Hormones controlling metabolism
Human metabolic disorders are often associated with defects in the production or release of key metabolic hormones.
Maurice Wilkins Centre investigators are strongly focused on studying metabolic hormone system defects and how these might lead to metabolic disease.
The primary objectives of this programme are to better understand the mechanisms regulating hormone secretion from neuroendocrine cells (including neurosecretory hypothalamic cells and insulin-produced beta cells from the pancreas), to assess the potential of novel compounds (for example, amylin analogues) to control metabolism, and to determine the roles of hormones and peptides such as calcitonin gene-related peptide and prolactin in regulating energy metabolism.
In addition, this programme aims to develop relevant model systems to allow study of the actions of hormones and metabolites in relation to diabetes and obesity.
The use of models has been pivotal in biomolecular research, particularly when it comes to measuring how certain adjustments to key factors or processes in the body can lead to the manifestation of particular diseases.