Reports & Publications

Page Index

Seek    Newsletters    Annual Reports    PEER REVIEWED PUBLICATIONS 2004-2006     2004     2005     2006    PATENTS 2004-2006     2004     2005     2006

Seek   

Seek is an attractive new publication from the MWC outlining major events and acheivements from the Centre.

1. Issue 3 November 2009 (pdf 1.9MB)

2. Issue 2 December 2007 (pdf 1MB)

3. Issue 1 March 2007 (pdf 3MB)

Newsletters   

The MWC publishes a newsletter to update on progress of the centre or to publicise any important events. These are available for download as PDF files below.

1. February 2006 (pdf 784KB)

2. October 2005 (pdf 895KB)

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Annual Reports   

1. CMB Year 1 Annual Report - June 2003 (PDF format)

2. CMB Year 2 Annual Report - June 2004 (PDF format)

3. CMB Year 3 Annual Report - 2004-2005 (PDF format)

4. CMB Year 4 Annual Report - 2005-2006 (PDF format)

5. CMB Year 5 Annual Report - 2006-2007 (PDF format)

6. CMB Year 6 Annual Report - 2007-2008 (PDF format)

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PEER REVIEWED PUBLICATIONS 2004-2006   

2004   

1. Abaffy T, Cooper GJS.(2004). GSK3 involvement in amylin signaling in isolated rat soleusmuscle. Peptides 25, 2119-25.
2. Ahn, G.-O., Ware, D.C., Denny, W.A., Wilson, W.R. (2004). Optimization of the auxiliaryligand shell of cobalt(III)(8-hydroxyquinoline) complexes as model hypoxia-selective radiationactivatedprodrugs. Radiation Res. 162(3),315-25.
3. Arcus, V. L., Backbro, K., Roos, A., Daniel, E. L. and Baker, E. N. (2004). Distant structuralhomology leads to the functional characterization of an archaeal PIN-domain as an exonuclease.J. Biol. Chem. 279, 16471-16478.
4. Backbro, K., Roos, A., Baker, E. N. and Arcus, V. L. (2004). Crystallization and preliminary Xrayanalysis of a conserved hypothetical protein from Pyrobaculum aerophilum and of a doubleLeu/Met mutant engineered for MAD phasing. Acta Cryst. sect. D. 60, 733-735.
5. Baker, E.N. (2004). From penicillin to the ribosome: Revolutions in the determination and useof molecular structure in chemisty and biology. Aust. J. Chem. 57, 829-836.
6. Baker, H.M. and Baker, E.N. (2004). Lactoferrin and iron: structural and dynamic aspects ofbinding and release. BioMetals 17, 206-216.
7. Baker, E. N., Arcus, V., Johnston, J., Peterson, N. and Lott, J. S. (2004). From genes to proteinsto drugs via crystallography: new approaches to a deadly pathogen. Mycobacteriumtuberculosis. Chem in NZ. 68, 29-33.
8. Baker H.M., Proft T., Webb P.D., Arcus V.L., Fraser J.D., Baker E.N. (2004). Crystallographicand mutational data show that the streptococcal pyrogenic exotoxin J (SPE-J) can use a commonbinding surface for T-cell receptor binding and dimerisation. J.Biol.Chem. 279,38571-38576.
9. Barker, D., Brimble, M. A. , McLeod, M. D. , and Savage, G. P. (2004). Synthesis of TricyclicAnalogues of Methyllycaconitine Using Ring Closing Metathesis to Append a B Ring to an AEAzabicyclic Fragment. Org. Biomol. Chem. 2, 1659-1669.
10. Brimble, M.A., Flowers, C.L., Hutchinson, J.K., Robinson, J.E. and Sidford, M. (2005).Synthesis of the Phthalide-containing anti-Helicobacter pylori Agents CJ-13,015, CJ-13,102,CJ-13,103, CJ-13,104 and CJ-13,108. Tetrahedron. 61, 10036-10047.
11. Brimble, M. A. and Furkert, D.(2004).Synthesis of the 1,6,8 Trioxadispiro[4.1.5.2]tetradec-11-ene Ring System Present in the Spirolide Family of Shellfish Toxins and its Conversion to a ,6,8-Trioxadispiro[4.1.5.2]-tetradec-9-en-12-ol via Base-induced Rearrangement of anEpoxide. Org. Biomol. 2, 3573-3583.
12. Brimble, M. A., Robinson, J. E. , Choi, K. W. and Woodgate, P. D.(2004). Synthesis of a NovelNucleoside Based on a Spiroacetal Framework. Aust. J. Chem. 57, 665-668.
13. Brimble, M. A., Burgess, C., Halim, R. , Petersson, M. and Ray, J. (2004).Synthesis ofPyrrolo[3,2-b]benzofurans and Pyrrolo[3,2-b]naphthofurans via Addition of a Silyloxypyrrole toActivated Quinones. Tetrahedron. 60, 5751-5758.
14. Brimble, M. A. and Trzoss, M. (2004). A Double Alkylation – Ring Closing MetathesisApproach to Spiroimines. Tetrahedron. 60, 5613-5622.
15. Brocke, C., Brimble, M. A., Lin, D. S.-H. and McLeod, M. D. (2004). Application of a DoubleMannich Reaction using Bis(aminol) ethers in the Synthesis of AE Ring Analogues ofMethyllycaconitine. Synlett. 2359-2363.
16. Burrowes, K.S., Tawhai, M.H. and Hunter, P.J. (2004). Modeling RBC and neutrophildistribution through an anatomically based pulmonary capillary network. Annals Biomed. Eng. 585-595.
17. Choi, K.L., Wang, Y., Tse, C.A., Lam, K.S.L., Cooper, G.J.S. and Xu, A. (2004). Proteomicanalysis of adipocyte differentiation: Evidence that a2 macroglobulin is involved in adiposeconversion of 3T3 L1 cells. Proteomics 4, 1840-1848.
18. Cooper G.J.S., Phillips A.R.J., Choong S.Y., Leonard B.L., Crossman D.J., Brunton D.H., Saafi‘E.L., Dissanayake A.M., Cowan B.R., Young A.A., Occleshaw C.J., Chan Y.K., Leahy F.E.,Keogh G.F., Gamble G.D., Allen G.R., Pope A.J., Boyd P.D.W., Poppitt S.D., Borg T.K.,Doughty R.N. and Baker J.R. (2004). Regeneration of the heart in diabetes mellitus by selectivecopper chelation. Diabetes. 53, 2501-2508.
19. Craig, P.R., Brothers, P.J., Clark, G.R., Wilson, W.R., Denny, W.A., and Ware, D.C. (2004).Anionic carbonato and oxalato cobalt(III) nitrogen mustard complexes. J. Chem. Soc. DaltonTrans. 4, 611-618.
20. Crampin, E.J., Schnell, S. and McSharry, P.E. (2004). Mathematical and computationaltechniques to deduce complex biochemical reaction mechanisms. Prog. Biophys. Mol. Biol. 86, 77-112.
21. Crampin, E.J. and Schnell, S. (2004). New approaches to modelling and analysis of biochemicalreactions, pathways and networks (Editorial). Prog. Biophys. Mol. Biol. 86, 1-4.
22. Crampin, E.J., Halstead, M., Hunter, P.J., Nielsen, P.M.F., Noble, D., Smith, N.P. and Tawhai,M. (2004). Computational physiology and the physiome project. Exp. Physiol. 89, 1-26.
23. Crampin, E.J., Smith, N.P. and Hunter, P.J. (2004). Multi-scale modelling and the IUPSPhysiome Project. J. Mol. Histol. 35, 707-714.
24. Denny, W.A. (2004). DNA minor groove alkylators. Frontiers in Medicinal Chemistry-Online 1,591-594.
25. Denny, W.A. (2004). Emerging DNA topoisomerase inhibitors as anticancer drugs. Expert Opin.Emerging Drugs 9, 105-133.
26. Denny, W.A. (2004). Hypoxia-activated prodrugs: a new approach to cancer chemotherapy.Chem. NZ, 68, 19-23.
27. Denny, W.A. (2004). The design of drugs that target tumour hypoxia. Aust. J. Chem. 57(9), 821-828.
28. Denny, W.A. (2004). Prospects for hypoxia-activated anticancer drugs. Curr. Med. Chem.-Anticancer Agents, 4, 395-399.
29. Denny, W.A. (2004). Tumor-activated prodrugs – a new approach to cancer chemotherapy.Cancer Inv., 22, 604-619.
30. Fernandez, J. W, Mithraratne, P., Tawhai, M. and Hunter, P. J. (2004). Geometric fitting andcustomization of anatomically based cubic Hermite finite element volume meshes.Biomechanics and Modelling in Mechanobiology. 2, 139-155.
31. Gamage, S.A., Rewcastle, G.W., Baguley, B.C., Charlton, P.A., Denny, W.A. Phenazine-1-carboxamides: structure-cytotoxicity relationships for 9-substituents and changes in the Hbondingpattern of the cationic side chain. Bioorg. Med. Chem. 14, 1160-1168.
32. Hay, M.P., Pruijn, F.B., Gamage, S.A., Liyanage, H.D.S., Kovacs, M.S., Patterson, A.V.,Wilson, W.R., Brown, J.M., and Denny, W.A. (2004). DNA–targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia–selective cytotoxin tirapazamine. J. Med. Chem. 47,5-488.
33. Helsby, N.A., Atwell, G.J., Yang, S., Palmer, B.D., Anderson, R.F., Pullen, S.M., Ferry, D.M.,Hogg, A., Wilson, W.R. and Denny, W.A. (2004). Aziridinyldinitrobenzamides: synthesis andstructure-activity relationships for activation by E. coli nitroreductase. J. Med. Chem. 47, 3295-3307.
34. Hunter, P.J. (2004). The IUPS physiome project: a framework for computational physiology.Prog. Biophys. Mol. Biol. 85, 551-569.
35. Hunter, P.J., Smith, N., Fenandez. J. and Tawhai, M. (2004). Integration from proteins to organs:the IUPS Physiome Project. Mech. Ageing Dev. 126/1, 187-192.
36. Koon, N., Squire, C. J. and Baker, E. N. (2004). Crystallization and preliminary X-ray analysisof a-isopropylmalate synthase from Mycobacterium tuberculosis. Acta Cryst. sect. D., 60, 1167-1169.
37. Koon, N., Squire, C. J. and Baker, E. N. (2004). Crystal structure of LeuA from Mycobacteriumtuberculosis, a key enzyme in leucine biosynthesis. Proc. Natl. Acad. Sci. USA. 101, 8295-8300.
38. Lott, J. S. and Baker, E. N. (2004). Using structural genomics to understand Mycobacteriumtuberculosis. IUBMB Life. 56, 113-117.
39. McCarthy, A.A., Peterson, N.A., Knijff, R. and Baker, E.N. (2004). Crystal structure of MshBfrom Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis. J. Mol.Biol. 335, 1131-1141.
40. Nelson, S.M., Ferguson. L.R. and Denny, W.A.(2004). DNA and the chromosome – variedtargets for chemotherapy. Cell Chromo. Rev. 3 (1):2.
41. Proft T.P., Webb P., Handley V. and Fraser J.D. (2004). Identification & characterisation of thetwo novel streptococcal pyrogenic exotoxins SPE-L & SPE-M. Ind. J. Med. Res. 119, 37-43.
42. Shinde, S., Anderson, R.F., Hay, M.P., Gamage, S.A. and Denny, W.A. (2004). Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-aminobenzotriazine 1,4-dioxides. J. Amer.Chem. Soc. 126, 7865-7874.
43. Smail, B.H., LeGrice, I.J., Hooks, D.A., Pullan, A.J., Caldwell, B.J. and Hunter, P.J. (2004).Cardiac structure and electrical activation:models and measurement. Clinical and ExperimentalPharmacology and Physiolcogy. 31: 913-919.
44. Smith N.P., Barclay C.J., Loiselle D.S. (2004). The Efficiency of Muscle Contraction, Prog.Biophys. Mol. Biol. 88(1), 1-58.
45. Smith, N.P. and Crampin, E.J. (2004). Development of models of active ion transport for wholecellmodelling: Cardiac sodium-potassium pump as a case study. Prog. Biophys. Mol. Biol. 85, 407-405.
46. Smith N.P., Crampin E.J. (2004). Modelling cellular and tissue function. Prog. Biophys. Mol.Biol. 85, 117-119.
47. Smith, N.P., Nickerson, D.P., Crampin, E.J. and Hunter, P.J. (2004). Multiscale computationalmodelling of the heart. Acta Numerica 13, 371-431.
48. Smith, N.P. and Hunter, P.J.(2004). Giving form to the function of the heart: embedding cellularmodels in an anatomical framework. Japanese Journal of Physiology. 54, 541-544.
49. Tawhai, M. H. and Hunter, P. J. (2004). Modeling water vapor and heat transfer in the normaland the intubated airway. Annals Biomed. Eng. 32, 609-622.
50. Tawhai, M.H., Hunter, P.J., Tschirren, J., Reinhardt, J., McLennan, G. and Hoffman. E. (2004).CT-based geometry analysis and finite element models of the human and ovine bronchial tree.Journal of Applied Physiology. 97, 2310 – 2321.
51. Thompson, A.M., Delaney, A.M., Hamby, J.M., Schroeder, M.C., Spoon, T.A., Showalter,H.D.H., Denny, W.A. (2005). Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dualinhibitors of the FGF and VEGF receptor tyrosine kinases. J. Med. Chem., 48, 4628-4653.
52. Walanj, R., Young, P., Baker, H.M., Baker, E.N., Metcalf, P., Chow, J.W., Lerner, S.,Vakulenko, S. and Smith, C. A. (2004). Purification, crystallization and preliminary X-rayanalysis of Enterococcus faecium aminoglycoside-2”-phosphotransferase-Ib [APH (2”)-Ib].Acta. Cryst. sect. F 61, 410-413.
53. Wang Y., Lu, G., Wong W.P., Vliegenthart J.F. Gerwig G.J., Lam K. S., Cooper G. J., and Xu.A. (2004). Proteomic and functional characterization of endogenous adiponectin purified fromfetal bovine serum. Proteomics. 4, 3933-3942.
54. Xu A., Wong L.C., Wang Y., Xu J.Y., Cooper G.J. and Lam K.S. (2004). Chronic treatmentwith growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes. FEBS. Lett. 2, 129-134.

2005   

1. Adams, A., Leong, C., Denny, W.A., Guss, J.M. (2005). Crystal structures of two minor groove binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)2 at 1.6 and 1.8 Å resolution. Acta. Cryst. D, D61, 1348-1353.
2. Anderson, R.F., Shinde, S.S., Hay, M.P., Gamage, S.A., Denny, W.A. (2005). Radical factors governing the hypoxia selectivity of antitumour 1,2,4-benzotriazine 1,4-dioxides. Org. Biomol. Chem., 3, 2167-2174.
3. Baker, E.N. and Dodson, G.G. (2005). Proteins - discovery and detail. Curr. Opin. Struct. Biol. 15, 652-654.
4. Barker, D., Lin, D.H.-S., Carland, J.E., Chu, C.P.-Y., Chebib, M., Brimble, M.A., SavageG.P., McLeod, M.D. (2005). Methyllycaconitine Analogues have Mixed Antagonist Effects at Nicotinic Acetylcholine Receptors, Bioorg. Med. Chem. 13, 4565-4575.
5. Brimble, M.A., Brocke, C. (2005). Efficient Synthesis of the Azabicyclo[3.3.1]nonane Ring System in the Alkaloid Methyllycaconitine using Bis(alkoxymethyl)alkylamines as Aminoalkylating Agents in a Double Mannich Reaction. Eur. J. Org. Chem., 2385-2396.
6. Brimble, M.A., Flowers, C.L., Hutchinson, J.K., Robinson, J.E., Sidford, M. (2005). Synthesis of the Phthalide-containing anti-Helicobacter pylori Agents CJ-13,015, CJ-13,102, CJ-13,103, CJ-13,104 and CJ-13,108. Tetrahedron, 61, 10036-10047.
7. Brimble, M.A., Levi, M.S. (2005). Alkylarsenic, -Antimony, and –Bismuth Compounds Chapter 2.09 in Comprehensive Organic Functional Group Transformations II, ed. A. R. Katritzky and R. J. K. Taylor, Elsevier Ltd., Oxford, vol 2, 463-484.
8. Brimble, M.A., Trotter, N.S., Harris, P.W.R., Levi, M.S., Sieg, F. (2005). Synthesis and Pharmacological Evaluation of Side Chain Modified Glutamic Acid Analogues of the Neuroprotective Agent Glycyl-L-Prolyl-L-Glutamic Acid (GPE). Bioorg. Med. Chem., 13, 519-532.
9. Bu, X., Chen, J., Deady, L.W., Smith, C.L., Baguley, B.C., Greenhalgh, D., Yang, S., Denny, W.A. (2005). Synthesis and cytotoxic activity of N-[(alkylamino)alkyl]carboxamide derivatives of 7-oxo-7H-benz[de]anthracene, 7-oxo-7H- naphtho[1,2,3-de]quinoline and 7-oxo-7H-benzo[e]perimidine. Bioorg. Med. Chem., 13, 3657-3665.
10. Buckley, B.R., Bulman Page, P.C., Heaney, H., Sampler, E.P., Carley, S., Brocke, C., Brimble, M.A. (2005). Use of Bis(aminol) Ethers derived from N-(S)-(-)-α -Methylbenzylamine in Reactions with Resorcinarenes and Double Mannich Reactions Tetrahedron, 61, 5876-5888.
11. Burrowes, K.S., Hunter, P.J. and Tawhai, M.H. (2005). ‘Investigation of the relative effects of vascular branching structure and gravity on pulmonary arterial blood flow heterogeneity via an image-based computational model’. Acad Radiol 12(11): 1464-1474.
12. Burrowes, K., Hunter, P.J. and Tawhai, M. (2005). Anatomically-based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels. J Applied Physiology 99(2), pp 731-738.
13. Burrowes, K.S., Tawhai, M.H. and Hunter, P.J. (2005). Evaluation of arterial blood flow heterogeneity via an image-based computational model. Physiology, Function, and Structure from Medical Images: Proc of SPIE, 2005 Vol. 5746, pp 257-266.
14. E. Brennesvik, C. Ktori, J. Ruzzin, E. Jebens, P. R. Shepherd, J. Jensen (2005) Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: Implications for cross talk between insulin and adrenaline – Cellular Signalling 17 1551-1559
15. Card, G.L., Peterson, N.A., Smith, C.A., Rupp, B., Schick, B.M. and Baker, E.N. (2005). The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis. J. Biol. Chem. 280, 13978-13986.
16. Carland, M, Tan, K.J., White, J.M., Stephenson, J, Murray, Denny, W.A., McFadyen, W.D. (2005). Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol. J. Inorg. Biochem., 99, 1738-1743.
17. Carland, M., Abrahams, B.F., Denny, W.A., Murray, V., McFadyen, W.D. (2005). Hydrogen-bonded networks from novel platinum(II) dimers. Crystal Eng. Comm., 7, 701-705.
18. Chen JL, Stewart-Jones G, Bossi G, Lissin NM, Wooldridge L, Choi EM, Held G, Dunbar PR, Esnouf RM, Sami M, Boulter JM, Rizkallah P, Renner C, Sewell A, van der Merwe PA, Jakobsen BK, Griffiths G, Jones EY, Cerundolo V (2005) Structural and kinetic basis for heightened immunogenicity of T cell vaccines. Journal of Experimental Medicine 201(8):1243-55.
19. Chuang D, Power SE, Dunbar PR and Hill AG (2005) Central nervous system interleukin-8 production following neck of femur fracture. Australia and New Zealand Journal of Surgery 75:813-6
20. Clark, G.R., Flowers, C. L., Brimble, M.A. (2005). 6,8'-Dimethoxy-2,2'-spirobichroman. Acta Crystallographica, Section E: Structure Reports Online, E61(4), 910-911.
21. Clark, G.R., Tsang, K.Y., Brimble, M.A. (2005). “5,8'-Dimethoxy-3H-1-benzofuran-2-spiro-2'-chroman. Acta Crystallographica, Section E: Structure Reports Online, E61(8), 2748-2749.
22. Clark, G.R., Tsang, K.Y., Brimble, M.A. (2005). 5-Methoxyspiro[1-benzofuran-2(3H),2'-chroman]. Acta Crystallographica, Section E: Structure Reports Online, E61(4), 1123-1124.
23. Cooper, G. J. S., Chan, Y. K., Dissanayake, A. M., Leahy, F. E., Keogh, G. F., Frampton, C. M., Gamble, G. D., Brunton, D. H., Baker, J. R., and Poppitt, S. D. (2005). Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals. Diabetes 54,1468–1476.
24. Crimmins, D., Trzoss, M., Brimble, M.A. (2005). Synthesis of Spirolactams via Diels-Alder Addition of 1,3-Butadienes to α-Methylenelactams. Archive for Organic Chemistry (ARKIVOC), 1, 39-52.
25. Deady, L.W., Rogers, M.L., Zhuang, L., Baguley, B.C., Denny, W.A. (2005). Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridin-(5H)ones. Bioorg. Med. Chem., 13, 1341-1355.
26. Denny, W.A. Hypoxia-activated anticancer drugs. (2005). Exp. Opin. Ther. Patents, 15, 635-646.
27. Dragunow, M., Trzoss, M., Brimble, M.A., Cameron, R., Beuzenberg, V., Holland, P., Mountfort, D. (2005). Investigations into the Cellular Actions of the Shellfish Gymnodimine and Analogues. Environmental Toxicology and Pharmacology, 20, 305-312.
28. Fernandez, J. W., Ho, A., Walt, S., Anderson, I., Hunter, P. J. (2005). A cerebral palsy assessment tool using anatomically based geometries and free-form deformation. Biomechanics and Modelling in Mechanobiology. 4(1), 39-56.
29. Fernandez, J.W., Hunter, P.J. (2005). An anatomically based patient-specific finite element model of patella articulation: Towards a diagnostic tool. Biomechanics and Modelling in Mechanobiology 4(1), 20-38.
30. Gniazdowski, M., Denny, W.A., Nelson, S.M., Czyz, M. (2005)Effects of anticancer drugs on transcription factor-DNA interactions. Exp. Opin. Ther. Targets, 9, 471-489.
31. Fernandez, J.W., Buist, M.L., Nickerson, D.P. and Hunter, P.J. (2005). Modelling the passive and nerve activated response of the rectus femoris muscle to a flexion loading: a finite element framework. Medical Engineering and Physics. 27(10):862-870.
32. Goldstone, D., Baker, E. N. and Metcalf, P. (2005). Crystallization and preliminary diffraction studies of the C-terminal domain of the DipZ homologue from Mycobacterium tuberculosis. Acta Cryst. sect. F 61, 243-245.
33. Goodall, K.J., Barker, D., Brimble, M.A. (2005). A Review of Advances in the Synthesis of Analogues of the Delphinium Alkaloid Methyllycaconitine. Invited Review. Synlett Account, 1809-1827.
34. Halim, R., Brimble, M.A., Merten, J. (2005). Synthesis of the ABC Fragment of the Pectenotoxins. Organic Lett., 7, 2659-2662.
35. Harris, P.W.R., Brimble, M.A., Muir, V.J., Lai, M.Y.H., Trotter, N.S., Callis, D.J. (2005). Sythesis of Proline-modified Analogues of the Neuroprotective Agent Glycyl-L-prolyl- glutamic acid (GPE). Tetrahedron, 61, 10018-10035.
36. Hay, M.P., Wilson, W.R., Denny, W.A. (2005). Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy. Bioorg. Med. Chem., 13, 4043-4055.
37. Hopkins PA, Fraser JD, Pridmore AC, Russell HH, Read RC, Sriskandan S (2005) Superantigen recognition by HLA class II on monocytes up-regulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin. Blood. 105(9) : 3655-3662
38. Hunter, P.J. (2006) Modeling living systems: the IUPS/EMBS Physiome Project. Proceedings of the IEEE. 94:678-691.
39. Hunter, P.J., Burrowes, K., Fernandez, J., Nielsen, P, Smith, N. and Tawhai, M. (2005). The IUPS Physiome Project: Progress and plans. Chapter 17 in ‘Computational Systems Biology’, Eds A. Kriete and R. Eils. Elsevier, pp 383-394.
40. Hunter, P.J. and Nielsen, P.M.F. (2005). A strategy for integrative computational physiology. Physiology. 20,316-325.
41. Jeffrey, S.C., Torgov, M.Y., Andreyka, J.B., Boddington, L., Cerveny, C.G., Denny, W.A., Gustin, D., Haugen, J., Kline, T., Nguyen, M.T., Senter, P.D. (2005). Design, synthesis and in vitro evaluation of dipeptide-based antibody minor groove binder conjugates. J. Med. Chem., 48, 1344-1355.
42. Johnston, J.M., Arcus, V.L. and Baker, E.N. (2005). Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms. Acta Cryst. sect. D 61, 1199-1206.
43. Jones , D.R., Paneda, C., Villar, A.V., Alonson, A., Goni, F. M., Buitikofer, P., Brodbeck, U., Shepherd, P.R., and Varela-Nieto, I., (2005) Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases FEBS Letters 579: 59-65
44. Kelly, D., Mackenzie, L., Hunter, P., Smaill, B. and Saint, D. (2005). Gene expression of stretch activated channels and mechano-electric feedback in the heart. http://www.aups.org.au/Proceedings/36/91-99/.
45. Konarkowska, B., Aitken, J. F., Kistler, J., Zhang, S., and Cooper, G. J. S. (2005). Thiol reducing compounds prevent human amylin-evoked cytotoxicity. FEBS J. 272, 4949-4959.
46. Lai, M.Y.H., Brimble, M.A., Callis, D.J., Harris, P.W.R., Levi M.S., Sieg, F. (2005). Synthesis and Pharmacological Evaluation of Glycine-Modified Analogues of the Neuroprotective Agent Glycyl-L-Prolyl-L-Glutamic Acid (GPE). Bioorg. Med. Chem., 13, 533-548.
47. Langley R, Wines B, Willoughby N, Basu I, Proft T, Fraser JD (2005) The staphylococcal superantigen-like protein 7 (SSL7) binds IgA and complement C5 and inhibits IgA-FcaRI binding and serum killing of bacteria.. Journal of Immunology. 174(5) : 2926-2933
48. Leonard, B. L., Watson, R. N., Loomes, K. M., Phillips, A. R. J., and Cooper, G. J. S. (2005). Insulin resistance in the Zucker diabetic fatty rat: a metabolic characterisation of obese and lean phenotypes. Acta Diabetologica 42, 162-170.
49. Li, S., Peterson, N.A., Kim, M-Y., Kim, C-Y., Hung, L-W., Yu, M., Lekin, T., Segelke, B.W., Lott, J.S. and Baker, E.N. (2005). Crystal structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin. J. Mol. Biol. 346, 1035-1046.
50. Line M. Grønning, Rommaneeya Tingsabadh, Kristine Hardy, Knut Tomas Dalen, Parmjit S. Jat, Luigi Gnudi, Peter R. Shepherd (2005) Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway Am J Physiol Endocrinol Metab 290 E599-606
51. Maczek C, Berger TG, Schuler-Thurner B, Schultz ES, Hamann A, Dunbar, PR, Cerundolo V, Steinkasserer A, Schuler G (2005) Differences in phenotype and function between spontaneously occurring melan-A-, tyrosinase- and influenza matrix peptide- specific CTL in HLA-A*0201 melanoma patients. International Journal of Immunology 115(3):450-5.
52. Meilert, K., Brimble, M.A. (2005). Synthesis of the Bis-spiroacetal Moiety of Spirolides B and D. Organic Lett., 7, 3497-3500.
53. Meilert, K.T., Clark, G.R., Groutso, T., Brimble, M.A. (2005). (1S,2S)-1-{2-[(4-Methoxybenzyl)oxy]ethyl}-2-methyl-3-butenyl (1S,4R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylate. Acta Crystallographica, Section E: Structure Reports Online, E61(1), o6-o7.
54. Moreland, N., Ashton, R., Baker, H.M., Ivanovic, I., Patterson, S., Arcus, V.L., Baker, E.N. and Lott, J.S. (2005). A flexible and economical medium-throughput strategy for protein production and crystallization. Acta Cryst. sect. D 61, 1378-1385.
55. Nelson, S.M., Ferguson, L.R., Denny, W.A. (2005), The biological consequences of cellular treatment with a new class of aminoindoline compounds assessed using real-time PCR approaches. Chem. Res. Tox., 18, 239-244.
56. Palmer, B.D., Smaill, J.B., Rewcastle, G.W., Dobrusin, E.M., Kraker, A., Moore, C.W., Steinkamp, R.W., Denny, W.A. (2005). Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase wee1. Bioorg. Med. Chem. Lett., 15, 1931-1935.
57. Nickerson, D., Smith, N.P. and Hunter, P.J. (2005). New developments in a strongly coupled cardiac electromechanical model. Europace, 7, S118-S127.
58. Proft T, Fraser JD (2005) Streptococcal Superantigenic Toxins.. in . The Comprehensive Sourcebook of Bacterial Protein Toxins. 3rd edition eds. Alouf JJ, Popoff M.. Academic Press, London, U.K. : 844-861
59. Proft TP, Schrage B, Fraser JD (2005) Superantigens - Microbial toxins that target the immune system. in Microbial Toxins. Molecular and Cellular Biology eds. Proft T. Horizon Bioscience 1(1) : 179-214 ISBN 1-90493309
60. Remme, E.W., Augenstein, K.F., Young, A.A. and Hunter, P.J. Parameter (2005). Distribution models for estimation of population based left ventricular deformation using sparse fiducial markers. IEEE Transactions on Medical Imaging. 24(3):381-388.
61. Rewcastle, G.W., Sutherland, H.S., Weir, C.A., Blackburn, A.G., Denny, W.A. (2005). An improved synthesis of isonitrosoacetanilides. Tet. Lett., 46, 8719-8721.
62. Richardson, C., Rewcastle, G.W., Denny, W.A. (2005). Palladium-catalyzed cross-coupling in the synthesis of pyridinyl Boxazomycin C analogues. J. Org. Chem, 70, 7436-7438.
63. Robinson, J., Brimble, M.A. (2005). The First Enantioselective Total Synthesis of the Anti-Helicobacter Pylori Agent (+)-Spirolaxine Methyl Ether. J. Chem. Soc. Chem. Commun., 1560-1562.
64. S .P. Jackson, H. H. Salem, W. S. Nesbitt, I. Goncalves, C. L. Yap, C. E. Wright, V. Kenche, S. M. Schoenwaelder, K. E. Anderson, S. M. Dopheide, Y. Yuan, S. Sturgeon, H. Prabaharan, P. E. Thompson, G. D. Smith, P. R. Shepherd, N. Daniele, S. Kulkarni, S. Turnbull, B. Abbott, L. Lu, C. Brand, S. Giuliano, S. C. Hughan, J. Angus and A. Robertson. (2005) PI 3-kinase β involvement in integrin αIIIbβ3 mechanostransduction and arterial thrombosis Nature Medicine 11:507-514
65. Sharpe, M.l., Baker, E.N. and Lott, J.S. (2005). Crystallization of a protein using dehydration without a precipitant. Acta Cryst. sect. F 61, 565-568.
66. Shepherd P. R. (2005) Mechanisms Regulating Phosphoinositide 3-kinase Signalling in Insulin Sensitive Tissues Acta Physiologica Scandinavica 183 3-14
67. Smith CL, Dunbar PR, Mirza F, Palmowski MJ, Shepherd D, Gilbert SC, Coulie P, Schneider J, Hoffman E, Hawkins R, Old LJ, Harris AL, Cerundolo V (2005) Recombinant Modified Vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence. International Journal of Cancer 113(2):259-66.
68. Smith CL, Mirza F, Pasquetto V, Tscharke DC, Palmowski MJ, Dunbar PR, Sette A, Harris AL Cerundolo V (2005) Immunodominance of poxviral-specific CTL in a human trial of recombinant-modified vaccinia Ankara. Journal of Immunology 175 (12):8431-7
69. Squire, C. J., Dickson, J. M., Ivanovic, I. and Baker, E. N. (2005). Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. Structure 12, 541-550.
70. Tawhai, M. H., Nash, M. P., Tschirren, J., Hoffman, E. A., and Hunter, P. J. (2005). An image based computational model of ovine lung mechanics and ventilation distribution. Physiology, Function, and Structure from Medical Imaging: Proc of SPIE, vol. 5746, pp 84-91.
71. Thompson, A.M., Delaney, A.M., Hamby, J.M., Schroeder, M.C., Spoon, T.A., Showalter, H.D.H., Denny, W.A. (2005). Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the FGF and VEGF receptor tyrosine kinases. J. Med. Chem., 48, 4628-4653.
72. Trew, M., Smaill, B.H., Bullivant, D.P., Hunter, P.J., and Pullan, A.J. (2005). A generalised finite difference method for modeling cardiac electrical activation on arbitrary, irregular computational meshes. Mathematical Biosciences. 198(2), 169-189.
73. Trotter, N.S., Brimble, M.A., Harris, P.W.R., Callis, D.J., Sieg, F. (2005). Synthesis and Neuroprotective Activity of Analogues of Glycyl-L-Prolyl-L-Glutamic Acid (GPE) Modified at the α-carboxylic Acid. Bioorg. Med. Chem., 13, 501-517.
74. van Essen, N.L., Anderson, I.A., Hunter, P.J., Carman, J., Clarke, R.D. and Pullan, A.J. (2005). Anatomically based modelling of the human skull and jaw. Cells, Tissues and Organs, Vol. 180, No. 1, pp 44 – 53.
75. Walanj, R., Young, P., Baker, H. M., Baker, E. N., Metcalf, P., Chow, J. W., Lerner, S., Vakulenko, S.and Smith, C. A. (2004). Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2"-phosphotransferase-Ib [APH(2")-Ib]. Acta Cryst. sect. F 61, 410-413.
76. Wang, Y., Lam, K. S., Xu, J. Y., Lu, G., Xu, L. Y., Cooper, G. J. S., and Xu, A. (2005). Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization dependent manner. J. Biol. Chem. 280, 18341-18347.
77. Watkins, H.A., Yu, M. and Baker, E.N. (2005). Cloning, expression, purification and preliminary crystallographic data for Rv3214 (EntD), a predicted cofactor-dependent phosphoglycerate mutase from Mycobacterium tuberculosis. Acta Cryst. sect. F 61, 753-755.
78. Webby, C.J., Baker, H.M., Lott, J.S., Baker, E.N. and Parker, E.J. (2005). The structure of 3-deoxy-D-arabino-heptulosonate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for Type I and Type II enzymes. J. Mol. Biol. 354, 927-939.
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81. Yang L, Eriksson BKG, Harrington Z, Curtis N, Lang S, Currie B, Fraser JD, Proft T (2005) Variations in the protective immune response against streptococcal superantigens in populations of different ethnicity.. Medical Microbiology And Immunology. 195(1) : 37-43
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2006   

1. Abdul Majid, A.M.S., Smythe, G., Denny, W.A., Wakelin, L.P.G. (2006). Structure of the d(CGCGAATTCGCG)2 complex of the minor groove binding alkylating agent Alkamin studied by mass spectrometry. Mol. Pharmacol., in press.
2. Anderson, R.F., Shinde, S., Hay, M.P., Denny, W.A. Redox equilibria of benzotriazine N-oxide compounds that potentiate the cytotoxicity of the anticancer benzotriazine 1,4-dioxide, tirapazamine. (2006). J. Amer. Chem. Soc., 128, 245-249.
3. Angel CE, George E, Brooks AES, Ostrovsky LL, Brown TLH, Dunbar PR (2006) Cutting Edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands. Journal of Immunology 176:5730-4
4. Arcus, V.L., Lott, J.S., Johnston, J.M. and Baker, E.N. (2005). The potential impact of structural genomics on Mycobacterium tuberculosis drug discovery. Drug Discovery Today 11, 28-34.
5. Atwell, G. J., Boyd, P. B., Denny, W. A., Yang, S. (2006). 2[-Bis(2-bromoethyl)amino]-N-(2-hydroxyethyl)-3,5-dinitrobenzamide Acta Cryst., E62, 5080-5082.
6. Atwell, G. J., Yang, S., Pullen, S.M., Hogg , A., Pruijn, F.B., Patterson, A.V., Wilson, W.R., Denny, W.A. (2006). synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the E. coli nitroreductase (NTR) in gene therapy. J. Med. Chem., in press.
7. Atwell, G.J., Denny, W.A. (2006). Synthesis of 3H- and 2H4-labelled versions of the hypoxia-activated pre-prodrug 2-[(2-bromoethyl)-2,4-dinitro-6-[[[2-(phosphonooxy)ethyl]amino]carbonyl]anilino]ethyl methanesulfonate (PR-104). J. Labelled Compounds Radiopharmaceuticals., in press.
8. Billett, N.G., Phillis, A.G., Main, L., Nicholson, B.K., Denny, W.A., Hay, M.P. (2006). The 3-N-phenyl amide of all-cis-cyclopentane-1,2,3,4-tetracarboxylic acid as a potential pH-sensitive amine-releasing prodrug; intervention of imide formation around neutral pH. ARKIVOC, 3, 184-201.
9. Bradbury JE, Richards KD, Niederer HA, Lee SA, Dunbar PR, Gardner RC (2006) A homozygous diploid subset of commercial wine yeast strains. Antonie van Leeuwenhoek 89(1):27-37
10. Brimble, M.A., Bryant, C.J. (2006). Synthesis of the Spiroacetal-Containing Anti-Helicobacter Pylori Agents CJ-12,954 and CJ-13,014. J. Chem. Soc. Chem. Commun, 4506-4508.
11. Brimble, M.A., Flowers, C., Trzoss, M., Tsang, K.Y. (2006). A Facile Synthesis of Fused Aromatic Spiroacetals Based on the 3,4,3’,4’-Tetrahydro-2,2’-spirobis(2H-1-benzopyran) Skeleton. Tetrahedron, 62, 5883-5896.
12. Brimble, M.A., Halim, R. (2006). Synthetic Studies Towards the Pectenotoxins: A Review Organic and Biomolecular Chemistry, 4, 4048-4058 (Invited Review).
13. Brimble, M.A., Laita, O.S., Robinson, J.E. (2006) Addition of 2-tert-Butyldimethylsilyloxythiophene to Activated Quinones: An Approach to Thia Analogues of Kalafungin. Tetrahedron, 62, 3021-3027.
14. Brimble, M.A., Levi, M.S. (2006). A Review of Agents Patented for their Neuroprotective Properties. Recent Patents in CNS Drug Discovery, 1, 139-146.
15. Brimble, M.A., Levi, M.S. (2006). A Review of Neuroprotective Agents. In Frontiers in Medicinal Chemistry, A.B. Reitz and Atta-ur-Rahman, Eds., Bentham Scientific Publications, Karachi, 3, 163-194.
16. Brimble, M.A., Robinson, J. E, Merten, J., Beuzenberg, V., Dragunow, M., Holland. P., Mountfort, D. (2006). A Novel Bromine-Induced Ring Expansion of the Spiroimine Moiety of the Shellfish Toxin Gymnodimine. Synlett., 1610-1612.
17. Brown, P. M., Caradoc-Davies, T. T., Dickson, J. M., Cooper, G. J. S., Loomes, K. M. and Baker, E. N. (2006). Crystal structure of a substrate complex of myo-inositol oxygenase, a novel di-iron oxygenase with a key role in inositol metabolism. Proc. Natl. Acad. Sci. USA 103, 15032-15037.
18. Brown, P. M., Caradoc-Davies, T. T., Dickson, J. M., Cooper, G. J. S., Loomes, K. M. and Baker, E. N. (2006). Purification, crystallization and preliminary crystallographic analysis of mouse myo-inositol oxygenase. Acta Cryst. sect. F 62, 811-813.
19. Brown, P. M., Caradoc-Davies, T. T., Dickson, J. M., Cooper, G. J. S., Loomes, K. M., and Baker, E. N. (2006). Purification, crystallization and preliminary crystallographic analysis of mouse myo-inositol oxygenase. Acta Cryst. sect. F 62 (Pt 8), 811-813.
20. Brown, P.M., Caradoc-Davies, T. T., Dickson, J., Cooper, G. J. S., Loomes, K., and Baker, E. N. (2006). Crystal structure of mouse kidney myoinositol oxygenase, a novel di-iron oxygenase with a key role in inositol metabolism. Proc. Natl. Acad. Sci. USA 103, 15032-15037.
21. Carland, M., Abrahams, B.F., Rede, T., Stephenson, J., Murray, V., Denny, W.A., McFadyen, W.D. (2006). Syntheses and structural studies of platinum(II) complexes of O-methylselenomethionine and related ligands. Inorg. Chim. Acta, 359, 3252-3256.
22. Clark, G.R., Robinson, J.E., Brimble, M.A. (2006). (2''S,5''R,7''S)-2-[2'-(2''-Methyl-1'',6''-dioxaspiro[4.5]dec-7''-yl)ethylsulfonyl]-1,3-benzothiazole. Acta Crystallographica, Section E: Structure Reports Online, E62, 1187-1189.
23. Clark, G.R., Tsang, K.Y., Brimble, M.A. (2006). 8'-Methoxy-3H-spiro[1-naphthofuran-2,2'-chroman]. Acta Crystallographica, Section E: Structure Reports Online, E62, 1075-1076.
24. Cooper, G. J. S. (2006). Fates intertwined. Nature Biotechnol. 24, 252-254.
25. Cornish, J., Callon, K., Grey, A., Bava, U., Buchanan, C. M., Cooper, G. J. S., Watson, M., Naot, D., and Reid, I. R. (2006). Preptin, another peptide product of the pancreatic -cell, is osteogenic in vitro and in vivo. Am. J. Physiol.: Endocrinol. Metab. Epubl. August 8th.
26. Denny, W.A. Deoxyribonucleic Acid Topoisomerase Inhibitors. (2006). Chapter 7.05 in Comprehensive Medicinal Chemistry II (Editors-in-Chief, Taylor, J.; Triggle, D), Volume 7, Cancer, Anti-infective, Inflammation, Diabetes and Dermatology (Editors; Plattner, J.; Desai, M.C.), in press.
27. Dunbar R, Findlay M, Stevens G (2006) Melanoma control: few answers, many questions. New Zealand Medical Journal 119(1242):
28. Fraser JD and Proft T (2006) The Streptococcal superantigens. in Superantigens: Molecular Basis for Their Role in Human Diseases. eds. Kotb M and Fraser JD. ASM Press : in press
29. Gamage, S.A., Rewcastle, G.W., Baguley, B.C., Charlton, P.A., Denny, W.A. (2006). Phenazine-1-carboxamides: structure-cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain. Bioorg. Med. Chem., 14, 1160-1168.
30. Glyn-Jones, S., Song, S., Black, M. A., Phillips, A. R. J., Choong, S. Y., and Cooper, G. J. S. (2006). Transcriptomic analysis of the cardiac left ventricle in a rodent model of diabetic cardiomyopathy: molecular snapshot of a severe myocardial disease. Physiol. Genomics Epubl. October 24th.
31. Gong, D., Lu, J., Chen, X., Choong, S. Y., Zhang, S., Chan, Y. K., Glyn-Jones, S., Gamble, G. D., Phillips, A. R. J., and Cooper, G. J. S. (2006). Molecular changes evoked by triethylenetetramine (TETA) treatment in the extracellular matrix of the heart and aorta in diabetic rats. Mol. Pharmacol., Epubl. September 15th.
32. Goodall, K., Brimble, M.A., Barker, D. (2006). 1H and 13C NMR Data for C-6 Substituted 3-Azabicyclo[3.3.1]nonane-1-carboxylates. Magnetic Resonance in Chemistry, 44, 980-983.
33. Halim, R., Brimble, M.A., Merten, J. (2006). Synthesis of the ABC Tricyclic Fragment of the Pectenotoxins via Stereocontrolled Cyclization of a γ-Hydroxyepoxide Appended to the AB Spiroacetal Unit. Organic and Biomolecular Chemistry, 4, 1387-1399.
34. Harris, P.W.R., Brimble, M.A. (2006). “Synthesis of Isotopically Labelled Glycyl-L-Prolyl-L-Glutamic Acid (Glypromate®) and Derivatives. Journal of Labelled Compounds and Radiopharmaceuticals, 49, 571-581.
35. Harris, P.W.R., Brimble, M.A. Synthesis of Macrocyclic Analogues of the Neuroprotective Agent Glycyl-L-Prolyl-L-Glutamic Acid (GPE).(2006). Organic and Biomolecular Chemistry, 4, 2696-2709.
36. Harrison, A. J., Yu, M., Gardenborg, T., Middleditch, M., Ramsay, R. J., Baker, E. N. and Lott, J. S. (2006). The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase. J. Bacteriol. 188, 6081-6091.
37. Hicks, K.O., Pruijn, F.B., Secomb, T.W., Hay, M.P., Hsu, R., Brown, J.M., Denny, W.A., Dewhirst, M.W., Wilson, W.R. (2006). Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs. J. Natl. Cancer Inst., 86, 1118-1128.
38. Hoffmann, G.R., Yin, C.A., Terry, C.E., Ferguson, L.R., Denny, W.A. (2006). Frameshift mutations induced by four isomeric nitroacridines and their des-nitro counterpart in the lacZ reversion assay in Escherichia coli. Envir. Mol. Mutagenesis, 47, 82-94.
39. Hunter, P.J., Li, W.W., McCulloch, A.D. and Noble, D. (2006). Multiscale modeling: Physiome project standards, tools, and databases. IEEE Computer, pp66-72.
40. Jørgen Jensen, Erlend O. Brennesvik , Yu-Chiang Lai and Peter R. Shepherd (2006) GSK-3 regulation in skeletal muscles by adrenaline and insulin: Evidence that PKA and PKB regulate different pools of GSK-3 Cellular Signalling In Press
41. Kelly, V.C., Kuy, S., Palmer, D. J., Xu, Z., Davis, S. R., and Cooper, G. J. S. (2006). Characterization of bovine seminal plasma by proteomics. Proteomics 6, 5826-5833.
42. Klutchko, S.R., Zhou, H., Winters, R.T., Tran, T.P., Bridges, A.J., Althaus, I.W., Amato, D.M., Elliott, W.L., Ellis, P.A., Meade, M.A., Roberts, B.J., Fry, D.W., Gonzales, A.J., Harvey, P.J., Nelson, J.M., Sherwood, V., Han, H.-K., Pace, G., Smaill, J.B., Denny, W.A., Showalter, H.D.H. (2006). Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J. Med. Chem., 49, 1475-1485.
43. Konarkowska, B., Aitken, J. F., Kistler, J., Zhang, S., and Cooper, G. J. S. (2006). The aggregation potential of human amylin determines its cytotoxicity towards islet -cells. FEBS J. 273, 3614-3624.
44. Kotb M and Fraser JD (2006) Superantigens: Molecular Basis for Their Role in Human Diseases. ASM Press in press
45. Lee, C.E., Goodfellow, C., Javid-Majd, F., Baker, E.N. and Lott, J.S. (2006). The crystal structure of TrpD, a metabolic enzyme essential for lung colonisation by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate. J. Mol. Biol. 355, 784-797.
46. Lehmann, A., Brocke, C.,Barker, D.,Brimble, M.A. Synthesis of N-(3-Phenylpropyl)-substituted Tricyclic ABE Ring Analogues of the Alkaloid Methyllycaconitine. (2006). Eur. J. Org. Chem, 3205-3215.
47. Lott, J.S., Delbaere, L.T.J., Banfield, M.J., Sigrell, J. and Baker, E.N. (2006). A phosphohistidine residue in the 1.45 Å resolution crystal structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation. J. Biol. Chem. 281, 22131-22141.
48. Lu, J., Chan, Y. K., Gamble, G. D., Poppitt, S. D., and Cooper, G. J. S. (2006). Triethylenetetramine (TETA) and metabolites: levels in relation to copper and zinc excretion in urine of healthy volunteers and type-2 diabetic patients. Drug Metab. Dispos. Epubl. November 15th.
49. Meilert, K., Brimble, M.A. Synthesis of the Bis-spiroacetal Moiety of the Shellfish Toxins Spirolides B and D using an Iterative Oxidative Radical Cyclization Strategy. (2006). Organic and Biomolecular Chemistry, 4, 2184-2192. (Hot article and selected for front cover page).
50. Nickerson, D., Nash, M.P., Nielsen, P.M.F., Smith, N.P. and Hunter, P.J. (2006). Computational multiscale modeling in the physiome project: modeling cardiac electromechanics. IBM Research J. In Press, 2006. On line at http://www.research.ibm.com/journal/rd/506/nickerson.html
51. Nickerson, D.P. and Hunter, P.J. (2006). The Noble cardiac ventricular electrophysiology models in CellML. Prog. Biophys. Molec. Biol. 90:346-359.
52. Niederer, S.A., Hunter, P.J. and Smith, N.P. (2006). A quantitative analysis of cardiac myocyte relaxation: A simulation study. Biophysical Journal, 90:1697–1722.
53. Palmer, B.D., Thompson., A.M., Booth, J.R., Dobrusin, E.M., Kraker, A.J., Lee, H.H., Lunney, E.A., Mitchell, L.H., Ortwine, D.F., Smaill, J., Swan, L.M., Denny, W.A. (2006). 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1; structure-activity relationships for chromophore modification and phenyl ring substitution. J. Med. Chem., 49, 4896-4911.
54. Palmer, D. J., Kelly, V. C., Smit, A. M., Kuy, S., Knight, C. G., and Cooper, G. J. S. (2006). Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6, 2208-2216.
55. Poppitt, S. D., Leahy, F. E., Keogh, G. F., Wang, Y., Mulvey, T. B., Stojkovic, M., Chan, Y. K., Choong, Y. S., McArdle, B. H., and Cooper, G. J. S. (2006). Effect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy men. Eur. J. Clin. Nutr. 60, 77-84.
56. Proft T, Fraser JD (2006) Streptococcal Superantigens. in Superantigens and Superallergens. Chemical Immunology and Allergy eds. Marone G. Karger AG, Basel -(-) : in press
57. Rodriguez Garcia, E, Brimble, M.A., Vogel, P. (2006). Synthesis of New Aza-C-disaccharides Linking 4-Deoxy-4-amino-β-L-erythro-furanose to C-2 of D-Glucose and D-Allose. Eur. J. Org. Chem, 3845-3855.
58. Schmid, H., Nash, M.P., Young, A.A. and Hunter, P.J. (2006). Myocardial Material Parameter Estimation - A comparative study for simple shear, Journal of Biomechanical Engineering, 128(5) pp742-750.
59. Schrage B, Duan T, Yang L, Fraser JD, Proft T (2006) Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens - implications for treatment of streptococcal toxic shock syndrome.. Clin. Infect. Dis. -(-) : in press
60. Wang, Y., Lam, K. S., Chan, L., Chan, K. W., Lam, J. B., Lam, M. C., Hoo, R. C., Mak, W. W., Cooper, G. J. S., and Xu, A. (2006). Posttranslational modifications on the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high-molecular-weight oligomeric complex. J. Biol. Chem. 281, 16391-16400.
61. Wang, Y., Xu, L. Y., Lam, K. S., Lu, G., Cooper, G. J. S., and Xu, A. (2006). Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin. Proteomics 6, 3862-3870.
62. Watkins, H. A. and Baker, E. N. (2006). Structural and functional analysis of Rv3214 from Mycobacterium tuberculosis, a protein with conflicting functional annotations, leads to its characterization as a phosphatase. J. Bacteriol. 188, 3589-3599.
63. White, J., McFadyen, D., Carland, M., Denny, W.A., Vincent Murray, V. (2006). 9,9a-Diphenyl-1,3,4,6,7,9a-hexahydro-2H-pyrazino[1,2-a]pyrimidine at 130 K. Acta Cryst. E62, 1846-1848.
64. Wines BD, Willoughby N, Fraser JD, Hogarth PM (2006) A competitive mechanism for Staphylococcal toxin SSL7 inhibiting the leukocyte IgA receptor, Fcalpha RI, is revealed by SSL7 binding at the Calpha 2/Calpha 3 interface of IgA.. J BIOL CHEM.. 281(3) : 1389-1393
65. Wu, C. S., Greenwood, D. R., Cooney, J. M., Jensen, D. J., Tatnell, M. A., Cooper, G. J. S., and Mountjoy, K. G. (2006). Peripherally administered desacetyl-MSH and MSH both influence post-natal rat growth and associated rat hypothalamic protein expression. Am. J. Physiol.: Endocrinol. Metab. 291:E1372-E1380.
66. Yang L, Thomas M, Woodhouse A, Martin D, Fraser JD, Proft T (2006) Involvement of streptococcal superantigens in streptococcal toxic shock syndrome.. Streptococci - New Insights Into an Old Enemy. International Congress Series eds. Sriprakash KS. Elsevier 1289: 125-128 ISBN 0444522050 .
67. Young, P., Smith, C. A., Sun, X., Baker, E. N. and Metcalf, P. (2006). Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosis folylpolyglutamate synthase (MtbFPGS). Acta Cryst. sect. F 62, 579-582.
68. Zhang, S., Liu, H., Liu, J., Tse, C. A., Dragunow, M., and Cooper, G. J. S. (2006). Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic beta-cells. FEBS J. 273, 3779-3791.

PATENTS 2004-2006   

2004   

1. Denny, W.A.; Wilson, W.R.; Ware, D.C.; Atwell, G.J.; Milbank, J.B.J.; Stevenson, R.J. Anticancer 2,3-dihydro-1H-pyrrolo[3,2-f]quinoline complexes of cobalt and chromium. US PatentAppln, 2004/0138195 A1 published 15 July 2004.
2. Denny, W.A., Atwell, G.J., Yang, S., Wilson, W.R., Patterson, A.V., Helsby, N.A. Novelnitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates andtheir use as targeted cytotoxic agents. PCT Int. Appl. WO 2005042471 A1 (85 pp), published 12th May 2005.
3. Denny, W.A., Hay, M.P., Hicks, K.O., Pruijn, F.B., Wilson, W.R., Pchalek, K. Novel 1,2,4-benzotriazine-1,4-dioxides. PCT Int. Appl. WO 2005082867 A1 (67 pp) published Apr 20th 2005
4. Denny, W.A.; Atwell, G.J.; Yang, S.; Wilson, W.R. Preparation of nitroaniline-basedunsymmetrical mustard alkylating agents as prodrugs. NZ patent 521851 issued 9th June 2005.
5. Hay, M.P., Blaser, A., Denny, W.A., Hicks, K.O., Lee, H.H., Pchalek, K., Pruijn, F.B., Siim,B.G., Wilson, W.R. Tricyclic 1,2,4-triazine oxides and compositions therefrom for therapeuticuse in cancer treatments. NZ Patent application NZ 539125 filed 31st March 2005.
6. Wilson, W.R.; Hay, M.P.; Siim, B.G.; Pruijn, F.B.; Gamage, S.A.; Denny, W.A. Preparation ofbenzoazine mono-N-oxides, benzoazine-1,4-dioxides, and related analogs as hypoxia-selectivedrugs and radiosensitizers in cancer therapy. US Pat. Appl. 2004192686 A1 (88 pp) published 30th Sept 2004.
7. Fraser JD, Langley R. SET protiens and Uses Thereof. Prov. AU awared Appl. No. 2004901570 US Pending. Published 24th March 2004

2005   

1. Baker J., Cooper, G.J. 4 X Fructosamine oxidase: Agonists and Inhibitors (007-A). USA (3),AUS (1); 2005.
2. Baker J., Cooper, G.J. Fructosamine oxidase assay: Materials and Methods (007-B). USA, AUS,NZ; 2005.
3. Baker J., Cooper, G.J. Fructosamine oxidase: Agonists and Inhibitors (007-A) NZ. PCT; 2005.
4. Cooper, G.J.S.; Baker. J.S.. Preventing and/or treating cardiovascular disease and/or associatedheart failure U.S. Patent No. 6,951,890.
5. Cooper, G.J., Buchanan, C.M. Peptide Having Preptin Functionality. NZ. 515722; 2005.
6. Cooper, G.J., Buchanan, C.M. Preptin having preptin functionality. Australia. 57178/00; 2005.
7. Cooper, G.J., Xu A., Wang Y. Phosphoprotein target for insulin and its antagonists. USA.114,540; 2005.
8. Cooper, G.J., Xu A., Wang Y.. A Novel Peptide and its uses thereof. NZ. PCT;2005.
9. Cooper, G.J. Copper Antagonist Compounds. NZ. PCT; 2005.
10. Baguley, B. C., Deady, L.W., Denny, W.A., Rodemann, T., Rogers, M.L. Anti-tumour polycyclic carboxamides EP 1507778A (89 pp), published 23rd Feb, 2005.
11. Denny, W.A., Atwell, G.J., Yang, S., Wilson, W.R., Patterson, A.V., Helsby, N.A. Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents. PCT Int. Appl. WO 2005042471 A1 (85 pp), published 12th May
12. Gluckman, P.D., Guan, J., Woodnorth, M., Brimble, M.A. Cognitive Enhancement and Cognitive Therapy using Glycyl-L-2-methylprolyl-L-glutamic acid. United States Patent Appl., 2005, Appl. No: 11/315,784, Published 21st December 2005.
13. Gluckman, P.D., Thomas, G.B., Guan, J., Dragunow, M., Anand, A.K., Kerlero de Rosbo, N., Sieg, F., Brimble, M.A. Effects of Glycyl-2 Methyl Prolyl-L-Glutamate on Neurodegeneration. United States Patent Appl., 2005, Appl. No: 11/314,424. Published 20th December 2005.

2006   

1. Brimble, M.A., Guan, J., Sieg, F. Cyclic G-2AllylP in Treatment of Parkinson’s Disease. United States Patent Appl., 2006, Appl. No: 11/399,974. Published 7th April 2006.
2. Brimble, M.A., Harris, P.R., Sieg, F. Analogs of Glycyl-Prolyl-Glutamate. PCT Int. Appl., 2006, 102pp, Appl. No: (number not assigned) Published 23rd May 2006.
3. Denny, W.A., Copp, B.R., Pearce, A.N., Berridge, M.V., Harper, J.L., Perry, N.B., Larsen, L., Godfrey, C.A. Anti-inflammatory compounds. PCT Int. Appl. WO 2006031134 A1 (45 pp). Published 23rd Mar 2006.
4. Denny, W.A., Patterson, L.H., Halbert, G.W., Ford, S.J. Formulations of anthraquinone derivatives (28 pp). (BTG plc). US Patent 7,074,835 B2 (13 pp). Published 11th July 2006.
5. Denny, W.A., Wilson, W.R., Stevenson, R.J., Tercel, M., Atwell, G.J., Yang, S, Patterson, A.V., Pruijn, F.B. Nitrobenzindoles, particularly 1-(chloromethyl)-5-nitro-3-(indol-2-ylcarbonyl)-1,2-dihydro-3H-benzo[e]indoles, and their preparation, activity, pharmacokinetics, pharmaceutical compositions, and use in cancer therapy. PCT Int. Appl. WO 2006043839A1 (154 pp). Published 27th May 2006.
6. Denny, W.A.; Wilson, W.R.; Ware, D.C.; Atwell, G.J.; Milbank, J.B.J.; Stevenson, R.J. Anti-cancer 2,3-dihydro-1H-pyrrolo[3,2-f]quinoline complexes of cobalt and chromium. US patent 7,064,117 (44 pp). Published 20th June 2006.
7. Gluckman, P.D., Brimble, M.A., Wilson, D., Tortella, F.C., Williams, A.J., Xi-Chun, M.L., Hartings, J.A., Gryder, D. Treatment of Non-convulsive Seizures in Brain Injury using G-2MePE. United States Patent Appl., 2006, Appl. No: 11/398,032. Published 4th April 2006.
8. Harris, P.R., Brimble MA., Muir, V. Synthetic Analogs of Neural Regeneration Peptides.United States Provisional Appl., 2006, Appl No: (number not assigned). Published 12th May 2006.
9. Hay, M.P., Blaser, A., Denny, W.A., Hicks, K.O., Lee, H.H., Pchalek, K., Pruijn, F.B., Siim, B.G., Wilson, W.R., Yang, S. Preparation of tricyclic 1,2,4-triazine oxides as cancer treatments. PCT Int. Appl. WO2006104406A1 (204 pp). Published 5th October 2006.
10. Sieg,F., Brimble, M.A., Muir, V. Neural Regeneration Peptides and Methods for their Use. PCT Int. Appl., 2006, Appl. No: (number not assigned). Published 5th May 2006.
11. Fraser JD, Wines B SSL7 mutants. Provisional AU Appl. No. 2006905858 Published 20th October 2006.