Publications //

Scientific Publications

Every year Maurice Wilkins Centre investigators produce a large number of peer-reviewed scientific papers and reviews published in international journals. Research directly supported by the Maurice Wilkins Centre generated the following scientific papers.

    2015

    Ahmed, F. H., Carr, P. D., Lee, B. M., Afriat-Jurnou, L., Mohamed, A. E., Hong, N. S., Flanagan, J., Taylor, M. C., Greening, C., & Jackson, C. J. Sequence-Structure-Function Classification of a Catalytically Diverse Oxidoreductase Superfamily in Mycobacteria. Journal of Molecular Biology (2015) 427(22): 3554-3571.

    Anderson, R. J., Compton, B. J., Tang, C. W., Authier-Hall, A., Hayman, C. M., Swinerd, G. W., Kowalczyk, R., Harris, P., Brimble, M. A., Larsen, D. S., Gasser, O., Weinkove, R., Hermans, I. F., & Painter, G. F. NKT cell-dependent glycolipid-peptide vaccines with potent anti-tumour activity. Chemical Science (2015) 6(9): 5120-5127.

    Andrews, E. S. V., & Arcus, V. L. The mycobacterial PhoH2 proteins are type II toxin antitoxins coupled to RNA helicase domains. Tuberculosis (2015) 95(4): 385-394.

    Atkinson, D. J., & Brimble, M. A. Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products. Natural Product Reports (2015) 32(6): 811-840.

    Aung, H. L., Dey, D., Janssen, P. H., Ronimus, R. S., & Cook, G. M. A high-throughput screening assay for identification of inhibitors of the A1AO-ATP synthase of the rumen methanogen Methanobrevibacter ruminantium M1. Journal of Microbiological Methods (2015) 110: 15-17.

    Aung, H. L., Dixon, L. L., Smith, L. J., Sweeney, N. P., Robson, J. R., Berney, M., Buxton, R. S., Green, J., & Cook, G. M. Novel regulatory roles of cAMP receptor proteins in fast-growing environmental mycobacteria. Microbiology (United Kingdom) (2015) 161(3): 648-661.

    Bashiri, G., & Baker, E. N. Production of recombinant proteins in Mycobacterium smegmatis for structural and functional studies. Protein Science (2015) 24(1): 1-10.

    Bashiri, G., Johnston, J. M., Evans, G. L., Bulloch, E. M. M., Goldstone, D. C., Jirgis, E. N. M., Kleinboelting, S., Castell, A., Ramsay, R. J., Manos-Turvey, A., Payne, R. J., Lott, J. S., & Baker, E. N. Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex. Acta Crystallographica Section D: Biological Crystallography (2015) 71: 2297-2308.

    Blackmore, N. J., Nazmi, A. R., Hutton, R. D., Webby, M. N., Baker, E. N., Jameson, G. B., & Parker, E. J. Complex formation between two biosynthetic enzymes modifies the allosteric regulatory properties of both: An example of molecular symbiosis. Journal of Biological Chemistry (2015) 290(29): 18187-18198.

    Blenkiron, C., Tsai, P., Brown, L. A., Tintinger, V., Askelund, K. J., Windsor, J. A., & Phillips, A. R. Characterisation of the small RNAs in the biomedically important green-bottle blowfly Lucilia sericata. PLoS ONE (2015) 10(3).

    Booe, J. M., Walker, C. S., Barwell, J., Kuteyi, G., Simms, J., Jamaluddin, M. A., Warner, M. L., Bill, R. M., Harris, P. W., Brimble, M. A., Poyner, D. R., Hay, D. L., & Pioszak, A. A. Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Molecular Cell (2015) 58(6): 1040-1052.

    Brimble, M. A., Edwards, P. J., Harris, P. W. R., Norris, G. E., Patchett, M. L., Wright, T. H., Yang, S. H., & Carley, S. E. Synthesis of the antimicrobial S-Linked glycopeptide, glycocin F. Chemistry - A European Journal (2015) 21(9): 3556-3561.

    Brings, S., Zhang, S., Choong, Y. S., Hogl, S., Middleditch, M., Kamalov, M., Brimble, M. A., Gong, D., & Cooper, G. J. S. Diabetes-induced alterations in tissue collagen and carboxymethyllysine in rat kidneys: Association with increased collagen-degrading proteinases and amelioration by Cu(II)-selective chelation. Biochimica et Biophysica Acta - Molecular Basis of Disease (2015) 1852(8): 1610-1618.

    Bull, M. R., Spicer, J. A., Huttunen, K. M., Denny, W. A., Ciccone, A., Browne, K. A., Trapani, J. A., & Helsby, N. A. The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents. European Journal of Drug Metabolism and Pharmacokinetics (2015) 40(4): 417-425.

    Bunker, R. D., Mandal, K., Bashiri, G., Chaston, J. J., Pentelute, B. L., Lott, J. S., Kent, S. B. H., Baker, E. N., & Petsko, G. A. A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Proceedings of the National Academy of Sciences of the United States of America (2015) 112(14): 4310-4315.

    Campen, R. L., Ackerley, D. F., Cook, G. M., & O'Toole, R. F. Development of a Mycobacterium smegmatis transposon mutant array for characterising the mechanism of action of tuberculosis drugs: Findings with isoniazid and its structural analogues. Tuberculosis (2015) 95(4): 432-439.

    Chai, A. F., Bulloch, E. M. M., Evans, G. L., Lott, J. S., Baker, E. N., & Johnston, J. M. A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket. Acta Crystallographica Section D: Biological Crystallography (2015) 71: 862-872.

    Chan, S., Han, K., Qu, R., Tong, L., Li, Y., Zhang, Z., Cheng, H., Lu, X., Patterson, A., Smaill, J., Ren, X., Ding, J., Xie, H., & Ding, K. 2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFRL858R/T790M. Bioorganic and Medicinal Chemistry Letters (2015) 25(19): 4277-4281.

    Chowdhury, M. K. H., Montgomery, M. K., Morris, M. J., Cognard, E., Shepherd, P. R., & Smith, G. C. Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver. Archives of Physiology and Biochemistry (2015) 121(3): 88-96.

    Chua, E. W., Cree, S., Barclay, M. L., Doudney, K., Lehnert, K., Aitchison, A., & Kennedy, M. A. Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers. Pharmacogenomics Journal (2015) 15(5): 414-421.

    Cookson, T. V. M., Evans, G. L., Castell, A., Baker, E. N., Lott, J. S., & Parker, E. J. Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry (2015) 54(39): 6082-6092.

    Cooling, M. T., & Yu, T. (2015) Distributed model construction with virtual parts. Vol. 1244. Methods in Molecular Biology (pp. 301-322): Humana Press Inc.

    Cursons, J., Angel, C. E., Hurley, D. G., Print, C. G., Dunbar, P. R., Jacobs, M. D., & Crampin, E. J. Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis. GigaScience (2015) 4(1): 1-6.

    Cursons, J., Gao, J., Hurley, D. G., Print, C. G., Dunbar, P. R., Jacobs, M. D., & Crampin, E. J. Regulation of ERK-MAPK signaling in human epidermis. BMC Systems Biology (2015) 9(1).

    De Bono, B., Safaei, S., Grenon, P., Nickerson, D. P., Alexander, S., Helvensteijn, M., Kok, J. N., Kokash, N., Wu, A., Yu, T., Hunter, P., & Baldock, R. A. The open physiology workflow: Modeling processes over physiology circuitboards of interoperable tissue units. Frontiers in Physiology (2015) 6(FEB).

    De Leon Rodriguez, L. M., Weidkamp, A. J., & Brimble, M. A. An update on new methods to synthesize cyclotetrapeptides. Organic and Biomolecular Chemistry (2015) 13(25): 6906-6921.

    Grattan, D. R. The hypothalamo-prolactin axis. Journal of Endocrinology (2015) 226(2): T101-T122.

    Guan, J., Harris, P., Brimble, M., Lei, Y., Lu, J., Yang, Y., & Gunn, A. J. The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders. Expert Opinion on Therapeutic Targets (2015) 19(6): 785-793.

    Hampe, L., Radjainia, M., Xu, C., Harris, P. W. R., Bashiri, G., Goldstone, D. C., Brimble, M. A., Wang, Y., & Mitra, A. K. Regulation and quality control of adiponectin assembly by endoplasmic reticulum chaperone ERp44. Journal of Biological Chemistry (2015) 290(29): 18111-18123.

    Hand, L. E., Usan, P., Cooper, G. J. S., Xu, L. Y., Ammori, B., Cunningham, P. S., Aghamohammadzadeh, R., Soran, H., Greenstein, A., Loudon, A. S. I., Bechtold, D. A., & Ray, D. W. Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit. Diabetes (2015) 64(1): 128-136.

    Hards, K., Robson, J. R., Berney, M., Shaw, L., Bald, D., Koul, A., Andries, K., & Cook, G. M. Bactericidal mode of action of bedaquiline. Journal of Antimicrobial Chemotherapy (2015) 70(7): 2028-2037.

    Harris, P. W. R., & Brimble, M. A. Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines. Peptide Science (2015) 104(2): 116-127.

    Harris, P. W. R., Squire, C., Young, P. G., & Brimble, M. A. Chemical synthesis of γ-secretase activating protein using pseudo-glutamines as ligation sites. Biopolymers - Peptide Science Section (2015) 104(1): 37-45.

    Hassan, N. P. S., Naysmith, B. J., Sperry, J., & Brimble, M. A. Formal synthesis of nanaomycin D via a Hauser-Kraus annulation using a chiral enone-lactone. Tetrahedron (2015) 71(39): 7137-7143.

    Hubert, J. G., Furkert, D. P., & Brimble, M. A. Preparation of cis-γ-hydroxycarvone derivatives for synthesis of sesterterpenoid natural products: Total synthesis of phorbin A. Journal of Organic Chemistry (2015a) 80(4): 2231-2239.

    Hubert, J. G., Furkert, D. P., & Brimble, M. A. Synthesis of the spirocyclic framework of sesterterpenoid natural products. Journal of Organic Chemistry (2015b) 80(5): 2715-2723.

    Kamalov, M., Harris, P. W. R., Hartinger, C. G., Miskelly, G. M., Cooper, G. J. S., & Brimble, M. A. Physicochemical studies on the copper(ii) binding by glycated collagen telopeptides. Organic and Biomolecular Chemistry (2015) 13(10): 3058-3063.

    Kamalov, M., Harris, P. W. R., Wood, J. M., & Brimble, M. A. On resin synthesis and cross-linking of collagen peptides containing the advanced glycation end-product pyrraline via Maillard condensation. Chemical Communications (2015) 51(46): 9475-9478.

    Kamato, D., Thach, L., Bernard, R., Chan, V., Zheng, W., Kaur, H., Brimble, M., Osman, N., & Little, P. J. Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Galpha/q,11. Frontiers in Cardiovascular Medicine (2015) 2: 14.

    Kaur, H., Harris, P. W. R., Little, P. J., & Brimble, M. A. Total synthesis of the cyclic depsipeptide YM-280193, a platelet aggregation inhibitor. Organic Letters (2015) 17(3): 492-495.

    Kay, E. I., Botha, R., Montgomery, J. M., & Mountjoy, K. G. HMRAPα, but not hMRAP2, enhances hMC4R constitutive activity in HEK293 cells and this is not dependent on hMRAPα induced changes in hMC4R complex N-linked glycosylation. PLoS ONE (2015) 10(10).

    Kelch, I. D., Bogle, G., Sands, G. B., Phillips, A. R. J., Legrice, I. J., & Rod Dunbar, P. Organ-wide 3D-imaging and topological analysis of the continuous microvascular network in a murine lymph node. Scientific Reports (2015) 5.

    Ko, K. Y., Wagner, S., Yang, S. H., Furkert, D. P., & Brimble, M. A. Improved Synthesis of the Unnatural Amino Acids AHMOD and AMD, Components of the Anticancer Peptaibol Culicinin D. Journal of Organic Chemistry (2015) 80(17): 8631-8636.

    Lagautriere, T., Bashiri, G., & Baker, E. N. Use of a "silver bullet" to resolve crystal lattice dislocation disorder: A cobalamin complex of δ1-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis. Journal of Structural Biology (2015) 189(2): 153-157.

    Lee, K. L., Middleditch, M. J., Williams, G. M., Brimble, M. A., & Cooper, G. J. S. Using mass spectrometry to detect, differentiate, and semiquantitate closely related peptide hormones in complex milieu: Measurement of IGF-II and vesiculin. Endocrinology (2015) 156(3): 1194-1199.

    Li, Y., Cheng, H., Zhang, Z., Zhuang, X., Luo, J., Long, H., Zhou, Y., Xu, Y., Taghipouran, R., Li, D., Patterson, A., Smaill, J., Tu, Z., Wu, D., Ren, X., & Ding, K. N-(3-ethynyl-2,4-difluorophenyl)sulfonamide derivatives as selective Raf inhibitors. ACS Medicinal Chemistry Letters (2015) 6(5): 543-547.

    Lorenz, N., Loef, E. J., Verdon, D. J., Chen, C. J. J., Mansell, C. J., Angel, C. E., Brooks, A. E. S., Dunbar, P. R., & Birch, N. P. Human T cell activation induces synaptic translocation and alters expression of the serine protease inhibitor neuroserpin and its target protease. Journal of Leukocyte Biology (2015) 97(4): 699-710.

    Lu, P., Heineke, M. H., Koul, A., Andries, K., Cook, G. M., Lill, H., Van Spanning, R., & Bald, D. The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress. Scientific Reports (2015) 5.

    Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. Bridging small molecules to modified bacterial microparticles using a disulphide linkage: MIS416 as a cargo delivery system. PLoS ONE (2015) 10(12).

    Marshall, A. J., Lill, C. L., Chao, M., Kolekar, S. V., Lee, W. J., Marshall, E. S., Baguley, B. C., Shepherd, P. R., Denny, W. A., Flanagan, J. U., & Rewcastle, G. W. Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: Synthesis, biological evaluation and molecular modelling. Bioorganic and Medicinal Chemistry (2015) 23(13): 3796-3808.

    McIntosh, J. D., Brimble, M. A., Brooks, A. E. S., Dunbar, P. R., Kowalczyk, R., Tomabechi, Y., & Fairbanks, A. J. Convergent chemo-enzymatic synthesis of mannosylated glycopeptides; targeting of putative vaccine candidates to antigen presenting cells. Chemical Science (2015) 6(8): 4636-4642.

    Medini, K., Harris, P. W. R., Hards, K., Dingley, A. J., Cook, G. M., & Brimble, M. A. Chemical synthesis of a pore-forming antimicrobial protein, caenopore-5, by using native chemical ligation at a Glu-Cys site. ChemBioChem (2015) 16(2): 328-336.

    Murphy, R., Jiang, Y., Booth, M., Babor, R., Maccormick, A., Hammodat, H., Beban, G., Barnes, R. M., & Vincent, A. L. Progression of diabetic retinopathy after bariatric surgery. Diabetic Medicine (2015) 32(9): 1212-1220.

    Musson, D. S., Naot, D., Chhana, A., Matthews, B. G., McIntosh, J. D., Lin, S. T. C., Choi, A. J., Callon, K. E., Dunbar, P. R., Lesage, S., Coleman, B., & Cornish, J. In vitro evaluation of a novel non-mulberry silk scaffold for use in tendon regeneration. Tissue Engineering - Part A (2015) 21(9-10): 1539-1551.

    Neumann, S., Young, K., Compton, B., Anderson, R., Painter, G., & Hook, S. Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8+ T-cell responses and prevent tumour progression. Vaccine (2015) 33(43): 5838-5844.

    Newman, T. A. C., Carleton, C. R., Leeke, B., Hampton, M. B., & Horsfield, J. A. Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biology (2015) 6: 648-655.

    Newton, M. S., Arcus, V. L., & Patrick, W. M. Rapid bursts and slow declines: On the possible evolutionary trajectories of enzymes. Journal of the Royal Society Interface (2015) 12(107).

    Palmer, B. D., Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., Denny, W. A., & Thompson, A. M. Synthesis and Structure-Activity Relationships for Extended Side Chain Analogues of the Antitubercular Drug (6 S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2015) 58(7): 3036-3059.

    Papst, S., Brimble, M. A., Evans, C. W., Verdon, D. J., Feisst, V., Dunbar, P. R., Tilley, R. D., & Williams, D. E. Cell-targeted platinum nanoparticles and nanoparticle clusters. Organic and Biomolecular Chemistry (2015) 13(23): 6567-6572.

    Parker, E. J. The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3. Structure (2015) 23(4): 608-609.

    Patassini, S., Begley, P., Reid, S. J., Xu, J., Church, S. J., Curtis, M., Dragunow, M., Waldvogel, H. J., Unwin, R. D., Snell, R. G., Faull, R. L. M., & Cooper, G. J. S. Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease. Biochemical and Biophysical Research Communications (2015) 468(1-2): 161-166.

    Petridis, M., Benjak, A., & Cook, G. M. Defining the nitrogen regulated transcriptome of Mycobacterium smegmatis using continuous culture. BMC Genomics (2015) 16(1): 1-13.

    Poral, V. L., Furkert, D. P., & Brimble, M. A. Total Synthesis and Structural Confirmation of the Antimalarial Naphthopyrone Lasionectrin. Organic Letters (2015) 17(24): 6214-6217.

    Sawhney, S., Hood, K., Shaw, A., Braithwaite, A. W., Stubbs, R., Hung, N. A., Royds, J. A., & Slatter, T. L. Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a Δ133p53α mimic. PLoS ONE (2015) 10(2).

    Sparrow, K. J., Carley, S., Söhnel, T., Barker, D., & Brimble, M. A. Studies towards development of asymmetric double-Mannich reactions of chiral 2-oxocyclohexanecarboxylate derivatives with bis(aminol)ethers. Tetrahedron (2015) 71(15): 2210-2221.

    Stach, M., Weidkamp, A. J., Yang, S. H., Hung, K. Y., Furkert, D. P., Harris, P. W. R., Smaill, J. B., Patterson, A. V., & Brimble, M. A. Improved Strategy for the Synthesis of the Anticancer Agent Culicinin D. European Journal of Organic Chemistry (2015) 2015(28): 6341-6350.

    Strauss, O., Dunbar, P. R., Bartlett, A., & Phillips, A. The immunophenotype of antigen presenting cells of the mononuclear phagocyte system in normal human liver - A systematic review. Journal of Hepatology (2015) 62(2): 458-468.

    Street, M., Thambyah, A., Dray, M., Amirapu, S., Tuari, D., Callon, K. E., McIntosh, J. D., Burkert, K., Dunbar, P. R., Coleman, B., Cornish, J., & Musson, D. S. Augmentation with an ovine forestomach matrix scaffold improves histological outcomes of rotator cuff repair in a rat model. Journal of Orthopaedic Surgery and Research (2015) 10(1).

    Stubbing, L. A., Lott, J. S., Dawes, S. S., Furkert, D. P., & Brimble, M. A. Synthesis of DOHNAA, a Mycobacterium tuberculosis Cholesterol CD Ring Catabolite and FadD3 Substrate. European Journal of Organic Chemistry (2015) 2015(27): 6075-6083.

    Sun, Y., Bell, J. L., Carter, D., Gherardi, S., Poulos, R. C., Milazzo, G., Wong, J. W. H., Al-Awar, R., Tee, A. E., Liu, P. Y., Liu, B., Atmadibrata, B., Wong, M., Trahair, T., Zhao, Q., Shohet, J. M., Haupt, Y., Schulte, J. H., Brown, P. J., Arrowsmith, C. H., Vedadi, M., MacKenzie, K. L., Hüttelmaier, S., Perini, G., Marshall, G. M., Braithwaite, A., & Liu, T. WDR5 supports an N-myc transcriptional complex that drives a protumorigenic gene expression signature in neuroblastoma. Cancer Research (2015) 75(23): 5143-5154.

    Sweetlove, M., Wrightson, E., Kolekar, S., Rewcastle, G. W., Baguley, B. C., Shepherd, P. R., & Jamieson, S. M. F. Inhibitors of pan-PI3K signaling synergize with BRAF or MEK inhibitors to prevent BRAF-mutant melanoma cell growth. Frontiers in Oncology (2015) 5(JUN).

    Thompson, A. M., Blaser, A., Palmer, B. D., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., & Denny, W. A. Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy. Bioorganic and Medicinal Chemistry Letters (2015) 25(18): 3804-3809.

    Ting, Y. T., Batot, G., Baker, E. N., & Young, P. G. Expression, purification and crystallization of a membrane-associated, catalytically active type I signal peptidase from Staphylococcus aureus.. Acta Crystallographica Section F: Structural Biology Communications (2015) 71: 61-65.

    Tomek, P., Palmer, B. D., Kendall, J. D., Flanagan, J. U., & Ching, L. M. Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine. Biochimica et Biophysica Acta - General Subjects (2015) 1850(9): 1772-1780.

    Tran, T. T., Palmer, H. R., Weimar, M. R., Arias, C. A., Cook, G. M., & Murray, B. E. Oral bacitracin: A consideration for suppression of intestinal vancomycin-resistant enterococci (VRE) and for VRE bacteremia from an apparent gastrointestinal tract source. Clinical Infectious Diseases (2015) 60(11): 1726-1728.

    Wadsworth, A. D., Naysmith, B. J., & Brimble, M. A. A review of the synthesis of α-carbolines. European Journal of Medicinal Chemistry (2015) 97(1): 816-829.

    Whiting, L., Stewart, K. W., Hay, D. L., Harris, P. W., Choong, Y. S., Phillips, A. R. J., Brimble, M. A., & Cooper, G. J. S. Glicentin‐related pancreatic polypeptide inhibits glucose‐stimulated insulin secretion from the isolated pancreas of adult male rats. Physiological Reports (2015) 3(12): e12638.

    Williams, E. M., Little, R. F., Mowday, A. M., Rich, M. H., Chan-Hyams, J. V. E., Copp, J. N., Smaill, J. B., Patterson, A. V., & Ackerley, D. F. Nitroreductase gene-directed enzyme prodrug therapy: Insights and advances toward clinical utility. Biochemical Journal (2015) 471(2): 131-153.

    Williamson, D. A., Smeesters, P. R., Steer, A. C., Steemson, J. D., Ng, A. C. H., Proft, T., Fraser, J. D., Baker, M. G., Morgan, J., Carter, P. E., & Moreland, N. J. M-protein analysis of streptococcus pyogenes isolates associated with acute rheumatic fever in New Zealand. Journal of Clinical Microbiology (2015) 53(11): 3618-3620.

    Xu, J., Jüllig, M., Middleditch, M. J., & Cooper, G. J. S. Modelling atherosclerosis by proteomics: Molecular changes in the ascending aortas of cholesterol-fed rabbits. Atherosclerosis (2015) 242(1): 268-276.

    Xu, S., Mao, L., Ding, P., Zhuang, X., Zhou, Y., Yu, L., Liu, Y., Nie, T., Xu, T., Xu, Y., Liu, J., Smaill, J., Ren, X., Wu, D., & Ding, K. 1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose. Bioorganic and Medicinal Chemistry (2015) 23(13): 3751-3760.

    Yosaatmadja, Y., Patterson, A. V., Smaill, J. B., & Squire, C. J. The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition. Acta Crystallographica Section D: Biological Crystallography (2015) 71: 525-533.

    Yosaatmadja, Y., Silva, S., Dickson, J. M., Patterson, A. V., Smaill, J. B., Flanagan, J. U., McKeage, M. J., & Squire, C. J. Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed. Journal of Structural Biology (2015) 192(3): 539-544.

    Zhang, L., Li, M. M., Corcoran, M., Zhang, S., & Cooper, G. J. S. Essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin. Molecular and Cellular Endocrinology (2015) 399: 164-177.

    2014

    Abendroth, J., Ollodart, A., Andrews, E. S. V., Myler, P. J., Staker, B. L., Edwards, T. E., Arcus, V.L. & Grundner, C.  Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution. Journal of Biological Chemistry (2014) 289(4): 2139-2147

    Ahmadi, O., Stringer, M. D., Black, M. A., & McCall, J. L. Influence of age and site of disease on lymph node yield in colorectal cancer. The New Zealand Medical Journal  (2014) 127 (1395): 31-40

    Anderson, R.J., Tang, C.W., Daniels, N.J., Compton, B.J., Hayman, C.M., Johnston, K.A., Knight, D.A., Gasser, O., Poyntz, H.C., Ferguson, P.M., Larsen, D.S., Ronchese, F., Painter, G.F., & Hermans, I.F. A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy. Nature Chemical Biology (2014) 10(11): 943-9

    Aung, H. L., Berney, M., & Cook, G. M.  Hypoxia-activated cytochrome bd expression in Mycobacterium smegmatis is cyclic AMP receptor protein dependent. Journal of Bacteriology (2014) 196(17): 3091-3097

    Bouchery, T., Kyle, R., Ronchese, F. & Le Gos, G.. The differentiation of CD4+ T-helper cell subsets in the context of helminth parasite infection. Review article. Frontiers of Immunology (2014) 5: Article 487, 1-13

    Bull, M. R., Spicer, J. A., Huttunen, K. M., Denny, W. A., Ciccone, A., Browne, K. A., Trapani, J.A. & Helsby, N. A. The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents. European Journal of Drug Metabolism and Pharmacokinetics (2014) pp 1-9

    Bulloch, E. M. M., & Kingston, R. L. Identifying protein domains by global analysis of soluble fragment data. Analytical Biochemistry (2014) 465: 53-62

    Chu, M. J. J., Hickey, A. J. R., Tagaloa, S., Zhang, L., Dare, A. J., MacDonald, J. R., Yeong, M-L., Adam, S.J., Bartlett, R. & Phillips, A. R. J. Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia. PLoS ONE (2014) 9(6)

    Chu, M. J. J., Vather, R., Hickey, A. J. R., Phillips, A. R. J., & Bartlett, A. S. J. R. Impact of ischaemic preconditioning on experimental steatotic livers following hepatic ischaemia-reperfusion injury: A systematic review. HPB (2014) 17(1): 1-10

    Commons, R. J., Smeesters, P. R., Proft, T., Fraser, J. D., Robins-Browne, R., & Curtis, N. Streptococcal superantigens: Categorization and clinical associations. Trends in Molecular Medicine (2014) 20(1): 48-62.

    Connor, L.M., Tang, S.C., Camberis, M., Le Gros, G. & Ronchese, F.. Helminth–conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo. Journal of Immunology (2014) 193(6): 2709-17.

    Cookson, T. V. M., Castell, A., Bulloch, E. M. M., Evans, G. L., Short, F. L., Baker, E. N., Lott, J. S.& Parker, E. J.  Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochemical Journal (2014) 461: (1)

    Cotton, T. R., Joseph, D. D. A., Jiao, W., & Parker, E. J.  Probing the determinants of phosphorylated sugar-substrate binding for human sialic acid synthase. Biochimica et Biophysica Acta - Proteins and Proteomics (2014) 1844 (12): 2257-2264. http://www.ncbi.nlm.nih.gov/pubmed/?term=25113848

    Dawes, S., Kendall, S., Baker, E.N. & Lott, J.S. Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (keto-steroid regulatory protein) from Mycobacterium tuberculosis. Acta Crystallographica. (2014) 70: 1643-1645.

    Dunn, E. A., Roxburgh, M., Larsen, L., Smith, R. A. J., McLellan, A. D., Heikal, A., Murphy, M.P. & Cook, G. M. Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis. Bioorganic and Medicinal Chemistry (2014) 22(19): 5320-5328.

    Evans, G. L., Gamage, S. A., Bulloch, E. M. M., Baker, E. N., Denny, W. A., & Lott, J. S.  Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis. ChemBioChem (2014) 15(6): 852-864.

    Feisst, V., Brooks, A. E., Chen, C. -J., & Dunbar, P. R. (2014). Characterization of Mesenchymal Progenitor Cell Populations Directly Derived from Human Dermis. Stem Cells and Development (2014) 23(6): 631-642.

    Flanagan, J. U., & Shepherd, P. R.  Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme. Biochemical Society Transactions (2014) 42(1): 120-124.

    Furkert, D. P., Breitenbach, B., Juen, L., Sroka, I., Pantin, M., & Brimble, M. A. Nonsymmetrical azocarbonamide carboxylates as effective Mitsunobu reagents. European Journal of Organic Chemistry (2014) 2014(35).

    Gebhard, S., Busby, J. N., Fritz, G., Moreland, N. J., Cook, G. M., Lott, J. S., Baker, E.N. & Money, V. A. Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis. Journal of Bacteriology (2014) 196(19): 3472-3481.

    Gibbins, J.D., Ancelet, L.R., Weinkove, R., Compton, B.J., Painter, G.F., Petersen, T.R. & Hermans, I.F.. An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment. Blood. (2014) 124(19): 2953.

    Gingell, J. J., Burns, E. R., & Hay, D. L.  Activity of Pramlintide, Rat and Human Amylin but not Aβ1-42 at Human Amylin Receptors. Endocrinology (2014) 155(1): 21-26

    Harris, P. W. R., Kowalczyk, R., Yang, S. H., Williams, G. M., & Brimble, M. A. An important side reaction using the thiol, 3,6-dioxa-1,8-octanedithiol (DODT), in 9-fluorenylmethoxycarbonyl-based solid phase peptide synthesis. Journal of Peptide Science (2014) 20(3):186-190.

    Harris, P. W. R., Yang, S. H., Molina, A., Lõpez, G., Middleditch, M., & Brimble, M. A.  Plant antimicrobial peptides snakin-1 and snakin-2: Chemical synthesis and insights into the disulfide connectivity. Chemistry - A European Journal (2014) 20(17): 5102-5110.

    Harris, P. W., Hampe, L., Radjainia, M., Brimble, M. A., & Mitra, A. K.  An investigation of the role of the adiponectin variable domain on the stability of the collagen-like domain.. Biopolymers (2014) 101(4): 313-321.

    Harris, P., Molenaar, G. T., Amso, Z., Savage, G. P., & Brimble, M. A. An Efficient Fmoc Solid-Phase Synthesis of an Amphiphile of the Neuroprotective Agent Glycyl-prolyl-glutamic Acid. Synlett (2014) 25(15): 2221-2224

    Harris, P.W.R., Hampe, Radjainia, L.M., Brimble, M.A. & Mitra, A.K. An Investigation of the Role of the Adiponectin Variable Domain on the Stability of the Collagen-like Domain, Biopolymers (Peptide Science) (2014) 102: 313-321.

    Hartman, T., Weinrick, B., Vilchèze, C., Berney, M., Tufariello, J., Cook, G. M., & Jacobs, W. R., Jr.  Succinate Dehydrogenase is the Regulator of Respiration in Mycobacterium tuberculosis. PLoS Pathogens (2014) 10(11).

    Hay, D. L., Harris, P. W. R., Kowalczyk, R., Brimble, M. A., Rathbone, D. L., Barwell, J. & Poyner, D. R.  Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: Key roles of alanine-5 and threonine-6 in receptor activation. British Journal of Pharmacology (2014) 171(2): 415-426.

    Heikal, A., Nakatani, Y., Dunn, E., Weimar, M. R., Day, C. L., Baker, E. N., Lott, J. S., Sazanov, L. A., & Cook, G. M. Structure of the bacterial type II NADH dehydrogenase: A monotopic membrane protein with an essential role in energy generation. Molecular Microbiology (2014) 91(5): 950-964.

    Huang, A., Baker, E.N. & Loomes, K.M.  Use of a novel micro-titration protocol to obtain diffraction quality crystals of 4-hydroxy-2-oxoglutarate aldolase from Bos taurus. Acta Crystallographica (2014) F 70: 1546-1549.

    Hume, P. A., Furkert, D. P., & Brimble, M. A.  Total synthesis of virgatolide b via exploitation of intramolecular hydrogen bonding. Journal of Organic Chemistry (2014) 79(11): 5269-5281.

    Hunn, M. K., Bauer, E., Wood, C. E., Gasser, O., Dzhelali, M., Ancelet, L. R., Mester, B., Sharples, K.J., Findlay, M.P., Hamilton, D.A. & Hermans, I. F. Dendritic cell vaccination combined with temozolomide retreatment: results of a phase I trial in patients with recurrent glioblastoma multiforme. Journal of Neuro-Oncology (2014) 121(2): 319-329

    Hussan, J.R., Hunter, P.J., Gladding, P.A., Greenberg, N., Christie, R., Wu, A., Sorby, H., Thomas, J.D. ICMA: an integrated cardiac modeling and analysis platform. Bioinformatics (2014) 31(6): 1331-1333.

    Joseph, D. D. A., Jiao, W., Kessans, S. A., & Parker, E. J. Substrate-mediated control of the conformation of an ancillary domain delivers a competent catalytic site for N-acetylneuraminic acid synthase. Proteins: Structure, Function and Bioinformatics (2014) 82(9), 2054-2066.

    Jüllig, M., Yip, S., Xu, A., Smith, G., Middleditch, M., Booth, M., Babor, R., Beban, G. & Murphy, R.  Lower Fetuin-A, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes. PLoS ONE (2014) 9(5): e96489.

    Jung, J., Bashiri, G., Johnston, J. M., Brown, A. S., Ackerley, D. F., & Baker, E. N. Crystal structure of the essential mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein. Journal of Structural Biology (2014) 188(3): 274-278.

    Kamalov, M., Harris, P. W. R., Cooper, G. J. S., & Brimble, M. A. Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts. Chemical Communications (2014) 50(38): 4944-4946

    Kamalov, M., Yang, S., Harris, P. W. R., Cooper, G. J. S., & Brimble, M. A.  Expedient synthesis of peptides containing Nε- carboxymethyllysine. Synlett (2014) 25(13): 1835-1838.

    Kang, H. J., Paterson, N. G., Kim, C. U., Middleditch, M., Chang, C., Ton-That, H., & Baker, E. N.  A slow-forming isopeptide bond in the structure of the major pilin SpaD from Corynebacterium diphtheriae has implications for pilus assembly. Acta Crystallographica Section D: Biological Crystallography (2014) 70(5): 1190-1201.

    Kaur, H., Heapy, A. M., Kowalczyk, R., Amso, Z., Watson, M., Cornish, J., & Brimble, M. A.  Synthesis and biological evaluation of the osteoblast proliferating cyclic peptides dianthins G and H. Tetrahedron (2014) 70(42): 7788-7794.

    Kendall, J. D., Marshall, A. J., Giddens, A. C., Tsang, K. Y., Boyd, M., Frédérick, R., Lill, C.L., Woo-Jeong, L., Kolekar, S., Chaor, M., Malik, A., Yu, S., Chaussade, C., Buchanan, C., Rewcastle, G.W., Baguley, B.C., Flanagan, J.U., Denny, W.A. & Shepherd, P. R.  Novel pyrazolo[1,5-a]pyridines as PI3K inhibitors: Variation of the central linker group. MedChemComm (2014) 5(1): 41-46.

    Kowalczyk, R., Brimble, M. A., Tomabechi, Y., Fairbanks, A. J., Fletcher, M., & Hay, D. L.  Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: Structure-activity relationships for amylin receptor agonism. Organic and Biomolecular Chemistry (2014) 12(41): 8142-8151.

    Kwon, H., Squire, C.J., Young, P.G. & Baker, E.N.  Autocatalytically-generated Thr-Gln ester bond crosslinks stabilize the repetitive Ig-domain shaft of a bacterial cell-surface adhesin. Proc. Natl. Acad. Sci. USA (2014) 111: 1367-1372.

    Lagautriere, T., Bashiri, G. & Baker, E.N. Use of a “silver bullet” to resolve crystal lattice disorder: a cobalamin complex of Δ1-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis. J. Struct. Biol. (2014) 189: 153-157.

    Lagautriere, T., Bashiri, G., Paterson, N. G., Berney, M., Cook, G. M., & Baker, E. N.  Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies. Acta Crystallographica Section D: Biological Crystallography (2014) 70(4): 968-980.

    Li, Y., Mortuza, R., Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. Investigation of the essentiality of glutamate racemase in mycobacterium smegmatis. Journal of Bacteriology (2014) 196(24): 4239-4244.

    Linke-Winnebeck, C., Paterson, N. G., Young, P. G., Middleditch, M. J., Greenwood, D. R., Witte, G., & Baker, E. N.  Structural model for covalent adhesion of the Streptococcus pyogenes pilus through a thioester bond. Journal of Biological Chemistry  (2014) 289(1): 177-189.

    Low, Y. S., Bircham, P. W., Maass, D. R., & Atkinson, P. H. Kinetochore genes are required to fully activate secretory pathway expansion in S. cerevisiae under induced ER stress. Molecular BioSystems (2014) 10(7): 1790-1802.

    McIntosh, J. D., Manning, K., Chokshi, S., Naoumov, N. V., Fraser, J. D., Dunbar, P. R., & Taylor, J. A. An engineered non-toxic superantigen increases cross presentation of hepatitis B virus nucleocapsids by human dendritic cells. PLoS One (2014) 9(4), e93598

    Moreland, N. J., Waddington, C. S., Williamson, D. A., Sriskandan, S., Smeesters, P. R., Proft, T., Street, A.C., Walker, M.J., Baker, E.N., Baker, M.G., Dunbar, R., Carapetis, J., & Fraser, J. D. Working towards a group A streptococcal vaccine: report of a collaborative Trans-Tasman workshop. Vaccine (2014) 32(30): 3713-3720.

    Nazmi, A. R., Schofield, L. R., Dobson, R. C. J., Jameson, G. B., & Parker, E. J. Destabilization of the homotetrameric assembly of 3-deoxy-d-arabino- heptulosonate-7-phosphate synthase from the hyperthermophile pyrococcus furiosus enhances enzymatic activity. Journal of Molecular Biology (2014) 426(3): 656-673.

    Neal, M. L., Cooling, M. T., Smith, L. P., Thompson, C. T., Sauro, H. M., Carlson, B. E., Cook, D.L.  & Gennari, J. H.  A Reappraisal of How to Build Modular, Reusable Models of Biological Systems. PLoS Computational Biology (2014) 10(10).

    Neumann, S., Burkert, K., Kemp, R., Rades, T., Dunbar, P. R., & Hook, S.  Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunology and Cell Biology (2014) 92(6): 535-542.

    Nyanhanda, T., Gould, E.M., McGhie, T., Shaw, O.M., Harper, J.L., & Hurst, R.D. Blackcurrant polyphenolic cultivar extracts suppress CCL26 secretion from alveolar epithelial cells. Food and Function (2014). 26 5(4): 671-7.

    Ochiai, S., Roediger, B., Abtin, A., Shklovskaya, E., Fazekas de St Groth, B., Yamane, H., Weninger, W., Le Gros, G. & Ronchese, F.. CD326loCD103loCD11blo dermal dendritic cells are activated by Thymic Stromal Lymphopoietin during contact sensitization in mice. Journal of Immunology. (2014) 193(5): 2504-2511.

    Park, S. M., Angel, C. E., McIntosh, J. D., Brooks, A. E., Middleditch, M., Chen, C. J., Ruggiero, K., Cebon, J., & Dunbar, P. R. Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes. European Journal of Immunology (2014) 44(8): 2425-2436.

    Park, S. M., Angel, C. E., McIntosh, J. D., Mansell, C. M., Chen, C. J., Cebon, J., & Dunbar, P. R.  Mapping the distinctive populations of lymphatic endothelial cells in different zones of human lymph nodes. PLoS One (2014) 9(4): e94781.

    Petersen, T. R., Knight, D. A., Tang, C. W., Osmond, T. L., & Hermans, I. F.  Batf3-independent langerin- CX3CR1-CD8α +splenic DCs represent a precursor for classical cross-presenting CD8α +DCs. Journal of Leukocyte Biology (2014) 96(6): 1001-1010.

    Pham, T., Loiselle, D., Power, A., & Hickey, A. J. R.  Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart. American Journal of Physiology - Cell Physiology (2014) 307(6): C499-C507.

    Prendergast, K.A., Osmond, T.L., Ochiai, S., Hermans, I.F. & Kirman, J.R.. Sustained in vivo depletion of splenic langerin+ CD8<alpha>+ dendritic cells is well-tolerated by lang-DTREGFP mice. Journal of Immunological Methods (2014) 406: 104-109

    Radcliff, F. J., Fraser, J. D., & Proft, T.  Vaccination with Streptococcus pyogenes nuclease A stimulates a high antibody response but no protective immunity in a mouse model of infection. Medical Microbiology and Immunology (2014) 204(2): 185-191.

    Rattanapak, T., Birchall, J. C., Young, K., Kubo, A., Fujimori, S., Ishii, M., & Hook, S.  Dynamic visualization of dendritic cell-antigen interactions in the skin following transcutaneous immunization. PLoS ONE (2014) 9(2).

    Schünemann, K., Furkert, D. P., Choi, E. C., Connelly, S., Fraser, J. D., Sperry, J., & Brimble, M. A.  Synthesis of the 2-methylene analogue of the HRV 3C protease inhibitor thysanone (2-carbathysanone). Organic and Biomolecular Chemistry (2014) 12(6): 905-912.

    Shaw, O.M., Pool, B., Dalbeth, N. & Harper, J.L.  The effect of diet-induced obesity on the inflammatory phenotype of non-adipose-resident macrophages in an in vivo model of gout. Rheumatology (2014) 53(10): 1901-1905.

    Shaw, O.M., Steiger, S., Liu, X., Hamilton, J.A., ^ Harper, J.L. Granulocyte-Macrophage Colony-Stimulating factor drives monosodium urate monohydrate crystal-induced inflammatory macrophage differentiation and NLRP3 inflammasome up-regulation in an in vivo mouse model. Arthritis & Rheumatology (2014). Vol.66:No. 9: 2423-2428.

    Smith, G.C., McEwen, H., Steinberg, J.D. & Shepherd, P.R. The activation of the Akt/PKB signalling pathway in the brains of clozapine-exposed rats is linked to hyperinsulinemia and not a direct drug effect. Psychopharmacology (2014) 231(23): 4553-4560

    Son, S. J., Harris, P. W. R., Squire, C. J., Baker, E. N., Kent, S. B. H., & Brimble, M. A.  Total chemical synthesis of an Orf virus protein, ORFV002, an inhibitor of the master gene regulator NF-κB. Biopolymers (2014) 102(2): 137-144.

    Steemson, J. D., Moreland, N. J., Williamson, D., Morgan, J., Carter, P. E., & Proft, T.  Survey of the bp/tee genes from clinical group A streptococcus isolates in New Zealand – Implications for vaccine development. Journal of Medical Microbiology (2014) 63: 1670-1678.

    Steemson, J.D., Baake, M., Rakonjac, J., Arcus, V.L., & Liddament, M.T.  Tracking Molecular Recognition at the Atomic Level with a New Protein Scaffold Based on the OB-Fold. PLoS ONE (2014) 9(1): e86050.

    Strauss, O., Dunbar, P. R., Bartlett, A., & Phillips, A.  The immunophenotype of antigen presenting cells of the mononuclear phagocyte system in normal human liver - A systematic review. Journal of Hepatology (2014) 62(2): 458-468.

    Troels, R., Petersen, Knight, D.A., Ching-Wen, T., Osmond, T.L., & Hermans, I.F.. Batf3-independent langerin-CX3CR1-CD8α+splenic DCs represent a precursor for classical cross-presenting CD8α+DC. Journal of Leukocyte Biology (2014) 96: 1001-1010

    Williamson, D. A., Mills, G., Johnson, J. R., Porter, S., & Wiles, S. In vivo correlates of molecularly inferred virulence among extraintestinal pathogenic Escherichia coli (ExPEC) in the wax moth Galleria mellonella model system. Virulence (2014) 5(3), 388-393.

    Williamson, D. A., Monecke, S., Heffernan, H., Ritchie, S. R., Roberts, S. A., Upton, A.,  & Fraser, J. D.  High usage of topical fusidic acid and rapid clonal expansion of fusidic acid-resistant Staphylococcus aureus: A cautionary tale. Clinical Infectious Diseases (2014) 59(10), 1451-1454.

    Yeung, H., Harris, P. W. R., Squire, C. J., Baker, E. N., & Brimble, M. A.  Preparation of truncated orf virus entry fusion complex proteins by chemical synthesis. Journal of Peptide Science (2014) 20(6), 398-405.

    Yin, Y. D., Fu, M., Brooke, D. G., Heinrich, D. M., Denny, W. A., & Jamieson, S. M. F. The activity of SN33638, an inhibitor of AKR1C3, on testosterone and 17β-estradiol production and function in castration-resistant prostate cancer and ER-positive breast cancer. Frontiers in Oncology  (2014) 4: 159.

    Young Jeong, J., Sperry, J., Taylor, J. A., & Brimble, M. A. Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease. European Journal of Medicinal Chemistry (2014) 87: 220-227.

    Young, P. G., Proft, T., Harris, P. W. R., Brimble, M. A., & Baker, E. N.  Structure and activity of Streptococcus pyogenes SipA: A signal peptidase-like protein essential for pilus polymerisation. PLoS ONE (2014) 9(6).

    Young, P.G., Moreland, N.J., Loh, J.M., Bell, A., Atatoa-Carr, P., Proft, T. & Baker, E.N.  Structural conservation, variability and immunogenicity of the T6 backbone pilin of serotype M6 Streptococcus pyogenes. Infection and Immunity. (2014) 82: 2949-2957.

    Zhang, S., Liu, H.,  Amarsingh, G.,  Cheung, C.,  Hogl, S., Narayanan, U., Zhang, L.,  McHarg, S.,  Xu, J.,  Gong, D.,  Kennedy, J., Barry, B., Soon Choong, Y., Phillips, A. R., Cooper, G. Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation. Cardiovascular Diabetology (2014) 13(1):100 

    Zhang, S., Liu, H., Chuang, C.L., Li, X., Au, M., Zhang, L., Phillips, A.R., Scott, D.W., & Cooper, G.J. The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet β cells. The FASEB Journal. (2014) 28(12): 5083-96.

    Patrick, W. M., & Gerth, M. L.  ITCHY: Incremental truncation for the creation of hybrid enzymes. Methods in Molecular Biology (2014) 1179: 225-44

    Parker, H. A., Magon, N. J., Green, J. N., Hampton, M. B., & Winterbourn, C. C.  Analysis of neutrophil bactericidal activity. Methods in Molecular Biology (2014) 1124: 291-306

    Williams, E. M., Copp, J. N., & Ackerley, D. F.  Site-saturation mutagenesis by overlap extension. Methods in Molecular Biology (2014) 1179: 83-101

    Jamieson, S.M.F., Gu, Y., Manesh, D.M., El-Hoss, J., Jing, D., Mackenzie, K.L., Guise, C.P., Foehrenbacher, A., Pullen, S., Benito, J., Smaill, J.B., Patterson, A.V., Mulaw, M.A., Konopleva, M., Bohlander, S.K., Lock, R.B. & Wilson, W.R., A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells. Biochemical Pharmacology (2014) 88(1) 36-45

    2013

    Affara, M., Sanders, D., Araki, H., Tamada, Y., Dunmore, B. J., Humphreys, S., Imoto, S., Savoie, C., Miyano, S., Kuhara, S., Jeffries, D., Print, C., & Charnock-Jones, D. S. Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis. BMC Genomics (2013) 14(1).

    Aitken, H. R. M., Furkert, D. P., Hubert, J. G., Wood, J. M., & Brimble, M. A. Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary. Organic and Biomolecular Chemistry (2013) 11(31): 5147-5155.

    Aitken, H. R. M., Johannes, M., Loomes, K. M., & Brimble, M. A. Synthesis of leptosin, a glycoside isolated from manuka honey. Tetrahedron Letters (2013).

    Benzler, J., Andrews, Z. B., Pracht, C., Stöhr, S., Shepherd, P. R., Grattan, D. R., & Tups, A. Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice. Endocrinology (2013) 154(12): 4737-4745.

    Blackmore, N. J., Reichau, S., Jiao, W., Hutton, R. D., Baker, E. N., Jameson, G. B., & Parker, E. J. Three sites and you are out: Ternary synergistic allostery controls aromatic amino acid biosynthesis in mycobacterium tuberculosis. Journal of Molecular Biology (2013) 425(9): 1582-1592.

    Blenkiron, C., Hurley, D. G., Fitzgerald, S., Print, C. G., & Lasham, A. Links between the oncoprotein YB-1 and small non-coding RNAs in breast cancer. PLoS ONE (2013) 8(11): e80171.

    Bobby, R., Medini, K., Neudecker, P., Lee, T. V., Brimble, M. A., McDonald, F. J., Lott, J. S., & Dingley, A. J. Structure and dynamics of human Nedd4-1 WW3 in complex with the alphaENaC PY motif. Biochimica et Biophysica Acta - Proteins and Proteomics (2013) 1834(8): 1632-1641

    Bridewell, D. J. A., Sperry, J., Smith, J. R., Kosim-Satyaputra, P., Ching, L. M., Jamie, J. F., & Brimble, M. A. Natural product-inspired pyranonaphthoquinone inhibitors of indoleamine 2,3-dioxygenase-1 (IDO-1)*. Australian Journal of Chemistry (2013) 66(1): 40-49.

    Britten, R. D., Christie, G. R., Little, C., Miller, A. K., Bradley, C., Wu, A., Yu, T., Hunter, P., & Nielsen, P. FieldML, a proposed open standard for the Physiome project for mathematical model representation. Med Biol Eng Comput (2013) 51(11): 1191-1207.

    Brooks, C. R., Van Dalen, C. J., Hermans, I. F., & Douwes, J. Identifying leukocyte populations in fresh and cryopreserved sputum using flow cytometry. Cytometry Part B - Clinical Cytometry (2013) 84 B(2): 104-113.

    Buchanan, C. M., Dickson, J. M. J., Lee, W. J., Guthridge, M. A., Kendall, J. D., & Shepherd, P. R. Oncogenic Mutations of p110a Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity. PLoS ONE (2013) 8(8): e71337

    Bunker, R. D., Bulloch, E. M. M., Dickson, J. M. J., Loomes, K. M., & Baker, E. N. Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. Journal of Biological Chemistry (2013) 288(3): 1643-1652.

    Busby, J. N., Panjikar, S., Landsberg, M. J., Hurst, M. R. H., & Lott, J. S. The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device. Nature (2013) 501(7468): 547-550.

    Camberis, M., Prout, M., Tang, S. C., Forbes-Blom, E., Robinson, M., Kyle, R., Belkaid, Y., Paul, W., & Le Gros, G. Evaluating the in vivo Th2 priming potential among common allergens. Journal of Immunological Methods (2013) 394(1-2): 62-72.

    Castell, A., Short, F. L., Evans, G. L., Cookson, T. V. M., Bulloch, E. M. M., Joseph, D. D. A., Lee, C. E., Parker, E. J., Baker, E. N., & Lott, J. S. The substrate capture mechanism of mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Biochemistry (2013) 52(10): 1776-1787.

    Chai, A. F., Johnston, J. M., Bunker, R. D., Bulloch, E. M., Evans, G. L., Lott, J. S., & Baker, E. N. Purification, crystallization and preliminary X-ray studies of MbtN (Rv1346) from Mycobacterium tuberculosis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2013) 69(Pt 12): 1354-1356.

    Chang, J. Y., Lu, G. L., Stevenson, R. J., Brothers, P. J., Clark, G. R., Botting, K. J., Ferry, D. M., Tercel, M., Wilson, W. R., Denny, W. A., & Ware, D. C. Cross-bridged cyclen or cyclam Co(III) complexes containing cytotoxic ligands as hypoxia-activated prodrugs. Inorganic Chemistry (2013) 52(13): 7688-7698.

    Cognard, E., Dargaville, C. G., Hay, D. L., & Shepherd, P. R. Identification of a pathway by which glucose regulates beta-catenin signalling via the cAMP/protein kinase A pathway in beta-cell models. Biochem Journal (2013) 449(3): 803-811.

    Cook, G. M., Robson, J. R., Frampton, R. A., McKenzie, J., Przybilski, R., Fineran, P. C., & Arcus, V. L. Ribonucleases in bacterial toxin-antitoxin systems. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms (2013) 1829(6-7): 523-531.

    Cross, P. J., Allison, T. M., Dobson, R. C., Jameson, G. B., & Parker, E. J. Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain. Proceedings of the National Academy of Sciences of the United States of America (2013) 110(6): 2111-2116

    Dickson, J. M., Lee, W. J., Shepherd, P. R., & Buchanan, C. M. Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase. Bioscience Reports (2013) 33(6).

    Domigan, L., Andersen, K. B., Sasso, L., Dimaki, M., Svendsen, W. E., Gerrard, J. A., & Castillo-Leon, J. Dielectrophoretic manipulation and solubility of protein nanofibrils formed from crude crystallins. Electrophoresis (2013) 34(7): 1105-1112.

    Erogbogbo, F., May, J., Swihart, M., Prasad, P. N., Smart, K., Jack, S. E., Korcyk, D., Webster, M., Stewart, R., Zeng, I., Jullig, M., Bakeev, K., Jamieson, M., Kasabov, N., Gopalan, B., Liang, L., Hu, R., Schliebs, S., Villas-Boas, S., & Gladding, P. Bioengineering silicon quantum dot theranostics using a network analysis of metabolomic and proteomic data in cardiac ischemia. Theranostics (2013) 3(9): 719-728

    Ferguson, P. M., Feindel, K. W., Slocombe, A., MacKay, M., Wignall, T., Delahunt, B., Tilley, R. D., & Hermans, I. F. Strongly Magnetic Iron Nanoparticles Improve the Diagnosis of Small Tumours in the Reticuloendothelial System by Magnetic Resonance Imaging. PLoS ONE (2013) 8(2): e56572

    Ferguson, P. M., Slocombe, A., Tilley, R. D., & Hermans, I. F. Using Magnetic Resonance Imaging to Evaluate Dendritic Cell-Based Vaccination. PLoS ONE (2013) 8(5): e65318.

    Fullston, T., Ohlsson Teague, E. M., Palmer, N. O., DeBlasio, M. J., Mitchell, M., Corbett, M., Print, C. G., Owens, J. A., & Lane, M. Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB Journal (2013) 27(10): 4226-4243.

    Fung, S. P., Wang, H., Tomek, P., Squire, C. J., Flanagan, J. U., Palmer, B. D., Bridewell, D. J., Tijono, S. M., Jamie, J. F., & Ching, L. M. Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1). Bioorganic and Medicinal Chemistry (2013) 21(24): 7595-7603

    Gamage, S. A., Brooke, D. G., Redkar, S., Datta, J., Jacob, S. T., & Denny, W. A. Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1. Bioorganic and Medicinal Chemistry (2013) 21(11): 3147-3153.

    Garvey, M., Meehan, S., Gras, S. L., Schirra, H. J., Craik, D. J., Van der Weerden, N. L., Anderson, M. A., Gerrard, J. A., & Carver, J. A. A radish seed antifungal peptide with a high amyloid fibril-forming propensity. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2013) 1834(8): 1615-1623.

    Ge, Y., Mansell, A., Ussher, J. E., Brooks, A. E., Manning, K., Wang, C. J., & Taylor, J. A. Rotavirus NSP4 Triggers Secretion of Proinflammatory Cytokines from Macrophages via Toll-Like Receptor 2. Journal of Virology (2013) 87(20): 11160-11167.

    Gjuvsland, A. B., Vik, J. O., Beard, D. A., Hunter, P. J., & Omholt, S. W. Bridging the genotype-phenotype gap: what does it take? Journal of Physiology (2013) 591(Pt 8): 2055-2066.

    Green, L. K., Storey, M. A., Williams, E. M., Patterson, A. V., Smaill, J. B., Copp, J. N., & Ackerley, D. F. The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy. Cancers (2013) 5(3): 985-997.

    Green, L. K., Syddall, S. P., Carlin, K. M., Bell, G. D., Guise, C. P., Mowday, A. M., Hay, M. P., Smaill, J. B., Patterson, A. V., & Ackerley, D. F. Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy. Molecular Cancer (2013) 12: 58.

    Harris, P. W., & Brimble, M. A. A comparison of Boc and Fmoc SPPS strategies for the preparation of C-terminal peptide alpha-thiolesters: NY-ESO-1 (39) Cys-(68) Ala-COSR. Biopolymers (Peptide Science) (2013) 100(4): 356-365.

    Harris, P. W. R., Kowalczyk, R., Hay, D. L., & Brimble, M. A. A single pseudoproline and microwave solid phase peptide synthesis facilitates an efficient synthesis of human amylin 1-37. International Journal of Peptide Research and Therapeutics (2013) 19(2): 147-155.

    Harvie, M., Camberis, M., & Gros, G. L. Development of CD4 T cell dependent immunity against N. brasiliensis infection. Frontiers in Immunology (2013) 4(MAR).

    Heapy, A. M., Dragunow, M., & Brimble, M. A. Synthesis of the cysteine protease inhibitors CPI-2081a and CPI-2081b using a controlled SPPS byproduct forming reaction. Synlett (2013) 24(14): 1818-1824.

    Heapy, A. M., Patterson, A. V., Smaill, J. B., Jamieson, S. M. F., Guise, C. P., Sperry, J., Hume, P. A., Rathwell, K., & Brimble, M. A. Synthesis and cytotoxicity of pyranonaphthoquinone natural product analogues under bioreductive conditions. Bioorganic and Medicinal Chemistry (2013) 21(24): 7971-7980.

    Heinrich, D. M., Flanagan, J. U., Jamieson, S. M., Silva, S., Rigoreau, L. J., Trivier, E., Raynham, T., Turnbull, A. P., & Denny, W. A. Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3. European Journal of Medicinal Chemistry (2013) 62: 738-744.

    Hobbs, J. K., Jiao, W., Easter, A. D., Parker, E. J., Schipper, L. A., & Arcus, V. L. Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates. ACS Chemical Biology (2013) 8(11): 2388-2393.

    Holtfreter, S., Radcliff, F. J., Grumann, D., Read, H., Johnson, S., Monecke, S., Ritchie, S., Clow, F., Goerke, C., Broker, B. M., Fraser, J. D., & Wiles, S. Characterization of a mouse-adapted Staphylococcus aureus strain. PLoS One (2013) 8(9): e71142.

    Huisman, F. H., Squire, C. J., & Parker, E. J. Amino-acid substitutions at the domain interface affect substrate and allosteric inhibitor binding in alpha-isopropylmalate synthase from Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications (2013) 433(2): 249-254.

    Hume, P. A., Brimble, M. A., & Reynisson, J. DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems. Computational and Theoretical Chemistry (2013) 1005: 9-15.

    Hume, P. A., Furkert, D. P., & Brimble, M. A. Total synthesis of virgatolide B. Organic Letters (2013) 15(17): 4588-4591.

    Hunter, P., Chapman, T., Coveney, P. V., de Bono, B., Diaz, V., Fenner, J., Frangi, A. F., Harris, P., Hose, R., Kohl, P., Lawford, P., McCormack, K., Mendes, M., Omholt, S., Quarteroni, A., Shublaq, N., Skar, J., Stroetmann, K., Tegner, J., Thomas, S. R., Tollis, I., Tsamardinos, I., van Beek, J. H., & Viceconti, M. A vision and strategy for the virtual physiological human: 2012 update. Interface Focus (2013) 3(2): 20130004.

    Johnston, J. M., Jiang, M., Guo, Z., & Baker, E. N. Crystal structures of E. coli native MenH and two active site mutants. PLoS One (2013) 8(4): e61325.

    Jose, J., Gamage, S. A., Harvey, M. G., Voss, L. J., Sleigh, J. W., & Denny, W. A. Structure-activity relationships for ketamine esters as short-acting anaesthetics. Bioorganic and Medicinal Chemistry (2013) 21(17): 5098-5106.

    Joseph, D. D., Jiao, W., & Parker, E. J. Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis. Biochemistry (2013) 52(15): 2609-2619.

    Kim, R. J., Yin, T., Chen, C. J., Mansell, C. J., Wood, A., Dunbar, P. R., & Douglas, R. G. The interaction between bacteria and mucosal immunity in chronic rhinosinusitis: a prospective cross-sectional analysis. American Journal of Rhinology and Allergy (2013) 27(6): e183-189.

    Kim, U. B., Dalebrook, A. F., Furkert, D. P., & Brimble, M. A. Total synthesis of chaetoquadrins H and i. Synlett (2013) 24(6): 723-726.

    Kim, U. B., Furkert, D. P., & Brimble, M. A. Total synthesis of chaetoquadrins A-C. Organic Letters (2013) 15(3): 658-661.

    Kueh, J. T., Choi, K. W., Williams, G. M., Moehle, K., Bacsa, B., Robinson, J. A., & Brimble, M. A. Synthesis of a 6,6-spiroketal amino acid and its incorporation into a peptide turn sequence using solid-phase peptide synthesis. Chemistry (2013) 19(12): 3807-3811.

    Kuhn, S., Hyde, E. J., Yang, J., Rich, F. J., Harper, J. L., Kirman, J. R., & Ronchese, F. Increased numbers of monocyte-derived dendritic cells during successful tumor immunotherapy with immune-activating agents. Journal of Immunology (2013) 191(4): 1984-1992.

    Liu, Y., Lai, Y. C., Hill, E. V., Tyteca, D., Carpentier, S., Ingvaldsen, A., Vertommen, D., Lantier, L., Foretz, M., Dequiedt, F., Courtoy, P. J., Erneux, C., Viollet, B., Shepherd, P. R., Tavare, J. M., Jensen, J., & Rider, M. H. Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle. Biochem Journal (2013) 455(2): 195-206.

    Liu, J., Xu, A., Lam, K. S., Wong, N. S., Chen, J., Shepherd, P. R., & Wang, Y. Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation. Oncotarget (2013) 4(10): 1804-1818.

    Lorenz, N., Clow, F., Radcliff, F. J., & Fraser, J. D. Full functional activity of SSL7 requires binding of both complement C5 and IgA. Immunology and Cell Biology (2013) 91(7): 469-476.

    Lu, G.-L., Ashoorzadeh, A., Anderson, R. F., Patterson, A. V., & Smaill, J. B. Synthesis of substituted 5-bromomethyl-4-nitroimidazoles and use for the preparation of the hypoxia-selective multikinase inhibitor SN29966. Tetrahedron (2013) 69(43): 9130-9138.

    Lu, J., Pontre, B., Pickup, S., Choong, S. Y., Li, M., Xu, H., Gamble, G. D., Phillips, A. R., Cowan, B. R., Young, A. A., & Cooper, G. J. Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment. Cardiovascular Diabetology (2013) 12: 28.

    Naysmith, B. J., & Brimble, M. A. Synthesis of the griseusin B framework via a one-pot annulation-methylation-double deprotection-spirocyclization sequence. Organic Letters (2013) 15(8): 2006-2009.

    Noisier, A. F., Harris, C. S., & Brimble, M. A. Novel preparation of chiral alpha-amino acids using the Mitsunobu-Tsunoda reaction. Chemical Communications (2013) 49(70): 7744-7746.

    Prendergast, K. A., & Kirman, J. R. Dendritic cell subsets in mycobacterial infection: control of bacterial growth and T cell responses. Tuberculosis (2013) 93(2): 115-122.

    Prosser, G. A., Copp, J. N., Mowday, A. M., Guise, C. P., Syddall, S. P., Williams, E. M., Horvat, C. N., Swe, P. M., Ashoorzadeh, A., Denny, W. A., Smaill, J. B., Patterson, A. V., & Ackerley, D. F. Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A. Biochemical Pharmacology (2013) 85(8): 1091-1103.

    Quach, R., Furkert, D. P., & Brimble, M. A. Synthesis of benzannulated spiroacetals using chiral gold-phosphine complexes and chiral anions. Tetrahedron Letters (2013) 54(44): 5865-5868.

    Quek, N. C., Matthews, J. H., Bloor, S. J., Jones, D. A., Bircham, P. W., Heathcott, R. W., & Atkinson, P. H. The novel equisetin-like compound, TA-289, causes aberrant mitochondrial morphology which is independent of the production of reactive oxygen species in Saccharomyces cerevisiae. Molecular BioSystems (2013) 9(8): 2125-2133.

    Rattanapak, T., Birchall, J., Young, K., Ishii, M., Meglinski, I., Rades, T., & Hook, S. Transcutaneous immunization using microneedles and cubosomes: Mechanistic investigations using Optical Coherence Tomography and Two-Photon Microscopy. Journal of Controlled Release (2013) 172(3): 894-903.

    Reichau, S., & Parker, E. J. Active site plasticity of a critical enzyme from Mycobacterium tuberculosis. [10.1039/C3RA00037K]. RSC Advances (2013) 3(10): 3209-3212.

    Rewcastle, G. W., Gamage, S. A., Flanagan, J. U., Kendall, J. D., Denny, W. A., Baguley, B. C., Buchanan, C. M., Chao, M., Kestell, P., Kolekar, S., Lee, W. J., Lill, C. L., Malik, A., Singh, R., Jamieson, S. M., & Shepherd, P. R. Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474). European Journal of Medicinal Chemistry (2013) 64: 137-147.

    Roediger, B., Kyle, R., Yip, K. H., Sumaria, N., Guy, T. V., Kim, B. S., Mitchell, A. J., Tay, S. S., Jain, R., Forbes-Blom, E., Chen, X., Tong, P. L., Bolton, H. A., Artis, D., Paul, W. E., De St Groth, B. F., Grimbaldeston, M. A., Le Gros, G., & Weninger, W. Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nature Immunology (2013) 14(6): 564-573.

    Shaw, O. M., & Harper, J. L. An efficient single prime protocol for the induction of antigen-induced airways inflammation. Journal of Immunological Methods (2013) 395(1-2): 79-82.

    Sheppard, H. M., Ussher, J. E., Verdon, D., Chen, J., Taylor, J. A., & Dunbar, P. R. Recombinant adeno-associated virus serotype 6 efficiently transduces primary human melanocytes. PLoS One (2013) 8(4): e62753.

    Slaney, C. Y., Toker, A., Fraser, J. D., Harper, J. L., & Backstrom, B. T. A modified superantigen rescues Ly6G- CD11b+ blood monocyte suppressor function and suppresses antigen-specific inflammation in EAE. Autoimmunity (2013) 46(4): 269-278.

    Smith, G. C., Ong, W. K., Costa, J. L., Watson, M., Cornish, J., Grey, A., Gamble, G. D., Dickinson, M., Leung, S., Rewcastle, G. W., Han, W., & Shepherd, P. R. Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength. FEBS Journal (2013) 280(21): 5337-5349.

    Son, S. J., Brimble, M. A., Yang, S., Harris, P. W. R., Reddingius, T., Muir, B. W., Hutt, O. E., Waddington, L., Guan, J., & Savage, G. P. Synthesis and self-assembly of a peptide-amphiphile as a drug delivery vehicle. Australian Journal of Chemistry (2013) 66(1): 23-29.

    Spicer, J. A., Lena, G., Lyons, D. M., Huttunen, K. M., Miller, C. K., O'Connor, P. D., Bull, M., Helsby, N., Jamieson, S. M., Denny, W. A., Ciccone, A., Browne, K. A., Lopez, J. A., Rudd-Schmidt, J., Voskoboinik, I., & Trapani, J. A. Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. Journal of Medicinal Chemistry (2013) 56(23): 9542-9555.

    Stone, A., Cowley, M. J., Valdes-Mora, F., McCloy, R. A., Sergio, C. M., Gallego-Ortega, D., Caldon, C. E., Ormandy, C. J., Biankin, A. V., Gee, J. M., Nicholson, R. I., Print, C. G., Clark, S. J., & Musgrove, E. A. BCL-2 hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer. Molecular Cancer Therapeutics (2013) 12(9): 1874-1885.

    Strover, L. T., Malmström, J., Laita, O., Reynisson, J., Aydemir, N., Nieuwoudt, M. K., Williams, D. E., Dunbar, P. R., Brimble, M. A., & Travas-Sejdic, J. A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution. Polymer (United Kingdom) (2013) 54(4): 1305-1317.

    Stubbing, L. A., Savage, G. P., & Brimble, M. A. N-alkylsulfonylimines as dipolarophiles in cycloaddition reactions. Chemistry- An Asian Journal (2013) 8(1): 42-48.

    Su, J., Gu, Y., Pruijn, F. B., Smaill, J. B., Patterson, A. V., Guise, C. P., & Wilson, W. R. Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence. Journal of Biological Chemistry (2013) 288(52): 37138-37153.

    Thomas, D., Powell, J. A., Green, B. D., Barry, E. F., Ma, Y., Woodcock, J., Fitter, S., Zannettino, A. C., Pitson, S. M., Hughes, T. P., Lopez, A. F., Shepherd, P. R., Wei, A. H., Ekert, P. G., & Guthridge, M. A. Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. PLoS Biology (2013) 11(3): e1001515.

    Till, M., Goldstone, D. C., Attwood, G. T., Moon, C. D., Kelly, W. J., & Arcus, V. L. Structure and function of an acetyl xylan esterase (Est2A) from the rumen bacterium Butyrivibrio proteoclasticus. Proteins: Structure, Function and Bioinformatics (2013) 81(5): 911-917.

    Tomek, P., Palmer, B. D., Flanagan, J. U., Fung, S. P., Bridewell, D. J., Jamie, J. F., & Ching, L. M. Formation of an N-formylkynurenine-derived fluorophore and its use for measuring indoleamine 2,3-dioxygenase 1 activity. Analytical and Bioanalytical Chemistry (2013) 405(8): 2515-2524.

    Tran, A. T., Wen, D., West, N. P., Baker, E. N., Britton, W. J., & Payne, R. J. Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry (2013) 11(46): 8113-8126.

    Trevarton, A. J., Mann, M. B., Knapp, C., Araki, H., Wren, J. D., Stones-Havas, S., Black, M. A., & Print, C. G. MelanomaDB: A Web Tool for Integrative Analysis of Melanoma Genomic Information to Identify Disease-Associated Molecular Pathways. Frontiers in Oncology (2013) 3: 184.

    Valery, C., Pandey, R., & Gerrard, J. A. Protein beta-interfaces as a generic source of native peptide tectons. Chemical Communications (2013) 49(27): 2825-2827.

    Van Panhuys, N., Camberis, M., Yamada, M., Tegoshi, T., Arizono, N., & Le Gros, G. Mucosal trapping and degradation of Nippostrongylus brasiliensis occurs in the absence of STAT6. Parasitology (2013) 140(7): 833-843.

    Wang, Y. K., Hurley, D. G., Schnell, S., Print, C. G., & Crampin, E. J. Integration of steady-state and temporal gene expression data for the inference of gene regulatory networks. PLoS One (2013) 8(8): e72103.

    Wang, Y. K., Print, C. G., & Crampin, E. J. Biclustering reveals breast cancer tumour subgroups with common clinical features and improves prediction of disease recurrence. BMC Genomics (2013) 14: 102.

    Watkins, H. A., Au, M., Bobby, R., Archbold, J. K., Abdul-Manan, N., Moore, J. M., Middleditch, M. J., Williams, G. M., Brimble, M. A., Dingley, A. J., & Hay, D. L. Identification of key residues involved in adrenomedullin binding to the AM1 receptor. British Journal of Pharmacology (2013) 169(1): 143-155.

    Weinkove, R., Brooks, C. R., Carter, J. M., Hermans, I. F., & Ronchese, F. Efficient depletion of chronic lymphocytic leukemia B cells using serial rounds of immunomagnetic depletion. Journal of Immunological Methods (2013a) 396(1-2): 152-156.

    Weinkove, R., Brooks, C. R., Carter, J. M., Hermans, I. F., & Ronchese, F. Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: Implications for immunotherapy. Haematologica (2013b) 98(3): 376-384.

    Whiting, L., Danaher, R. N., Ruggiero, K., Lee, C. C., Chaussade, C., Mulvey, T., Phillips, A., & Loomes, K. M. D-chiro-inositol attenuates epinephrine-stimulated hepatic glucose output in the isolated perfused liver independently of insulin. Hormone and Metabolic Research (2013) 45(5): 394-397.

    Williams, G. M., Cooper, G. J., Lee, K., Whiting, L., & Brimble, M. A. Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds. Organic and Biomolecular Chemistry (2013) 11(19): 3145-3150.

    Woods, T. M., Cooper, G. J., & Brimble, M. A. Synthesis of stable isotope-labelled monolysyl advanced glycation endproducts. Amino Acids (2013) 45(2): 319-325.

    Wright, T. H., Brooks, A. E., Didsbury, A. J., Williams, G. M., Harris, P. W., Dunbar, P. R., & Brimble, M. A. Direct peptide lipidation through thiol-ene coupling enables rapid synthesis and evaluation of self-adjuvanting vaccine candidates. Angewandte Chemie - International Edition (2013) 52(40): 10616-10619.

    Xiong, X., Xu, Z., Yang, Z., Liu, Y., Wang, D., Dong, M., Parker, E. J., & Zhu, W. Key targets and relevant inhibitors for the drug discovery of tuberculosis. Curr Drug Targets (2013) 14(6): 676-699.

    Yang, S. H., Wojnar, J. M., Harris, P. W., DeVries, A. L., Evans, C. W., & Brimble, M. A. Chemical synthesis of a masked analogue of the fish antifreeze potentiating protein (AFPP). Organic and Biomolecular Chemistry (2013) 11(30): 4935-4942.

    Young, P. G., Kang, H. J., & Baker, E. N. An arm-swapped dimer of the Streptococcus pyogenes pilin specific assembly factor SipA. Journal of Structural Biology (2013) 183(1): 99-104.

    Yuen, T. Y., Ng, Y. P., Ip, F. C. F., Chen, J. L. Y., Atkinson, D. J., Sperry, J., Ip, N. Y., & Brimble, M. A. Telomerase inhibition studies of novel spiroketal-containing rubromycin derivatives. Australian Journal of Chemistry (2013) 66(5): 530-533.

    Zeng, I. S. L., Lumley, T., Ruggiero, K., Middleditch, M., Woon, S. T., & Stewart, R. A. H. Two optimization strategies of multi-stage design in clinical proteomic studies. Statistical Applications in Genetics and Molecular Biology (2013) 12(2): 263-283.

    Zhang, L., Ward, M. L., Phillips, A. R., Zhang, S., Kennedy, J., Barry, B., Cannell, M. B., & Cooper, G. J. Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats. Cardiovascular Diabetology (2013) 12: 123.

    2012

    Ancelet, L. R., Aldwell, F. E., Rich, F. J., & Kirman, J. R. Oral vaccination with lipid formulated BCG induces a long-lived, multifunctional CD4+ T cell memory immune response. PLoS ONE (2012) 7(9): e45888

    Ancelet, L., Rich, F. J., Delahunt, B., & Kirman, J. R. Dissecting memory T cell responses to TB: Concerns using adoptive transfer into immunodeficient mice. Tuberculosis (2012) 92(5): 422-433.

    Araki, H., Knapp, C., Tsai, P., & Print, C. GeneSetDB: A comprehensive metadatabase, statistical and visualisation framework for gene set analysis. FEBS Open Bio (2012) 2: 76-82.

    Araki H, Hurley D, Crampin E, Print C, Kuhara S. Gene network analysis and
    application. Seibutsu Butsuri. Journal of The Biophysical Society of Japan (2012) 51:
    182-185.

    Bailey, R. J., Walker, C. S., Ferner, A. H., Loomes, K. M., Prijic, G., Halim, A., Whiting, L., Phillips, A. R. J., & Hay, D. L. Pharmacological characterization of rat amylin receptors: Implications for the identification of amylin receptor subtypes. British Journal of Pharmacology (2012) 166(1): 151-167.

    Baker, H. M., & Baker, E. N. A structural perspective on lactoferrin function. Biochemistry and Cell Biology (2012) 90(3): 320-328. 

    Bashiri, G., Perkowski, E. F., Turner, A. P., Feltcher, M. E., Braunstein, M., & Baker, E. N. Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis. PLoS ONE (2012) 7(10): e45003.

    Benzler, J., Ganjam, G. K., Kruger, M., Pinkenburg, O., Kutschke, M., Stohr, S.,
    Steger, J., Koch, C. E., Olkrug, R., Schwartz, M. W., Shepherd, P. R., Grattan, D.
    R., & Tups, A. Hypothalamic glycogen synthase kinase 3beta has a central role in the
    regulation of food intake and glucose metabolism. Biochemical Journal (2012) 447:
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    Barwell, J., Gingell, J. J., Watkins, H. A., Archbold, J. K., Poyner, D. R., & Hay, D. L. Calcitonin and calcitonin receptor-like receptors: Common themes with family B GPCRs? British Journal of Pharmacology (2012) 166(1): 51-65.

    Blumenstein, M., McCowan, L. M. E., Wu, S., Cooper, G. J. S., & North, R. A. Plasma clusterin increased prior to small for gestational age (SGA) associated with preeclampsia and decreased prior to SGA in normotensive pregnancies. Reproductive Sciences (2012) 19(6): 650-657.

    Berney, M., Weimar, M. R., Heikal, A., & Cook, G. M. Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia. Molecular Microbiology (2012) 84(4): 664-681.

    Bogle, G., & Dunbar, P. R. On-lattice simulation of T cell motility, chemotaxis, and trafficking in the lymph node paracortex. PLoS ONE (2012) 7(9): e45258.

    Brimble, M. A., Haym, I., Sperry, J., & Furkert, D. P. Synthesis of the tetracyclic core of berkelic acid using gold(I)-catalyzed hydroarylation and oxidative radical cyclizations. Organic Letters (2012) 14(23): 5820-5823.

    Broadbent, E., Kahokehr, A., Booth, R. J., Thomas, J., Windsor, J. A., Buchanan, C. M., Wheeler, B. R. L., Sammour, T., & Hill, A. G. A brief relaxation intervention reduces stress and improves surgical wound healing response: A randomised trial. Brain, Behavior, and Immunity (2012) 26(2): 212-217.

    Buchanan, C. M., Shih, J. H., Astin, J. W., Rewcastle, G. W., Flanagan, J. U., Crosier, P. S., & Shepherd, P. R. DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. Clinical Science (2012) 122(10): 449-457.

    Bunker, R. D., Dickson, J. M. J., Caradoc-Davies, T. T., Loomes, K. M., & Baker, E. N. Use of a repetitive seeding protocol to obtain diffraction-quality crystals of a putative human D-xylulokinase. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2012) 68(10): 1259-1262.

    Busby, J. N., Landsberg, M. J., Simpson, R. M., Jones, S. A., Hankamer, B., Hurst, M. R. H., & Lott, J. S. Structural analysis of Chi1 chitinase from Yen-Tc: The multisubunit insecticidal ABC toxin complex of Yersinia entomophaga. Journal of Molecular Biology (2012) 415(2): 359-371.

    Caldon, C. E., Sergio, C. M., Kang, J., Muthukaruppan, A., Boersma, M. N., Stone, A., Barraclough, J., Lee, C. S., Black, M. A., Miller, L. D., Gee, J. M., Nicholson, R. I., Sutherland, R. L., Print, C. G., & Musgrove, E. A. Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells. Molecular Cancer Therapeutics (2012) 11(7): 1488-1499.

    Chi, G., Manos-Turvey, A., O’Connor, P. D., Johnston, J. M., Evans, G. L., Baker, E. N., Payne, R. J., Lott, J. S., & Bulloch, E. M. M. Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry (2012) 51(24): 4868-4879.

    Chiu, E., Coulibaly, F., & Metcalf, P. Insect virus polyhedra, infectious protein crystals that contain virus particles. Current Opinion in Structural Biology (2012) 22(2): 234- 240.

    Chorley, D. F., Chen, J. L. Y., Furkert, D. P., Sperry, J., & Brimble, M. A. Total synthesis of danshenspiroketallactone. Synlett (2012) 1: 128-130.

    Clark, G. R., Pytel, P. D., & Squire, C. J. The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages. Nucleic Acids Research (2012) 40(12): 5731-5738.

    Cook, G. M., & Heikal, A. Bridging the gap between a TB drug and its target. Science Translational Medicine (2012) 4(150) fs33.

    Cooper, G. J. S. Selective divalent copper chelation for the treatment of diabetes mellitus. Current Medicinal Chemistry (2012) 19(17): 2828-2860.

    Coulibaly, F., Lassalle, E., Baker, H. M., & Baker, E. N. Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis. Acta Crystallographica Section D: Biological Crystallography (2012) 68(5): 553-563.

    Dangerfield, E. M., Cheng, J. M. H., Knight, D. A., Weinkove, R., Dunbar, P. R., Hermans, I. F., Timmer, M. S. M., & Stocker, B. L. Species-specific activity of glycolipid ligands for invariant NKT cells. ChemBioChem (2012) 13(9): 1349-1356.

    Dbouk, H. A., Vadas, O., Shymanets, A., Burke, J. E., Salamon, R. S., Khalil, B. D., Barrett, M. O., Waldo, G. L., Surve, C., Hsueh, C., Perisic, O., Harteneck, C., Shepherd, P. R., Harden, T. K., Smrcka, A. V., Taussig, R., Bresnick, A. R., Nurnberg, B., Williams, R. L., & Backer, J. M. G protein-coupled receptor-mediated activation of p110 beta by G beta gamma is required for cellular transformation and invasiveness. Science Signaling (2012) 5(253): ra89.

    De Bono, B., & Hunter, P. Integrating knowledge representation and quantitative modelling in physiology. Biotechnology Journal (2012) 7(8): 958-972.

    Dimitrov, I., Furkert, D. P., Fraser, J. D., Radcliff, F. J., Finch, O., & Brimble, M. A. Synthesis and anti-Helicobacter pylori activity of analogues of spirolaxine methyl ether. MedChemComm (2012) 3(8): 944-949.

    Donges, C. E., Burd, N. A., Duffield, R., Smith, G. C., West, D. W. D., Short, M. J., Mackenzie, R., Plank, L. D., Shepherd, P. R., Phillips, S. M., & Edge, J. A. Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men. Journal of Applied Physiology (2012) 112(12): 1992-2001.

    Enomoto, N., Hyde, E., Ma, J. Z. I., Yang, J., Forbes-Blom, E., Delahunt, B., Le Gros, G., & Ronchese, F. Allergen-specific CTL require perforin expression to suppress allergic airway inflammation. Journal of Immunology (2012) 188(4): 1734-1741.

    Evans, C. W., Hellman, L., Middleditch, M., Wojnar, J. M., Brimble, M. A., & Devries, A. L. Synthesis and recycling of antifreeze glycoproteins in polar fishes. Antarctic Science (2012) 24(3): 259-268.

    Evans, C. W., Williams, D. E., Vacchi, M., Brimble, M. A., & DeVries, A. L. Metabolic and behavioural adaptations during early development of the Antarctic silverfish, Pleuragramma antarcticum. Polar Biology (2012) 35(6): 891-898.

    Evans, G. E., Martinez-Conejero, J. A., Phillipson, G. T. M., Simon, C., Mcnoe, L. A., Sykes, P. H., Horcajadas, J. A., Lam, E. Y. N., Print, C. G., Sin, I. L., & Evans, J. J. Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. Fertility and Sterility (2012) 97(6): 1365-1373.

    Fernandez, J. W., Haque, M. Z. U., Hunter, P. J., & Mithraratne, K. Mechanics of the foot Part 1: A continuum framework for evaluating soft tissue stiffening in the pathologic foot. International Journal for Numerical Methods in Biomedical Engineering (2012) 28(10): 1056-1070.

    Fernandez, J. W., Shim, V. B., & Hunter, P. J. Integrating degenerative mechanisms in bone and cartilage: A multiscale approach. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) (2012): 6616-6619.

    Flanagan, J. U., Yosaatmadja, Y., Teague, R. M., Chai, M. Z. L., Turnbull, A. P., & Squire, C. J. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PLoS ONE (2012) 7(8): e43965.

    Forbes-Blom, E., Camberis, M., Prout, M., Tang, S. C., & Le Gros, G. Staphylococcalderived superantigen enhances peanut induced Th2 responses in the skin. Clinical and Experimental Allergy (2012) 42(2): 305-314.

    Ge, Q., Moir, L. M., Trian, T., Niimi, K., Poniris, M., Shepherd, P. R., Black, J. L., Oliver, B. G., & Burgess, J. K. The phosphoinositide 3'-kinase p110delta modulates contractile protein production and IL-6 release in human airway smooth muscle. Journal of Cellular Physiology (2012) 227(8): 3044-3052.

    Geng, H., Chen, J. Y., Furkert, D., Jiang, S., & Brimble, M. A. A convergent synthesis of the 2-formylpyrrole spiroketal natural product acortatarin A. Synlett (2012) 23(6): 855-858.

    Goodall, K. J., Brimble, M. A., & Barker, D. A tandem Diels-Alder/Mannich approach to the synthesis of AE and ABE ring analogues of Delphinium alkaloids. Tetrahedron (2012) 68(29): 5759-5778.

    Han, J. C., Taberner, A. J., Tran, K., Goo, S., Nickerson, D. P., Nash, M. P., Nielsen, P. M. F., Crampin, E. J., & Loiselle, D. S. Comparison of the Gibbs and Suga formulations of cardiac energetics: The demise of “isoefficiency”. Journal of Applied Physiology (2012) 113(7): 996-1003.

    Han, J. C., Taberner, A. J., Tran, K., Nickerson, D. P., Nash, M. P., Nielsen, P. M. F., Crampin, E. J., & Loiselle, D. S. Relating components of pressure-volume area in Suga’s formulation of cardiac energetics to components of the stress-time integral. Journal of Applied Physiology (2012) 113(7): 988-995.

    Han, J. C., Tran, K., Taberner, A. J., Nickerson, D. P., Kirton, R. S., Nielsen, P. M. F., Ward, M. L., Nash, M. P., Crampin, E. J., & Loiselle, D. S. Myocardial twitch duration and the dependence of oxygen consumption on pressure-volume area: Experiments and modelling. Journal of Physiology (2012) 590(18): 4603-4622.

    Harris, P. W., Lee, D. J., & Brimble, M. A. A slow gradient approach for the purification of synthetic polypeptides by reversed phase high performance liquid chromatography. Journal of Peptide Science (2012) 18(9): 549-555.

    Harris, P. W. R., & Brimble, M. A. The chemical synthesis of the collagenous domain of the hormone adiponectin. International Journal of Peptide Research and Therapeutics (2012) 18(1): 63-70.

    Harrison, A. N., Reichau, S., & Parker, E. J. Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Bioorganic and Medicinal Chemistry Letters (2012) 22(2): 907-911.

    Haym, I., & Brimble, M. A. The Kulinkovich hydroxycyclopropanation reaction in natural product synthesis. Organic & Biomolecular Chemistry (2012) 10(38): 7649- 7665.

    Heapy, A. M., Williams, G. M., Fraser, J. D., & Brimble, M. A. Synthesis of a dicarba analogue of human beta-defensin-1 using a combined ring closing metathesis-native chemical ligation strategy. Organic Letters (2012) 14(3): 878-881.

    Henare, K., Wang, L., Wang, L. C., Thomsen, L., Tijono, S., Chen, C. J., Winkler, S., Dunbar, P. R., Print, C., & Ching, L. M. Dissection of stromal and cancer cell-derived signals in melanoma xenografts before and after treatment with DMXAA. British Journal of Cancer (2012) 106(6): 1134-1147.

    Herbert, K. R., Williams, G. M., Cooper, G. J. S., & Brimble, M. A. Synthesis of glycosylated 5-hydroxylysine, an important amino acid present in collagen-like proteins such as adiponectin. Organic and Biomolecular Chemistry (2012) 10(6): 1137-1144.

    Herbst, T., Esser, J., Prati, M., Kulagin, M., Stettler, R., Zaiss, M. M., Hewitson, J. P., Merky, P., Verbeek, J. S., Bourquin, C., Camberis, M., Prout, M., Maizels, R. M., Le Gros, G., & Harris, N. L. Antibodies and IL-3 support helminth-induced basophil expansion. Proceedings of the National Academy of Sciences of the United States of America (2012) 109(37): 14954-14959

    Hermans, S. J., Baker, H. M., Sequeira, R. P., Langley, R. J., Baker, E. N., & Fraser, J. D. Structural and functional properties of staphylococcal superantigen-like protein 4. Infection and Immunity (2012) 80(11): 4004-4013.

    Whiting, L., Danaher, R. N., Ruggiero, K., Lee, C. C., Chaussade, C., Mulvey, T., Phillips, A., & Loomes, K. M. D-chiro-inositol attenuates epinephrine-stimulated hepatic glucose output in the isolated perfused liver independently of insulin. Hormone and Metabolic Research (2012).

    Wang, L., Hurley, D. G., Watkins, W., Araki, H., Tamada, Y., Muthukaruppan, A., Ranjard, L., Derkac, E., Imoto, S., Miyano, S., Crampin, E. J., & Print, C. G. Cell cycle gene networks are associated with melanoma prognosis. PLoS ONE (2012) 7(4): e34247.

    Wang, Y. P., Gjuvsland, A. B., Vik, J. O., Smith, N. P., Hunter, P. J., & Omholt, S. W. Parameters in dynamic models of complex traits are containers of missing heritability. PLoS Computational Biology (2012) 8(4): e1002459.

    Watkins, H. A., Au, M., & Hay, D. L. The structure of secretin family GPCR peptide ligands: Implications for receptor pharmacology and drug development. Drug Discovery Today (2012) 17(17-18): 1006-1014.

    Watkins, H. A., & Hay, D. L. Recent progress in unraveling the complexities of receptor biology: Towards new therapeutics. Expert Review of Clinical Pharmacology (2012) 5(2): 145-147.

    Wilmes, A., Hanna, R., Heathcott, R. W., Northcote, P. T., Atkinson, P. H., Bellows, D. S., & Miller, J. H. Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae. Gene (2012) 497(2): 140- 146.

    Woods, T. M., Kamalov, M., Harris, P. W. R., Cooper, G. J. S., & Brimble, M. Synthesis of monolysyl advanced glycation endproducts and their incorporation into collagen model peptides. Organic Letters (2012) 14(22): 5740-5743.

    Yeung, H., Lee, D. J., Williams, G. M., Harris, P. W. R., Dunbar, R. P., & Brimble, M. A. A method for the generation of Pam(2)Cys-based lipopeptide mimics via CuAAC click chemistry. Synlett (2012) 11: 1617-1620.

    Yuen, T. Y., & Brimble, M. A. Total synthesis of 7’,8’-dihydroaigialospirol. Organic Letters (2012) 14(19): 5154-5157.

    Hickey, A. J. R., Jüllig, M., Aitken, J., Loomes, K., Hauber, M. E., & Phillips, A. R. J. Birds and longevity: Does flight driven aerobicity provide an oxidative sink? Ageing Research Reviews (2012) 11(2): 242-253.

    Hobbs, J. K., Shepherd, C., Saul, D. J., Demetras, N. J., Haaning, S., Monk, C. R., Daniel, R. M., & Arcus, V. L. On the origin and evolution of thermophily: Reconstruction of functional precambrian enzymes from ancestors of Bacillus. Molecular Biology and Evolution (2012) 29(2): 825-835.

    Horsfield, J. A., Print, C. G., & Monnich, M. Diverse developmental disorders from the one ring: Distinct molecular pathways underlie the cohesinopathies. Frontiers in Genetics (2012) 3: 171.

    Huisman, F. H. A., Koon, N., Bulloch, E. M. M., Baker, H. M., Baker, E. N., Squire, C. J., & Parker, E. J. Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding. Biochemistry (2012) 51(11): 2289- 2297.

    Hume, P., Furkert, D. P., & Brimble, M. A. Regioselective iridium(I)-catalysed remote borylation of oxygenated naphthalenes. Tetrahedron Letters (2012) 53(29): 3771- 3773.

    Hume, P. A., Brimble, M. A., & Reynisson, J. The bioreductive alkylation of DNA by kalafungin: A theoretical investigation. Australian Journal of Chemistry (2012) 65(4): 402-408.

    Hume, P. A., Brimble, M. A., & Reynisson, J. DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems. Computational and Theoretical Chemistry (2012).

    Hung, K. Y., Harris, P. W. R., & Brimble, M. A. Synthesis of the peptaibol framework of the anticancer agent culicinin D: Stereochemical assignment of the AHMOD moiety. Organic Letters (2012) 14(22): 5784-5787.

    Hunn, M. K., Farrand, K. J., Broadley, K. W. R., Weinkove, R., Ferguson, P., Miller, R. J., Field, C. S., Petersen, T., McConnell, M. J., & Hermans, I. F. Vaccination with irradiated tumor cells pulsed with an adjuvant that stimulates NKT cells is an effective treatment for glioma. Clinical Cancer Research (2012) 18(23): 6446-6459.

    Hunter, F. W., Wang, J., Patel, R., Hsu, H. L., Hickey, A. J. R., Hay, M. P., & Wilson, W. R. Homologous recombination repair-dependent cytotoxicity of the benzotriazine di- N-oxide CEN-209: Comparison with other hypoxia-activated prodrugs. Biochemical Pharmacology (2012) 83(5): 574-585.

    Hurley, D., Araki, H., Tamada, Y., Dunmore, B., Sanders, D., Humphreys, S., Affara, M., Imoto, S., Yasuda, K., Tomiyasu, Y., Tashiro, K., Savoie, C., Cho, V., Smith, S., Kuhara, S., Miyano, S., Charnock-Jones, D. S., Crampin, E. J., & Print, C. G. Gene network inference and visualization tools for biologists: Application to new human transcriptome datasets. Nucleic Acids Research (2012) 40(6): 2377-2398.

    Jackson, V. J., Yosaatmadja, Y., Flanagan, J. U., & Squire, C. J. Structure of AKR1C3 with 3-phenoxybenzoic acid bound. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2012) 68(4): 409-413.

    Jamieson, S. M. F., Brooke, D. G., Heinrich, D., Atwell, G. J., Silva, S., Hamilton, E. J., Turnbull, A. P., Rigoreau, L. J. M., Trivier, E., Soudy, C., Samlal, S. S., Owen, P. J., Schroeder, E., Raynham, T., Flanagan, J. U., & Denny, W. A. 3-(3,4-dihydroisoquinolin-2(1 H)-ylsulfonyl)benzoic acids: Highly potent and selective inhibitors of the type 5 17-beta-hydroxysteroid dehydrogenase AKR1C3. Journal of Medicinal Chemistry (2012) 55(17): 7746-7758.

    Jiao, W., Hutton, R. D., Cross, P. J., Jameson, G. B., & Parker, E. J. Dynamic crosstalk among remote binding sites: The molecular basis for unusual synergistic allostery. Journal of Molecular Biology (2012) 415(4): 716-726.

    Jiao, W. T., & Parker, E. J. Using a combination of computational and experimental techniques to understand the molecular basis for protein allostery. Structural and Mechanistic Enzymology: Bringing Together Experiments and Computing (2012) 87: 391-413.

    Kang, H. J., & Baker, E. N. Structure and assembly of Gram-positive bacterial pili: Unique covalent polymers. Current Opinion in Structural Biology (2012) 22(2): 200- 207.

    Kaur, H., Heapy, A. M., & Brimble, M. A. Synthesis of the all-l cyclopentapeptides versicoloritides A, B, and C. Synlett (2012) 23(15): 2284-2288.

    Kaur, H., Heapy, A. M., & Brimble, M. A. Synthesis of the antifungal cyclic peptides tunicyclins C and D. Synlett (2012) 2: 275-277.

    Kendall, J. D., Giddens, A. C., Tsang, K. Y., Frédérick, R., Marshall, E. S., Singh, R., Lill, C. L., Lee, W. J., Kolekar, S., Chao, M., Malik, A., Yu, S., Chaussade, C., Buchanan, C., Rewcastle, G. W., Baguley, B. C., Flanagan, J. U., Jamieson, S. M. F., Denny, W. A., & Shepherd, P. R. Novel pyrazolo[1,5-a]pyridines as p110alpha-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR. Bioorganic and Medicinal Chemistry (2012) 20(1): 58-68.

    Kendall, J. D., O’Connor, P. D., Marshall, A. J., Frédérick, R., Marshall, E. S., Lill, C. L., Lee, W. J., Kolekar, S., Chao, M., Malik, A., Yu, S., Chaussade, C., Buchanan, C., Rewcastle, G. W., Baguley, B. C., Flanagan, J. U., Jamieson, S. M. F., Denny, W. A., & Shepherd, P. R. Discovery of pyrazolo[1,5-a]pyridines as p110alpha-selective PI3 kinase inhibitors. Bioorganic and Medicinal Chemistry (2012) 20(1): 69-85.

    Kowalczyk, R., Brimble, M. A., Callon, K. E., Watson, M., & Cornish, J. How to blast osteoblasts? Novel dicarba analogues of amylin-(1-8) to treat osteoporosis. Bioorganic and Medicinal Chemistry (2012) 20(20): 6011-6018.

    Kowalczyk, R., Harris, P. W. R., Brimble, M. A., Callon, K. E., Watson, M., & Cornish, J. Synthesis and evaluation of disulfide bond mimetics of amylin-(1-8) as agents to treat osteoporosis. Bioorganic and Medicinal Chemistry (2012) 20(8): 2661-2668.

    Kueh, J. T. B., Choi, K. W., & Brimble, M. A. Enantioselective synthesis of C-linked spiroacetal-triazoles as privileged natural product-like scaffolds. Organic and Biomolecular Chemistry (2012) 10(30): 5993-6002.

    Lancaster, G. I., Skiba, B., Yang, C., Nicholls, H. T., Langley, K. G., Chan, M. H., Bruce, C. R., Rewcastle, G. W., Shepherd, P. R., Karin, M., & Febbraio, M. A. IkappaB kinase beta (IKKbeta) does not mediate feedback inhibition of the insulin signalling cascade. Biochemical Journal (2012) 442(3): 723-732.

    Lasham, A., Samuel, W., Cao, H., Patel, R., Mehta, R., Stern, J. L., Reid, G., Woolley, A. G., Miller, L. D., Black, M. A., Shelling, A. N., Print, C. G., & Braithwaite, A. W. YB-1, the E2F pathway, and regulation of tumor cell growth. Journal of the National Cancer Institute (2012) 104(2): 133-146.

    Lee, D. J., Yang, S. H., Williams, G. M., & Brimble, M. A. Synthesis of multivalent neoglyconjugates of MUC1 by the conjugation of carbohydrate-centered, triazolelinked glycoclusters to MUC1 peptides using click chemistry. Journal of Organic Chemistry (2012) 77(17): 7564-7571.

    Lim, S. N., Kuhn, S., Hyde, E., & Ronchese, F. Combined TLR stimulation with Pam3Cys and Poly I: C enhances Flt3-ligand dendritic cell activation for tumor immunotherapy. Journal of Immunotherapy (2012) 35(9): 670-679.

    Linke, C., Siemens, N., Middleditch, M. J., Kreikemeyer, B., & Baker, E. N. Purification, crystallization and preliminary crystallographic analysis of the adhesion domain of Epf from Streptococcus pyogenes. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2012) 68(7): 793-797.

    Linke, C., Siemens, N., Oehmcke, S., Radjainia, M., Law, R. H. P., Whisstock, J. C., Baker, E. N., & Kreikemeyer, B. The extracellular protein factor epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an n-terminal domain containing a carbohydrate-binding module. Journal of Biological Chemistry (2012) 287(45): 38178-38189.

    Liu, X., Chia, E., Shaw, O. M., Martin, W. J., & Harper, J. L. Rapid CCL2 release by membrane stromal cells initiates monosodium urate crystal-induced monocyte recruitment in a peritoneal model of gouty inflammation. European Journal of Inflammation (2012) 10(2): 165-174.

    McKee, S. J., Young, V. L., Clow, F., Hayman, C. M., Baird, M. A., Hermans, I. F., Young, S. L., & Ward, V. K. Virus-like particles and a-galactosylceramide form a self-adjuvanting composite particle that elicits anti-tumor responses. Journal of Controlled Release (2012) 159(3): 338-345.

    McLeod, M. C., Brimble, M. A., Rathwell, D. C. K., Wilson, Z. E., & Yuen, T. Y. Synthetic approaches to [5,6]-benzannulated spiroketal natural products. Pure and Applied Chemistry (2012) 84(6): 1379-1390.

    McLeod, M. C., Wilson, Z. E., & Brimble, M. A. Formal synthesis of berkelic acid: A lesson in alpha-alkylation chemistry. Journal of Organic Chemistry (2012) 77(1): 400-416.

    Noble, D., Kurachi, Y., Hunter, P., Wang, X., Gordon, M., & Boron, W. Physiology without borders 2. Physiology (2012) 27(1): 2. 

    Pantham, P., Rosario, R., Chen, Q., Print, C. G., & Chamley, L. W. Transcriptomic analysis of placenta affected by antiphospholipid antibodies: following the TRAIL of trophoblast death. Journal of Reproductive Immunology (2012) 94(2): 151-154.

    Papst, S., Noisier, A., Brimble, M. A., Yang, Y., & Krissansen, G. W. Tyrosine modified analogues of the alpha4beta7 integrin inhibitor biotin-R8ERY prepared via Click Chemistry: Synthesis and biological evaluation. Bioorganic and Medicinal Chemistry (2012) 20(8): 2638-2644.

    Papst, S., Noisier, A. F. M., Brimble, M. A., Yang, Y., Chan, Y. C., & Krissansen, G. W. Synthesis and SAR of a library of cell-permeable biotin-R8ERY*peptidomimetics inhibiting alpha4beta7 integrin mediated adhesion of TK-1 cells to MAdCAM -1-Fc. Australian Journal of Chemistry (2012) 65(9): 1349-1358.

    Papst, S., Noisier, A. F. M., Brimble, M. A., Yang, Y., & Krissansen, G. W. Synthesis and biological evaluation of tyrosine modified analogues of the alpha4beta7 integrin inhibitor biotin-R8ERY. Bioorganic and Medicinal Chemistry (2012) 20(17): 5139-5149.

    Peltier, R., Siah, W. R., Williams, G. V. M., Brimble, M. A., Tilley, R. D., & Williams, D. E. Novel phosphopeptides as surface-active agents in iron nanoparticle synthesis. Australian Journal of Chemistry (2012) 65(6): 680-685.

    Poyner, D. R., & Hay, D. L. Secretin family (Class B) G protein-coupled receptors - From molecular to clinical perspectives. British Journal of Pharmacology (2012) 166(1): 1-3.

    Radcliff, F. J., Loh, J. M. S., Ha, B., Schuhbauer, D., McCluskey, J., & Fraser, J. D. Antigen targeting to major histocompatibility complex class II with streptococcal mitogenic exotoxin Z-2 M1, a superantigen-based vaccine carrier. Clinical and Vaccine Immunology (2012) 19(4): 574-586.

    Radjainia, M., Huang, B., Bai, B., Schmitz, M., Yang, S. H., Harris, P. W. R., Griffin, M. D. W., Brimble, M. A., Wang, Y., & Mitra, A. K. A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin. FEBS Journal (2012) 279(14): 2495-2507.

    Rennison, D., Laita, O., Bova, S., Cavalli, M., Hopkins, B., Linthicum, D. S., & Brimble, M. A. Design and synthesis of prodrugs of the rat selective toxicant norbormide. Bioorganic and Medicinal Chemistry (2012) 20(13): 3997-4011.

    Rich, F. J., Kuhn, S., Hyde, E. J., Harper, J. L., Ronchese, F., & Kirman, J. R. Induction of T cell responses and recruitment of an inflammatory dendritic cell subset following tumor immunotherapy with Mycobacterium smegmatis. Cancer Immunology, Immunotherapy (2012) 61(12): 2333-2342.

    Richter, S., Richter, J. P., Mehta, S. Y., Gribble, A. M., Sutherland-Smith, A. J., Stowell, K. M., Print, C. G., Ronimus, R. S., & Wilson, W. R. Expression and role in glycolysis of human ADP-dependent glucokinase. Molecular and Cellular Biochemistry (2012) 364(1-2): 131-145.

    Rosario, R., Araki, H., Print, C. G., & Shelling, A. N. The transcriptional targets of mutant FOXL2 in granulosa cell tumours. PLoS ONE (2012) 7(9): e46270.

    Schünemann, K., Connelly, S., Kowalczyk, R., Sperry, J., Wilson, I. A., Fraser, J. D., & Brimble, M. A. A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors. Bioorganic and Medicinal Chemistry Letters (2012) 22(15): 5018-5024.

    Shepherd, P. R., & Denny, W. A. Beta-testing of PI3-kinase inhibitors: Is beta better? Cancer Discovery (2012) 2(5): 393-394.

    Shepherd, P. R., & Denny, W. A. Drug discovery in the academic environment: The academic model. Biochemist (2012) 34(1): 4-6.

    Smith, G. C., Ong, W. K., Rewcastle, G. W., Kendall, J. D., Han, W., & Shepherd, P. R. Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo. Biochemical Journal (2012) 442(1): 161-169.

    Sparrow, K., Barker, D., & Brimble, M. A. An efficient synthesis of 3-alkyl-1,5,3- dioxazepanes and their use as electrophiles in double-Mannich reactions. Tetrahedron (2012) 68(4): 1017-1028.

    Stubbing, L. A., Li, F. F., Furkert, D. P., Caprio, V. E., & Brimble, M. A. Access to 2-alkyl chromanones via a conjugate addition approach. Tetrahedron (2012) 68(34): 6948-6956.

    Swe, P. M., Copp, J. N., Green, L. K., Guise, C. P., Mowday, A. M., Smaill, J. B., Patterson, A. V., & Ackerley, D. F. Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954. Biochemical Pharmacology (2012) 84(6): 775-783.

    Tang, R. Y., Li, K. Y., Wilson, M., Both, G. W., Taylor, J. A., & Young, S. L. Potent antietumor immunity in mice induced by vaccination with an ovine atadenovirus vector. Journal of Immunotherapy (2012) 35(1): 32-41.

    Wadsworth, A. D., Furkert, D. P., Sperry, J., & Brimble, M. A. Total synthesis of the initially reported and revised structures of the neuroprotective agent palmyrolide A. Organic Letters (2012) 14(20): 5374-5377.

    Yibmantasiri, P., Leahy, D. C., Busby, B. P., Angermayr, S. A., Sorgo, A. G., Boeger, K., Heathcott, R., Barber, J. M., Moraes, G., Matthews, J. H., Northcote, P. T., Atkinson, P. H., & Bellows, D. S. Molecular basis for fungicidal action of neothyonidioside, a triterpene glycoside from the sea cucumber, Australostichopus mollis. Molecular BioSystems (2012) 8(3): 902-912.

    Zheng, Z. H., Amran, S. I., Zhu, J. X., Schmidt-Kittler, O., Kinzler, K. W., Vogelstein, B., Shepherd, P. R., Thompson, P. E., & Jennings, I. G. Definition of the binding mode of a new class of phosphoinositide 3-kinase alpha-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis. Biochemical Journal (2012) 444(3): 529-535.

    2011

    Affara, M., Dunmore, B. J., Sanders, D. A., Johnson, N., Print, C. G., & Charnock- Jones, D. S. MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms. BMC Genomics (2011) 12:43.

    Allison, T. M., Hutton, R. D., Cochrane, F. C., Yeoman, J. A., Jameson, G. B., & Parker, E. J. Targeting the role of a key conserved motif for substrate selection and catalysis by 3-Deoxy-D-Manno-octulosonate 8-Phosphate synthase. Biochemistry (2011) 50(18): 3686-3695.

    Allison, T. M., Hutton, R. D., Jiao, W., Gloyne, B. J., Nimmo, E. B., Jameson, G. B., & Parker, E. J. An extended beta7alpha7 substrate-binding loop is essential for efficient catalysis by 3-deoxy-d-Manno-octulosonate 8-Phosphate synthase. Biochemistry (2011) 50(43): 9318-9327.

    Archbold, J. K., Flanagan, J. U., Watkins, H. A., Gingell, J. J., & Hay, D. L. Structural insights into RAMP modification of secretin family G protein-coupled receptors: Implications for drug development. Trends in Pharmacological Sciences (2011) 32(10): 591-600.

    Arcus, V. L., McKenzie, J. L., Robson, J., & Cook, G. M. The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array. Protein Engineering, Design and Selection (2011) 24(1-2): 33-40.

    Atkinson, D. J., Sperry, J., & Brimble, M. A. Synthesis of benzotriazole analogues of the helicobactericidal agents CJ-13,015, CJ-13,102, CJ-13,108, and CJ-13,104 using a regioselective 1,3-dipolar cycloaddition. Synlett (2011) 1: 99-103.

    Benson, M. A., Lilo, S., Wasserman, G. A., Thoendel, M., Smith, A., Horswill, A. R., Fraser, J., Novick, R. P., Shopsin, B., & Torres, V. J. Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner. Molecular Microbiology (2011) 81(3): 659-675.

    Best, N., Fraser, J. D., Rainey, P. B., Roberts, S. A., Thomas, M. G., & Ritchie, S. R. Nasal carriage of Staphylococcus aureus in healthy Aucklanders. New Zealand Medical Journal (2011) 124(1332): 30-39.

    Bircham, P. W., Maass, D. R., Roberts, C. A., Kiew, P. Y., Low, Y. S., Yegambaram, M., Matthews, J., Jack, C. A., & Atkinson, P. H. Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Molecular BioSystems (2011) 7(9): 2589-2598.

    Bonnet, M., Flanagan, J. U., Chan, D. A., Lai, E. W., Nguyen, P., Giaccia, A. J., & Hay, M. P. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells. Bioorganic and Medicinal Chemistry (2011) 19(11): 3347-3356.

    Bradley, C., Bowery, A., Britten, R., Budelmann, V., Camara, O., Christie, R., Cookson, A., Frangi, A. F., Gamage, T. B., Heidlauf, T., Krittian, S., Ladd, D., Little, C., Mithraratne, K., Nash, M., Nickerson, D., Nielsen, P., Nordbo, O., Omholt, S., Pashaei, A., Paterson, D., Rajagopal, V., Reeve, A., Rohrle, O., Safaei, S., Sebastian, R., Steghofer, M., Wu, T., Yu, T., Zhang, H. Y., & Hunter, P. OpenCMISS: A multi-physics & multi-scale computational infrastructure for the VPH/Physiome project. Progress in Biophysics & Molecular Biology (2011) 107(1): 32-47.

    Brimble, M. A., Finch, O. C., Heapy, A. M., Fraser, J. D., Furkert, D. P., & O’Connor, P. D. A convergent synthesis of the [4.4]-Spiroacetal-gamma-lactones cephalosporolides E and F. Tetrahedron (2011) 67(5): 995-1001.

    Broadley, K., Larsen, L., Herst, P. M., Smith, R. A. J., Berridge, M. V., & McConnell, M. J. The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress. Journal of Cellular Biochemistry (2011) 112(7): 1869- 1879.

    Broadley, K. W. R., Hunn, M. K., Farrand, K. J., Price, K. M., Grasso, C., Miller, R. J., Hermans, I. F., & McConnell, M. J. Side population is not necessary or sufficient for a cancer stem cell phenotype in glioblastoma multiforme. Stem Cells (2011) 29(3): 452-461.

    Chan, D. A., Sutphin, P. D., Nguyen, P., Turcotte, S., Lai, E. W., Banh, A., Reynolds, G. E., Chi, J. T., Wu, J., Solow-Cordero, D. E., Bonnet, M., Flanagan, J. U., Bouley, D. M., Graves, E. E., Denny, W. A., Hay, M. P., & Giaccia, A. J. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Science Translational Medicine (2011) 3(94): 94ra70.

    Chang, A., Khemlani, A., Kang, H., & Proft, T. Functional analysis of Streptococcus pyogenes nuclease A (SpnA), a novel group A streptococcal virulence factor. Molecular Microbiology (2011) 79(6): 1629-1642.

    Chen, J. L. Y., & Brimble, M. A. Synthesis of the bis-spiroacetal core of the antimitotic agent spirastrellolide B. Journal of Organic Chemistry (2011) 76(22): 9417-9428.

    Chen, J. L. Y., Sperry, J., Ip, N. Y., & Brimble, M. A. Natural products targeting telomere maintenance. MedChemComm (2011) 2(4): 229-245.

    Cheng, J. M. H., Chee, S. H., Knight, D. A., Acha-Orbea, H., Hermans, I. F., Timmer, M. S. M., & Stocker, B. L. An improved synthesis of dansylated alpha-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells. Carbohydrate Research (2011) 346(7): 914-926.

    Chim, N., Habel, J. E., Johnston, J. M., Krieger, I., Miallau, L., Sankaranarayanan, R., Morse, R. P., Bruning, J., Swanson, S., Kim, H., Kim, C. Y., Li, H., Bulloch, E. M., Payne, R. J., Manos-Turvey, A., Hung, L. W., Baker, E. N., Lott, J. S., James, M. N. G., Terwilliger, T. C., Eisenberg, D. S., Sacchettini, J. C., & Goulding, C. W. The TB Structural Genomics Consortium: A decade of progress. Tuberculosis (2011) 91(2): 155-172.

    Cooper, G. J. S. Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer’s disease. Drugs (2011) 71(10): 1281- 1320.

    Costa, J. L., Smith, G., Watson, M., Lin, J. M., Callon, K., Gamble, G., Cheng, A., Vickers, M. H., Shepherd, P. R., Cornish, J., & Grey, A. The atypical anti-psychotic clozapine decreases bone mass in rats in vivo. Schizophrenia Research (2011) 126(1-3): 291-297.

    Cross, P. J., Dobson, R. C. J., Patchett, M. L., & Parker, E. J. Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis. Journal of Biological Chemistry (2011) 286(12): 10216-10224.

    Didsbury, A., Wang, C., Verdon, D., Sewell, M., McIntosh, J., & Taylor, J. Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells. Virology Journal (2011) 8(1): 551.

    Dogra, M., Palmer, B. D., Bashiri, G., Tingle, M. D., Shinde, S. S., Anderson, R. F., O’Toole, R., Baker, E. N., Denny, W. A., & Helsby, N. A. Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver. British Journal of Pharmacology (2011) 162(1): 226-236.

    Flanagan, J. U., & Smythe, M. L. Sigma-class glutathione transferases. Drug Metabolism Reviews (2011) 43(2): 194-214.

    Fraser, J. D. Clarifying the mechanism of superantigen toxicity. PLoS Biology (2011) 9(9):e1001145.

    Girvan, R. C., Knight, D. A., O’Loughlin, C. J., Hayman, C. M., Hermans, I. F., & Webster, G. A. MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity. Vaccine (2011) 29(3): 545-557.

    Guéret, S. M., & Brimble, M. A. Synthetic studies toward the spiroimine unit of the spirolides. Pure and Applied Chemistry (2011) 83(3): 425-433.

    Hagbom, M., Istrate, C., Engblom, D., Karlsson, T., Rodriguez-Diaz, J., Buesa, J., Taylor, J. A., Loitto, V. M., Magnusson, K. E., Ahlman, H., Lundgren, O., & Svensson, L. Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting. PLoS Pathogens (2011) 7(7): e1002115.

    Harris, P. W. R., Yang, S. H., & Brimble, M. A. An improved procedure for the preparation of aminomethyl polystyrene resin and its use in solid phase (peptide) synthesis. Tetrahedron Letters (2011) 52(45): 6024-6026.

    Hay, D. L., Walker, C. S., & Poyner, D. R. Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: Opportunities and challenges. Endocrine-Related Cancer (2011) 18(1): C1-C14.

    Ho, H., Suresh, V., Kang, W., Cooling, M. T., Watton, P. N., & Hunter, P. J. Multiscale modeling of intracranial aneurysms: Cell signaling, hemodynamics, and remodeling. IEEE Transactions on Biomedical Engineering (2011) 58(10 PART 2): 2974-2977.

    Hume, P. A., Sperry, J., & Brimble, M. A. Enantioselective synthesis of pyranonaphthoquinone antibiotics using a CBS reduction/cross-metathesis/oxa- Michael strategy. Organic and Biomolecular Chemistry (2011) 9(15): 5423-5430.

    Hung, K. Y., Harris, P. W. R., Heapy, A. M., & Brimble, M. A. Synthesis and assignment of stereochemistry of the antibacterial cyclic peptide xenematide. Organic and Biomolecular Chemistry (2011) 9(1): 236-242.

    Hurley, D., Araki, H., Tamada, Y., Dunmore, B., Sanders, D., Humphreys, S., Affara, M., Imoto, S., Yasuda, K., Tomiyasu, Y., Tashiro, K., Savoie, C., Cho, V., Smith, S., Kuhara, S., Miyano, S., Charnock-Jones, D. S., Crampin, E. J., & Print, C. G. Gene network inference and visualization tools for biologists: application to new human transcriptome datasets. Nucleic Acids Research (2011): 1-22.

    Jamieson, S., Flanagan, J. U., Kolekar, S., Buchanan, C., Kendall, J. D., Lee, W. J., Rewcastle, G. W., Denny, W. A., Singh, R., Dickson, J., Baguley, B. C., & Shepherd, P. R. A drug targeting only p110 alpha can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochemical Journal (2011) 438: 53-62.

    Jullig, M., Browett, P., Middleditch, M. M. J., Prijic, G., Kilfoyle, D., Angelo, N., & Cooper, G. J. S. A unique case of neural amyloidoma diagnosed by mass spectrometry of formalin-fixed tissue using a novel preparative technique. Amyloid (2011) 18(3): 147-155.

    Kang, H. J., & Baker, E. N. Intramolecular isopeptide bonds: Protein crosslinks built for stress? Trends in Biochemical Sciences (2011) 36(4): 229-237.

    Kang, H. J., Coulibaly, F., Proft, T., & Baker, E. N. Crystal structure of spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly. PLoS ONE (2011) 6(1): e15969.

    Kaur, H., Heapy, A. M., & Brimble, M. A. The synthesis of dehydrotryptophan and dehydrotryptophan-containing peptides. Organic and Biomolecular Chemistry (2011) 9(17): 5897-5907.

    Le Nours, J., Bulloch, E. M. M., Zhang, Z., Greenwood, D. R., Middleditch, M. J., Dickson, J. M. J., & Baker, E. N. Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide. Journal of Biological Chemistry (2011) 286(47): 40706-40716.

    Lee, D. J., Harris, P. W. R., & Brimble, M. A. Synthesis of MUC1 Neoglycopeptides using efficient microwave-enhanced chaotrope-assisted click chemistry. Organic and Biomolecular Chemistry (2011) 9(5): 1621-1626.

    Leung, E., Kim, J. E., Rewcastle, G. W., Finlay, G. J., & Baguley, B. C. Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifenresistant breast cancer cells. Cancer Biology & Therapy (2011) 11(11): 938-946.

    Locke, M., Feisst, V., & Dunbar, P. R. Concise review: Human adipose-derived stem cells: Separating promise from clinical need. Stem Cells (2011) 29(3): 404-411.

    Locke, M., Ussher, J. E., Mistry, R., Taylor, J. A., & Dunbar, P. R. Transduction of human adipose-derived mesenchymal stem cells by recombinant adeno-associated virus vectors. Tissue Engineering - Part C: Methods (2011) 17(9): 949-959.

    Loomes, K. M. Survival of an islet beta-cell in type 2 diabetes Curbing the effects of amyloid cytotoxicity. Islets (2011) 3(1): 38-39.

    Lu, G. L., Stevenson, R. J., Chang, J. Y. C., Brothers, P. J., Ware, D. C., Wilson, W. R., Denny, W. A., & Tercel, M. N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7- trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f] quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs. Bioorganic and Medicinal Chemistry (2011) 19(16): 4861-4867.

    MacDonald, J. R., Oellermann, M., Rynbeck, S., Chang, G., Ruggiero, K., Cooper, G. J. S., & Hickey, A. J. R. Transmural differences in respiratory capacity across the rat left ventricle in health, aging, and streptozotocin-induced diabetes mellitus: Evidence that mitochondrial dysfunction begins in the subepicardium. American Journal of Physiology - Cell Physiology (2011) 300(2): C246-C255.

    McLeod, M. C., Wilson, Z. E., & Brimble, M. A. An enantioselective formal synthesis of berkelic acid. Organic Letters (2011) 13(19): 5382-5385.  

    McMillan, D. G. G., Ferguson, S. A., Dey, D., Schröder, K., Aung, H. L., Carbone, V., Attwood, G. T., Ronimus, R. S., Meier, T., Janssen, P. H., & Cook, G. M. A 1A o-ATP synthase of Methanobrevibacter ruminantium couples sodium ions for ATP synthesis under physiological conditions. Journal of Biological Chemistry (2011) 286(46): 39882- 39892.

    Miller, A. K., Yu, T., Britten, R., Cooling, M. T., Lawson, J., Cowan, D., Garny, A., Halstead, M. D. B., Hunter, P. J., Nickerson, D. P., Nunns, G., Wimalaratne, S. M., & F Nielsen, P. M. Revision history aware repositories of computational models of biological systems. BMC Bioinformatics (2011) 12:22.

    Misirli, G., Hallinan, J. S., Yu, T., Lawson, J. R., Wimalaratne, S. M., Cooling, M. T., & Wipat, A. Model annotation for synthetic biology: Automating model to nucleotide sequence conversion. Bioinformatics (2011) 27(7): 973-979.

    Mittal, A., Hickey, A. J. R., Chai, C. C., Loveday, B. P. T., Thompson, N., Dare, A., Delahunt, B., Cooper, G. J. S., Windsor, J. A., & Phillips, A. R. J. Early organ-specific mitochondrial dysfunction of jejunum and lung found in rats with experimental acute pancreatitis. HPB (Oxford) (2011) 13(5): 332-341.

    Moir, L. M., Trian, T., Ge, Q., Shepherd, P. R., Burgess, J. K., Oliver, B. G. G., & Black, J. L. Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function. Journal of Pharmacology and Experimental Therapeutics (2011) 337(2): 557-566.

    Mönnich, M., Kuriger, Z., Print, C. G., & Horsfield, J. A. A zebrafish model of roberts syndrome reveals that esco2 depletion interferes with development by disrupting the cell cycle. PLoS ONE (2011) 6(5): e20051.

    Negron, L., & Parker, E. J. Fluorinated substrates result in variable leakage of a reaction intermediate during catalysis by dehydroquinate synthase. Organic and Biomolecular Chemistry (2011) 9(8): 2861-2867.

    Paterson, N. G., & Baker, E. N. Structure of the full-length major pilin from Streptococcus pneumoniae: Implications for isopeptide bond formation in grampositive bacterial pili. PLoS ONE (2011) 6(7): e22095.

    Pather, K., Helsby, N.A., Palmer, B.D. & Ching, L.M. Development and validation of a high performance liquid chromatography assay for the determination of a fluorinated analogue of thalidomide, N-(2,6-dioxopiperidin-3-yl)-3,4,5,6- tetrafluorophthalamic acid and lenalidomide. Journal of Liquid Chromatography & Related Technologies (2011) 34(2): 83-92.

    Pearce, F. G., Dobson, R. C. J., Jameson, G. B., Perugini, M. A., & Gerrard, J. A. Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization. Biochimica Et Biophysica Acta-Proteins and Proteomics (2011) 1814(12): 1900-1909.

    Petersen, T. R., Sika-Paotonu, D., Knight, D. A., Simkins, H. M. A., & Hermans, I. F. Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines. PLoS ONE (2011) 6(3): e17657.

    Qi, T., Ly, K., Poyner, D. R., Christopoulos, G., Sexton, P. M., & Hay, D. L. Structurefunction analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors. Peptides (2011) 32(5): 1060-1067.

    Rehan, A. M., Bashiri, G., Paterson, N. G., Baker, E. N., & Squire, C. J. Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2011) 67(10): 1274- 1277.

    Reichau, S., Jiao, W., Walker, S. R., Hutton, R. D., Baker, E. N., & Parker, E. J. Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: Combining mechanism- and modeling-based design. Journal of Biological Chemistry (2011) 286(18): 16197-16207.

    Rewcastle, G. W., Gamage, S. A., Flanagan, J. U., Frederick, R., Denny, W. A., Baguley, B. C., Kestell, P., Singh, R., Kendall, J. D., Marshall, E. S., Lill, C. L., Lee, W. J., Kolekar, S., Buchanan, C. M., Jamieson, S. M. F., & Shepherd, P. R. Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(Difluoromethyl)-1-[4,6-di(4- morpholinyl)-1,3,5-triazin-2- yl]-1 H -benzimidazole (ZSTK474). Journal of Medicinal Chemistry (2011) 54(20): 7105- 7126.

    Ritchie, S. R., Fraser, J. D., Libby, E., Morris, A. J., Rainey, P. B., & Thomas, M. G. Demographic variation in community-based MRSA skin and soft tissue infection in Auckland, New Zealand. New Zealand Medical Journal (2011) 124(1332): 21-30.

    Shaw, O. M., & Harper, J. L. Bradykinin receptor 2 extends inflammatory cell recruitment in a model of acute gouty arthritis. Biochemical and Biophysical Research Communications (2011) 416(3–4): 266-269.

     

    Simkins, H. M. A., Hyde, E., Farrand, K. J., Ong, M. L., Degli-Esposti, M. A., Hermans, I. F., & Ronchese, F. Administration of alpha-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo. Journal of Leukocyte Biology. (2011) 89(5): 753-762.

    Smith, G. C., Vickers, M. H., & Shepherd, P. R. Olanzapine effects on body composition, food preference, glucose metabolism and insulin sensitivity in the rat. Archives of Physiology and Biochemistry (2011) 117(4): 241-249.

     

    Sparrow, K., Barker, D., & Brimble, M. A. The enantioselective synthesis of tetracyclic methyllycaconitine analogues. Tetrahedron (2011) 67(41): 7989-7999.

    Sperry, J., Liu, Y. C., Wilson, Z. E., Hubert, J. G., & Brimble, M. A. Synthesis of benzannulated spiroketals using an oxidative radical cyclization. Synthesis (2011) (9): 1383-1398.

    Stevenson, R. J., Denny, W. A., Ashoorzadeh, A., Pruijn, F. B., Van Leeuwen, W. F., & Tercel, M. The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy. Bioorganic and Medicinal Chemistry (2011) 19(20): 5989-5998.

    Stewart, K. W., Phillips, A. R. J., Whiting, L., Jüllig, M., Middleditch, M. J., & Cooper, G. J. S. A simple and rapid method for identifying and semi-quantifying peptide hormones in isolated pancreatic islets by direct-tissue matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry (2011) 25(22): 3387-3395.

    Szwergold, B. S., Bunker, R. D., & Loomes, K. M. The physiological substrates of fructosamine-3-kinase-related-protein (FN3KRP) are intermediates of nonenzymatic reactions between biological amines and ketose sugars (fructation products). Medical Hypotheses (2011) 77(5): 739-744.

    Tercel, M., Atwell, G. J., Yang, S., Ashoorzadeh, A., Stevenson, R. J., Botting, K. J., Gu, Y., Mehta, S. Y., Denny, W. A., Wilson, W. R., & Pruijn, F. B. Selective treatment of hypoxic tumor cells in vivo: Phosphate pre-prodrugs of nitro analogues of the duocarmycins. Angewandte Chemie - International Edition (2011) 50(11): 2606-2609.

    Thompson, A. M., Sutherland, H. S., Palmer, B. D., Kmentova, I., Blaser, A., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., & Denny, W. A. Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6 S)-2-nitro- 6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2011) 54(19): 6563-6585.

     

    Tran, D., Pietersma, A. L., Schofield, L. R., Rost, M., Jameson, G. B., & Parker, E. J. Investigating the role of the hydroxyl groups of substrate erythrose 4-phosphate in the reaction catalysed by the first enzyme of the shikimate pathway. Bioorganic & Medicinal Chemistry Letters (2011) 21 (22): 6838-6841.

    Vaghefi, E., Pontre, B. P., Jacobs, M. D., & Donaldson, P. J. Visualizing ocular lens fluid dynamics using MRI: Manipulation of steady state water content and water fluxes. American Journal of Physiology - Regulatory Integrative and Comparative Physiology (2011) 301(2): R335-R342.

    Waardenberg, A. J., Bernardo, B. C., Ng, D. C. H., Shepherd, P. R., Cemerlang, N., Sbroggio, M., Wells, C. A., Dalrymple, B. P., Brancaccio, M., Lin, R. C. Y., & McMullen, J. R. Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure. Journal of Biological Chemistry   (2011) 286(35): 30837-30846.

    Walker, S. R., Jiao, W., & Parker, E. J. Synthesis and evaluation of dual site inhibitors of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase. Bioorganic and Medicinal Chemistry Letters (2011) 21(17): 5092-5097.

    Waltemath, D., Adams, R., Beard, D. A., Bergmann, F. T., Bhalla, U. S., Britten, R., Chelliah, V., Cooling, M. T., Cooper, J., Crampin, E. J., Garny, A., Hoops, S., Hucka, M., Hunter, P., Klipp, E., Laibe, C., Miller, A. K., Moraru, I., Nickerson, D., Nielsen, P., Nikolski, M., Sahle, S., Sauro, H. M., Schmidt, H., Snoep, J. L., Tolle, D., Wolkenhauer, O., & le Novère, N. Minimum information about a simulation experiment (MIASE). PLoS Computational Biology (2011) 7(4).

    Wilson, W. R., & Hay, M. P. Targeting hypoxia in cancer therapy. Nature Reviews Cancer (2011) 11(6): 393-410.

    Wilson, Z. E., Hubert, J. G., & Brimble, M. A. A flexible approach to 6,5-benzannulated spiroketals. European Journal of Organic Chemistry (2011) (20-21): 3938-3945.

    Win, S. J., Ward, V. K., Dunbar, P. R., Young, S. L., & Baird, M. A. Cross-presentation of epitopes on virus-like particles via the MHC I receptor recycling pathway. Immunology and Cell Biology (2011) 89(6): 681-688.

    Wines, B. D., Ramsland, P. A., Trist, H. M., Gardam, S., Brink, R., Fraser, J. D., & Hogarth, P. M. Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor. Journal of Biological Chemistry (2011) 286(38): 33118-33124.

    Wojnar, J. M., Evans, C. W., Devries, A. L., & Brimble, M. A. Synthesis of an isotopically-labelled antarctic fish antifreeze glycoprotein probe. Australian Journal of Chemistry (2011) 64(6): 723-731.

    Wood AJ, Fraser J, Swift S, Amirapu S, Douglas RG. Are biofilms associated with an inflammatory response in chronic rhinosinusitis? International Forum of Allergy and Rhinology (2011) 1 (5): 335-339.


    Yang, S. H., Lee, D. J., & Brimble, M. A. Synthesis of an NDPK phosphocarrier domain peptide containing a novel triazolylalanine analogue of phosphohistidine using click chemistry. Organic Letters (2011) 13(20): 5604-5607.

    Yu, T., Lloyd, C. M., Nickerson, D. P., Cooling, M. T., Miller, A. K., Garny, A., Terkildsen, J. R., Lawson, J., Britten, R. D., Hunter, P. J., & Nielsen, P. M. The physiome model repository 2. Bioinformatics (2011) 27(5): 743-744.

    Yuen, T. Y., Yang, S. H., & Brimble, M. A. Total synthesis of paecilospirone. Angewandte Chemie - International Edition (2011) 50(36): 8350-8353.

    Zhang, Y. C., Furkert, D. P., Guéret, S. M., Lombard, F., & Brimble, M. A. Gold(I)- catalysed intramolecular hydroamination of alpha-quaternary alkynes: synthetic studies towards spiroimine marine toxins. Tetrahedron Letters (2011) 52(38): 4896-4898.

    Zulian, A., Šileikyte, J., Petronilli, V., Bova, S., Dabbeni-Sala, F., Cargnelli, G., Rennison, D., Brimble, M. A., Hopkins, B., Bernardi, P., & Ricchelli, F. The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide. Biochimica et Biophysica Acta - Bioenergetics (2011) 1807(12): 1600-1605.

    2010

    Aitken, J. F., Loomes, K. M., Scott, D. W., Reddy, S., Phillips, A. R. J., Prijic, G., Fernando, C., Zhang, S., Broadhurst, R., L’Huillier, P., & Cooper, G. J. S. Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/ islet amyloid polypeptide transgenic mice. Diabetes (2010) 59(1): 161-171.

    Atkinson, D. J., Sperry, J., & Brimble, M. A. Improved synthesis of the benzyne precursor 2-(trimethylsilyl) phenyl trifluoromethane sulfonate. Synthesis (2010) (6): 911- 913.

    Bashiri, G., Rehan, A. M., Greenwood, D. R., Dickson, J. M. J., & Baker, E. N. Metabolic engineering of cofactor F420 production in mycobacterium smegmatis. PLoS ONE (2010) 5(12).

    Brauer, R., Wang, L. C., Woon, S. T., Bridewell, D. J., Henare, K., Malinger, D., Palmer, B. D., Vogel, S. N., Kieda, C., Tijono, S. M., & Ching, L. M. Labeling of oxidizable proteins with a photoactivatable analog of the antitumor agent DMXAA: evidence for redox signaling in its mode of action. Neoplasia (2010) 12(9): 755-765.

    Bogle, G., & Dunbar, P. R. Agent-based simulation of T-cell activation and proliferation within a lymph node. Immunology and Cell Biology (2010) 88(2): 172-179.

     

    Bogle, G. & Dunbar, P. R. T cell responses in lymph nodes. Wiley Interdisciplinary Reviews: Systems Biology & Medicine (2010) 2: 107-116.

    Buchanan, C. M., Phillips, A. R. J., & Cooper, G. J. S. A novel two-chain IGF-II-derived peptide from purified b-cell granules. Growth Hormone and IGF Research (2010) 20(5): 360-366.

    Chan, Y., Balle, J., Kevin Sparrow, J., Boyd, P. D. W., Brimble, M. A., & Barker, D. A double Mannich approach to the synthesis of substituted piperidones - Application to the synthesis of substituted E-ring analogues of methyllycaconitine. Tetrahedron (2010) 66(35): 7179-7191.

    Chang, J. Y. C., Stevenson, R. J., Lu, G. L., Brothers, P. J., Clark, G. R., Denny, W. A., & Ware, D. C. Syntheses of 8-quinolinolatocobalt(III) complexes containing cyclen based auxiliary ligands as models for hypoxia-activated prodrugs. Dalton Transactions (2010) 39(48): 11535-11550.

    Chen, J. L. Y., & Brimble, M. A. Synthesis of the bis-spiroacetal C25-C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence. Chemical Communications (2010) 46(22): 3967-3969.

    Chien, V., Aitken, J. F., Zhang, S., Buchanan, C. M., Hickey, A., Brittain, T., Cooper, G. J. S., & Loomes, K. M. The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of beta-sheet-containing aggregates by human amylin: A potential role for defective chaperone biology in Type 2 diabetes. Biochemical Journal (2010) 432(1): 113-121.

    Choi, P. J., Sperry, J., & Brimble, M. A. Heteroatom-directed reverse Wacker oxidations. Synthesis of the reported structure of (-)-herbaric acid. Journal of Organic Chemistry (2010) 75(21): 7388-7392.

    Cooper, G. J. S., Aitken, J. F., & Zhang, S. Is type 2 diabetes an amyloidosis and does it really matter (to patients)? Diabetologia (2010) 53(6): 1011-1016.

    Denny, W. A. Hypoxia-activated prodrugs in cancer therapy: Progress to the clinic. Future Oncology (2010) 6(3): 419-428.

    Denny, W. A., & Palmer, B. D. The nitroimidazooxazines (PA-824 and analogs): Structure-activity relationship and mechanistic studies. Future Medicinal Chemistry (2010) 2(8): 1295-1304.

    Garny, A., Cooper, J., & Hunter, P. J. Toward a VPH/Physiome ToolKit. Wiley interdisciplinary reviews. Systems biology and medicine (2010) 2(2): 134-147.

    Gianni, D., McKeever, S., Yu, T., Britten, R., Delingette, H., Frangi, A., Hunter, P., & Smith, N. Sharing and reusing cardiovascular anatomical models over the Web: A step towards the implementation of the virtual physiological human project. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (2010) 368(1921): 3039-3056.

    Graham, E. S., Angel, C. E., Schwarcz, L. E., Dunbar, P. R., & Glass, M. Detailed characterisation of CB2 receptor protein expression in peripheral blood immune cells from healthy human volunteers using flow cytometry. International Journal of Immunopathology and Pharmacology (2010) 23(1): 25-34.

    Grey, A., Chaussade, C., Empson, V., Lin, J. M., Watson, M., O’Sullivan, S., Rewcastle, G., Naot, D., Cornish, J., & Shepherd, P. Evidence for a role for the p110-alpha isoform of PI3K in skeletal function. Biochemical and Biophysical Research Communications (2010) 391(1): 564-569.

     

    Guéret, S. M., Boyd, P. D. W., & Brimble, M. A. (1R,6R,13R,18R)-(Z,Z)-1,18-Bis[(4R)- 2,2-dimethyl-1,3-dioxolan-4-yl]-3, 16-dimethylene-8,20-diazadispiro-[5.6.5.6]tetracosa- 7,19-diene. Acta Crystallographica Section E: Structure Reports Online (2010) 66(7).

    Guéret, S. M., & Brimble, M. A. Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: Isolation, structure, biological activity and synthesis. Natural Product Reports (2010) 27(9): 1350-1366.

    Guéret, S. M., Furkert, D. P., & Brimble, M. A. Synthesis of a functionalized 7,6-bicyclic spiroimine ring fragment of the spirolides. Organic Letters (2010) 12(22): 5226-5229.

    Harris, P. W., & Brimble, M. A. Toward the total chemical synthesis of the cancer protein NY-ESO-1. Biopolymers (2010) 94(4): 542-550. 

    Hay, M. P., Turcotte, S., Flanagan, J. U., Bonnet, M., Chan, D. A., Sutphin, P. D., Nguyen, P., Giaccia, A. J., & Denny, W. A. 4-Pyridylanilinothiazoles that selectively target von Hippel - Lindau deficient renal cell carcinoma cells by inducing autophagic cell death. Journal of Medicinal Chemistry (2010) 53(2): 787-797.

    Heapy, A. M., & Brimble, M. A. Synthesis of the FG ring fragment of pectenotoxins 1-9. Tetrahedron (2010) 66(29): 5424-5431.

    Hicks, K. O., Siim, B. G., Jaiswal, J. K., Pruijn, F. B., Fraser, A. M., Patel, R., Hogg, A., Liyanage, H. D. S., Dorie, M. J., Brown, J. M., Denny, W. A., Hay, M. P., & Wilson, W. R. Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors. Clinical Cancer Research (2010) 16(20): 4946-4957.

    Ho, H., Mithraratne, K., Schmid, H., Sands, G., & Hunter, P. Computer simulation of vertebral artery occlusion in endovascular procedures. International Journal of Computer Assisted Radiology and Surgery (2010) 5(1): 29-37.

    Hung, K. Y., Harris, P. W. R., & Brimble, M. A. Synthesis of methyl N-Boc-(2 S,4 R)-4- methylpipecolate. Journal of Organic Chemistry (2010) 75(24): 8728-8731.

    Hunter, P., Coveney, P. V., De Bono, B., Diaz, V., Fenner, J., Frangi, A. F., Harris, P., Hose, R., Kohl, P., Lawford, P., McCormack, K., Mendes, M., Omholt, S., Quarteroni, A., Skår, J., Tegner, J., Thomas, S. R., Tollis, I., Tsamardinos, I., Van Beek, J. H. G. M., & Viceconti, M. A vision and strategy for the virtual physiological human in 2010 and beyond. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (2010) 368(1920): 2595-2614.

    Jameson, M. B., Rischin, D., Pegram, M., Gutheil, J., Patterson, A. V., Denny, W. A., & Wilson, W. R. A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors. Cancer Chemotherapy and Pharmacology (2010) 65(4): 791-801.

    Johnston, J. M., Jiang, M., Guo, Z., & Baker, E. N. Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: Testing a putative role in menaquinone biosynthesis. Acta Crystallographica Section D: Biological Crystallography (2010) 66(8): 909-917.

    Jongbloed, S. L., Kassianos, A. J., McDonald, K. J., Clark, G. J., Ju, X., Angel, C. E., Chen, C. J. J., Dunbar, P. R., Wadley, R. B., Jeet, V., Vulink, A. J. E., Hart, D. N. J., & Radford, K. J. Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. Journal of Experimental Medicine (2010) 207(6): 1247-1260.

    Jor, J. W. Y., Nash, M. P., Nielsen, P. M. F., & Hunter, P. J. Estimating material parameters of a structurally based constitutive relation for skin mechanics. Biomechanics and Modeling in Mechanobiology (2010): 1-12.

    Jüllig, M., Chen, X., Middleditch, M. J., Vazhoor, G., Hickey, A. J., Gong, D., Lu, J., Zhang, S., Phillips, A. R. J., & Cooper, G. J. S. Illuminating the molecular basis of diabetic arteriopathy: A proteomic comparison of aortic tissue from diabetic and healthy rats. Proteomics (2010) 10(18): 3367-3378.

    Kenny, L. C., Broadhurst, D. I., Dunn, W., Brown, M., North, R. A., McCowan, L., Roberts, C., Cooper, G. J. S., Kell, D. B., & Baker, P. N. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension (2010) 56(4): 741-749.

     

    Kim, N., Cannell, M. B., & Hunter, P. J. Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart. Progress in Biophysics and Molecular Biology (2010) 103(1): 28-34.

    Kmentova, I., Sutherland, H. S., Palmer, B. D., Blaser, A., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., Denny, W. A., & Thompson, A. M. Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6 S)-2- nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H-imidazo[2,1-b][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2010) 53(23): 8421-8439.

    Koch, C., Augustine, R. A., Steger, J., Ganjam, G. K., Benzler, J., Pracht, C., Lowe, C., Schwartz, M. W., Shepherd, P. R., Anderson, G. M., Grattan, D. R., & Tups, A. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. Journal of Neuroscience (2010) 30(48): 16180-16187.

     

    Kolnes, A. J., Ingvaldsen, A., Bolling, A., Stuenæs, J. T., Kreft, M., Zorec, R., Shepherd, P. R., & Jensen, J. Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles. Acta Physiologica (2010) 200(1): 65-74.

    Langley, R., Patel, D., Jackson, N., Clow, F., & Fraser, J. D. Staphylococcal superantigen super-domains in immune evasion. Critical Reviews in Immunology (2010) 30(2): 149-165.

    Laursen, N. S., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Wines, B., Spillner, E., Christensen, J. B., Jensen, M., Fredslund, F., Bjerre, M., Sottrup-Jensen, L., Fraser, J. D., & Andersen, G. R. Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America (2010) 107(8): 3681-3686.

    Lee, D. J., Harris, P. W. R., Kowalczyk, R., Dunbar, P. R., & Brimble, M. A. Microwaveassisted synthesis of fluorescein-labelled GalNAca1-O-Ser/ Thr (Tn) glycopeptides as immunological probes. Synthesis (2010) 5: 763-769.

     

    Linke, C., Young, P. G., Kang, H. J., Bunker, R. D., Middleditch, M. J., Caradoc- Davies, T. T., Proft, T., & Baker, E. N. Crystal structure of the minor pilin FctB reveals determinants of group A streptococcal pilus anchoring. Journal of Biological Chemistry (2010) 285(26): 20381-20389.

     

    Linke, C., Young, P. G., Kang, H. J., Proft, T., & Baker, E. N. Purification, crystallization and preliminary crystallographic analysis of the minor pilin FctB from Streptococcus pyogenes. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2010) 66(2): 177-179.

    Lu, J., Gong, D., Choong, S. Y., Xu, H., Chan, Y. K., Chen, X., Fitzpatrick, S., Glyn- Jones, S., Zhang, S., Nakamura, T., Ruggiero, K., Obolonkin, V., Poppitt, S. D., Phillips, A. R. J., & Cooper, G. J. S. Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: Comparisons between triethylenetetramine and three less copper-selective transitionmetal- targeted treatments. Diabetologia (2010) 53(6): 1217-1226.

    Lu, J., Poppitt, S. D., Othman, A. A., Sunderland, T., Ruggiero, K., Willett, M. S., Diamond, L. E., Garcia, W. D., Roesch, B. G., & Cooper, G. J. S. Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: An open-label trial. Journal of Clinical Pharmacology (2010) 50(6): 647-658.

    Manos-Turvey, A., Bulloch, E. M. M., Rutledge, P. J., Baker, E. N., Lott, J. S., & Payne, R. J. Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI). ChemMedChem (2010) 5(7): 1067-1079. 

    Maroz, A., Shinde, S. S., Franzblau, S. G., Ma, Z., Denny, W. A., Palmer, B. D., & Anderson, R. F. Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent. Organic and Biomolecular Chemistry (2010) 8(2): 413-418.

     

    Martin, S. K., Fitter, S., Bong, L. F., Drew, J. J., Gronthos, S., Shepherd, P. R., & Zannettino, A. C. W. NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells. Journal of Bone and Mineral Research (2010) 25(10): 2126-2137.

    McKay, V. A., Thompson, S. J., Tran, P. M., Goodall, K. J., Brimble, M. A., & Barker, D. Stereoselective synthesis of 4-substituted 4-hydroxypiperidines via epoxidation-ring opening of 4-methylenepiperidines. Synlett (2010) 17: 2631-2635.

    Miller, N., Williams, G. M., & Brimble, M. A. Synthesis of Neoglycopeptides via Click Chemistry. International Journal of Peptide Research and Therapeutics (2010): 1-8.

    Mittal, A., Göke, F., Flint, R., Loveday, B. P. T., Thompson, N., Delahunt, B., Kilmartin, P. A., Cooper, G. J. S., MacDonald, J., Hickey, A., Windsor, J. A., & Phillips, A. R. J. The redox status of experimental hemorrhagic shock as measured by cyclic voltammetry. Shock (2010) 33(5): 460-466.

    Mittal, A., Middleditch, M., Ruggiero, K., Loveday, B., Delahunt, B., Jüllig, M., Cooper, G. J. S., Windsor, J. A., & Phillips, A. R. J. Changes in the mesenteric lymph proteome induced by hemorrhagic shock. Shock (2010) 34(2): 140-149.

    Nikac, M., Brimble, M. A., Crumbie, R. L., & Bailey, T. D. Metal binding studies using spiroacetal thiacrown ethers. Tetrahedron Letters (2010) 51(7): 1072-1074.

    Palmer, B. D., Thompson, A. M., Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., & Denny, W. A. Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro- 5H-imidazo[2,1-b][1,3]oxazine (PA-824). Journal of Medicinal Chemistry (2010) 53(1): 282-294.

    Patel, D., Wines, B. D., Langley, R. J., & Fraser, J. D. Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain. Journal of Immunology (2010) 184(11): 6283-6292.

    Peltier, R., Brimble, M. A., Wojnar, J. M., Williams, D. E., Evans, C. W., & DeVries, A. L. Synthesis and antifreeze activity of fish antifreeze glycoproteins and their analogues. Chemical Science (2010) 1(5): 538-551.

    Peltier, R., Evans, C. W., Devries, A. L., Brimble, M. A., Dingley, A. J., & Williams, D. E. Growth habit modification of ice crystals using antifreeze glycoprotein (AFGP) analogues. Crystal Growth and Design (2010) 10(12): 5066-5077.

    Prosser, G. A., Copp, J. N., Syddall, S. P., Williams, E. M., Smaill, J. B., Wilson, W. R., Patterson, A. V., & Ackerley, D. F. Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochemical Pharmacology (2010) 79(5): 678-687.

    Prosser, G. A., Patterson, A. V., & Ackerley, D. F. uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954. Journal of Biotechnology (2010) 150(1): 190-194.

    Rathwell, K., Sperry, J., & Brimble, M. A. Synthesis of triazole analogues of the nanaomycin antibiotics using ‘click chemistry’. Tetrahedron (2010) 66(23): 4002-4009.

    Reynolds, H. M., Walker, C. G., Dunbar, P. R., O’Sullivan, M. J., Uren, R. F., Thompson, J. F., & Smith, N. P. Functional anatomy of the lymphatics draining the skin: A detailed statistical analysis. Journal of Anatomy (2010) 216(3): 344-355.

    Shinde, S. S., Maroz, A., Hay, M. P., Patterson, A. V., Denny, W. A., & Anderson, R. F. Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4- benzotriazine 1,4-dioxide (tirapazamine). Journal of the American Chemical Society (2010) 132(8): 2591-2599.

    Smith, W. D., Pointon, J. A., Abbot, E., Kang, H. J., Baker, E. N., Hirst, B. H., Wilson, J. A., Banfield, M. J., & Kehoe, M. A. Roles of minor pilin subunits Spy0125 and Spy0130 in the serotype M1 Streptococcus pyogenes strain SF370. Journal of Bacteriology (2010) 192(18): 4651-4659.

    Sperry, J., Harris, E. B. J., & Brimble, M. A. Total synthesis and absolute configuration of (-)-berkeleyamide A. Organic Letters (2010) 12(3): 420-423.

    Sperry, J., Liu, Y. C., & Brimble, M. A. Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction. Organic and Biomolecular Chemistry (2010) 8(1): 29-38.

     

    Sperry, J., Wilson, Z. E., Rathwell, D. C. K., & Brimble, M. A. Isolation, biological activity and synthesis of benzannulated spiroketal natural products. Natural Product Reports (2010) 27(8): 1117-1137.

     

    Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., Wan, B., Wang, Y., Ma, Z., Palmer, B. D., Denny, W. A., & Thompson, A. M. Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains. Journal of Medicinal Chemistry (2010) 53(2): 855-866.

    Tercel, M., Yang, S., Atwell, G. J., Smith, E., Gu, Y., Anderson, R. F., Denny, W. A., Wilson, W. R., & Pruijn, F. B. Hypoxic selectivity and solubility - Investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e] indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy. Bioorganic and Medicinal Chemistry (2010) 18(14): 4997-5006.

    Tups, A., Anderson, G. M., Rizwan, M., Augustine, R. A., Chaussade, C., Shepherd, P. R., & Grattan, D. R. Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of Neuroendocrinology (2010) 22(6): 534-542.

    Ussher, J. E., & Taylor, J. A. Optimized transduction of human monocyte-derived dendritic cells by recombinant adeno-associated virus serotype 6. Human Gene Therapy (2010) 21(12): 1675-1686.

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