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New antimicrobials through genomics and protein structure.

Rational drug design using protein structure analysis.

High throughput proteomics for novel therapeutics.

Mathematics and engineering to model biological systems.

Peptide based vaccines and novel drug candidates.

Cell signalling pathways in diabetes and metabolic disorders.

Developing cell based immunotherapy for cancer and other diseases.

Proteomics in diabetes and heart disease therapies

Led by Profs. Garth Cooper & Peter Hunter

This component of the CoRE focuses on the development of advanced proteomics for the identification of proteins and peptides that can either be developed as therapeutics in their own right or provide targets for structure-based drug design. The main goal is to identify new peptide therapeutics for diabetes and heart disease and to develop advanced mass spectrometry techniques for large scale proteomic analysis of major cell types involved in fuel metabolism.

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Structure based drug design for tuberculosis. Read about Professor Bill Denny and Dr. Brian Palmer who are developing new agents to treat one of man's oldest and most intractable diseases.