Advanced mathematical modelling

Led by Profs. Peter Hunter, Garth Cooper, John Fraser & Rod Dunbar

We are developing a framework for modelling cellular and sub-cellular processes using advanced mathematical approaches. It will provide a means of integrating genomic and proteomic data for a novel description of whole cell behaviour. The key objectives include the development of XML based data models to present information about cellular processes and pathways, the use of physiological and proteomic data to develop testable models for cell behaviour, the development of simulation and visualisation tools to better reveal the connections between components of sub-cellular pathways and to develop computational modelling of protein structure from sequence data. The CellML project, aimed at modelling cellular pathways, is stimulating wide international interest and many collaborative links. Ontologies of cell structure and function are being developed to facilitate the modelling of cellular processes such as transport, metabolism, signalling, motility, cyto-skeletal organisation and the cell cycle. The markup language 'CellML' is being developed to encapsulate the mathematical descriptions of cell functions. For more information on this project see The BioEngineering Institute website