Nucleic Acids Research (2011): 1-22.

    Jamieson, S., Flanagan, J. U., Kolekar, S., Buchanan, C., Kendall, J. D., Lee, W. J., Rewcastle, G. W., Denny, W. A., Singh, R., Dickson, J., Baguley, B. C., & Shepherd, P. R. A drug targeting only p110 alpha can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochemical Journal (2011) 438: 53-62.

    Jullig, M., Browett, P., Middleditch, M. M. J., Prijic, G., Kilfoyle, D., Angelo, N., & Cooper, G. J. S. A unique case of neural amyloidoma diagnosed by mass spectrometry of formalin-fixed tissue using a novel preparative technique. Amyloid (2011) 18(3): 147-155.

    Kang, H. J., & Baker, E. N. Intramolecular isopeptide bonds: Protein crosslinks built for stress? Trends in Biochemical Sciences (2011) 36(4): 229-237.

    Kang, H. J., Coulibaly, F., Proft, T., & Baker, E. N. Crystal structure of spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly. PLoS ONE (2011) 6(1): e15969.

    Kaur, H., Heapy, A. M., & Brimble, M. A. The synthesis of dehydrotryptophan and dehydrotryptophan-containing peptides. Organic and Biomolecular Chemistry (2011) 9(17): 5897-5907.

    Le Nours, J., Bulloch, E. M. M., Zhang, Z., Greenwood, D. R., Middleditch, M. J., Dickson, J. M. J., & Baker, E. N. Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide. Journal of Biological Chemistry (2011) 286(47): 40706-40716.

    Lee, D. J., Harris, P. W. R., & Brimble, M. A. Synthesis of MUC1 Neoglycopeptides using efficient microwave-enhanced chaotrope-assisted click chemistry. Organic and Biomolecular Chemistry (2011) 9(5): 1621-1626.

    Leung, E., Kim, J. E., Rewcastle, G. W., Finlay, G. J., & Baguley, B. C. Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifenresistant breast cancer cells. Cancer Biology & Therapy (2011) 11(11): 938-946.

    Locke, M., Feisst, V., & Dunbar, P. R. Concise review: Human adipose-derived stem cells: Separating promise from clinical need. Stem Cells (2011) 29(3): 404-411.

    Locke, M., Ussher, J. E., Mistry, R., Taylor, J. A., & Dunbar, P. R. Transduction of human adipose-derived mesenchymal stem cells by recombinant adeno-associated virus vectors. Tissue Engineering - Part C: Methods (2011) 17(9): 949-959.

    Loomes, K. M. Survival of an islet beta-cell in type 2 diabetes Curbing the effects of amyloid cytotoxicity. Islets (2011) 3(1): 38-39.

    Lu, G. L., Stevenson, R. J., Chang, J. Y. C., Brothers, P. J., Ware, D. C., Wilson, W. R., Denny, W. A., & Tercel, M. N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7- trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f] quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs. Bioorganic and Medicinal Chemistry (2011) 19(16): 4861-4867.

    MacDonald, J. R., Oellermann, M., Rynbeck, S., Chang, G., Ruggiero, K., Cooper, G. J. S., & Hickey, A. J. R. Transmural differences in respiratory capacity across the rat left ventricle in health, aging, and streptozotocin-induced diabetes mellitus: Evidence that mitochondrial dysfunction begins in the subepicardium. American Journal of Physiology - Cell Physiology (2011) 300(2): C246-C255.

    McLeod, M. C., Wilson, Z. E., & Brimble, M. A. An enantioselective formal synthesis of berkelic acid. Organic Letters (2011) 13(19): 5382-5385.  

    McMillan, D. G. G., Ferguson, S. A., Dey, D., Schröder, K., Aung, H. L., Carbone, V., Attwood, G. T., Ronimus, R. S., Meier, T., Janssen, P. H., & Cook, G. M. A 1A o-ATP synthase of Methanobrevibacter ruminantium couples sodium ions for ATP synthesis under physiological conditions. Journal of Biological Chemistry (2011) 286(46): 39882- 39892.

    Miller, A. K., Yu, T., Britten, R., Cooling, M. T., Lawson, J., Cowan, D., Garny, A., Halstead, M. D. B., Hunter, P. J., Nickerson, D. P., Nunns, G., Wimalaratne, S. M., & F Nielsen, P. M. Revision history aware repositories of computational models of biological systems. BMC Bioinformatics (2011) 12:22.

    Misirli, G., Hallinan, J. S., Yu, T., Lawson, J. R., Wimalaratne, S. M., Cooling, M. T., & Wipat, A. Model annotation for synthetic biology: Automating model to nucleotide sequence conversion. Bioinformatics (2011) 27(7): 973-979.

    Mittal, A., Hickey, A. J. R., Chai, C. C., Loveday, B. P. T., Thompson, N., Dare, A., Delahunt, B., Cooper, G. J. S., Windsor, J. A., & Phillips, A. R. J. Early organ-specific mitochondrial dysfunction of jejunum and lung found in rats with experimental acute pancreatitis. HPB (Oxford) (2011) 13(5): 332-341.

    Moir, L. M., Trian, T., Ge, Q., Shepherd, P. R., Burgess, J. K., Oliver, B. G. G., & Black, J. L. Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function. Journal of Pharmacology and Experimental Therapeutics (2011) 337(2): 557-566.

    Mönnich, M., Kuriger, Z., Print, C. G., & Horsfield, J. A. A zebrafish model of roberts syndrome reveals that esco2 depletion interferes with development by disrupting the cell cycle. PLoS ONE (2011) 6(5): e20051.

    Negron, L., & Parker, E. J. Fluorinated substrates result in variable leakage of a reaction intermediate during catalysis by dehydroquinate synthase. Organic and Biomolecular Chemistry (2011) 9(8): 2861-2867.

    Paterson, N. G., & Baker, E. N. Structure of the full-length major pilin from Streptococcus pneumoniae: Implications for isopeptide bond formation in grampositive bacterial pili. PLoS ONE (2011) 6(7): e22095.

    Pather, K., Helsby, N.A., Palmer, B.D. & Ching, L.M. Development and validation of a high performance liquid chromatography assay for the determination of a fluorinated analogue of thalidomide, N-(2,6-dioxopiperidin-3-yl)-3,4,5,6- tetrafluorophthalamic acid and lenalidomide. Journal of Liquid Chromatography & Related Technologies (2011) 34(2): 83-92.

    Pearce, F. G., Dobson, R. C. J., Jameson, G. B., Perugini, M. A., & Gerrard, J. A. Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization. Biochimica Et Biophysica Acta-Proteins and Proteomics (2011) 1814(12): 1900-1909.

    Petersen, T. R., Sika-Paotonu, D., Knight, D. A., Simkins, H. M. A., & Hermans, I. F. Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines. PLoS ONE (2011) 6(3): e17657.

    Qi, T., Ly, K., Poyner, D. R., Christopoulos, G., Sexton, P. M., & Hay, D. L. Structurefunction analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors. Peptides (2011) 32(5): 1060-1067.

    Rehan, A. M., Bashiri, G., Paterson, N. G., Baker, E. N., & Squire, C. J. Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2011) 67(10): 1274- 1277.

    Reichau, S., Jiao, W., Walker, S. R., Hutton, R. D., Baker, E. N., & Parker, E. J. Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: Combining mechanism- and modeling-based design. Journal of Biological Chemistry (2011) 286(18): 16197-16207.

    Rewcastle, G. W., Gamage, S. A., Flanagan, J. U., Frederick, R., Denny, W. A., Baguley, B. C., Kestell, P., Singh, R., Kendall, J. D., Marshall, E. S., Lill, C. L., Lee, W. J., Kolekar, S., Buchanan, C. M., Jamieson, S. M. F., & Shepherd, P. R. Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(Difluoromethyl)-1-[4,6-di(4- morpholinyl)-1,3,5-triazin-2- yl]-1 H -benzimidazole (ZSTK474). Journal of Medicinal Chemistry (2011) 54(20): 7105- 7126.

    Ritchie, S. R., Fraser, J. D., Libby, E., Morris, A. J., Rainey, P. B., & Thomas, M. G. Demographic variation in community-based MRSA skin and soft tissue infection in Auckland, New Zealand. New Zealand Medical Journal (2011) 124(1332): 21-30.

    Shaw, O. M., & Harper, J. L. Bradykinin receptor 2 extends inflammatory cell recruitment in a model of acute gouty arthritis. Biochemical and Biophysical Research Communications (2011) 416(3–4): 266-269.

     

    Simkins, H. M. A., Hyde, E., Farrand, K. J., Ong, M. L., Degli-Esposti, M. A., Hermans, I. F., & Ronchese, F. Administration of alpha-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo. Journal of Leukocyte Biology. (2011) 89(5): 753-762.

    Smith, G. C., Vickers, M. H., & Shepherd, P. R. Olanzapine effects on body composition, food preference, glucose metabolism and insulin sensitivity in the rat. Archives of Physiology and Biochemistry (2011) 117(4): 241-249.

     

    Sparrow, K., Barker, D., & Brimble, M. A. The enantioselective synthesis of tetracyclic methyllycaconitine analogues. Tetrahedron (2011) 67(41): 7989-7999.

    Sperry, J., Liu, Y. C., Wilson, Z. E., Hubert, J. G., & Brimble, M. A. Synthesis of benzannulated spiroketals using an oxidative radical cyclization. Synthesis (2011) (9): 1383-1398.

    Stevenson, R. J., Denny, W. A., Ashoorzadeh, A., Pruijn, F. B., Van Leeuwen, W. F., & Tercel, M. The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy. Bioorganic and Medicinal Chemistry (2011) 19(20): 5989-5998.

    Stewart, K. W., Phillips, A. R. J., Whiting, L., Jüllig, M., Middleditch, M. J., & Cooper, G. J. S. A simple and rapid method for identifying and semi-quantifying peptide hormones in isolated pancreatic islets by direct-tissue matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry (2011) 25(22): 3387-3395.

    Szwergold, B. S., Bunker, R. D., & Loomes, K. M. The physiological substrates of fructosamine-3-kinase-related-protein (FN3KRP) are intermediates of nonenzymatic reactions between biological amines and ketose sugars (fructation products). Medical Hypotheses (2011) 77(5): 739-744.

    Tercel, M., Atwell, G. J., Yang, S., Ashoorzadeh, A., Stevenson, R. J., Botting, K. J., Gu, Y., Mehta, S. Y., Denny, W. A., Wilson, W. R., & Pruijn, F. B. Selective treatment of hypoxic tumor cells in vivo: Phosphate pre-prodrugs of nitro analogues of the duocarmycins. Angewandte Chemie - International Edition (2011) 50(11): 2606-2609.

    Thompson, A. M., Sutherland, H. S., Palmer, B. D., Kmentova, I., Blaser, A., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., & Denny, W. A. Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6 S)-2-nitro- 6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2011) 54(19): 6563-6585.

     

    Tran, D., Pietersma, A. L., Schofield, L. R., Rost, M., Jameson, G. B., & Parker, E. J. Investigating the role of the hydroxyl groups of substrate erythrose 4-phosphate in the reaction catalysed by the first enzyme of the shikimate pathway. Bioorganic & Medicinal Chemistry Letters (2011) 21 (22): 6838-6841.

    Vaghefi, E., Pontre, B. P., Jacobs, M. D., & Donaldson, P. J. Visualizing ocular lens fluid dynamics using MRI: Manipulation of steady state water content and water fluxes. American Journal of Physiology - Regulatory Integrative and Comparative Physiology (2011) 301(2): R335-R342.

    Waardenberg, A. J., Bernardo, B. C., Ng, D. C. H., Shepherd, P. R., Cemerlang, N., Sbroggio, M., Wells, C. A., Dalrymple, B. P., Brancaccio, M., Lin, R. C. Y., & McMullen, J. R. Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure. Journal of Biological Chemistry   (2011) 286(35): 30837-30846.

    Walker, S. R., Jiao, W., & Parker, E. J. Synthesis and evaluation of dual site inhibitors of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase. Bioorganic and Medicinal Chemistry Letters (2011) 21(17): 5092-5097.

    Waltemath, D., Adams, R., Beard, D. A., Bergmann, F. T., Bhalla, U. S., Britten, R., Chelliah, V., Cooling, M. T., Cooper, J., Crampin, E. J., Garny, A., Hoops, S., Hucka, M., Hunter, P., Klipp, E., Laibe, C., Miller, A. K., Moraru, I., Nickerson, D., Nielsen, P., Nikolski, M., Sahle, S., Sauro, H. M., Schmidt, H., Snoep, J. L., Tolle, D., Wolkenhauer, O., & le Novère, N. Minimum information about a simulation experiment (MIASE). PLoS Computational Biology (2011) 7(4).

    Wilson, W. R., & Hay, M. P. Targeting hypoxia in cancer therapy. Nature Reviews Cancer (2011) 11(6): 393-410.

    Wilson, Z. E., Hubert, J. G., & Brimble, M. A. A flexible approach to 6,5-benzannulated spiroketals. European Journal of Organic Chemistry (2011) (20-21): 3938-3945.

    Win, S. J., Ward, V. K., Dunbar, P. R., Young, S. L., & Baird, M. A. Cross-presentation of epitopes on virus-like particles via the MHC I receptor recycling pathway. Immunology and Cell Biology (2011) 89(6): 681-688.

    Wines, B. D., Ramsland, P. A., Trist, H. M., Gardam, S., Brink, R., Fraser, J. D., & Hogarth, P. M. Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor. Journal of Biological Chemistry (2011) 286(38): 33118-33124.

    Wojnar, J. M., Evans, C. W., Devries, A. L., & Brimble, M. A. Synthesis of an isotopically-labelled antarctic fish antifreeze glycoprotein probe. Australian Journal of Chemistry (2011) 64(6): 723-731.

    Wood AJ, Fraser J, Swift S, Amirapu S, Douglas RG. Are biofilms associated with an inflammatory response in chronic rhinosinusitis? International Forum of Allergy and Rhinology (2011) 1 (5): 335-339.


    Yang, S. H., Lee, D. J., & Brimble, M. A. Synthesis of an NDPK phosphocarrier domain peptide containing a novel triazolylalanine analogue of phosphohistidine using click chemistry. Organic Letters (2011) 13(20): 5604-5607.

    Yu, T., Lloyd, C. M., Nickerson, D. P., Cooling, M. T., Miller, A. K., Garny, A., Terkildsen, J. R., Lawson, J., Britten, R. D., Hunter, P. J., & Nielsen, P. M. The physiome model repository 2. Bioinformatics (2011) 27(5): 743-744.

    Yuen, T. Y., Yang, S. H., & Brimble, M. A. Total synthesis of paecilospirone. Angewandte Chemie - International Edition (2011) 50(36): 8350-8353.

    Zhang, Y. C., Furkert, D. P., Guéret, S. M., Lombard, F., & Brimble, M. A. Gold(I)- catalysed intramolecular hydroamination of alpha-quaternary alkynes: synthetic studies towards spiroimine marine toxins. Tetrahedron Letters (2011) 52(38): 4896-4898.

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