|Led by Profs. Peter Shepherd & Bill Denny|
Every human cell is controlled by highly complex networks of proteins called signaling molecules that work together like the wiring of a computer to regulate all the functions of a cell. Research in recent years has started to unravel these complex networks and this knowledge is beginning to show that defects in these pathways can play a major role in the development of major diseases. The studies under theme 6 are focussing on understanding how defects in these cell signaling pathways contribute to diabetes and cancer. This first requires a solid understanding of the biology of the signaling pathways in a normal state and comparing this with disease states. This knowledge then allows us to develop strategies to overcome these defects and this in turn is leading us to the development of new drugs to treat these major diseases.