New modalities for challenging drug discovery
Advances in molecular biology have heralded an expansion of protein-based therapeutics, and sophisticated peptide chemistry has also opened up new therapeutic options.
Maurice Wilkins Centre researchers will combine their expertise across different fields of molecular and chemical biology to investigate new modalities in drug design with potential to modulate difficult-to-treat biological processes.
Novel chemical entities will be synthesised by combining different classes of compounds to give molecular conjugates with desirable properties. Examples include stabilised and/or cyclic peptides, nucleic acid-based therapeutics, and conjugation of small molecules and peptides to antibody-drug conjugates.
Investigators at the Maurice Wilkins Centre will also continue to explore the use of enzymes for therapeutic and diagnostic applications using directed evolution techniques.